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This meeting took place in 2004
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siRNAs and miRNAs (E1)
Organizer(s) Thomas Tuschl and Victor Ambros
April 14—19, 2004
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Dec 16, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 17, 2004
Sponsored by Alnylam Pharmaceuticals, Inc. and Merck Research Laboratories
Summary of Meeting:
Short double-stranded RNA molecules are important sequence-specific posttranscriptional regulators of gene expression. Two classes of such RNA molecules have been identified: small interfering RNAs (siRNAs) and microRNAs (miRNAs). While siRNAs are generally complementary to mRNAs and mediate mRNA degradation, most miRNAs are only partially complementary and are believed to act predominantly as translational regulators. siRNAs and microRNA-like siRNA precursors have become important tools for studying gene function in mammalian cells and organisms. miRNAs represent an extensive class of evolutionary conserved noncoding RNAs of about 22 nucleotide in length that are thought to regulate gene expression in metazoans. The first miRNAs to be identified were the products of the lin-4 and let-7 genes of Caenorhabditis elegans. The miRNA and RNAi pathways are fundamentally related as members of the Dicer and the Argonaute protein families are involved in both of these RNA-mediated silencing processes. The aim of this meeting is to report on progress in understanding the molecular mechanisms underlying siRNA/miRNA function, as well as the technological adaptation of these cellular mechanisms to genome-wide analysis of gene function in mammalian systems and as therapeutic agents.
View Scholarships/Awards
Short double-stranded RNA molecules are important sequence-specific posttranscriptional regulators of gene expression. Two classes of such RNA molecules have been identified: small interfering RNAs (siRNAs) and microRNAs (miRNAs). While siRNAs are generally complementary to mRNAs and mediate mRNA degradation, most miRNAs are only partially complementary and are believed to act predominantly as translational regulators. siRNAs and microRNA-like siRNA precursors have become important tools for studying gene function in mammalian cells and organisms. miRNAs represent an extensive class of evolutionary conserved noncoding RNAs of about 22 nucleotide in length that are thought to regulate gene expression in metazoans. The first miRNAs to be identified were the products of the lin-4 and let-7 genes of Caenorhabditis elegans. The miRNA and RNAi pathways are fundamentally related as members of the Dicer and the Argonaute protein families are involved in both of these RNA-mediated silencing processes. The aim of this meeting is to report on progress in understanding the molecular mechanisms underlying siRNA/miRNA function, as well as the technological adaptation of these cellular mechanisms to genome-wide analysis of gene function in mammalian systems and as therapeutic agents.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
WEDNESDAY, APRIL 14
THURSDAY, APRIL 15
FRIDAY, APRIL 16
SATURDAY, APRIL 17
SUNDAY, APRIL 18
MONDAY, APRIL 19
Conference Program Print | View meeting in 12 hr (am/pm) time
WEDNESDAY, APRIL 14
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.
Ronald H. Plasterk,
Ministry of Education, Culture and Science, Netherlands
RNAi as the Immune System of the C. elegans Genome
RNAi as the Immune System of the C. elegans Genome
08:00—11:15
RNomics of miRNAs and Other Non-Coding RNAs. Session Sponsored in part by ISIS Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.
Alexander Hüttenhofer,
Universität Innsbruck, Austria
Experimental RNomics: Identification of Small Non-Messenger RNAs in Model Organisms
Experimental RNomics: Identification of Small Non-Messenger RNAs in Model Organisms
Mark A. Kay,
Stanford University, USA
RNAi Therapeutics in Animal Models of Human Hepatitis Infection
RNAi Therapeutics in Animal Models of Human Hepatitis Infection
Oliver Hobert,
Columbia University, USA
Short Talk: Two Asymmetrically Distributed and Sequentially Acting microRNAs Control Chemosensory Laterality in C.elegans
Short Talk: Two Asymmetrically Distributed and Sequentially Acting microRNAs Control Chemosensory Laterality in C.elegans
James C. Carrington,
Donald Danforth Plant Science Center, USA
Small RNAs, Development and Viruses in Plants
Small RNAs, Development and Viruses in Plants
André Verdel,
Harvard Medical School, USA
Short Talk: RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
Short Talk: RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
17:00—19:00
miRNAs in Development and Disease, microRNA Targets
Meeting has ended...abstracts no longer viewable online.
