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This meeting took place in 2005



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Molecular Regulation of Stem Cells (B3)


Organizer(s) Margaret A. Goodell, James A. Thomson and Jonas Frisen
February 10—15, 2005
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 11, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 10, 2004

Supported by The Director's Fund

Summary of Meeting:
Stem cells continue to be of enormous scientific and clinical interest, due to the myriad therapeutic possibilities promised by their use. The initial excitement generated by identification of novel stem cell populations has given way to more focused effort on methods to manipulate their differentiation and self-renewal capacities. A number of genome-scale studies are now underway to catalog stem cell gene expression profiles or generate mouse mutants in stem cell-control genes. Coupled with more classical single-gene or pathway approaches to stem cell biology, by 2005, some of the nuts-and-bolts of stem cell function should begin to be revealed. Such fundamental understanding will provide the foundation for more rapid advances toward the clinic. This conference will bring together top stem cell biologists, particularly in the areas of embryonic, neural, and hematopoietic stem cells, to discuss molecular mechanisms of stem cell function.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 10

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Margaret A. Goodell, Baylor College of Medicine, USA

Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Transcriptional Regulation of Stem Cells


FRIDAY, FEBRUARY 11

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Transcriptional Control in Stem Cells
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Irving L. Weissman, Stanford University, USA

Ihor R. Lemischka, Icahn School of Medicine at Mount Sinai, USA
Systems Biology and Stem Cells

Margaret A. Goodell, Baylor College of Medicine, USA
Genetic Regulation of Hematopoietic Stem Cells

Timm Schroeder, ETH Zürich, Switzerland
Short Talk: Tracking Hematopoiesis at the Single Cell Level

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Induction of Mesoderm and Endoderm from Embryonic Stem Cells

Chad A. Cowan, Harvard University, USA
Short Talk: Using Human ES Cells to Study Nuclear Reprogramming

Vincent van den Boom, University Medical Center Groningen, Netherlands
Short Talk: Characterization of the Undifferentiated Embryonic Cell Transcription Factor 7

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Mutational Analysis of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Gordon M. Keller, University Health Network, MaRS Centre, Canada

Judith E. Kimble, University of Wisconsin, Madison, USA
Control of Germline Stem Cells in C. elegans

Hans-Willem E. Snoeck, Columbia University Medical Center, USA
Short Talk: Role of TGFbeta2 in the Regulation of Hematopoietic Stem and Progenitor Cells in Stress State and During Stress

Irving L. Weissman, Stanford University, USA
Hematopoietic Stem Cells

Bruno Péault, University of California, Los Angeles, USA
Human Stem Cells: Assays and Assets

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 1

Alberta/New Brunswick/Riverview

SATURDAY, FEBRUARY 12

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:15
Genetic Control of Stem Cells
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Jonas Frisén, Karolinska Institutet, Sweden

James A. Thomson, Morgridge Institute for Research, University of Wisconsin, USA
Recent Progress in Human Embryonic Stem Cell Culture

Thomas P. Zwaka, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Programmed Cell Death Pathways are Essential for Maintaining Pluripotency

David J. Anderson, California Institute of Technology, USA
Stem and Progenitor Cells in the Developing Spinal Cord

Jean-Pyo Lee, University of California, San Diego, USA
Short Talk: Neural Stem Cell Transplantation Extends Life Span and Improves Neurological Symptoms of Sandhoff Mice

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
The Regulation of Stem Cell Self-Renewal and Aging by Senesence Pathways

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Skin Stem Cells and their Lineages

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:15
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
14:30—16:30
Workshop 1: Hematopoietic Stem Cells

Caroline E. Burns, Harvard Medical School, Massachusetts General Hospital, USA
Notch Signaling is Necessary and Sufficient for Runx1-Dependent Stem Cell Induction in the Embryonic Aorta-Gonad-Mesonephros (AGM) Region

Samir Taoudi, Institute for Stem Cell Research, University of Edinburgh, UK
Embryonic Hematopoietic Stem Cells are Affiliated with the Endothelial Lineage during Emergence and are Dependent upon it for Differentiation

Hanna K.A. Mikkola, University of California, Los Angeles, USA
Placenta is a Niche for Hematopoietic Stem Cells

Bernd Giebel, Heinrich-Heine-University Düsseldorf, Germany
Asymmetric Cell Division of Primitive Hematopoietic Stem and Progenitor Cells

* R. Keith Humphries, British Columbia Cancer Agency, Canada
Multi-Log Clonal ex-vivo Expansion of Long Term Lympho-Myeloid Hematopoietic Stem Cells by Nup98-Hox Fusion Genes

Lina Thorén, Novo Nordisk A/S, Denmark
A Novel Road Map for Blood Lineage Commitment and Development: Identification of a Lympho-Myeloid Stem/Progenitor Cell Lacking Erythro-Megakaryocytic Potential

* Mickie Bhatia, McMaster University, Canada
Hierarchical and Ontogenic Position Serve to Define the Molecular Basis of Human Hematopoietic Stem Cell Behavior

Petter S. Woll, University of Oxford, UK
Functional Natural Killer Cells Derived from Human Embryonic Stem Cells

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Epigenetic Regulation and Reprogramming
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* James A. Thomson, Morgridge Institute for Research, University of Wisconsin, USA

