Sagebrush Inn & Suites Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2005



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Genome Instability and Repair (C2)


Organizer(s) Vihelm A. Bohr, Nancy Maizels and Erling C. Seeberg
March 15—20, 2005
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Nov 15, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 18, 2005

Supported by The Director's Fund

Summary of Meeting:
Genomic stability is essential for normal cellular function, and highly conserved pathways have evolved to repair DNA damage and prevent genomic instability. This meeting will focus on recent advances in understanding the nature and causes of genomic instability, the mechanisms of normal DNA repair, and the consequences of failure in DNA repair. Dramatic increases in the level of genomic instability can occur during normal cell development and aging, and genomic instability is also associated with genetic disease and cancer. Emphasis will be placed on advances that provide mechanistic understanding of specific repair pathways that maintain genomic integrity to prevent disease. The goal of this meeting is to bring together leaders in these areas of research, and via presentations, workshops and discussions to identify new areas of investigation and possible therapeutic strategies that will contribute to the maintenance of genomic integrity. The Passing of Erling Seeberg Erling Seeberg passed away last December at the age of 58 years. He was an outstanding scientist, a terrific colleague and a good friend. He was a co organizer of this conference. He will be sorely missed for his knowledge, insight and wits. I (VB) have collaborated with Erling over years and worked with him on many projects and in the organization of various arrangements. He had a clear and strong sense of quality and was a great asset to an organizing committee like the one for this meeting. His input on this meeting is greatly appreciated and has been an important help for us. We will miss Erling's presence at the meeting and his knowledge and incisive questions. And we will miss his presence at the social events, because he enjoyed a good time with friends, and we will miss the after dinner speech with a funny story or two that he would most certainly have delivered at this event. Let us take the opportunity to remember him throughout this meeting and think not only about all his very important scientific contributions, but also about the wonderful person that he was. ~ Vilhelm A. Bohr and Nancy Maizels

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 15

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—19:45
Opening Address and Tribute to Erling Seeberg
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Vilhelm A. Bohr, NIA, National Institutes of Health, USA

Nancy Maizels, University of Washington School of Medicine, USA

19:45—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair in Cancer and Aging

Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Telomeres and Telomerase in Response to DNA Damage Signaling


WEDNESDAY, MARCH 16

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Recognition of DNA Damage
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Hans E. Krokan, Norwegian University of Science and Technology, Norway
Uracil in DNA - Consequences and Mechanisms of Repair

Sankar Mitra, University of Texas Medical Branch, Galveston, USA
Newly Discovered Human DNA Glycosylases (NEILs) are Functionally Distinct from the Previously Characterized OGG1/NTH1

Keith W. Caldecott, University of Sussex, UK
Chromosomal Single-Strand Break Repair and Neurodegenerative Disease

Lars Eide, National Hospital of Norway, Norway
Short Talk: The Sensitivity of Cockayne Syndrome B Cells to Oxidative Stress is Promoted by the Action of the Ogg1 Mitochondrial 8-Oxoguanine DNA Glycosylase

Arne Klungland, National Hospital, University of Oslo, Norway
Short Talk: Knockout, Knockin and Knockdown of FEN1

John M. Essigmann, Massachusetts Institute of Technology, USA
Sources and Fates of DNA Damage

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Responses to DNA Damage
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Leona D. Samson, Massachusetts Institute of Technology, USA
Global Responses to DNA Damaging Agents

Eric T. Larson, University of Washington, USA
Short Talk: Abasic Endonuclease Activity of MRE11/RAD50

Kenna L. Anderes, Cylene Pharmaceuticals, USA
Therapeutic Implications of DNA Repair and Checkpoint Inhibition

Fumio Hanaoka, Osaka University, Japan
Molecular Mechanisms of Translesion DNA Synthesis by XPV Polymerase

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, MARCH 17

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Mechanisms of DNA Repair, Base Modifications
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Samuel H. Wilson, NIEHS, National Institutes of Health, USA
Structural Biology of Repair Polymerases

Bruce Demple, Stony Brook University Medical School, USA
Roles of Mammalian BER in Handling Endogenous and Environmental DNA damage

Bernd Kaina, University of Mainz, Germany
Short Talk: Apoptotic Signaling Triggered by O6-Alkylguanine Lesions

Grigory L. Dianov, Medical Research Council, UK
Short Talk: Protein Dynamics on Damaged DNA during Base Excision Repair in Human Cell Extracts

Akira Yasui, Institute of Development, Aging and Cancer, Tohoku University, Japan
Dynamic Responses to Single-Strand Breaks in Human Cells

John A. Tainer, The Scripps Research Institute, USA
DNA Repair Choreography: Conformational Controls for Chemistry and Coordination

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Mechanisms of Processing Repair Intermediates
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Penny A. Jeggo, University of Sussex, UK
A Novel Role for ATM in DNA Double Strand Break Rejoining

Laura J. Niedernhofer, The Scripps Research Institute, USA
Premature Aging in Crosslink Repair-Deficient Ercc1-/- Mice

Anna Marie Skalka, Fox Chase Cancer Center, USA
Short Talk: Histone H2AX is Phosphorylated at Sites of Retroviral DNA Integration, but is Dispensable for Post-Integration Repair

Stephen C. West, Francis Crick Institute, UK
Double-Strand Break Repair by Homologous Recombination

19:00—20:00
Social Hour

Chamisa Ballroom 2
20:00—22:00
Workshop 1: Genomic Instability in Cancer and Aging

Chamisa Ballroom 1
* Lawrence A. Loeb, University of Washington, USA
Introduction

