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This meeting took place in 2004



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Apoptosis in Development (J5)


Organizer(s) Michael O. Hengartner, Sally A. Kornbluth and Scott W. Lowe
February 3—8, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 2, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 3, 2003

Supported by Keystone Symposia


Summary of Meeting:
The importance of apoptosis in disease development is well documented. However, its role in normal development is still lagging. Nevertheless, it is clear that apoptosis plays a crucial role in development, and that pathways that mediate developmental apoptosis are often mutated in disease. We now have a quite good understanding of the identity of the proteins that mediate apoptotic cell death. What are the roles of these proteins in normal development? How similar are the programs that mediate apoptotic cell death in different tissues? How similar are the death programs in different species? Many of the apoptotic proteins are conserved through evolution. Can one thus use information gained in one species to learn about apoptosis regulation in other species? Is apoptosis the only type of programmed cell death used during development in mammals? In other species? By bringing together scientists working on the same problem but in different systems (tissues and/or species), this meeting aims to: - Allow attendees to discern which genes and aspects of apoptosis are fundamental, and which might be system-specific. - Increase the transfer of knowledge between experimental systems - such that "rules" established in one system can be tested and verified in others. - Encourage the study of apoptosis in development to better understand apoptotic pathways that can be altered in disease states.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 3

15:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—19:30
Orientation

Longs Peak
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Shigekazu Nagata, IFReC, Osaka University, Japan
A Role of DNA Degradation in Mammalian Development

19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
Xiaodong Wang, BeiGene, China
Biochemical Dissection of Apoptotic Pathways


WEDNESDAY, FEBRUARY 4

07:00—08:00
Breakfast

Torreys/Grays
08:00—11:00
Death of the Spineless - Apoptosis in Invertebrates
Meeting has ended...abstracts no longer viewable online.

Longs Peak
John M. Abrams, University of Texas Southwestern Medical Center, USA
Dying like Flies: Programmed and Unprogrammed Cell Death in Drosophila

Barbara Conradt, Ludwig-Maximilians-Universitat, Germany
Cell-Death Specification in C. elegans

Kristin White, Harvard Medical School, USA
Apoptotic Pathways in Drosophila Development

* Michael O. Hengartner, University of Zürich, Switzerland
Apoptotic Pathways in C. elegans

Kristen Cullen, Cell Signaling Technology, USA
Short Talk: A Role for Programmed Cell Death in Patterning the Drosophila Arista

08:00—11:00
Caspase Activation and Inhibition
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
Christopher W. Akey, Boston University School of Medicine, USA
Structure of the Human Apoptosome Determined by Electron Cryo-Microscopy

* Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Mechanisms of Caspase Activation: Conservation and Variation

Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Structural and Biochemical Studies of p35 and XIAP

Bruce A. Hay, California Institute of Technology, USA
MicroRNA Regulators of Cell Death

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Developmental Role of Apoptotic Genes I
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Sally A. Kornbluth, Duke University Medical Center, USA
Regulation of Apoptosis by Reaper

Juan M. Hurle, University of Cantabria, Spain
Apoptosis during Vertebrate Limb Development

Joel H. Rothman, University of California, Santa Barbara, USA
Apoptotic Suppression in C. elegans

Erick J. Morris, Massachusetts General Hospital, USA
Short Talk: Functional Identification of a Synthetic Lethal Interaction between Aac11 and the Rb-E2F Pathway

17:00—19:00
Death Receptor Pathway
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
* Vishva M. Dixit, Genentech, Inc., USA
Identification and Characterization of c-Jun Ubiquitin Ligase in Arabidopsis Photomorphogenesis

E. Yvonne Jones, Wellcome Trust Centre for Human Genetics, UK
Structural Mechanisms of Death Receptor Activation

Milton H. Werner, Celtaxsys, USA
Rethinking the Conformation of the Death-Inducing Signaling Complex: A Unified Theory for Death Motif Interactions

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 1

Grays Peak

THURSDAY, FEBRUARY 5

07:00—08:00
Breakfast

Torreys/Grays
08:00—11:00
Developmental Roles of Apoptotic Genes II
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Junying Yuan, Harvard Medical School, USA
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

Razq Hakem, University Health Network, Canada
Role of Caspase 8 in Proliferation and Survival

Francesco Cecconi, University of Rome Tor Vergata, Italy
The Centrality of the Apoptosome in Neurodevelopment

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Role of BH3-Only Pro-Apoptotic Bcl-2 Family Mmembers in Programmed Cell Death and Pathology

Maryanne Donovan, University College Cork, Ireland
Short Talk: Transcriptional Regulation of Pro-Apoptotic Bcl-2 Family Members during Retinal Development and Distinct Pathways of Photoreceptor Cell Death

08:00—11:00
Mitochondria in Apoptosis
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
Yigong Shi, Tsinghua University School of Medicine, China
A Re-Evaluation of the Induced Proximity Model for Caspase Activation

* John C. Reed, F. Hoffmann-La Roche AG, Switzerland
Regulation of the ER Cell Death Pathway by BI-1

Yoshihide Tsujimoto, Osaka University Medical School, Japan
A Role of Mitochondria in Cell Death

Guido Kroemer, Cordeliers Research Center, France
Biochemical Characterization of AIF-Mediated Apoptosis

Xiao-Ming Yin, Indiana University SOM, USA
Short Talk: An Orchestrated Activation of Multiple Mitochondrial Apoptotic Events by Bid

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Tissue-Specific Apoptotic Regulation
Meeting has ended...abstracts no longer viewable online.

