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This meeting took place in 2003



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Molecular Aspects of Transmissible Spongiform Encephalopathies (Prion Diseases) (E4)


Organizer(s) Byron Caughey, Charles Weissmann, Suzette Priola and Bruce Chesebro
April 2—6, 2003
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Dec 3, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 3, 2003

Sponsored by Roche Diagnostics

Summary of Meeting:
The epidemic of bovine spongiform encephalopathy and its spread into humans has led to a marked expansion of research on the molecular bases of transmissible spongiform encephalopathies (TSE) or prion diseases. Studies with transgenic and prion protein (PrP)-knockout mice have established that PrP is critical in TSE transmission and pathogenesis. Much has been learned about the normal structure and folding options of recombinant PrP molecules and the interactions and interconversions between normal and TSE-associated PrP isoforms. Functional studies have suggested possible normal and disease associated roles for PrP. However, the essential nature of the infectious agent, the structure of TSE-associated PrP isoforms, and the mechanism(s) by which they cause disease are not yet clear. Furthermore, practical therapies and ante-mortem diagnostic tests are sorely lacking. This symposium will attempt to summarize the state of the field and to consider solutions to the problems posed by these enigmatic diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 2

15:00—19:00
Registration

Third Floor Foyer
18:15—19:15
Welcome

Third Floor Foyer
19:15—19:30
Orientation

Peaks 4-5
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Stanley B. Prusiner, University of California, San Francisco, USA
Prion Diagnostics and Therapeutics


THURSDAY, APRIL 3

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
TSE Agents and Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Byron Caughey, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA

Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunobiology of Prion Diseases

Bruce W. Chesebro, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Changes in PrP-res Conformation Associated with Scrapie Strains and Cross-Species Scrapie Infection

John Collinge, Institute of Neurology, University College London, UK
Prion Strains and Interspecies Transmission

Pierluigi Gambetti, Case Western Reserve University, USA
PrPsc Species in Human Prion Diseases

Richard A. Bessen, Montana State University, USA
Short Talk: Rapid Prion Neuroinvasion Following Extraneural Inoculation of the Tongue is Independent of Agent Replication in the Lymphoreticular System

Glenn L. Millhauser, University of California, Santa Cruz, USA
Short Talk: The “Holo” Story of the Prion Protein – A First Look at PrP With All of its Copper Sites

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Structures and Propagation of Prion Proteins
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Witold K. Surewicz, Case Western Reserve University, USA

Kurt Wüthrich, ETH Zürich, Switzerland
Species Variation of the 3D Structure of the Cellular Prion Protein

Reed B. Wickner, National Institutes of Health, USA
[URE3] Prion is a Self-Propagating Amyloid of Ure2p: Mechanisms

Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Yeast to Mice: Model Systems in Neurodegenerative Disease

Susan W. Liebman, University of Illinois, USA
Short Talk: Prions Destabilize Other Prions: Unstable [PSI+] Variants

19:00—20:00
Social Hour

Peaks 1-3
20:00—22:00
Poster Session 1

Peaks 1-3

FRIDAY, APRIL 4

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Prion Protein and Pathogenesis
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Pierluigi Gambetti, Case Western Reserve University, USA

Charles Weissmann, Scripps Institute, USA
Propagation of Prions

Jean C. Manson, Institute for Animal Health, Edinburgh, UK
Targeting the Murine Prnp Gene

Suehiro Sakaguchi, Nagasaki University Graduate School of Medicine, Japan
Roles of PrP and PrP-Like Protein (Doppel) in Neurodegeneration

Martin Jeffrey, Lasswade Veterinary Laboratory, UK
Pathogenetic Significance of Disease-Specific PrP Accumulation Phenotypes

Gerald S. Baron, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Short Talk: Effect of GPI-Anchor-Dependent and –Independent Prion Protein Association with Raft Membranes on Conversion to the Protease-Resistant Isoform

Vilma R. Martins, Ludwig Institute for Cancer Research, Brazil
Short Talk: Is PrPc Loss-of-Function Associated to Human Epilepsies?

