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This meeting took place in 2005



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Cell Polarity and Asymmetric Cell Divisions (X1)


Organizer(s) Norbert Perrimon, Francois Schweisguth and Ben Margolis
March 4—8, 2005
Coeur d'Alene Resort • Coeur d'Alene, Idaho USA
Abstract Deadline: Nov 4, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 4, 2005

Supported by The Director's Fund


Summary of Meeting:
The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia, segregation of membrane proteins into apical and basolateral compartments is critical for cell morphology, tissue physiology, and cell signaling. In the past few years, significant discoveries have been made that gave numerous insights on the mechanisms that restrict these determinants to the cell surface. Our understanding of these mechanisms has deep implications in our understanding of cell signaling and cancer for example, as mutations in some of the components involved in organizing cell polarity are associated with tumorous phenotypes. Further, recent studies on the mechanisms underlying asymmetric cell divisions, the process by which one cell gives rise to two daughters of different sizes, have implicated some of the proteins initially thought to be devoted to cell polarity in this process. Finally, reorganization of cell polarity determinants appears to be a critical step in the process of cell delamination and migration from an epithelium. Considering the exciting new findings emerging from studies on cell polarity, cell asymmetry, signal transduction and cell migration, we propose to organize a meeting that will bring together leaders in these fields. The goal of the meeting is to bring together the leading experts that study the mechanism of cell polarization and cell asymmetry to discuss emerging concepts.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 4

15:00—19:30
Registration

Conference Center Lobby
18:30—19:30
Refreshments

Bay 4
19:30—21:30
Keith R. Porter Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
Yuh-Nung Jan, University of California, San Francisco, USA
Extreme Cell Polarity: Morphogenesis of Dendrites versus Axons.

J. Victor Small, Austrian Academy of Sciences, Austria
Tailoring the Actin Cytoskelaton for Cell Movement


SATURDAY, MARCH 5

07:00—08:00
Breakfast

Bay 4
08:00—11:00
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
Norbert Perrimon, Harvard Medical School, USA
Signaling Pathways, Cell Polarity and Cytoskeletal Organization during Morphogenesis of Epithelia

* Clare M. Waterman-Storer, National Heart, Lung and Blood Institute National Institutes of Health, USA
Spatial Regulation of Microtuble Dynamics by Rac1 in Migrating Epithelial Cells

Gregg G. Gundersen, Columbia University, USA
Rho GTPase Regulation of Microtubule Stabilization and Centrosome Position during Cell Migration

Ilan Davis, University of Edinburgh, UK
Short Talk: Dynein Dependent mRNA Transport and Anchoring

09:20—09:40
Coffee Break

Conference Center Lobby
11:00—13:00
Poster Setup

Bay 5-6
13:00—22:00
Poster Viewing

Bay 5-6
16:30—17:00
Coffee & Snacks Available

Bay 5-6
17:00—19:00
Epithelial Polarity
Meeting has ended...abstracts no longer viewable online.

Bay 2
* Ben Margolis, University of Michigan, USA
Apical Polarity Complexes in Mammalian Cells

Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Protein Complexes and Interaction Networks in Polarity

Elisabeth Knust, Max Planck Institute of Molecular Cell Biology and Genetics, MPICBG, Germany
Drosophila Crumbs – From Epithelial Cell Polarity to Retinal Degeneration

Ian G. Macara, University of Virginia School of Medicine, USA
Short Talk: Par Proteins and Polarity in Epithelial Nuerons

Tony J.C. Harris, University of North Carolina at Chapel Hill, USA
Short Talk: Establishing the Apical Domain in the Early Drosophila Epithelium

17:00—19:15
Molecular Mediators of Cytoskeleton Crosslinking
Meeting has ended...abstracts no longer viewable online.

Bay 3
* Tony Koleske, Yale University, USA
Regulation fo Cell and Neuronal Morphogenesis by Abl Kinases

Lee A. Ligon, University of Pennsylvania, USA
Short Talk: Microtubule Plus-End Proteins and Microtubule-Cortex Interactions

John A. Hammer, NHLBI, National Institutes of Health, USA
MyosinV, Melanophilin and EB1at Microtubule plus Ends

Miki Tsukada, Max-Planck-Institute for Experimental Endocrinology, Germany
Short Talk: Doublecortin Association with Actin Filaments is regulated by Neurabin II

William S. Trimble, Hospital for Sick Children, Canada
Septin Activate Rho Kinase to Mediate Myosis Light Chain Phosphorylation

19:00—20:00
Social Hour

Bay 5-6
19:30—22:00
Poster Session 1

Bay 5-6

SUNDAY, MARCH 6

07:00—08:00
Breakfast

Bay 4
08:00—11:00
Microtubule/Actin Interactions during Cell Polarization (Joint)
Meeting has ended...abstracts no longer viewable online.

Bay 2-3
Inke S. Näthke, University of Dundee, UK
The Adenomatous Polyposis coli Protein in Directed Cell Migration

Keith E. Mostov, University of California, San Francisco, USA
Polarized Membrane Traffic and Epithelial Morphogenesis

* Geraldine Seydoux, Johns Hopkins School of Medicine, USA
Par-2 and Stabilzation of Cortical Polatity in the C. elegans Zygote

Kerry S. Bloom, University of North Carolina at Chapel Hill, USA
The Role of Kar3p, a Minus-End Directed Kinesin, in Mitosis, Spindle Orientation and Karyogamy

Monica Gotta, Institute of Biochemistry, ETH, Switzerland
Short Talk: New Genes Required for PAR-Dependent Polarity

09:20—09:40
Coffee Break

Conference Center Lobby
11:00—13:00
Poster Setup

Bay 5-6
13:00—22:00
Poster Viewing

Bay 5-6
16:30—17:00
Coffee & Snacks Available

Bay 5-6
17:00—19:15
Polarity Establishment during Development
Meeting has ended...abstracts no longer viewable online.