Longs Peak
Christine J. Watson, University of Cambridge, UK
Molecular Pathways Controlling Apoptosis in Mammary Gland Involution

* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Apoptosis Links Cancer Genetics and Cancer Therapy

Malia B. Knezek, University of North Carolina at Chapel Hill, USA
Short Talk: Post-Cytochrome c Regulation of Apoptosis: Similarities between Neurons and Cardiomyoctyes

David Wallach, Weizmann Institute of Science, Israel
Exploring the in vivo Functions of Caspase-8 by Its Conditional Knockout in Mouse

17:00—19:00
Bcl-2 Family Proteins
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
Joseph T. Opferman, St. Jude Children's Research Hospital, USA
Gateways to Apoptosis

Nico Tjandra, National Institutes of Health, USA
Bax and Mitochondrial Fission

* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Growth Factor Withdrawl Induced Cell Death: Apoptosis of Necrosis

David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia
Short Talk: Interactions between Pro-Apoptotic BH3-Only Proteins and their Pro-Survival Bcl-2-Like Targets

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 2

Grays Peak

FRIDAY, FEBRUARY 6

07:00—08:00
Breakfast

Torreys/Grays
08:00—11:00
Plants and Other Distant Relatives
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Pierre Golstein, Centre d'Immunologie de Marseille-Luminy, France
Developmental Cell Death in Dictyostelium

Hanna Engelberg-Kulka, Hebrew University of Jerusalem, Israel
Programmed Cell Death in Bacteria

John Mundy, University of Copenhagen, Denmark
Arabidopsis Accelerated Cell Death 11 (Acd11): A Link between Sphingolipids and PCD

Luis Covarrubias, Independent National University of Mexico, Mexico
Short Talk: Growth Factor Interactions in the Activation of Interdigital Cell Death

Yohannes Tesfaigzi, Lovelace Respiratory Research Institute, USA
Short Talk: Regulation of Airway Epithelial Cell Homeostasis

08:00—11:00
Mitochondria in Apoptosis: Therapeutic Potentials
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
* Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Exploring the Therapeutic Potential of IAP Inhibitors

Ziwei Huang, Sanford-Burnham Medical Research Institute, USA
De Novo Design of Inhibitors of the Bcl-2 Family Proteins

Jeanne A. Hardy, University of Massachusetts Amherst, USA
Discovery of an Orphan Allosteric Site in Caspase by Tethering

Leigh Zawel, Merck Research Labs, USA
Development of Smac Mimetics as Anti-Cancer Therapeutics

Martin Holcik, Children's Hospital-Eastern Ontario Research Institute, Canada
Short Talk: IRES-Mediated Translational Activation of Apaf1 is Essential for UV-Induced Cell Death

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
The Last Word - Phagocytosis and Apoptotic Cell Degradation
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Nathalie C. Franc, University College London, UK
Phagocytosis of Apoptotic Cells in Drosophila

Richard A. Lang, Cincinnati Children's Hospital Medical Center, USA
Macrophage-Mediated Programmed Capillary Regression is Dependent upon Wnt Signaling

Katharina Germaine D'Herde, Ghent University, Belgium
Short Talk: Internalization Mechanisms of Macrophages for Clearance of Apoptotic and Necrotic L929 Cells Studied in a Coculture System by TEM

Jens Böse, German Research Center for Biotechnology (GBF), Germany
Short Talk: Essential Functions of Ptdsr during Embryogenesis, Distinct from Apoptotic Cell Removal

17:00—19:00
Late Breaking Developments
Meeting has ended...abstracts no longer viewable online.

Quandry Peak
Ding Xue, University of Colorado, USA
An Important Role for Mitochondria in the Programmed Cell Death of C. elegans

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Mechanisms of PARP-1 Dependent AIF-Mediated Cell Death

* Jürg Tschopp, University of Lausanne, Switzerland
Activation of Initiator Caspases

George L. McLendon, Duke University, USA
Short Talk: Novel Targets for Apoptosis

19:00—20:00
Social Hour

Longs Peak Foyer
19:30—22:00
Poster Session 3

Grays Peak

SATURDAY, FEBRUARY 7

07:00—08:00
Breakfast

Torreys/Grays
08:00—11:00
Regulators of Apoptosis (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandry
Gabriel Nuñez, University of Michigan, USA
The NOD Family of Proteins: Role in Apoptosis and Inflammation

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Mitochondrial Morphology: Structure and Function

* Hermann Steller, Rockefeller University, USA
Integration of Apoptotic Signaling Pathways

Richard N. Kitsis, Albert Einstein College of Medicine, USA
Inhibition of Both Extrinsic and Intrinsic Death Pathways by Novel Death-Fold Interactions

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Too Hot to Print - Exciting New Developments (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Quandry
Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Short Talk: Control of p73 Degradation in DNA Damage

Maya Saleh, McGill University, Canada
Short Talk: Association of a Human Caspase-12 Polymorphism with Endotoxin Hypo-Responsiveness and Severe Sepsis but not Alzheimer's Disease

* Douglas R. Green, St. Jude Children's Research Hospital, USA
The Caspase-Mitochondrial Axis: 25 Minutes in the Death of a Cell

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Apoptotic Gene Function in Immune System Development

19:00—20:00
Social Hour

Longs Peak Foyer
20:00—23:00
Entertainment

Torreys/Grays

SUNDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI58469-01




We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation

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