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This meeting took place in 2003



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The Enzymology of Chromatin and Transcription (D4)


Organizer(s) Shelley L. Berger and Jerry L. Workman
March 10—16, 2003
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Nov 11, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 10, 2003

Supported by Keystone Symposia

Summary of Meeting:
Enzymes have a direct role in transcriptional regulation. Enzymes that affect chromatin structure and function alter the template and so regulate transcription. In addition, the transcriptional machinery itself contains enzymes that carry out and regulate RNA synthesis. It is critical to determine how these different levels of regulation work together to alter gene expression. One major issue in transcription is the function of two major enzyme classes that affect chromatin: the histone modifiers and the ATP-dependent remodelers. The overarching question is how these two classes of chromatin enzymes work together to influence the basal transcriptional machinery to ultimately regulate genes. The meeting goals are to discuss functions of chromatin modification and remodeling enzymes, mechanisms involved in transcriptional initiation/elongation, and finally, how alteration of chromatin translates into regulation of basal transcription. The program will bring together experts in chromatin and transcriptional regulation to focus on the intersection between these areas.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 10

15:00—19:00
Registration

Promenade
18:15—19:15
Welcome

Promenade
19:15—19:30
Orientation

Mesa Ballroom
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Jerry L. Workman, Stowers Institute for Medical Research, USA

* Shelley L. Berger, University of Pennsylvania, USA

C. David Allis, Rockefeller University, USA
Deciphering and Translating the Histone Code: A Tale of Tails


TUESDAY, MARCH 11

06:30—08:00
Breakfast

Chamisa/Piñon
08:00—11:00
Histone and Factor Acetylation
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Dimitris Thanos, Columbia University, USA
Deciphering the Transcriptional Code of Human Genes

* Robert G. Roeder, Rockefeller University, USA
Integrated Functions of Diverse Coactivators in vitro

Patrick A. Grant, University of Virginia, USA
Short Talk: The Role of Dysfunctional Chromatin Modification in Neurodegenerative Disorders

Edith H. Wang, University of Washington, USA
Short Talk: Function of TAF1 Histone Acetyltransferase Activity in Sp1 Mediated Activation of Cyclin D1 Transcription

John C. Lucchesi, Emory University, USA
Short Talk: An Experimental Paradigm for the Study of the MSL Complex and Dosage Compensation in Drosophila

09:20—09:40
Coffee Break

Promenade/Front Lobby
11:00—13:00
Poster Setup

Mesa C/Aspen/Promenade
13:00—22:00
Poster Viewing

Mesa C/Aspen/Promenade
14:30—16:30
Workshop 1

Mesa Ballroom
* Jerry L. Workman, Stowers Institute for Medical Research, USA

Shaun M. Cowley, University of Leicester, UK
Functional Analysis of the Co-Repressor mSin3A

Colyn Crane-Robinson, University of Portsmouth, UK
Developmental Changes in Core Histone Acetylation across the Chicken Lysozyme Locus during Macrophage Maturation

Jorge A. Gomez, Emory University, USA
Global Regulation of the MHC Locus by Class II Transactivator

Todd S. Macfarlan, NICHD, National Institutes of Health, USA
TBIP, a Novel Transcriptional Regulator Linking Chromatin Modifications and Transcriptional Repression

Hyangyee Oh, Baylor College of Medicine, USA
Extent of Chromatin Spreading Determined by roX RNA Recruitment of MSL Proteins

Jacques Côté, Laval University Cancer Research Center, Canada
Recruitment of Chromatin Modifying Activities by Phosphorylation of Histone H2A

Jocelyn E. Krebs, University of Alaska, Anchorage, USA
Role of the Histone H2A C-Terminal Tail in Double Strand Break Repair in Yeast

Michael R. Hubner, European Molecular Biology Laboratory, Germany
Estrogen Receptor Alpha Transcriptional Cycles are Proteasome Dependent

16:30—17:00
Coffee & Snacks Available

Promenade/Front Lobby
17:00—19:15
Histone Deacetylation. Session Sponsored by Upstate Biotechnology, Inc.
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Michael Grunstein, University of California, Los Angeles, USA
Evidence for the Mechanism by which Yeast Heterochromatin Initiates, Spreads and is Blocked from Spreading

* Rolf Sternglanz, Stony Brook University, USA
The BAH Domain of Sir3 and Orc1 can Substitute for Sir3 at the HM Loci

Danny F. Reinberg, HHMI/New York University, USA
Chromatin and its Impact on Gene Expression and Cellular Memory

