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This meeting took place in 2004



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Lymphocyte Activation and Signaling (A3)


Organizer(s) Susan K. Pierce and Gary A. Koretzky
January 8—13, 2004
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 10, 2003

Sponsored by Berlex Biosciences and the Director's Sponsor Fund

Summary of Meeting:
The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. Indeed, for many immune cell receptors the second messenger pathways have been described in exquisite detail and have been the focus of several national and international meetings. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. Frameworks for understanding signaling at the level of the whole cell have been provided by important new concepts emerging in both cell and molecular biology. These concern the spatial organization of signaling receptors, the integration of signals emanating for multiple receptors and the influence of such signals on gene expression. Significantly, much of the recently gained knowledge of immune cell signaling is having a direct impact on important clinical areas including: autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases. Distinguished scientists working at the cutting edge of immune cell signaling will describe their new findings and address how these issues relate to human disease. Speakers will describe the spatial organization of immune cell receptors in the plasma membrane and interactions of receptors with the cytoskeleton and molecular adaptors. The molecular nature of the integration of signals will be described for both the adaptive immune system’s antigen receptors and coreceptors as well as the innate system’s receptors. How the integrated signals ultimately affect chromatin structure and gene regulation will be described. Signaling will also be discussed in the global processes of chemotaxis, homeostasis, response to viral infection, apoptosis and immune deficiencies. Lastly, the next frontier--visualizing signaling in vivo--will be addressed. The proposed meeting will provide a view of how the initial encounter of immune cell signaling receptor with their ligands ultimately leads to the biological response be it activation, differentiation, movement, or cell death and how this knowledge is being translated to important clinical problems.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 8

15:00—19:00
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—19:30
Orientation

Storm Peak/Mt. Werner
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Arthur Weiss, University of California, San Francisco, USA
Regulating Antigen Receptor Signaling


FRIDAY, JANUARY 9

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Spatial Organization of Immune Cell Receptors: Rafts, Polarization, Synapse Formation
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Susan K. Pierce, NIAID, National Institutes of Health, USA
Spatial Organization of B Cell Signaling Receptors

Abraham Kupfer, Johns Hopkins University, USA
Visualizing T Cell Activation in SMACs

Michael L. Dustin, University of Oxford, UK
Molecular and Physical Dissection of the Immunological Synapse

Akihiro Kusumi, Kyoto University, Japan
Engagement a GPI-Anchored Protein Creates Signaling Rafts from Smaller, Transient, Lipid Rafts: A Single-Molecule Approach

Edward J. Evans, University of Oxford, UK
Short Talk: Signalling Implications of the Structure of CD28:Fab Complex

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Early Events in Signaling: Adaptors and the Cytoskeleton
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Integration of Proximal Signals Following TCR Engagement

Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA
Bipolar Order: Cytoskeletal Control of T Cell Activation

Burkhart L. Schraven, Otto-von-Guericke University Magdeburg, Germany
Transmembrane Adaptor Proteins in Lymphocyte Signaling

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak

SATURDAY, JANUARY 10

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Integration and Regulation of Signaling in the Adaptive System
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Michael Reth, Albert-Ludwigs University Freiburg, Germany
Rebuilding the Signaling Pathways from the BCR

Jeffrey V. Ravetch, Rockefeller University, USA
The Fc Receptors in Immune Responses

Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA
Integrating T Cell Signaling

* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Immunogenic versus Tolerogenic Signaling by Antigen Receptors

Amrie C. Grammer, AMPEL BioSolutions LLC, USA
Short Talk: Abnormal Signaling Associated with a Naturally Occuring CD40 Mutation in Patients with Systemic Lupus Erythematosus

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:00—16:00
Workshop 1: Regulation of Signaling in the Adaptive System

Storm Peak/Mt. Werner
* Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA

Lisa A. Miosge, John Curtin School of Medical Research, Australia
Elevated Immunoglobulin Isotypes are a Consequence of Inefficient TCR Signaling Resulting from a slp-76 Hypomorphic Allele

Stephen C. Bunnell, Tufts University School of Medicine, USA
Cooperative Interactions Govern the Persistence and Translocation of the T Cell Signalosome

Thomas Gajewski, University of Chicago, USA
T Cell Anergy is Reversed by Active Ras and Regulated by Diacylglycerol Kinase

Jin H. Kim, University of North Carolina at Chapel Hill, USA
Independent Trafficking of Ig-a/b and mm is Facilitated by Dissociation of the BCR Complex

Ingrid Mecklenbräuker, Rockefeller University, USA
PKC delta Controls Survival of Peripheral B Cells

