Fairmont Banff Springs Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2005



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Role of Microenvironment in Tumor Induction and Progression (J5)


Organizer(s) Mina Bissell, Ronald DePinho and Luis Parada
February 5—10, 2005
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Oct 5, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 6, 2004

Sponsored by Abbott Laboratories


Summary of Meeting:
A shift has begun to take place in both the cancer research community and in funding agencies that support tumor biology as to the relative importance of microenvironmental control in differentiation and cancer. There is increased appreciation of the role of the microenvironment and "context" in both normal tissue function and cancer initiation and progression. Indeed, NCI has initiated an "extraordinary funding opportunity" program to extend its signatures of the cancer cell to its microenvironment (http://plan.cancer.gov/discovery/sigs.htm). An excerpt follows: "Six years ago, NCI established "Defining the Signatures of Cancer Cells"- Extraordinary Opportunity to promote research aimed at identifying and characterizing the full compendium of signature changes that occur within cancer cells. Now, as increasing evidence suggests that the host microenvironment plays a pivotal role in cancer development, we need to expand our effort to consider how the interaction of the cancer cell and microenvironment permits, and even encourages tumor development. Scientists pursuing this promising new scientific opportunity will read not only the signatures of cancer cells but also signatures of seemingly normal cells within the tumor microenvironment and signatures that reflect changes that occur as cancer cells interact with the host microenvironment." Thus, thinking of both normal and cancer cells in context and as part of a larger structural entity is an area ripe for a sea of change. However, the general understanding and appreciation of the complexity and the extent of the microenvironment's influence on tissue function and dysfunction is limited, and at times simplistic. To move the field in this area so that thoughtful and significant research could be accomplished would require an in-depth dialogue between the vast majority of cell and molecular biologists who concentrate on the molecules and the cells and those who have worked in the context of the tissue and the host. Nevertheless, an interesting aspect of these developments is that before the advent and the excitement of molecular biology in the 70s and 80s, there was a considerable amount of important work in this area, which now could lend itself to mechanistic scrutiny. This body of work needs to be rediscovered, sorted, and built upon. The goal of this meeting is not only to bring together past and the present research in this field, but also point the way to where we need to go. We will bring together a number of experts who have done pioneering work in this complex area, and some of the new talents to the field, and showcase recent exciting developments and chart a map for accelerating future exploration and interactions. We need to capture more brilliant minds to enter this area. In this meeting, we propose to unravel the excitement and the promise of the field.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 5

15:00—19:30
Registration

Van Horne Foyer
18:30—19:30
Refreshments

Van Horne Foyer
19:30
Introductory Remarks

Van Horne Ballroom A/B
Mina J. Bissell, Lawrence Berkeley National Laboratory, USA

Suresh Mohla, NCI, National Institutes of Health, USA

19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
Zena Werb, University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis as a Developmental Problem


Following Session is for Cancer and Development (J6)

19:30—21:30
Keynote Session: Development, Cancer, and the Microenvironment (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
Zena Werb, University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis as a Developmental Problem


SUNDAY, FEBRUARY 6

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Angiogenesis and the Microenvironment
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Luisa Iruela-Arispe, University of California, Los Angeles, USA
Microenvironmental Regulation of Vascular Patterning

Nancy J. Boudreau, NCI, National Institutes of Health, USA
Co-Ordinate Loss of Hox D10 in Breast Tumor Progression and Angiogenesis; Bi-Directional Communication between Breast Tumor Epithelium and Angiogenic Stroma

Randall S. Johnson, University of Cambridge, UK
The Role of Endothelial Cell Hypoxic Response in Tumor Formation

Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
The Epigenetic Effect of the Metastatic Microenvironment on Tumor Cell Plasticity

Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Short Talk


Following Session is for Cancer and Development (J6)

08:00—11:00
Signal Transduction Pathways in Development and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
* Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Wnt Signaling and Dishevelled Function

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Growth Control

Matthew P. Scott, Stanford University, USA
Development and Cancer of the Cerebellum

Matthias Hebrok, University of California, San Francisco, USA
Embryonic Signaling Pathways in Pancreatic Cancer

JoMichelle D. Corrales, Impact Communications, USA
Short Talk: Gli2 Mediates the Mitogenic Function of Sonic Hedgehog in the Developing Mouse Cerebellum

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Microenvironmental Influence on Metastasis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages Promote Mammary Tumor Progression and Metastasis.