Masami Horikoshi, University of Tokyo, Japan
Short Talk: Novel Chromatin Modulating Mechanisms in Both Trancription and Silencing/Anti-Silencing

Ed Seto, H. Lee Moffitt Cancer Center, University of South Florida, USA
Short Talk: Targeted Recruitment of a Histone H4-Specific Methyltransferase by the Transcription Factor YY1

19:15—20:15
Social Hour

Mesa C/Aspen/Promenade
20:00—22:00
Poster Session 1

Mesa C/Aspen/Promenade

WEDNESDAY, MARCH 12

06:30—08:00
Breakfast

Chamisa/Piñon
08:00—11:15
Histone Methylation. Session Sponsored in part by Abcam, Ltd.
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Role of RNAi Machinery in Heterochromatin Assembly and Chromosome Dynamics

Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Histone Methylation in Polycomb Silencing and X-Inactivation

Tony Kouzarides, University of Cambridge, UK
Histone Modifications in Transcriptional Control

Michael R. Stallcup, University of Southern California, USA
Arginine Methylation of Proteins in Transcriptional Regulation

Uwe Sauer, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Short Talk: Epigenetic Activation of Transcription by ASH1-Mediated Methylation of Nucleosomal Histones

Brian D. Strahl, University of North Carolina at Chapel Hill, USA
Short Talk: Phosphorylation of RNA Polymerase II CTD Regulates H3 Methylation in Yeast

09:20—09:40
Coffee Break

Promenade/Front Lobby
11:15—13:00
Poster Setup

Mesa C/Aspen/Promenade
13:00—22:00
Poster Viewing

Mesa C/Aspen/Promenade
14:30—16:30
Workshop 2

Mesa Ballroom
* Craig L. Peterson, University of Massachusetts Medical School, USA

Barbara A. Burkhart, NIEHS, National Institutes of Health, USA
Repression of the MMTV Promoter by NFkappaB p65 and E1A is Regulated by Chromatin Remodeling

Geetha Vani Rayasam, National Institutes of Health, USA
Ligand Specific Displacement of the Progesterone Receptor (PR) during Chromatin Remodeling at the MMTV Promoter

Ann Dean, NIDDK, National Institutes of Health, USA
An Enhancer Causes both Discrete and Widespread Alterations of Chromatin Structure

Thomas G. Fazzio, University of Massachusetts Medical School, USA
S. cerevisiae Isw2 Complex Utilizes a Nucleosome Sliding Mechanism to Remodel Chromatin in vivo

Andrew K. Dingwall, Loyola University Chicago, USA
SNR1 (SNF5/INI1), a Conserved Component of the Brahma (Brm) Chromatin Remodeling Complex, Exhibits Multiple Roles in Facilitating Brm Complex Activities during Development

Julie Huang, Harvard Medical School, USA
Specific Recruitment of the RENT Silencing Complex to the rDNA Recombination Hotspot

Ann E. Ehrenhofer-Murray, Humboldt-Universität zu Berlin, Germany
Restoration of Histone Modifications after DNA Replication: The Sas2-Containing SAS-I Complex Interacts with the Large Subunit of the Chromatin Assembly Complex CAF-1 and with Asf1

Mohamedi N. Kagalwala, Siragen Pharmaceuticals, Inc., USA
ISW2 Interaction with Linker DNA Dictates the Direction and Extent of Nucleosomes Sliding

16:30—17:00
Coffee & Snacks Available

Promenade/Front Lobby
17:00—19:15
Ubiquitination/Proteolysis
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Joan W. Conaway, Stowers Institute for Medical Research, USA
Elongin BC-Based Ubiquitin Ligases and Transcriptional Regulation

Thomas Kodadek, The Scripps Research Institute, USA
The Role of Proteasomal Proteins in Transcription

* Mary Ann Osley, University of New Mexico School of Medicine, USA
Histone Ubiquitylation and Transcriptional Activation

Karl W. Henry, Wistar Institute, USA
Short Talk: Covalent Modifications of Histones in Gene Activation

Jessica S. Uhren, University of Alberta, Canada
Short Talk: Regulation of Histone Modification State by the Anaphase Promoting Complex

19:15—20:15
Social Hour

Mesa C/Aspen/Promenade
20:00—22:00
Poster Session 2

Mesa C/Aspen/Promenade

THURSDAY, MARCH 13

06:30—08:00
Breakfast

Chamisa/Piñon
08:00—11:15
ATP-Dependent Chromatin Remodeling
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Craig L. Peterson, University of Massachusetts Medical School, USA
Chromatin Remodeling Machines

