Fairmont Chateau Whistler Floorplan

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This meeting took place in 2004



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Jaks and Stats: Development to Disease (E2)


Organizer(s) Robert D. Schreiber, David E. Levy and John J. O'Shea
April 15—20, 2004
Fairmont Chateau Whistler • Whistler, British Columbia Canada
Abstract Deadline: Dec 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 17, 2004

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
The study of the Jak-Stat signaling pathway has now reached an extremely sophisticated level. Nevertheless, significant new insights continue to rapidly emerge involving either novel pathway components or novel actions of known pathway components that have profound influences on signaling through both the Jak-Stat pathway as well as other signaling pathways. Recent work has also shown that Jak and Stats are evolutionarily conserved signaling molecules that regulate a diverse group of fundamental processes ranging from stem cell renewal and embryogenesis to organogenesis and development of hematopoietic and lymphoid cells. Furthermore their roles in preventing or promoting infectious, malignant and autoimmune diseases have now become areas of intense study and exciting new findings are being made in these areas that have wide applicability to several fields of biology. The goals of this meeting are as follows: -Identify novel interactions between members of the Jak-Stat pathway not only with one another but also with receptors and components of other signal transduction pathways with special emphasis on positive and negative acting mechanisms that regulate Jak-Stat pathway signaling. -Define the roles of the Jak-Stat pathway and its components in development of primitive and higher organisms with special emphasis being placed on model genetic organisms and on the hematopoietic and immune systems. -Discuss the various protective versus disease-promoting effects of the Jak-Stat signaling pathway in infectious and neoplastic diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, APRIL 15

15:00—19:00
Registration

Macdonald Foyer
18:15—19:15
Refreshments

Macdonald C
19:15—19:30
Orientation

Macdonald AB
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
James E. Darnell, Rockefeller University, USA
Integrating STATs in Transcriptional and Developmental Function


FRIDAY, APRIL 16

07:00—08:00
Breakfast

Macdonald C
08:00—11:00
Jaks and Receptors
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

* Sandra Pellegrini, Institut Pasteur, France
Jaks and Cytokine Receptor Traffic

Peter C. Heinrich, Universitätsklinikum Aachen, Germany
IL-6-type Cytokine Receptor-JAK-STAT-Interactions and Modulation of Signaling

Christin Carter-Su, University of Michigan Medical School, USA
Short Talk: Sites of JAK2 Autophosphorylation and Their Function in Cytokine Signaling

Paul J. Hertzog, Hudson Institute of Medical Research, Australia
Short Talk: SOCI Regulation of Signalling through the Type IIFN Receptor

09:20—09:40
Coffee Break

Macdonald Foyer
11:00—13:00
Poster Setup

Macdonald C
13:00—22:00
Poster Viewing

Macdonald C
16:30—17:00
Coffee & Snacks Available

Macdonald Foyer
17:00—19:00
Stats: Structure and Function
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
George R. Stark, Case Western Reserve University, USA
Role of Unphosphorylated STAT3 in Cancer and in Response to Cytokines

* Nancy C. Reich, Stony Brook University, USA
Regulation of STAT Nuclear Trafficking

Christian W. Schindler, Columbia University, USA
Wrestling with IFNs - Wrestling with SUMO

Friedemann Horn, Universitat Leipzig, Germany
Short Talk: Stat3 Serine Phosphorylation Reevaluated

19:00—20:00
Social Hour

Macdonald C
19:30—22:00
Poster Session 1

Macdonald C

SATURDAY, APRIL 17

07:00—08:00
Breakfast

Macdonald C
08:00—11:00
Negative Regulation
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
* Douglas J. Hilton, Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Proteins Regulate the Quantity and Quality of Jak/Stat Signaling

Akihiko Yoshimura, Keio University, Japan
SOCS1 and SOCS3; Key Positive and Negative Regulators for Macrophage and Dendritic Cell Activation

Ke Shuai, University of California, Los Angeles, USA
Negative Regulation of Cytokine Signaling in the Nucleus

Benjamin G. Neel, Ontario Cancer Institute, Canada
Role of Shp2 in Normal and Abnormal Hematopoiesis

Michelle Ann Soriano, Harvard School of Public Health, USA
Short Talk: Isolation and Characterization of a Novel Negative Regulator of STAT4 Signaling

09:20—09:40
Coffee Break

Macdonald Foyer
11:00—13:00
Poster Setup

Macdonald C
13:00—22:00
Poster Viewing

Macdonald C
14:00—16:00
Workshop 1: IRFs and Other Transcription Factors

Macdonald AB
* Keiko Ozato, NICHD, National Institutes of Health, USA
IRFs as Downstream Effectors of Stat-Dependent Biologic Responses

Isabelle J. Marie, New York University School of Medicine, USA
Activation of IRF7 during Pathogen Infection: Kinases, Phosphorylation Sites and Regulatory Mechanisms

Niamh E. Buckley, Queen's University, Northern Ireland
IRF-7 Plays a Key Role in the BRCA 1/Interferon Gamma Mediated Apoptotic Response

Oanh Dang, University of California, San Diego, USA
Anthrax Lethal Toxin Inhibits Activation of Interferon Regulatory Factor 3 by LPS

Mirjam J. Eckert, University of Lausanne, Switzerland
The Extreme C-Terminus of IRF-1 has an effect on its Transcriptional Activity

Lisa N. Haubein, University of Pennsylvania, USA
Regulation of Stat5 Function by c-Myb

16:30—17:00
Coffee & Snacks Available

Macdonald Foyer
17:00—19:00
Jak-Stat Pathway in Non-Mammalian Development
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
* Norbert Perrimon, Harvard Medical School, USA
Drosophila JAK/STAT Pathway and Septic Injury

