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This meeting took place in 2004



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Golgi Apparatus and Secretory Pathway of Eukaryotic Cells (J4)


Organizer(s) L. Andrew Staehelin, Benjamin Glick and Kathryn E. Howell
January 20—25, 2004
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 22, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 20, 2003

Supported by Keystone Symposia


Summary of Meeting:
The Golgi apparatus plays a central role in the biosynthesis, post-translational modification, and sorting and packaging of secretory molecules. The principal biosynthetic functions of this organelle include the assembly of proteoglycans and polysaccharides for the extracellular matrix or cell wall, the processing of the oligosaccharide side chains of soluble and membrane-associated glycoproteins, and the synthesis and processing of membrane lipids. The trafficking functions of the Golgi include the transport of cargo molecules from their sites of synthesis to their final destinations. Finally, the sorting and packaging functions involve the incorporation of various cargo molecules into different types of transport carriers for delivery to other organelles, as well as the internal recycling of resident Golgi molecules. In contrast to these well-defined functions, the structural and dynamic properties of the Golgi apparatus have remained controversial. At the center of this controversy is the fact that the Golgi apparatus continually exchanges components with other organelles, including the ER, endosomes, lysosomes/vacuoles, and the plasma membrane. A further complication is that Golgi architecture differs between organisms, can change during the cell cycle, and can vary in a tissue- and developmental stage-specific manner. The resulting diversity of experimental data has continued to fuel debate about how cargo molecules move through the Golgi, how the different cisternal elements maintain their identities despite the constant flux of components, and how and where cargo molecules are sorted and packaged into transport carriers. The central goal of this symposium is to bring together a broad group of researchers interested in the secretory pathway, with an emphasis on events that occur during transport to, through, and from the Golgi apparatus. Speakers include not only researchers studying yeast and mammalian cells but also a representative group of plant researchers. This meeting addresses biosynthetic functions of the Golgi in addition to the more frequently addressed cell biological functions. In retrospect, it is now obvious that the 1998 Golgi Centennial Meeting in Pavia, Italy was instrumental in promoting the paradigm shift from the vesicular transport model to the cisternal progression/maturation model of Golgi trafficking. The central challenge for this meeting will be to identify the current frontiers in secretory pathway research, and to stimulate new avenues of investigation by integrating insights from a wide range of experimental systems.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 20

15:00—19:00
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—19:30
Orientation

Peaks 4-5
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Benjamin Glick, University of Chicago, USA

Randy W. Schekman, University of California at Berkeley, USA
The Molecular Mechanism of Protein Sorting Early in the Secretory Pathway

Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Rab Domains in Endosome Organization and Signaling


WEDNESDAY, JANUARY 21

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Redefining Golgi Architecture and Composition
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Alberto Luini, Consozio Mario Negri Sud, Italy

L. Andrew Staehelin, University of Colorado, USA
Testing of Structural Predictions of the Golgi Cisternal Progression Model by Electron Tomography

Kathryn E. Howell, University of Colorado Health Sciences Center, USA
Part 1: 3D Structure Supports Multiple Transport Mechanisms To, Through and From the Golgi Complex Part 2: Characterization of a Novel Post Translational Modification of A Dimethyl-Argenine Protein

Todd R. Graham, Vanderbilt University, USA
Drs2p: A Lipid-Flipping, Vesicle-Forming ATPase in the Yeast Golgi Complex

John R. Yates III, The Scripps Research Institute, USA
Mass Spectrometry of Large Cellular Structures

08:00—11:00
Cargo Loading and Vesicle Budding
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Charles K. Barlowe, Dartmouth Medical School, USA

Suzanne R. Pfeffer, Stanford University, USA
A GDI Displacement Factor to Localize Rab GTPases

Stephen Ferguson, Robarts Research Institute, UWO, Canada
Angiotensin II Type 1A Receptor Trafficking and Rab GTPases

Keith E. Mostov, University of California, San Francisco, USA
Regulation of Membrane Traffic in Polarized Epithelial Cells

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Golgi-Cytoskeletal Interaction
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA

Mark A. McNiven, Mayo Clinic, USA
A Dynamin and Cortactin Complex Mediates Membrane Traffic in the Endocytic and Secretory Pathways

Viki J. Allan, University of Manchester, UK
Cytoplasmic Dynein in the Secretory Pathway during Apoptosis and during Mitosis

Chris Hawes, Oxford Brookes University, UK
ER Exit Sites and Golgi Dynamics in Plants