* Robert E. Kingston, Massachusetts General Hospital, USA
Distinct Roles for ATP-Dependent Chromatin Remodeling Complexes

Bradley R. Cairns, HHMI/University of Utah, USA
Mechanism and Regulation of the Chromatin Remodeling Complex RSC

Tom Owen-Hughes, University of Dundee, Scotland
Mechamisms for Nucleosome sliding

Anthony N. Imbalzano, University of Massachusetts Medical School, USA
Short Talk: In vivo Binding of Muscle Regulators to a Muscle-Specific Promoter Requires SWI/SNF Chromatin Remodeling Enzymes: SWI/SNF-Mediated Activator Binding, Not Activator-Mediated Targeting of SWI/SNF

Liming Li, Northwestern University Medical School, USA
Short Talk: Prion-Mediated Regulation of Yeast SWI/SNF Function

09:20—09:40
Coffee Break

Promenade/Front Lobby
11:15—13:00
Poster Setup

Mesa C/Aspen/Promenade
13:00—22:00
Poster Viewing

Mesa C/Aspen/Promenade
14:30—16:30
Workshop 3

Mesa Ballroom
* Shelley L. Berger, University of Pennsylvania, USA

Cheng-Ming Chiang, Case Western Reserve University, USA
Human Papillomavirus E2 Protein Assembles a Novel Coactivator Complex Containing SWI/SNF, GCN5 and TFIID

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
Transcriptional Regulation and Chromatin Remodeling at the IL-13 Locus

Antonin Morillon, Institut Curie, France
Yeast Isw1p Chromatin Remodeling ATPase Regulates RNA Pol II Functions Involved in Early and Late Transcription Events

Marjorie C. Brand, Fred Hutchinson Cancer Research Center, USA
Qualitative and Quantitative Differences in the Association of Chromatin Modifying Complexes with a Specific Transcription Factor at Different Stages of Erythroid Differentiation Revealed by a Quantitative Mass Spectrometry Study

Kyoko Yokomori, University of California, Irvine, USA
Specific Recruitment of SMC-Containing Complexes to Chromosomes

Benoit Miotto, IBDM, France
The MYST Acetyltransferase Chameau is a New JNK Signaling Pathway Nuclear Cofactor Linking JNK Activity to Chromatin Structure Regulation

Astrid E. Visser, University of Amsterdam, Netherlands
Epigenetic Inheritance of Centromeres: Timing of CENP-A Incorporation into Centromeres

Abbie Saunders, Cornell University, USA
Kinetic Analysis of the Transcription Apparatus on Drosophila Hsp70

16:30—17:00
Coffee & Snacks Available

Promenade/Front Lobby
17:00—19:15
Silencing
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Lori Wallrath, University of Iowa, USA
The Role of HPI in Gene Silencing - Heterochromatic and Euchromatic Sites

Sarah C.R. Elgin, Washington University, USA
HP1, HP2, and the Organization of the Fourth Chromosome

Robin C. Allshire, University of Edinburgh, UK
Fission Yeast Centromeres: Silencing and Function

Daniel R. Mallin, University of Minnesota, USA
Short Talk: Functional Analysis of the SCM Polycomb Group Repressor in vivo and in vitro

Yuya Ogawa, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Xite, X-Inactivation Intergenic Transcription Elements that Regulate the Probability of X-Chromosome Choice

19:15—20:15
Social Hour

Mesa C/Aspen/Promenade
20:00—22:00
Poster Session 3

Mesa C/Aspen/Promenade

FRIDAY, MARCH 14

06:30—08:00
Breakfast

Chamisa/Piñon
08:00—11:15
Recruitment/Initiation/Elongation
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Steven Hahn, Fred Hutchinson Cancer Research Center, USA
Probing the Mechanism of Transcription Initiation Using Small Molecule Inhibitors and Site-Specific Photocrosslinking

* Stephen Buratowski, Harvard Medical School, USA
Connecting Transcription with Chromatin and mRNA Processing

Caroline M. Kane, University of California, Berkeley, USA
The Continuing TFIIS Story: New Molecular Interactions and Identification of Genes Regulated in vivo in Saccharomyces cerevisiae

Jesper Q. Svejstrup, Francis Crick Institute, UK
Histone Acetylation and Transcript Elongation

Nicholas J. Proudfoot, University of Oxford, UK
Short Talk: Interconnections Between mRNA Processing and Trascription

Erica Y. Jacobs, Rockefeller University, USA
Short Talk: Role of the Pol II Large Subunit C-Terminal Domain (CTD) in snRNA Transcription and Processing