Gary B. Ruvkun,
Massachusetts General Hospital, Harvard Medical School, USA
Enhanced RNAi Mutants of C. elegans
Enhanced RNAi Mutants of C. elegans
Frank J. Slack,
BIDMC Cancer Center/Harvard Medical School, USA
Temporally Expressed miRNAs and the Control of Developmental Timing
Temporally Expressed miRNAs and the Control of Developmental Timing
Ann Rougvie,
, USA
MicroRNAs and the Control of Developmental Time
MicroRNAs and the Control of Developmental Time
Javier F. Palatnik,
Institute of Molecular and Cell Biology of Rosario, Argentina
Short Talk: Control of Leaf Morphogenesis by microRNAs
Short Talk: Control of Leaf Morphogenesis by microRNAs
08:00—11:15
Molecular Mechanisms of RNAi and miRNA Biogenesis and Function - 1. Session Sponsored by Dharmacon, Inc.
Meeting has ended...abstracts no longer viewable online.
Craig C. Mello,
University of Massachusetts Medical School, USA
RNAi and Development in C. elegans
RNAi and Development in C. elegans
Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Biochemical Analysis of Dicer in Mammalian Cells
Biochemical Analysis of Dicer in Mammalian Cells
Thomas Tuschl,
HHMI/Rockefeller University, USA
Transcriptional and Posttranscriptional Gene Regulation by dsRNA-Derived Small RNAs
Transcriptional and Posttranscriptional Gene Regulation by dsRNA-Derived Small RNAs
Young Sik Lee,
Northwestern University, USA
Short Talk: Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways
Short Talk: Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways
Qinghua Liu,
University of Texas Southwestern Medical Center, USA
Short Talk: R2D2 Bridges the Initiation and Effector Steps of the Drosophila RNAi Pathway
Short Talk: R2D2 Bridges the Initiation and Effector Steps of the Drosophila RNAi Pathway
17:00—19:00
Molecular Mechanisms of RNAi and miRNA Biogenesis and Function - 2. Session Sponsored in part by Promega Corporation.
Meeting has ended...abstracts no longer viewable online.
Phillip D. Zamore,
University of Massachusetts Medical School, USA
RNA Interference: Combining Genetics and Biochemistry to Understand Biology and Mechanism
RNA Interference: Combining Genetics and Biochemistry to Understand Biology and Mechanism
Anastasia Khvorova,
University of Massachusetts Medical School, USA
Mechanistic Aspects of Rational siRNA Design
Mechanistic Aspects of Rational siRNA Design
Keqiong Ye,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway
Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway
19:30—22:00
Poster Session 2: Molecular Mechanisms of siRNA and miRNA Biogenesis and Function
08:00—11:00
Large-Scale RNAi Screens in Cultured Mammalian Cells
Meeting has ended...abstracts no longer viewable online.
Gregory J. Hannon,
University of Cambridge, UK
RNAi Mechanism and Application
RNAi Mechanism and Application
René Bernards,
Netherlands Cancer Institute, Netherlands
High-Throughput Loss-of-Function Genetic Screens in Mammalian Cells Using RNA Interference
High-Throughput Loss-of-Function Genetic Screens in Mammalian Cells Using RNA Interference
Peter S. Linsley,
AVI BioPharma, USA
What Expression Profiles Tell Us About siRNAs
What Expression Profiles Tell Us About siRNAs
Iwao Nozawa,
TagCyx Biotechnologies, Japan
Enzymatic Production of siRNA Expression Library
Enzymatic Production of siRNA Expression Library
Mark R. Edbrooke,
GlaxoSmithKline, UK
Short Talk: The Use of RNAi in the Drug Discovery Process
Short Talk: The Use of RNAi in the Drug Discovery Process
17:00—19:00
Large-Scale RNAi Screens in Non-Mammalian Organisms Session Sponsored in part by Cenix BioScience and Mirus Corporation
Meeting has ended...abstracts no longer viewable online.