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Formation and Misfolding of PrP
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Jean C. Manson, Institute for Animal Health, Edinburgh, UK

Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
PrP-res and Strain Glycoform Variation

David A. Harris, Washington University School of Medicine, USA
Biosynthesis and Metabolism of Wild-Type, Mutant, and Transmembrane PrP

Witold K. Surewicz, Case Western Reserve University, USA
Folding, Misfolding and Fibrillization of the Recombinant Prion Protein

Jerson Lima da Silva, Federal University of Rio de Janeiro, Brazil
Short Talk: Catalytic Action of Nucleic Acids on the Conversion of Prion Protein into the Beta-Sheet Conformation

19:00—20:00
Social Hour

Peaks 1-3
20:00—22:00
Poster Session 2

Peaks 1-3

SATURDAY, APRIL 5

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Biochemical Aspects of Neuropathogenesis
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* David A. Harris, Washington University School of Medicine, USA

Fabrizio Tagliavini, Carlo Besta National Neurological Institute, Italy
Neurotoxicity of Abnormal Forms and Fragments of PrP

Sylvain Lehmann, Centre National de la Recherche Scientifique, France
Cellular Responses to Prion Infection

David R. Brown, University of Bath, UK
Copper Binding and Antioxidant Activity of PrP

James Hope, , UK
Detection of Proteinase-K Resistant PrP in Sheep Blood by Immuno-Capillary Electrophoresis (ICE) and its Association with Scrapie : An Interim Report

Rafael Linden, Instituto de Biofísica, Universidade Federal do Rio de Janeiro, Brazil
Short Talk: The Cellular Prion Protein Modulates Phagocytosis and Inflammatory Response

Teresa J.T. Pinheiro, University of Warwick, UK
Short Talk: Aggregation and Fibrillization of Prion Proteins in Lipid Membranes

09:20—09:40
Coffee Break

Foyer
14:30—16:50
Workshop: Short Talks on Hot Topics

* Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA

E. Fiona Houston, Institute for Animal Health, UK
Transmission of BSE to Sheep Thought to be Genetically Resistant to Infection

Anna A. Bencsik, AFSSA, Agence Française de Sécurité Sanitaire des Aliments, France
A Neural Graft Approach in the Understanding of Florid Plaques Occurrence in Ovine BSE Infected Tg(OvPrP4) Mice

Joëlle Chabry, Institut de Pharmacologie Moléculaire et Cellulaire, France
in vivo and in vitro Neurotoxicity of the Human Prion Protein Fragment P118-135 Independently to PrP Expression

Angela Y. Jen, King's College London, UK
PrPc Moves Out of Lipid Rafts to be Internalised

Heike Eberl, Institut for Molecular Biology and Biophysics, Switzerland
Structure and Stability of Membrane-Attached, Recombinant Prion Protein

Kerstin Elfrink, Heinrich-Heine-Universität, Germany
Conformational Transition of PrPC in vitro

Ilia V. Baskakov, University of Maryland School of Medicine, USA
Pathway Complexity of the Prion Protein Assembly

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Diagnostics and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* James Hope, , UK

Dominique Dormont, Commissariat a l'Energie Atomique, France
Therapeutic Strategies for Transmissible Spongiform Encephalopathies

Hans Kretzschmar, Ludwig Maximilians University, Germany
Post-Exposure Prophylaxis against Prion Disease using a Stimulator of Innate Immunity

Jiri G. Safar, University of California, San Francisco, USA
Detection and Strain-Dependent Differences in the Disease-Causing Prion Protein (PrPSc)

Robert B. Peterson, Case Western Reserve University, USA
Short Talk: Diagnostics and TSEs: A Case for Simplicity

19:00—20:00
Social Hour

Peaks 1-3
20:00—23:00
Entertainment

Peaks 1-3

SUNDAY, APRIL 6

 
Departure


*Session Chair †Invited, not yet responded.



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Roche Diagnostics GmbH

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