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Nuclear Cloning, Stem Cells, and Reprogramming of the Genome

Azim Surani, University of Cambridge, UK
Epigenetic Mechanism of Germ Cell Specification in Mice

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Epigenetic Regulation of Adult Neurogenesis

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Short Talk: Acquisition and Extinction of Gene Expression Programs are Separable Processes in Nuclear Reprogramming via Heterokeryons

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 2

Alberta/New Brunswick/Riverview

SUNDAY, FEBRUARY 13

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:15
Environmental Regulation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Ronald D. McKay, Lieber Institute for Brain Development, USA

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Hematopoietic Stem Cell Formation during Embrogenesis

Shahin Rafii, Weill Cornell Medical College, USA
Growth Factor and Protease Control of Stem Cell Activation

Fiona M. Watt, King's College London School of Medicine, UK
The Epidermal Stem Cell Niche

Cristina Lo Celso, Imperial College London, UK
Short Talk: Transient Activation of beta-Catenin Signaling in Adult Mouse Epidermis is Sufficient to Induce New Hair Follicles but Continuous Activation is Required to Maintain Hair Follicle Tumors

Arturo Alvarez-Buylla, University of California, San Francisco, USA
The Identification and Origin of adult Neural Stem Cells

D. Chichung Lie, University of Erlangen, Germany
Short Talk: Wnt Signaling Regulates Adult Hippocampal Neurogenesis

09:20—09:40
Coffee Break

Van Horne Foyer
11:15—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Control of Differentiation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Fiona M. Watt, King's College London School of Medicine, UK

Ronald D. McKay, Lieber Institute for Brain Development, USA
Directed Differentiation of ES Cells

Catherine M. Verfaillie, University of Minnesota, USA
Multipotency of Adult Stem Cells

Olle Lindvall, University of Lund, Sweden
Stem Cells for Neural Replacement

Brian D. Hendrich, University of Edinburgh, UK
Short Talk: MBD3 and the NuRD Complex are Required for Embryonic Differentiation of Pluripotent Cells in vitro and in vivo

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 3

Alberta/New Brunswick/Riverview

MONDAY, FEBRUARY 14

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:15
Self Renewal/Maintenance of Pluripotency
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* George Q. Daley, HHMI/Boston Children's Hospital, USA

Jonas Frisén, Karolinska Institutet, Sweden
Regulation of Stem Cell Proliferation in the Adult Brain

Kirsty L. Spalding, Karolinska Institute, Sweden
Short Talk: Analysis of Neuronal Turnover in the Adult Human Brain by the Retrospective Birthdating of Cells

Guy Sauvageau, IRIC/Université de Montréal, Canada
Modulation of Hematopoietic Stem Cell Self-Renewal

Austin Smith, University of Cambridge, UK
Symmetric Self-Renewal of Pluripotent and Somatic Tissue Stem Cells

Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Factors Maintaining Pluripotency

Frank Edenhofer, Institute of Reconstructive Neurobiology, Germany
Short Talk: Modulating Stem Cell Properties by Protein Transduction: A Powerful Tool for Engineering Stem Cells

09:20—09:40
Coffee Break

Van Horne Foyer
14:30—16:30
Workshop 2: Human ES Cells

* Linzhao Cheng, Johns Hopkins School of Medicine, USA
Defining the Role of Wnt/beta-Catenin Signaling in Survival, Proliferation and Self-Renewal of Human ES Cells

Seon Hye Cheon, Mizmedi Hospital, South Korea
Crosstalk between FGF and Wnt Signals Supports the Self-Renewal Maintenance of Human Embryonic Stem Cells

Henrik Semb, University of Copenhagen, Denmark
Differentiation of Human ES Cells Towards Endoderm and Pancreatic Cell Types

Anne Wiblin, Abcam, UK
Nuclear Organization of Human Embryonic Stem Cells

Peter Rugg-Gunn, University of Cambridge, UK
Maintenance of Epigenetic Stability in Human Embryonic Stem Cells

* Melissa K. Carpenter, Robarts Research Institute, Canada
Human Embryonic Stem (hES) Cell Lines Exhibit Varying Patterns of X Inactivation

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Tissue Stem Cells, Generation and Regulation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Margaret A. Goodell, Baylor College of Medicine, USA

George Q. Daley, HHMI/Boston Children's Hospital, USA
Hematopoietic Stem Cells and Germ Cells from ES Cells

Hans R. Schöler, Max Planck Institute for Molecular Biomedicine, Germany
Reprogramming of Somatic Nuclei in Oocytes and Embryonic Stem Cells

Shin-Ichi Nishikawa, RIKEN Center for Developmental Biology, Japan
Stem Cell Niche for Melanocytes

András Simon, Karolinska Institutet, Sweden
Short Talk: Functional Recovery from a Parkinson-Like State in the Newt

Markus Grompe, Oregon Health & Science University, USA
Short Talk

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
20:00—23:00
Entertainment

Alberta/New Brunswick/Riverview

TUESDAY, FEBRUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-GM073351-01




National Institutes of Health
Department of Defense (DOD)

Grant No. W911NF-04-1-0312




We gratefully acknowledge additional support for this conference from:

JDRF March of Dimes Foundation
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



RIKEN, Center for Developmental Biology


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