Jeffrey G. Williams, University of Dundee, School of Biological Sciences, UK
Functional Analysis of the Four Dictyostelium STAT Proteins and a Crystal Structure for Activated Dd-STATa in its DNA-Unbound Form

Toshio Hirano, Osaka University Graduate School of Medicine, Japan
Jaks and Stats in Epithelial-Mesenchymal Transition of Zebrafish Gastrula Organizer

Erika A. Bach, New York University School of Medicine, USA
Short Talk: Epidermal Growth Factor Receptor (Egfr) Signaling in the Drosophila Embryo Requires a Functional JAK/STAT Pathway

19:00—20:00
Social Hour

Macdonald C
19:30—22:00
Poster Session 2

Macdonald C

SUNDAY, APRIL 18

07:00—08:00
Breakfast

Macdonald C
08:00—11:00
Jak-Stat Pathway in Mammalian Development
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
James N. Ihle, St. Jude Children's Research Hospital, USA
Stat5 Function Revisited

* Lothar Hennighausen, National Institutes of Health, USA
Cell-Specific and Temporal Inactivation of the Stat5 Locus in the Mouse

Christine J. Watson, University of Cambridge, UK
Short Talk: The Multiple Roles of Stat Factors, and their Downstream Effectors, in Regulating Differentiation, Apoptosis and Remodeling in Mammary Gland

Michael A. Farrar, University of Minnesota, USA
Short Talk: Differential Regulation of B and T Cell Development by STAT5

Valeria Poli, University of Turin, Italy
Short Talk: Non-Redundant Functions of STAT3alpha and STAT3beta revealed by Specific Ablation of Either Isoform

09:20—09:40
Coffee Break

Macdonald Foyer
11:00—13:00
Poster Setup

Macdonald C
13:00—22:00
Poster Viewing

Macdonald C
14:00—16:00
Workshop 2: New Cytokines, Cytokine Receptors and Signaling Regulators

Macdonald AB
* Paul B. Rothman, University of Iowa, USA

Alexander S. Banks, Harvard Medical School, USA
Suppressor of Cytokine Signaling-7 Deficiency Results in Decreased Body Size, Increased Growth of Pancreatic Islets, and Altered Glucose Homeostasis

Christine Brender, St. Vincent's Institute of Medical Research, Australia
Regulation of T Cell Homeostasis by SOCS1 and SOCS3

Andrei Thomas-Tikhonenko, Children's Hospital of Philadelphia and University of Pennsylvania, USA
An Essential Role of Th1 Responses and Interferon gamma/STAT1 Signaling in Infection-Mediated Anti-Angiogenesis and Suppression of Neoplastic Growth

Ana P. Costa-Pereira, Cancer Research UK, UK
Novel Signaling Requirements for the Class II HLA and Antiviral Responses to Interferon-gamma

Alejandro Villarino, National Institutes of Health, USA
The IL-27R (WSX-1) is Required to Suppress Effector T Cell Functions during Infection

Pravin B. Sehgal, New York Medical College, USA
Disruption of Endothelial-Cell Caveolin-1/Raft Scaffolding and STAT3 Activation in the Lung during Development of Monocrotaline-Induced Pulmonary Hypertension

16:30—17:00
Coffee & Snacks Available

Macdonald Foyer
17:00—19:00
Jak-Stat Pathway in Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Stats in T Helper Cell Development

Xiaomin Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Structural and Biochemical Studies of STAT Proteins

Olli J. Silvennoinen, University of Tampere, Finland
Short Talk: Regulation of Jaks and Stats in Cytokine Receptor Signaling

Azad Bonni, Harvard Medical School, USA
Short Talk: Deregulation of the LIFRbeta-STAT3 Signaling Pathway In Brain Tumors

Mariusz A. Wasik, University of Pennsylvania, USA
Short Talk: Stat3-Mediated Epigenetic Silencing of SHP-1 Phosphatase Expression in Malignant T-Cell

19:00—20:00
Social Hour

Macdonald C
19:30—22:00
Poster Session 3

Macdonald C

MONDAY, APRIL 19

07:00—08:00
Breakfast

Macdonald C
08:00—11:00
Jak-Stat Pathway in Cancer
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
Robert D. Schreiber, Washington University School of Medicine, USA
Stat 1 and Cancer Immunoediting

David E. Levy, New York University School of Medicine, USA
Multiple Distinct Mechanisms Underline the Role of Stat3 in Malignant Transformation

* Jacqueline F. Bromberg, Memorial Sloan Kettering Cancer Center, USA
Stats and Tumorigenesis in Epithelial Cells - Breast and Prostate Cancer

Richard Jove, Vaccine & Gene Therapy Institute of Florida, USA
Stats as Novel Targets for Cancer Therapy

Jennifer Rubin Grandis, University of Pittsburgh Eye & Ear Institute, USA
Short Talk: STAT Alterations in Head and Neck Cancer

09:20—09:40
Coffee Break

Macdonald Foyer
16:30—17:00
Coffee & Snacks Available

Macdonald Foyer
17:00—19:00
Jak-Stat Pathway in Infectious Disease
Meeting has ended...abstracts no longer viewable online.

Macdonald AB
Jean-Laurent Casanova, Rockefeller University, USA
Inherited Disorders of Human Stat-1 and Infectious Diseases

* Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria
Interferons and Stats in Machrophage Responses to Intracellular Bacteria

Christine A. Biron, Brown University, USA
STATs in Immune Responses to Viral Infections - Type 1 IFNs

Curt M. Horvath, Northwestern University, USA
Short Talk: Viral Coalitions Uncover Weapons of STAT Destruction

19:00—20:00
Social Hour

Macdonald C
20:00—23:00
Entertainment

Macdonald C

TUESDAY, APRIL 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA108074-01




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