Sheraton Steamboat Resort Floorplan

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This meeting took place in 2004



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Biological Discovery Using Diverse High-Throughput Data (D5)


Organizer(s) David K. Gifford, Edward M. Rubin and Richard A. Young
March 30—April 4, 2004
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 1, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 30, 2004

Supported by Keystone Symposia

Summary of Meeting:
The meeting will explore the frontiers of biology and medicine from the perspective of genomes, transcriptomes, proteomes and other forms of global information. Its aim is to bring together investigators with interests in high-throughput interdisciplinary biomedical research. Diverse high-throughput technologies are providing information useful for understanding evolutionary processes, mapping regulatory networks, and developing new disease diagnostics and therapeutics. How these different high-throughput witnesses to cellular function can be merged to generate predictive models that improve our understanding of biology will be a key theme of the meeting. Upon completion of this conference, participants should be able to: -Identify the most exciting developments and challenges in genomics, proteomics and computational biology. -Discuss the emerging concepts and technologies that will be key to future high-throughput interdisciplinary biomedical research. -Learn how diverse high-throughput data can be optimally combined to develop predictive models of cellular and organism function. -Understand the successes and failures to date in applying high-throughput biology to normal and disease-related processes. -Discover how new technology and high-throughput information are generating new approaches to the development and use of diagnostics and therapeutics. -Explore and plan effective collaborations with biologists and computational experts who will be in attendance.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 30

15:00—19:00
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—19:30
Orientation

Storm Peak/Mt. Werner
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Eric S. Lander, Broad Institute, Massachusetts Institute of Technology, USA
Beyond the Human Genome


WEDNESDAY, MARCH 31

07:00—08:00
Breakfast

Sevens
08:00—11:00
Integrative Approaches to Sequence Analysis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
* Svante Pääbo, Max Planck Institute for Evolutionary Anthropology, Germany
Comparative Primate Genomics

Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Trolling Vertebrate Evolution for Insights into the Annotation of the Human Genome

David Haussler, University of California, Santa Cruz, USA
The Power of Multiple Vertebrate Genome Sequences

Ewan Birney, Wellcome Trust Sanger Institute, UK
Ensembl as Genome Infrastrucure and Cis-Regulation in Vertebrates

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Regulation of Genome Expression
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
Richard A. Young, Whitehead Institute for Biomedical Research, USA
A Draft Transcriptional Regulatory Code for Yeast

* Martha L. Bulyk, Brigham & Women's Hospital and Harvard Medical School, USA
Analysis of Yeast Transcription Factor DNA Binding Specificities Using in vitro Protein Binding Microarray (PBM) Experiments

Duncan Odom, University of Cambridge, UK
Short Talk: Determining Transcriptional Regulatory Networks in Human Tissues

Bing Ren, Ludwig Institute for Cancer Research, USA
Short Talk: Mapping Transcriptional Regulatory Elements in Human DNA

19:00—20:00
Social Hour

Sunshine Peak
19:30—22:00
Poster Session 1

Sunshine Peak

THURSDAY, APRIL 1

07:00—08:00
Breakfast

Sevens
08:00—11:00
High-Throughput Analysis of Proteins and Cells
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
Jack F. Greenblatt, University of Toronto, Canada
Protein Complexes and Functional Pathways in Yeast

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Quantitative Proteomics: Current Status, Challenges and New Directions

* Erin K. O'Shea, Harvard University, USA
High-Throughput Analysis of Subcellular Localization in Budding Yeast

Michael P. Snyder, Stanford University School of Medicine, USA
Molecular, Cellular, Genetic and Genome Approaches to Study Cell Structure and Division

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Computational Fusion / Systems Biology I
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
David K. Gifford, Massachusetts Institute of Technology, USA
Transcriptional Regulatory Network Reconstruction with Complementary Data

* Daphne Koller, Stanford University, USA
From Heterogeneous Data to Regulatory Models: A Probabilistic Approach

Dana Pe'er, Memorial Sloan Kettering Cancer Center, USA
From Genome-Wide Data to Regulatory Programs: A Modular Approach

19:00—20:00
Social Hour

Sunshine Peak

FRIDAY, APRIL 2

07:00—08:00
Breakfast

Sevens
08:00—11:00
Computational Fusion / Systems Biology II
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
* Stuart K. Kim, Stanford University Medical Center, USA
Global Analysis of Conserved Genetic Modules

Julie Ahringer, University of Cambridge, UK
Genome Wide RNAi Screening in C. elegans

Thijn Brummelkamp, Netherlands Cancer Institute, Netherlands
High-Throughput Loss-of-Function Genetic Screens in Mammalian Cells using RNA Interference

Michael Q. Zhang, Cold Spring Harbor Laboratory, USA
Combinatorial Regulation of Transcriptional Gene Networks

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Human Disease and High-Throughput Data
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Proteins, Health and Disease

David A. Relman, Stanford University, USA
Exploration of the Host-Pathogen Interaction

Kelly A. Frazer, University of California, San Diego, USA
Whole Genome Haplotype Map of Humans

19:00—20:00
Social Hour

Sunshine Peak
19:30—22:00
Poster Session 2

Sunshine Peak

SATURDAY, APRIL 3

07:00—08:00
Breakfast

Sevens
08:00—11:00
Diagnostics, Therapeutics and Pharmacogenomics
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
Kathleen M. Giacomini, University of California, San Francisco, USA
Pharmacogenomics of Membrane Transporters

* Todd R. Golub, Broad Institute, USA
Genomic Information and Cancer

Ronald W. Davis, Stanford University, USA
Bar Codes and Drug Discovery

Stephen K. Burley, Rutgers University, USA
Fragment Based Drug Discovery for Protein Kinase Targets

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Emerging Concepts and Technologies
Meeting has ended...abstracts no longer viewable online.

Storm Peak/ Mt. Werner
* Leroy E. Hood, Institute for Systems Biology, USA
Systems Approaches to Development and Physiology

Marc Vidal, Dana-Farber Cancer Institute, USA
Interactome Networks

Michael Boutros, German Cancer Research Center (DKFZ), Germany
Short Talk: Genome-Wide Cell based RNAi Screens in Drosophila

19:30—20:30
Social Hour

Sunshine Peak
20:00—23:00
Entertainment

Sunshine Peak

SUNDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HG003214-01




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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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