17:00—19:00
Vesicle Tethering
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Suzanne R. Pfeffer, Stanford University, USA

William T. Wickner, Dartmouth Medical School, USA
Yeast Vacuole Fusion

Francis Barr, University of Oxford, UK
Grasp-Golgin Complexes: Rab Effectors Required for Normal Golgi Function

Rytis Prekeris, University of Colorado Health Sciences Center, USA
Short Talk: FIP3 is a Rab11 and ARF6 Binding Protein Involved in Regulating of Cell Motility

Cecilia I. Alvarez, Facultad de Ciencias Quimicas, Argentina
Short Talk: Rab1-Mediated COPI Recruitment

Ellen Tisdale, Wayne State University, USA
Short Talk: Rab2 Interacts Directly with Atypical Protein Kinase C iota/lambda to Regulate Microtubule Dynamics at the VTC

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

THURSDAY, JANUARY 22

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Regulation of Vesicle Production and ER-to-Golgi Transport (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Randy W. Schekman, University of California at Berkeley, USA

William E. Balch, The Scripps Research Institute, USA
Rab Trafficking Networks

Charles K. Barlowe, Dartmouth Medical School, USA
Mechanisms in Transport between the ER and Golgi without Ypt1p

Susan Ferro-Novick, University of California, San Diego, USA
Vesicle Traffic and Organelle Inheritance

Benjamin Glick, University of Chicago, USA
Golgi Structure and Inheritance in Budding Yeasts

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Transport Through the Golgi Apparatus
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Judith Klumperman, University Medical Center Utrecht, Netherlands

Felix Wieland, Universität Heidelberg, Germany
Biogenesis of a Transport Vesicle: Players and Rules

Alberto Luini, Consozio Mario Negri Sud, Italy
Morpho-Functional Analysis of a Single Traffic Wave Passing through an Individual Stack: The Mode of Intra-Golgi Traffic

Anne Spang, Max-Planck-Gesellschaft, Germany
Short Talk: Why Don't Vesicles Fuse Back to the Donor Membrane

David K. Banfield, Hong Kong University of Science and Technology, China
Short Talk: COPI-Coated Vesicle Formation and SNAREs

17:00—19:00
Exocytosis
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Burton F. Dickey, University of Texas MD Anderson Cancer Center, USA

Peter Novick, University of California, San Diego, USA
Spatial Regulation of Exocytosis in Yeast

Michael L. Nonet, Washington University, USA
Regulation of Transmitter Release by Rab-3 and Associated Regulators

Thomas C. Südhof, Stanford School of Medicine, USA
Rab Function in Synaptic Vesicle Exocytosis

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

FRIDAY, JANUARY 23

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Biosynthesis and Bioengineering of Carbohydrates
Meeting has ended...abstracts no longer viewable online.

Peak 4
* L. Andrew Staehelin, University of Colorado, USA

Kelley W. Moremen, University of Georgia, USA
Class 1 alpha1,2-mannosidase Structure and Function in N-Glycan Biosynthesis and Quality Control

Gideon Davies, University of York, UK
The Structural Enzymology of Glycosyl Transfer: Structures and Mechanisms

Loic Faye, Université de Rouen, France
From Glycobiology to Glycoengineering in Plants

Tillman U. Gerngross, Adimab, Inc., USA
Engineering the Secretory Pathway of the Yeast Pichia pastoris to Produce Mammalian-Type Glycoproteins

08:00—11:00
Rab-Cytoskeletal Interactions
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Peter Novick, University of California, San Diego, USA

Stéphanie Miserey-Lenkei, Institut Curie, France
Role of the Golgi-Associated Rab6 GTPase in Interphasic and Mitotic Cells

John A. Hammer, NHLBI, National Institutes of Health, USA
Roles of Rab GTPases in Motor:Organelle Interactions

James R. Goldenring, Vanderbilt University Medical Center, USA
Regulation of Plasma Membrane Recycling by Myosin Vb and Rab11-FIP2

Jacques Neefjes, Netherlands Cancer Institute, Netherlands
Rab7 Controlling Transport of MHC Class II Molecules

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Sorting of Cargo to Post Golgi Sites
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Kathryn E. Howell, University of Colorado Health Sciences Center, USA

Judith Klumperman, University Medical Center Utrecht, Netherlands
Sorting Domains in the Secretory Pathway

Sean Munro, Medical Research Council, UK
Arf-Like GTPases in Vesicular Transport

Willaim J. Brown†, Cornell University, USA
Short Talk: The Surprising Properties of the Lysophospholipid Acyltransferase Inhibitor CI-976 on Membrane Tubule and Vesicle Formation

Christopher Burd, University of Pennsylvania School of Medicine, USA
Short Talk: ARF Like GTPases (ARL1p) is the Golgi Receptor for GRIP Domains

17:00—19:00
Membrane Association and Structure
Meeting has ended...abstracts no longer viewable online.