Kenneth J. Pienta, Cue Biopharma, Inc., USA
Metastatic Cancer is a Heterogeneous Group of Diseases

* Richard O. Hynes, Massachusetts Institute of Technology, USA
ECM Receptors and Metastasis

Pepper Jo Schedin, Oregon Health & Science University, USA
Short Talk: Remodeling of the Mammary Tumor Microenvironment Following Pregnancy Promotes Tumor Cell Metastasis; a Plausible Mechanism for Poor Prognosis of Pregnancy-Associated Breast Cancer


Following Session is for Cancer and Development (J6)

17:00—19:00
Cell Cycle
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
* Iswar K. Hariharan, University of California, Berkeley, USA
Pathways that Regulate Growth and Cell Proliferation in Drosophila and Humans

Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Growth and Metastasis in Drosophila

Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
The Role of the Rb Family in Retinal Development and Retinoblastoma

Erica L. Jackson, University of California, San Francisco, USA
Short Talk: PDGF Signaling in Neural Stem Cells and Glioma Formation

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 1

Alberta/New Brunswick/Riverview

MONDAY, FEBRUARY 7

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Stromal-Epithelial and Heterotypic Interactions
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Harold L. Moses, Vanderbilt University, USA
Stromal and Epithelial TGF-ß Signaling in Carcinoma Initiation and Progression

Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Modulation of Mammary Stromal-Epithelial Interactions During Radiation Carcinogenesis

Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Selective Inactivation of P53 in Prostate Stroma in Response to Epithelial Tumorigenesis; Coevolution of Both Compartments During Tumor Progression

Leland W.K. Chung, Emory University School of Medicine, USA
Stromal-Epithelial Interaction in Prostate Cancer Bone Metastasis

Olivier De Wever, University of Ghent, Belgium
Short Talk: Implication of Stromal Myofibroblasts in Cancer Invasion


Following Session is for Cancer and Development (J6)

08:00—11:00
Cancer Gene Functions
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
Dean Walton Felsher, Stanford University, USA
Conditional Transgenic Mouse Models of Oncogenesis in a Developmental Context

Charles J. Sherr, St. Jude Children's Research Hospital, USA
The Ink4a/Arf Tumor Suppressor Network

* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells and Prostate Cancer Development

Thomas Curran, Children's Hospital of Philadelphia, USA
Mouse Models and Molecular Targeted Therapies: Sonic Hedgehog Pathway Antagonist in Medulloblastoma

Robert B. Clarke, University of Manchester, UK
Short Talk: Isolation and Characterization of Human Mammary Stem Cells

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Recent Advances in Signaling in 3D Microenvironments
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways in Morphogenesis and Apoptosis

Valerie M. Weaver, University of California, San Francisco, USA
Tissue Polarity and the Mechanism of Epithelial Resistance to Chemotherapy

Edna Cukierman, Fox Chase Cancer Center, USA
Primed Stroma 3D-Adhesions; Inciters of Tumor Permissiveness

John L. Muschler, California Pacific Medical Center, USA
Short Talk: Loss of dystroglycan function alters responses to laminin-1 in carcinoma cells


Following Session is for Cancer and Development (J6)

17:00—19:00
Cancer Origins
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
* Elizabeth H. Blackburn, The Salk Institute, USA
Distinct growth responses of human cancer cells to perturbing telomeres and telomerase

Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Identification of Developmentally Regulated Genes in Human Colorectal Cancer (CRC)

Ling-Jie Kong, Merck Research Laboratories, USA
Short Talk: The Role of the Rb Family Protein p130 in Telomere Length Control

Sumana Datta, Texas A & M University, USA
Short Talk: Brain Development and Prostate Cancer: From Flies to Humans

Ellen E. McCarthy, Columbia University, USA
Short Talk: Bard1 and Mammary Tumorigenesis

19:00—20:00
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 2

Alberta/New Brunswick/Riverview

TUESDAY, FEBRUARY 8

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Cancer Models (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A/B
* Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Genetics and Biology of Pancreas Cancer

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Stem Cells and their Lineages in Skin

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Epigenetic Changes in Cancer and the Reversibility of the Malignant Phenotype

Derek Radisky, Mayo Clinic, USA
Short Talk: MMP-3-Induced Malignancy in Mammary Epithelial Cells

James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: A Genetic Model of Testicular Cancer in the Zebrafish

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/New Brunswick/Riverview
13:00—22:00
Poster Viewing

Alberta/New Brunswick/Riverview
14:30—16:30
Workshop: Cancer, Aging and the Microenvironment

Van Horne Ballroom A
* Judith Campisi, Buck Institute for Research on Aging, USA
Cancer and Aging: Role of the Senescent Microenvironment

