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This meeting took place in 2004



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Biology of Hypoxia: The Role of Oxygen Sensing in Development, Normal Function and Disease (D3)


Organizer(s) Randall S. Johnson, Amato Giaccia and M. Celeste Simon
March 25—30, 2004
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 24, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 26, 2004

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Upon completion of this conference, participants should be able to: - Understand the most current and important aspects of hypoxia research generally - Appreciate current understanding of relationships between hypoxia and angiogenesis - Understand the relationship between oxygen sensing and metabolic function, particularly as it relates to cell and tissue survival during hypoxic injury - Appreciate current thinking on the role of oxygen sensing and hypoxic response in ischemic injuries, such as stroke and myocardial infarction - Gain an understanding of current ideas about the molecular sensing and signaling mechanisms induced by hypoxia - Understand the developmental roles oxygen sensing fulfill in model organisms, and gain insights into how these are relevant to human biology/pathology. A chief objective will be to bring the very disparate groups that work on hypoxia together. There is currently no other meeting where this occurs, and it will allow, we believe, unprecedented opportunities for cross-fertilization and collaboration to occur. A number of controversies on the mechanisms and effects of oxygen exist in the current literature; this meeting will bring the various points of view into the same setting and will allow a consensus on these issues to be built.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 25

15:00—19:00
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—19:30
Orientation

Storm Peak/Mt. Werner
19:30—21:00
Presentations on Hypoxia: Current State of the Field and Future Directions
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
M. Celeste Simon, University of Pennsylvania, USA
Oxygen Sensing in Development and Disease

Randall S. Johnson, University of Cambridge, UK
The Physiology of Hypoxia: The Role of Molecular Adaptation

Amato J. Giaccia, Stanford University, USA
Molecular Therapeutics Based on the Proteomic/Genomic Response in Hypoxia


FRIDAY, MARCH 26

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Function of Hypoxic Response in Development I: Model Organisms and Mammals
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Robert O. Poyton, University of Colorado, Boulder, USA
Mitochondrial-Nuclear Interaction in O2 Sensing

Christopher Bradfield, University of Wisconsin, USA
Understanding Hypoxia Signalling from a Superfamily Perspective

* Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Functional Analysis of the Role of the Oxygen Sensors PHD1, PHD2 and PHD3 Using Gene-Inactivation in Mice And Morpholino-Knockdown in Zebrafish

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:15
Function of Hypoxic Response in Development II: Mammalian Systems
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Max Gassmann, University of Zürich, Switzerland
Hypoxia-Independent Erythropoietin Gene Expression

Jeffrey M. Arbeit, Washington University School of Medicine, USA
Persistent Neonatal Quiescent Hypervascularity Produced by Chronic Constitutive HIF-1alpha Signaling in Transgenic Mice

Roland H. Wenger, University of Zürich, Switzerland
HIF-1, PASKIN and the Hypoxic Response in Male Germ Cell Differentiation

Ernestina Schipani, University of Michigan, USA
Chondrogenesis and Hypoxia

David C. Beebe, Washington University, USA
Short Talk: Oxygen Regulates Lens Cell Proliferation and Governs Lens Growth in Adult Rats

19:15—20:15
Social Hour

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak

SATURDAY, MARCH 27

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Pulmonary Hypoxia
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Stella Kourembanas, Children's Hospital Boston, Harvard Medical School, USA
Molecular and Cellular Responses of the Lung to Hypoxia

Larrisa A. Shimoda, Johns Hopkins School of Medicine, USA
Hypoxia-Induced Alterations in Smooth Muscle Cell Ion Homeostasis

Ivan F. McMurtry, University of Colorado Health Sciences Center, USA
Role of RhoA/Rho Kinase Signaling in Hypoxic Pulmonary Hypertension

* Stephen L. Archer, Queen's University, Canada
O2 Sensors in the Ductus Arteriosis and the Pulmonary Artery

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:00—16:00
Workshop: HIF-1 and Drug Development

Storm Peak/Mt. Werner
* M. Celeste Simon, University of Pennsylvania, USA

Alexey V. Bazarov, University of California, San Francisco, USA
Reaching for Fresh Air: Implication of HIF-1a in Astrocytoma Invasion

Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Electron Transport Chain Regulates HIF-1alpha Protein Stabilization Independent of Respiration

Cormac Taylor, University College Dublin, Ireland
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1alpha

L. Eric Huang, University of Utah, USA
A Paradoxial Role for Hypoxia in Cell Growth

Till Acker, University of Giessen, Germany
Regulation of HIF and HPHD Function in Malignant Brain Tumors

Koh Nakayama, Sanford-Burnham Medical Research Institute, USA
Regulation of PHD Abundance by SIAH2 E3 Ligase Modulates the Expresession of HIF1alpha Level in Hypoxia

16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
Carotid Body Sensing of Oxygen: Hypoxic Sensing and Physiology
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Nanduri R. Prabhakar, University of Chicago, USA
Plasticity in Hypoxic Sensing at the Carotid Body

José López-Barneo, Hospital Universitario Virgen del Rocío, Spain
Regulation of O2 Sensing by Ion Channels

Frank J. Giordano, Yale University, USA
HIF-1alpha in the Heart: The Good, the Bad, the Ugly

* Kenneth Walsh, Boston University School of Medicine, USA
Growth Signals in the Heart and Vasculature

John W. Severinghaus, University of California, San Francisco, USA
Consensus Proposal for Hypoxic Ventilatory Response

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 2

Sunshine Peak

SUNDAY, MARCH 28

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Hypoxia-Induced Cell Death and Drug Discovery
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Dietmar W. Siemann, University of Florida, USA
Vascular Targeting: Induction of Ischemic Cell Death in Cancer Therapy

Martin Brown, Stanford University, USA
Exploiting Tumor Hypoxia in Cancer Therapy

Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA
Targeting HIF-1 for Development of Cancer Therapeutics

Mark W. Dewhirst, Duke University Medical Center, USA
Paradoxical HIF-1alpha Signaling during Tumor Reoxygenation: The Role of Free Radicals and Stress Granules

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:00
Hypoxia and Tumorigenesis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine, UK
Hypoxia and Tumorigenesis

William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Molecular Pathogenesis of the von Hippel-Lindau Hereditary Cancer Syndrome

Volker H. Haase, Vanderbilt University, USA
Functional Consequences of Conditional Inactivation of Vhl: The Role of Hif

Peter Vaupel, University of Mainz, Germany
Tumors: Out of Oxygen, but Still Alive and Kicking

Short Talk(s) Chosen from Abstracts

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak

MONDAY, MARCH 29

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Signaling of Hypoxia
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Jacques Pouysségur, University of Nice, France
Interplay between Oxygen-Sensors in HIF-1 Signaling

Paul T. Schumacker, Northwestern University, USA
Reactive Oxygen Species and Signaling of Hypoxia

* Peter J. Ratcliffe, University of Oxford, UK
The Role of VHL and Protein Hydroxylation in Hypoxia Signaling

Frank S. Lee, University of Pennsylvania School of Medicine, USA
Short Talk: A P582S Polymorphism of Hypoxia Inducible Factor-1alpha (HIF-1a) Does Not Impair Pro-564 Hydroxylation

Wayne S. Zundel, University of Colorado Health Sciences Center, USA
Short Talk: Distinct Aerobic and Hypoxic Mechanisms of HIF-1 Regulation by CSN5

09:20—09:40
Coffee Break

Foyer
16:30—16:45
Coffee & Snacks Available

Foyer
16:45—19:15
Signaling of Hypoxia II
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
Lorenz Poellinger, Karolinska Institutet, Sweden
Structure of HIF-1 and Relationship to Hypoxia Signaling

* H. Franklin Bunn, Brigham and Women's Hospital, USA
HIF Activation and Oxygen-Dependent Gene Expression in Invertebrates

Daniel J. Peet, University of Adelaide, Australia
Normoxic Activation of HIF2 alpha by NEMO

Joseph A. Garcia, University of Texas Southwestern Medical Center, USA
Insights from EPAS1/HIF-2a Null Mice: The Role of HIF-2 in ROS & Mitochondrial Homeostasis

Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Hypoxia Response Pathways in Drosophila

20:00—21:00
Social Hour

Foyer
20:00—23:00
Entertainment

Sunshine Peak/Mt. Werner

TUESDAY, MARCH 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG023493-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676