Eldorado Hotel & Spa Floorplan

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This meeting took place in 2005



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Molecular Targets for Cancer Therapy (A2)


Organizer(s) Sara A. Courtneidge and Frank McCormick
January 6—11, 2005
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Sep 15, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 8, 2004

Sponsored by Genentech, Inc. and Novartis Institutes for BioMedical Research

Summary of Meeting:
Recent years have seen the approval of several targeted cancer therapeutics. For example, Herceptin (which targets Her2) is used for the treatment of some breast cancers, Gleevec (targeting Bcr-Abl and c-Kit) for chronic myelogenous leukemia and gastrointestinal stromal tumors, and Iressa (targeting the EGF receptor) for lung cancer. These new drugs highlight that we have entered an exciting era, in which cancer therapy involves identifying and targeting key molecular drivers of the disease. Yet many very important questions remain, including: Which are the best molecular targets? What is the role of combination therapy? And anti-angiogenesis therapy? Which animal models are most predictive of the human disease? Should we be targeting "cancer stem cells"? The goal of this meeting is to bring together leaders from all areas of cancer research to discuss these issues surrounding the identification of new molecular targets, and the generation and testing of therapeutics directed against them.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 6

15:00—19:30
Registration

Zia Concourse
18:30—19:30
Refreshments

Sunset Room
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Sara A. Courtneidge, Sanford-Burnham Medical Research Institute, USA

* Frank McCormick, University of California, San Francisco, USA

Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
3-Dimensional Models of Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
TGF-beta and Cancer


FRIDAY, JANUARY 7

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Mouse Models of Cancer. Session Sponsored by Genentech, Inc.
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Genetics of Drug Sensitivity and Resistance

Irving L. Weissman, Stanford University, USA
Cancer Stem Cells

Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Tumors of the Nervous System

Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Inducible Onco-Transgene Models for Identification of Tumor Maintenance Targets

Louise R. Howe, Weill-Cornell Medical College, USA
Short Talk: HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis are Reduced in Cox-2-Deficient Mice

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee & Snacks Available

Zia Concourse
17:30—19:00
Proliferation
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Charles J. Sherr, St. Jude Children's Research Hospital, USA
Oncogene Suppression by Arf

Jeffrey Settleman, Calico Life Sciences, USA
Drug-Sensitive EGF Receptor Mutations in Human Lung Cancer

Spiros Linardopoulos, Breakthrough Breast Cancer Research Centre, UK
Short Talk: IkappaBalpha Phosphorylation by STK15 is Critical for NF-kappaB Activation

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

SATURDAY, JANUARY 8

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Genomic and Proteomic Strategies
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Richard M. Caprioli, Vanderbilt University Medical Center, USA
New Proteomic Approaches

Elise C. Kohn, National Institutes of Health, USA
Proteomics: Application to Serum and Tissue Biomarkers

Michael Stratton, Wellcome Trust Sanger Institute, UK
Mutational Screens of the Protein Kinase Gene Family in Human Cancers

* René Bernards, Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens

Britta Weigelt, Netherlands Cancer Institute, Netherlands
Short Talk: Breast Cancer Lymph Node Metastasis Involves Tumor-Specific Sets of ECM-Remodeling and Growth Factor Signaling Genes

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee & Snacks Available

Zia Concourse
17:00—19:00
Stem Cells
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Tyler Jacks, Massachusetts Institute of Technology, USA
Lung Cancer

Fiona M. Watt, King's College London School of Medicine, UK
Epidermal Stem Cells

Cédric Blanpain, Universite Libre de Bruxelles, Belgium
The Skin Stem Cell Niche

Ugur Ozerdem, La Jolla Institute for Molecular Medicine, USA
Short Talk: Pericytes in Angiogenesis in Neurofibromatosis Type 1

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

SUNDAY, JANUARY 9

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Apoptosis and Cell Cycle
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Karen H. Vousden, Crick Institute, UK
The p53 Tumor Suppressor Pathway

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Signaling Pathways that Promote Survival/Death of Proliferating Cells

Gerard I. Evan, University of Cambridge, UK
Determining the Requirements for Tumor Maintenance in vivo

Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
ABL Kinase Inhibitor Resistance in Chronic Myeloid Leukemia: Mechanisms and Potential Solutions

Mark R. Philips, New York University Cancer Institute, USA
Short Talk: A Farnesyl-Electrostatic Switch Regulates K-Ras Association with Mitochondria and Stimulates Apoptosis

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee & Snacks Available

Zia Concourse
17:00—19:00
Genomic Integrity/Epigenetic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Thea D. Tlsty, University of California, San Francisco, USA
Targeting Early Events in Cancer for Prevention

Victoria M. Richon, Sanofi, USA
HDAC Inhibitors in the Clinic

Carl Barrett, AstraZeneca, USA
Title to be Determined

Debajit K. Biswas, Dana Farber Cancer Institute, USA
Short Talk: NF-kappaB Activation as a Target Directed Therapy for Estrogen Receptor-Negative Human Breast Cancers

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room

MONDAY, JANUARY 10

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Angiogenesis and Metastasis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Joan S. Brugge, Harvard Medical School, USA
Use of a 3D Breast Epithelial Model to Investigate Signaling Pathways that Regulate Morphogenesis and Oncogenesis

Napoleone Ferrara, University of California, San Diego, USA
VEGF and Tumor Angiogenesis: Basic Science and Clinical Progress

Zena Werb, University of California, San Francisco, USA
Metalloproteases, Inflammation and Invasion during Tumor Progression

Sara A. Courtneidge, Sanford-Burnham Medical Research Institute, USA
The Roles of Src and its Substrate Fish in Tumor Cell Invasion

Pran K. Datta, Vanderbilt University Medical Center, USA
Short Talk: A Specific Inhibitor of TGF-beta Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Advanced Human Cancers

09:20—09:40
Coffee Break

Zia Concourse
16:30—17:00
Coffee & Snacks Available

Zia Concourse
17:00—19:00
Alternative Strategies/New Developments
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Frank McCormick, University of California, San Francisco, USA
Adenoviruses as Therapeutics

Patrick Lee, Dalhousie University, Canada
Reovirus Oncolysis

* Michelle D. Garrett, ICR Sutton, UK
New Targets/Small Molecule Drugs Heading for the Clinic

Nathan T. Ihle, MD Anderson Cancer Center, USA
Short Talk: Potentiation of the Antitumor Activity of Iressa by PX-866 a Novel Inhibitor of Phosphoinositide-3-Kinase

19:00—20:00
Social Hour

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

TUESDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-CA112983-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Genentech, Inc.
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Merck Research Laboratories


Merck Research Laboratories


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