Robert D. Shereda, University of Wisconsin Medical School, USA
Protein-Protein Interactions Involving E. coli RecQ DNA Helicase

Carla Grandori, SEngine Precision Medicine and Cure First, USA
Role of Werner Protein in Myc-Induced DNA Damage

Nicholas D. Chester, Harvard Medical School, USA
Induction of a Global Secondary Genomic Instability in Bloom’s Syndrome Tumor Cell Lines is Preceded by Chromosome Loss

Ashwini S. Kamath-Loeb, University of Washington, USA
The Enzymatic Activities of the Werner Syndrome Protein are Disabled by the Amino Acid Polymorphism, R834C

Bernard S. Lopez, Institut Gustave Roussy, France
Genome Rearrangements Induced by Double Strand Breaks and NHEJ In Mammalian Cells

Michelle L. Duquette, University of Washington, USA
Transcription of c-MYC Induces DNA Structure Formation in Translocation Breakpoint Associated Regions

Heng-Kuan Wong, NIA, National Institutes of Health, USA
The XRCC1 and DNA Polymerase b Interaction Contributes to Cellular Alkylating-Agent Resistance and Single-Strand Break Repair

Rhoderick H. Elder, Paterson Institute for Cancer Research, UK
Compensating for DNA Glycosylase Deficiency

Sophie Bellon, Medical Research Council, UK
Effect of NAD+ in Base Excision Repair of Simple or Clustered DNA Damaged Sites

Yousin Suh, Albert Einstein College of Medicine, USA
Apoptosis, Genome Maintenance, and Aging


FRIDAY, MARCH 18

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Repair and Recombination in Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Nancy Maizels, University of Washington School of Medicine, USA
Mutagenic Repair and Recombination in the Immune Response

Mark P. Mattson, National Institute on Aging, and Johns Hopkins University School of Medicine, USA
DNA Damage and Repair in the Nervous System

Susanna Maxwell Lewis, Harvard Medical School, USA
Short Talk: True Perfect Palindromes in the Human Genome: Validation and Analysis of Rearrangement Hyper-Hotspots

David B. Roth, New York University School of Medicine, USA
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Aging
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Human Premature Aging Proteins: Links between Aging and DNA Repair

Judith Campisi, Buck Institute for Research on Aging, USA
Postponing Aging and Cancer: Cellular Functions of the BLM and WRN Helicases

Wen-Hsing Cheng, , USA
Short Talk: WRN Functions in the Cellular Response to DNA Cross-Links

Jan Vijg, Albert Einstein College of Medicine, USA
Genome Instability and Aging

19:00—20:00
Social Hour

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

SATURDAY, MARCH 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Chromosomal Outcomes of Genomic Instability
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Alan R. Lehman, University of Sussex, UK
The XPD Gene: Genotypes and Phenotypes

Patricia L. Opresko, University of Pittsburgh, USA
RecQ Helicases and DNA Repair Pathways at Telomeric DNA

Weihang Chai, Washington State University, USA
Short Talk: The Role of DNA Repair Factors in Telomere End Processing

Thomas E. Wilson, University of Michigan, USA
Short Talk: Separation-of-Function Mutants of Ku80 and Xrs2; Evidence for a Concerted NHEJ Repairosome

Peter M. Lansdorp, BC Cancer Research Center, Canada
Helicase-Like Proteins Required to Prevent Instability of G-Rich DNA in C. elegans and Mice

09:20—09:40
Coffee Break

Chamisa Lobby
15:00—16:30
Workshop 2: Dynamics, Modulation and Regulation of DNA Repair

Chamisa Ballroom 1
* Michael M. Seidman, NIA, National Institutes of Health, USA
Introduction

Michael J. Siciliano, University of Texas, USA
Microsatellite Instability (MSI) Increases in PBLs of Normals with Age and in Older Persons Approaches Levels Seen in the PBLs of Younger Patients Carrying Germline Mutations for Cancer Predisposition

Yiduo Hu, Editas Medicine, USA
RecQ DNA Helicases Blm and Recql5 have Non-Redundant Functions in the Suppression of Mitotic Crossovers in Mouse

Ramiro G. Dip, University of Zurich, Switzerland
Molecular Analysis of the Xeroderma pigmentosum Group A Protein Function by Site-Directed Mutagenesis

Jinhu Yin, NIA, National Institutes of Health, USA
BLAP75, an Essential Component of Bloom Syndrome Protein Complexes and Required for Maintaining Genome Integrity

Barbara C. Godthelp, Leiden University Medical Center, Netherlands
BRCA2, A True Member of the Fanconi anemia/BRCA DNA Repair Pathway?

Patricia L. Foster, Indiana University, USA
Error-Prone DNA Polymerase IV (DinB) and the Stress-Responses of E. coli

Barbara Kraatz Fortini, University of Southern California, USA
Dna2 Helicase/Nuclease is a Substrate of Mec1

16:30—17:00
Coffee & Snacks Available

Chamisa Lobby
17:00—19:00
Diseases of DNA Repair
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Ian D. Hickson, University of Copenhagen, Denmark
Genomic Instability and Cancer: Defining the Role of the Bloom’s Syndrome Helicase

Curtis C. Harris, NCI, National Institutes of Health, USA
p53 and Genomic Instability Diseases: At the Crossroads of DNA Repair and Recombination

Tomas Lindahl, Cancer Research UK, UK
Recent Progress on Repair of Alkylated and Oxidized DNA Bases in Mammalian Cells

19:00—20:00
Social Hour

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, MARCH 20

00:00—00:00
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-AG025621-01




We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676