Granlibakken Tahoe Floorplan

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This meeting took place in 2003



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Molecular and Cellular Basis of Septic Shock (D3)


Organizer(s) Richard Bucala, Seamas Donnelly and Barbara Sherry
March 7—11, 2003
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 7, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 7, 2003

Supported by Keystone Symposia

Summary of Meeting:
Despite important advances in our ability to diagnose and treat infectious diseases, the mortality attributed to septic shock - the most severe complication of infection - remains a significant medical problem. The last several years have witnessed important advances in our understanding of host-pathogen interactions, particularly in the areas of inflammatory cell interaction with gram-positive and gram-negative bacteria, endotoxin recognition and signaling, and genetic differences in susceptibility to septic complications. Important new mediators of sepsis, and novel mechanisms of host cell toxicity such as apoptosis also have been identified. This information, together with data from recently completed clinical trials targeting pathways considered central to sepsis pathogenesis, provide an important foundation for defining the molecular and cellular basis of sepsis and formulating new strategies for intervention. The goal of this Keystone symposium will be to integrate this new information into an interdisciplinary approach toward understanding sepsis pathogenesis.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 7

15:00—19:00
Registration

Pre-Function
19:15—19:30
Orientation

Mountain/Lake Rooms
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Richard J. Bucala, Yale University School of Medicine, USA

Edward Abraham, University of Alabama at Birmingham, USA
Sepsis: Definitions, Epidemiology and Therapeutic Approaches


SATURDAY, MARCH 8

07:00—08:00
Breakfast

Granhall
08:00—11:00
Overview of Sepsis and Multi-Organ Failure
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Seamas C. Donnelly, University College Dublin, Ireland
Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Failure Syndrome (MOFS)

Jonathan Cohen, University of Brighton, UK
Sepsis in the Immuno-Compromised Host

Thierry F. Calandra, Centre Hospitalier Universitaire Vaudois, Switzerland
Macrophage Migration Inhibitory Factor (MIF) Regulation of Innate Immunity

Thomas J. Murphy, , Ireland
Short Talk: A Central Role for CD4+ T-Cells in Regulating the Pro-Inflammatory Response to TLR Agonists after Injury

Claudia Farias Benjamim, Biomedical of Science, Brazil
Short Talk: Septic Mice Fail to Mount an Appropriate Innate Immune Response during Secondary Infection by Aspergillus fumigatus

Mark M. Wurfel†, University of Washington, USA
Short Talk: Patterns of Inter-Individual Variation in Inflammatory Responses to Lipopolysaccharide Revealed by Gene Expression Arrays

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Biology of the Innate Immune Response
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Drosophila Immunity

Daniel G. Remick, University of Michigan Medical School, USA
Heterogeneity of the Septic Inflammatory Response

Donald N. Cook, NIEHS, National Institutes of Health, USA
A Genetic Analysis of the Innate Immune Response to Endotoxin

19:00—20:00
Dinner

Granhall
20:00—21:00
Social Hour

Bay Room
20:00—22:00
Poster Session 1

Bay Room

SUNDAY, MARCH 9

07:00—08:00
Breakfast

Granhall
08:00—11:00
Microbial and Molecular Pathogenesis of Sepsis
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Immunogenetics and Susceptibility to Infectious Diseases

* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Cell Signaling Pathways in Innate Immunity

Alice Prince, Columbia University, USA
Bacterial Interactions with Pulmonary Epithelium

Paul W. Noble, Yale University School of Medicine, USA
Role of CD44 in the Resolution of Lung Inflammation

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Downstream Effects of Microbial Invasion
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Peter A. Ward, University of Michigan Medical School, USA
Role of C5a and C5aR in Sepsis

Adriano Giorgio Rossi, University of Edinburgh, UK
Apoptosis and the Resolution of Inflammation

Barbara Sherry, North Carolina State University, USA
Cell Trafficking Abnormalities in Sepsis

19:00—20:00
Dinner

Granhall
20:00—21:00
Social Hour

Bay Room
20:00—22:00
Poster Session 2

Bay Room

MONDAY, MARCH 10

07:00—08:00
Breakfast

Granhall
08:00—11:00
Regulatory Pathways of the Systemic Inflammatory Response
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Richard J. Bucala, Yale University School of Medicine, USA

Joost J. Oppenheim, National Institutes of Health, USA
Many Chemokines and Defensins Exhibit Antimicrobial as well as Immunoadjuvant Activities

Akihiko Yoshimura, Keio University, Japan
Suppression of TLR Signaling and Inflammation by SOCS Family Proteins

Kevin J. Tracey, Feinstein Institute for Medical Research, USA
Systemic Inflammation and Nerve Stimulators: From TNF to HMGB-1

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Therapeutic Intervention in Septic Shock
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Barbara Sherry, North Carolina State University, USA

Richard J. Bucala, Yale University School of Medicine, USA
Mif Alleles and the Genetic Basis for Macrophage Responsiveness

Charles T. Esmon, Oklahoma Medical Research Foundation, USA
Protein C Pathways Critical for Septic Shock

Fletcher B. Taylor Jr., Oklahoma Medical Research Foundation, USA
Some New Observations on the Pathophysiology of Primate E. coli Sepsis

19:00—20:00
Social Hour

Granhall
20:00—21:00
Dinner

Granhall
21:00—12:00
Entertainment

Granhall

TUESDAY, MARCH 11

 
Departure


*Session Chair †Invited, not yet responded.



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