Peak 5
* William E. Balch, The Scripps Research Institute, USA

Miguel C. Seabra, Imperial College London, UK
Membrane Targeting of Rab GTPases

David G. Lambright, University of Massachusetts Medical School, USA
Structural Insights into the Mechanism and Specificity of Rab Regulated Membrane Trafficking

Roger S. Goody, Max Planck Institute for Molecular Physiology, Germany
Structural and Mechanistic Aspects of Rab GTPases in Intracellular Vesicular Transport

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

SATURDAY, JANUARY 24

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Lipid Biosynthesis, Signaling and Sorting
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Maria Antonella De Matteis, Consorzio Mario Negri Sud, Italy

Vytas A. Bankaitis, Texas A&M University, USA
Phosphatidylinositol Transfer Protein-Dependent Signaling and Yeast Golgi Function

Scott D. Emr, Cornell University, USA
Lipid Signaling and Ubiquitin-Dependent Sorting at the Endosome in Yeast

Vivek Malhotra, ICREA, Spain
Regulating Vesicle Formation from Golgi Membranes and Using Golgi to Regulate Mitotic Progression

Marisa S. Otegui, University of Wisconsin, USA
Short Talk: Analysis of Golgi and Multivesicular Body Functions during Protein Storage Vacuole Formation in Arabidopsis thaliana

Vangelis Kondylis, University Medical Center, Utrecht, Netherlands
Short Talk: Do Golgi Matrix Proteins also Play a Role in tER Organization?

08:00—11:00
Regulation of the Rab GTPase Cycle
Meeting has ended...abstracts no longer viewable online.

Peak 5
* William T. Wickner, Dartmouth Medical School, USA

Nava Segev, University of Illinois at Chicago, USA
Exocytic Ypt/Rab GTPases: Novel Mechanisms and Coordination

Yoshimi Takai, Osaka University Graduate School of Medicine, Japan
Rab3 Regulators

Ruth N. Collins, Cornell University, USA
Molecular Genetic Studies of Rab GTPase Activation

Jean M. Wilson, University of Arizona, USA
Short Talk: The Small GTPase Rab14 Regulates Apical Trafficking

Ryota Kunita, Institute of Medical Sciences, Tokai University, Japan
Short Talk: ALS2 is a Novel Guanine Nucleotide Exchange Factor for Rab5 and in Implicated in Endosomal Dynamics

Angela Wandinger-Ness, University of New Mexico, USA
Short Talk: Regulation of Late Endosomal Phosphatidylinositol Lipid Dynamics by Rab7

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Golgi Maintenance and Inheritance
Meeting has ended...abstracts no longer viewable online.

Peak 4
* Benjamin Glick, University of Chicago, USA

Maria Antonella De Matteis, Consorzio Mario Negri Sud, Italy
The Role of the Cycling of the Matrix Protein GM130 in the Biogenesis of the Golgi Complex

Graham B. Warren, Medical University of Vienna, USA
Tethers of the Golgi Apparatus

Jennifer A. Lippincott-Schwartz, Howard Hughes Medical Institute - Janelia Farm, USA
A Role For Arf1 In Mitotic Golgi Disassembly, Chromosome Segregation and Cytokinesis

17:00—19:00
Intersection with Signaling
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

Philip D. Stahl, Washington University in St. Louis, School of Medicine, USA
Rab5 and Rin1 - Regulation of Receptor Mediated Endocytosis

Giorgio Scita, IFOM Foundation at Campus IFOM-IEO, Italy
Up and Down Small GTPases: Signaling Mechanisms Regulating Actin Based Endocytosis

Peter van der Sluijs, University Medical Center Utrecht, Netherlands
Rab4 Function in Recycling from Endosomes

19:00—20:00
Social Hour

Peaks 14-16
20:00—23:00
Entertainment

Peaks 14-16

SUNDAY, JANUARY 25

 
Departure


*Session Chair †Invited, not yet responded.



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