Bay 2
* Jeffrey D. Axelrod, Stanford University, USA
Understanding the Logic of Planar Cell Polarity Signaling

Daniel St Johnston, University of Cambridge, UK
Cell Polarity during Drosophila Oogenesis

Jennifer A. Zallen, Sloan-Kettering Institute, USA
Molecular Control of Polarized Cell Movement

Thomas Lecuit, Universite of Marseille, France
Junction Assembly and Remodeling Underlying Epithelial Morphogenesis

17:00—19:15
Interactions between Cytoskeletal Systems in Neuronal Function
Meeting has ended...abstracts no longer viewable online.

Bay 3
Shelley Halpain, University of California, San Diego, USA
MAP2 as a Mediator of Microtubule/Actin Interactions in Neurons

Fengquan Zhou, Johns Hopkins University, USA
Short Talk: Par3/6-PKCzeta Pathway Regulates GSK-3beta Activity and the Function of APC to Mediate Axon Growth

* Paul Forscher, Yale University, USA
Microtubule-Actin Interactions and their Role in Signaling in Neuronal Growth Cones

Angela I.M. Barth, Stanford University, USA
Short Talk: APC and beta-Catenin in Neurite Outgrowth and Polarization

Anthony Brown, Ohio State University, USA
Axonal Transport of Neurofilaments

19:15—20:15
Social Hour

Bay 5-6
19:30—22:00
Poster Session 2

Bay 5-6

MONDAY, MARCH 7

07:00—08:00
Breakfast

Bay 4
08:00—11:00
Asymmetric Cell Division
Meeting has ended...abstracts no longer viewable online.

Bay 2
* François Schweisguth, Ecole Normale Superieure, France
Function and Regulation of the Cell-Fate Determinant Neuralized in Drosophila

Andrea H. Brand, University of Cambridge, UK
Asymetric Cell Division and Cell Regulation

Yohanns Bellaïche, Institut Curie, France
Analysing the Function of the Exocyst During Sensory Organ Precursor Cell Asymmetric Division

08:00—11:00
Cytoskeletal Systems Crosstalk during Transient Cellular Asymmetries
Meeting has ended...abstracts no longer viewable online.

Bay 3
* William M. Bement, University of Wisconsin-Madison, USA
Conserved RhoA and Cdc42 Signaling Zones in Single Cell Wound Healing and Cytokinetic Apparatus Specification

Victoria Foe, University of Washington, USA
Three Cytomechanical Modules Collaborate to Postition and Time Contractile Furrow Formation: Lessons from Flies, Worms, and Urchins

Mark Peifer, University of North Carolina at Chapel Hill, USA
How is Epithelial Polarity Established in Development

Dahong Zhang, Oregon State University, USA
Microtubule-Mediated Redistribution of Actin Filaments during Contractile Ring Assembly

Paymaan Jafar-Nejad, Baylor College of Medicine, USA
Short Talk: Sec15, a COmponent of the Ecocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Oragan Precursor

09:20—09:40
Coffee Break

Conference Center Lobby
16:30—17:00
Coffee & Snacks Available

Bay 5-6
17:00—19:15
Cell Signaling and Polarity
Meeting has ended...abstracts no longer viewable online.

Bay 2
* Alfonso Martinez Arias, University of Cambridge, UK
Epithelial Cell Movements During Drosophila Dorsal Closure

Tadashi Uemura, Kyoto University, Japan
Short Talk: Planar Cell Polarity: Directional Transport of Frizzled and Polarized Organization of Microtubules

David Bilder, University of California, Berkeley, USA
Tumor Suppressor Genes and Cell Polarity

Ronen Zaidel-Bar, Weizmann Institute of Science, Israel
Short Talk: Focal Adhesion Signaling Mediates Flow-Induced Cell Polarity

Hernán López-Schier, Centre de Regulació Genòmica, Spain
Short Talk: Development and Maintenance of Planar Cell Polarity in the Lateral-line Organ of the Zebrafish

Piyi Papadaki, European Molecular Biology Laboratory, Germany
Short Talk: A Chemical Genetic Screen to Identify New Par-1 Targets

17:00—19:15
Regulation of Cytoskeletal Interactions
Meeting has ended...abstracts no longer viewable online.

Bay 3
Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA
Regulation of Actin Dynamics at the Immunological Synapse

Sophie G. Martin, Columbia University, USA
Short Talk: Tea4p Links Microtubule Plus Ends with the Actin Nuceator for For3p

Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity and Axon Specification

Shigenobu Yonemura, RIKEN Center for Developmental Biology, Japan
Short Talk: Microtubule-dependent regulatory mechanism of RhoA localization at the cleavage plane determination

* Gary M. Bokoch, The Scripps Research Institute, USA
GEF-H1, a Microtubule-Regulated Rho Exchange Factor, Modulates Rho Function Required for Cytokinesis

19:00—20:00
Social Hour

Bay 5-6
20:00—23:00
Entertainment

Bay 5-6

TUESDAY, MARCH 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Institute of Mental Health (NIMH)

Grant No. 1R13-MH073229-01




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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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