Virginia S. Shapiro, Mayo Graduate School College of Medicine, USA
Role for a Novel Adaptor, ALX, in CD28 Signaling

Takeshi Tsubata, Tokyo Medical and Dental University, Japan
Immunoglobulin Isotype-Specific Regulation of B Cell Antigen Receptor Signaling

Timothy S. Gomez, Mayo Graduate School, USA
The Large GTPase Dynamin2 Physically Interacts with Vav1 and is Required for T Cell Activation

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Integration of Signaling in the Innate System through Activating and Inhibitory Receptors
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* David H. Raulet, University of California, Berkeley, USA
NK Receptors and the Regulation of Immunity

Rafi Ahmed, Emory University School of Medicine, USA
Memory CD8 T Cell Differentiation During Acute Versus Chronic Viral Infection

Oreste Acuto, University of Oxford, UK
Short Talk: Costimulation-Induced Protein Methylation in T Cells

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 2

Sunshine Peak

SUNDAY, JANUARY 11

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Signaling through Innate System Receptors
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Recognition and Signaling in the Immune Response of Drosophila

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll Mediated Control of Adaptive Immunity

* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Toll Receptor Ligands in Systemic Autoimmune Disease

Daniel M. Davis, Imperial College London, UK
Short Talk: The NK Cell Immune Synapse

Christopher E. Rudd, University of Montreal, Canada
Short Talk: A Revised Model of CTLA-4 Signaling

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:00—16:00
Workshop 2: Immunological Memory and Effector Functions

Storm Peak/Mt. Werner
* Rafi Ahmed, Emory University School of Medicine, USA

Shannon Anderson, University of California, San Francisco, USA
Development and Maintenance of a Memory B Cell Population

Sarah E. Bell, Babraham Institute, UK
PLCgamma2 Regulates Development of Follicular and Marginal Zone B Cells through a Bcl2-Dependent Mechanism

Jessica C. Fanzo, Doris Duke Charitable Foundation, USA
Requirement of IBP in T Cell Effector Function

Laurent P. Malherbe, The Scripps Research Institute, USA
Impact of TCR Binding Properties on T Helper Cell Clonal Expansion and Survival in vivo

Jeffrey C. Rathmell, Vanderbilt University, USA
Trophic Signal Accessibility Regulates Bax Activation, Homeostatic Proliferation, and Chemotaxis

David A. Schaer, Memorial Sloan-Kettering Cancer Center, USA
TCR Signaling Defects Abrogate Lytic Function in CD8+ Tumor Infiltrating Lymphocytes

Andrea L. Szymczak-Workman, St. Jude Children's Research Hospital, USA
Contrasting Requirements of AP-2-Mediated Internalization of the T Cell Receptor: CD3 Complex

Yoshimasa Takahashi, National Institute of Infectious Diseases, Japan
Unique Role of p21ras Cascade on the Memory B Cell Response

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Late Events in Immune Cell Signaling: Chromatin Structure and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Yehudit Bergman, Hebrew University Medical School, Israel
Allelic Exclusion in the Immune System

Katia Georgopoulos, Massachusetts General Hospital, USA
Regulation of Lymphocyte Development by Ikaros

Gerald R. Crabtree, Stanford University, USA
Preparing Chromatin to Receive Signals: The Earliest Step in Signal Transduction

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak

MONDAY, JANUARY 12

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Signals Controlling Biological Responses
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Philippa C. Marrack, HHMI/National Jewish Health, USA
Bim and IL-2 Related Cytokines and Lymphocyte Homeostasis

* Christine A. Biron, Brown University, USA
Cytokine Signals in Immune Responses to Viral Infections

Steven L. Reiner, Columbia University, USA
Fashioning and Re-Fashioning T Cell Fates

Deborah J. Fowell, University of Rochester, USA
Short Talk: TCR Signals for Regulated Cytokine Secretion

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Signaling and Cell Activation Imaged in Living Cells and in vivo
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Richard S. Lewis, Stanford University School of Medicine, USA
Positive Selection in 4 Dimensions: Visualizing Calcium Signals and Cell Motility in a Living Thymic Slice

Ellen A. Robey, University of California, Berkeley, USA
The Cellular Dynamics of MHC Recognition within Lymphoid Tissue

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Cell Interactions during Adaptive Immune Responses

19:00—20:00
Social Hour

Foyer
20:00—23:00
Entertainment

Sunshine/Mt. Werner

TUESDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Berlex Biosciences
Cell Signaling Technology, Inc.

Cell Signaling Technology, Inc.
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676