*
James C. Carrington,
Donald Danforth Plant Science Center, USA
Christophe J. Echeverri,
Cenix BioScience GmbH, Germany
Genome-Wide RNAi Screens from C. elegans and Drosophila to Human Cells and Back
Genome-Wide RNAi Screens from C. elegans and Drosophila to Human Cells and Back
David C. Baulcombe,
University of Cambridge, UK
Mechanisms and Applications of RNA Silencing in Plants
Mechanisms and Applications of RNA Silencing in Plants
Michael Metzlaff,
Bayer BioScience N.V., Belgium
Satellite RNA Virus-Based Gene Silencing Screens in Plants
Satellite RNA Virus-Based Gene Silencing Screens in Plants
19:30—22:00
Poster Session 3: Phenotypic Analysis and Screening Using dsRNA and RNA-Based Therapeutics
08:00—11:00
Development of Gene-Specific Double-Stranded RNA Drugs. Session Sponsored by Sirna Therapeutics, Inc.
Meeting has ended...abstracts no longer viewable online.
*
Peter S. Linsley,
AVI BioPharma, USA
Sailen Barik,
University of South Alabama, USA
RNA Interference Analysis of Host-Pathogen Signaling
RNA Interference Analysis of Host-Pathogen Signaling
Victor R. Ambros,
University of Massachusetts, USA
Classes of Small RNAs Associated with Widespread Gene Silencing in C. elegans
Classes of Small RNAs Associated with Widespread Gene Silencing in C. elegans
Muthiah Manoharan,
Alnylam Pharmaceuticals, Inc., USA
Short Talk: Chemically Modified Short Interfering RNAs: in vivo Systemic Delivery, Pharmacokinetics and Pharmacodynamics in Mouse
Short Talk: Chemically Modified Short Interfering RNAs: in vivo Systemic Delivery, Pharmacokinetics and Pharmacodynamics in Mouse
David V. Morrissey,
Intellia Therapeutics, Inc., USA
Short Talk: Progress in the Development of Therapeutic siRNAs Against Viral Hepatitis
Short Talk: Progress in the Development of Therapeutic siRNAs Against Viral Hepatitis
17:00—19:00
Characterization of Small-RNA-Regulated Networks and Escape from Regulation
Meeting has ended...abstracts no longer viewable online.
*
Craig C. Mello,
University of Massachusetts Medical School, USA
Phillip A. Sharp,
Massachusetts Institute of Technology, USA
Specificity of microRNAs and ES Cell-Specific Expression
Specificity of microRNAs and ES Cell-Specific Expression
Debora Marks,
Columbia University, USA
Computational Biology of miRNA Regulation
Computational Biology of miRNA Regulation
Julius Brennecke,
IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
Short Talk: Identification of miRNA Targets in Drosophila
Short Talk: Identification of miRNA Targets in Drosophila
Erik Sontheimer,
University of Massachusetts Medical School, USA
Short Talk: A Dicer-2-Dependent Assembly Pathway Generates an 80S Silencing Complex in Drosophila
Short Talk: A Dicer-2-Dependent Assembly Pathway Generates an 80S Silencing Complex in Drosophila
Ulrike Gaul,
Rockefeller University, USA
Short Talk: miRNA Function in Drosophila Development
Short Talk: miRNA Function in Drosophila Development
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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Cell Signaling Technology, Inc. |
GenoFunction, Inc. |
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SIRNA Therapeutics |
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Cell Signaling Technology, Inc. |
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Cenix BioScience GmbH |
Mirus Bio LLC |
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