Irmgard Irminger-Finger, University of Geneva, Switzerland
Short Talk: Function of BARD1 in Tumor Suppression and Aging

S. Ruby Chan, Washington University, USA
Short Talk: Characterization of Mammary Adenocarcinomas that Spontaneously Develop in Aged STAT1-Deficient Female Mice

Babett Bartling, Martin Luther University, Germany
Short Talk: RAGE Diminishes the Proliferative Effect of Fibroblasts on Human Lung Cancer Cells

Thea D. Tlsty, University of California, San Francisco, USA
Epigenetic and Genetic Changes Control Tumorigenic Phenotypes and Occur in vivo in Human Mammary Epithelia

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
The Extracellular Matrix and its Degrading Enzymes in Tumor Progression and Metastasis
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Lynn M. Matrisian, Vanderbilt University School of Medicine, USA
MMPs in Cancer

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Extracellular Matrix Degradome Contributes to a Novel Class of Tumor Suppressors

Seth L. Schor, University of Dundee, UK
Migration Stimulating Factor (MSF): A Potent Bi-Directional Mediator of Tumor-Stromal Interactions

James P. Quigley, The Scripps Research Institute, USA
Short Talk: Janus Nature of Tumor Microenvironment: MMPs from the Stromal Face and the Tumor Face


Following Session is for Cancer and Development (J6)

17:00—19:15
Signaling Pathways and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signal Transduction

* Hans C. Clevers, Hubrecht Institute, Netherlands
Beta-Catenin-TCF in Development and Cancer

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control

Lee L. Rubin, Harvard University, USA
The Hedgehog Signaling Pathway and Cancer: Therapeutic Use of Small Molecule Antagonists

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Short Talk: Molecular and Cellular Origins of Medulloblastoma

19:15—20:15
Social Hour

Alberta/New Brunswick/Riverview
19:30—22:00
Poster Session 3

Alberta/New Brunswick/Riverview

WEDNESDAY, FEBRUARY 9

07:00—08:00
Breakfast

Alberta/New Brunswick/Cascade
08:00—11:00
Role of Inflammatory Cells and Cytokines in the Tissue and Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
* Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Mast Cells and Tumor Induction Models

Douglas Hanahan, ISREC, Switzerland
Immune Enhancement and Therapy of Cancer

Lisa M. Coussens, Oregon Health & Science University, USA
Innate and Adaptive Immune Interactions Regulate Cancer Development

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Molecular Profile of the Tumor Microenvironment in Breast Cancer

Julia L. Wilson, , UK
Short Talk: Expression of the Chemokine Receptor CXCR4 Alters the Behavior of Ovarian Cancer Cells in vitro and in vivo


Following Session is for Cancer and Development (J6)

08:00—11:00
Growth Control
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
Max S. Wicha, University of Michigan, USA
Stem Cells in Human Human Breast Development and Cancer

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Growth Control in C. elegans

* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer

A. Thomas Look, Dana-Farber Cancer Institute, USA
Genetics of T-Cell Acute Lymphoblastic Leukemia: The Role of Notch

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: Genetic Mapping of Notch1 Activity in vivo

09:20—09:40
Coffee Break

Van Horne Foyer
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Concluding Session
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A
M. Judah Folkman, Children's Hospital Boston, USA
How Early Can Cancer be Treated?

Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
Summary of the Meeting: Looking to the Future


Following Session is for Cancer and Development (J6)

17:00—19:00
Checkpoints and Signal Transduction
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom B
Anindya Dutta, University of Virginia, USA
Checkpoint Pathways Monitor Levels of Replication Initiators in Cancer Cells

* Garry P. Nolan, Stanford University, USA
Single Cell Proteomics of Cancer: Remodeling of Networks on a Patient by Patient Basis

Esther M. Verheyen, Simon Fraser University, Canada
Short Talk: Control of Wnt and BMP Signaling by the Nemo-like Kinase during Drosophila Development

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: The Small GTPase Rap1, the cAMP Target Epac and Integrin- and Cadherin-Mediated Cell Adhesion

19:00—20:00
Social Hour

Cascade/Conservatory/Riverview
20:00—23:00
Entertainment

Cascade/Conservatory/Riverview

THURSDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-CA113258-01




National Institutes of Health
Department of Energy Nat'l Nuclear Security Administration (DOE)

Grant No. DE-FG02-05ER64025




We gratefully acknowledge additional support for this conference from:

Abbott Laboratories AVEO Pharmaceuticals, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676