09:20—09:40
Coffee Break

Promenade/Front Lobby
11:15—13:00
Poster Setup

Mesa C/Aspen/Promenade
13:00—22:00
Poster Viewing

Mesa C/Aspen/Promenade
14:30—16:30
Workshop 4

Mesa Ballroom
* Ronen Marmorstein, Wistar Institute, USA

John J. Wyrick, Washington State University, USA
Genome-Wide Analysis of Histone Acetylation and Heterochromatin

Bradley E. Bernstein, Massachusetts General Hospital, USA
Global Analyses of Histone Modifications in Yeast

Kristi L. Penheiter, University of Colorado Health Sciences Center, USA
Global Analysis of Primary and Secondary Targets of the Paf1/RNA Polymerase II Complex

Eli V. Hestermann, Dana Farber Cancer Institute, USA
Transcriptional Targets of the p160 Cofactors

Karishma Manzur, Mount Sinai School of Medicine, USA
Solution Structure and Substrate Specificity of a Histone Lysine Methyltransferase from Paramecium bursaria Chlorella Virus 1

Jinrong Min, University of Toronto, Canada
Structure of the Catalytic Domain of Human Dot1L, a Non-SET Domain Nucleosomal Histone Lysine Methyltransferase

16:30—17:00
Coffee & Snacks Available

Promenade/Front Lobby
17:00—19:15
Biology
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
Functions of Histone Modifying Enzymes

Frank J. Rauscher III, Wistar Institute, USA
Coordinating Histone Modification, Hp1 Deposition and DNA Methylation: A Model for Gene Variegation at Euchromatic Loci in Mammals

Ramin Shiekhattar, University of Miami, USA
Human ISWI-Containing Complexes

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Signal-Dependent Functions of HDACs in Muscle Development and Growth

19:15—20:15
Social Hour

Mesa C/Aspen/Promenade
20:00—22:00
Poster Session 4

Mesa C/Aspen/Promenade

SATURDAY, MARCH 15

06:30—08:00
Breakfast

Chamisa/Piñon
08:00—11:15
Structure
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Ronen Marmorstein, Wistar Institute, USA
Structural and Chemical Basis for Histone Acetylation

Karolin Luger, Colorado State University, USA
Crystallographic Studies of Nucleosomes Containing Sin Mutant Histones

* Steve Gamblin, Institute for Medical Research, UK
Histone Methyltransferases: A Structural and Functional View

Raymond C. Trievel, University of Michigan, USA
Short Talk: Crystal Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase

Andres Ernesto Leschziner, University of California, Berkeley, USA
Short Talk: The Electron Microscopic Structure of the Human SWI/SNF-B Chromatin Remodeling Complex at ~35Å Resolution

Rivka Dikstein, Weizmann Institute of Science, Israel
Short Talk: Evolutionary Conserved DNA Binding Activity by the H2A-Like TAF4

Donal S. Luse, Cleveland Clinic Foundation, USA
Short Talk: The Transition from Initiation to Elongation by RNA Polymerase II

Xing Zhang, Emory University, USA
Structure of Neurospora Histone Methyltransferase DIM-5 in Complex with a H3 Peptide

09:20—09:40
Coffee Break

Promenade/Front Lobby
16:30—17:00
Coffee & Snacks Available

Promenade/Front Lobby
17:00—19:15
Genomics/Proteomics/Regulatory Circuits
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Genome Regulatory Networks in Living Cells

* Peggy J. Farnham, University of Southern California, USA
Using Chromatin Immunoprecipitation and CpG Microarrays to Identify Genomic Sites Occupied by Components of E2F Transcription Complexes

Jack F. Greenblatt, University of Toronto, Canada
Short Talk: Transcriptional Elongation by RNA PO1 II in Saccharomyces cerevisiae

Min-Hao Kuo, Michigan State University, USA
Short Talk: Genetic Screen and Functional Studies of Novel Acetylated Histone-Binding Proteins

Ali Shilatifard, Northwestern University, USA
Short Talk: Functional Genomic Analyses of Histone Modification in the Regulation Gene Expression by RNA Polymerase II

B. Franklin Pugh, Pennsylvania State University, USA
Short Talk: Coordination of TFIID and SAGA

20:00—21:00
Social Hour

Mesa Ballroom
21:00—00:00
Entertainment

Mesa Ballroom

SUNDAY, MARCH 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA099198-01




We gratefully acknowledge additional support for this conference from:

Abcam plc

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