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This meeting took place in 2005



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Innate Immunity to Pathogens (A3)


Organizer(s) Wayne M. Yokoyama, Christine A. Biron and Stefan H.E. Kaufmann
January 8—13, 2005
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 15, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 8, 2004

Sponsored by Burroughs Wellcome Fund

Summary of Meeting:
The innate immune response is critical to control of pathogens during the early phases of infection. Recent advances have elaborated the orchestrated series of events involving innate immune cells, cytokines, chemokines, and other effector molecules that are required to restrain virus, bacteria, and parasite growth and dissemination. The innate immune system also influences adaptive immune responses. This meeting will be organized around mechanistic themes that are found in innate immune responses to a wide variety of pathogens. Students, post-doctoral fellows, and investigators will benefit from learning about emerging concepts of innate immunity to pathogens that may be applicable to their own studies of immunity to other organisms, and will illuminate new areas for exploration.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 8

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Siamon Gordon, University of Oxford, UK
Innate Immune Recognition by Macrophages


SUNDAY, JANUARY 9

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Innate Immune Cytokine and Chemokine Responses
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Christine A. Biron, Brown University, USA
Shaping Innate Cytokine Functions by Controlling Accessibility of STAT Signaling Pathways

Erik Barton, Wake Forest University School of Medicine, USA
and

Deborah J. Lenschow, Washington University School of Medicine, USA
New Roles for Interferons during Virus Infections and Approaches to IFN Mechanisms

* Sankar Ghosh, Columbia University, USA
TLR11 and Urinary Tract Infections

Jürg Tschopp, University of Lausanne, Switzerland
Activation of the Inflammasome by Muramyl-Dipeptide

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:00—16:00
Workshop 1: Cellular Responses to Pathogens

Storm Peak/Mt Werner
* Christine A. Biron, Brown University, USA

Roi Gazit, Hebrew University of Jerusalem, Israel
Influenza Infection is Lethal in NKp46 Knockout Mice

Eric C. Mossel, Colorado State University, USA
IFN-beta And IFN-gamma Synergistically Inhibit the Replication of SARS-Coronavirus

Mark T. Orr, Infectious Disease Research Institute, USA
MyD88 and TLR9-Mediated Immunity to Herpes Simplex Virus

Andre Boonstra, Erasmus Medical Center, Netherlands
Endogenous IL-10 Profoundly Inhibits IL-12p70 Production upon TLR Ligation by Bone Marrow-derived Myeloid and Splenic Dendritic Cells, but not Plasmacytoid Precursor Dendritic Cells

Franck Housseau, Johns Hopkins School of Medicine, USA
A Murine type I IFN-producing Cell Subset is Endowed with Natural Killing and Antigen Presenting Functions upon TLR-9 Activation

Mitsutoshi Yoneyama, Tokyo Metropolitan Institute of Medical Science, Japan
The CARD-Containing DExD/H Box RNA Helicase, RIG-I, Plays an Essential Role in Innate Antiviral Responses

Anasuya Sarkar, Ohio State University, USA
ASC is a Dual Regulator in Caspase-1 Mediated Inflammation and NF-kappaB Activation

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Effector Molecules in Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Alberto Mantovani, Humanitas University, Italy
The Long Pentraxin PTX3 In Antimicrobial Innate Immunity

Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
Neutrophils Release Extracellular Structures against Bacteria

* Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Complement-Like Proteins in Mosquito Innate Immunity and Malaria Infections

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak

MONDAY, JANUARY 10

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Innate Intracellular Responses
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Anthony W. Segal, University College London, UK
The Function of the Neutrophil NADPH Oxidase is to Induce K+ and Cl- Fluxes across the Membrane of the Phagocytic Vacuole, thereby Activating Granule Enzymes to Kill and Digest Microbes

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Toll-Like Receptor Signal Transduction

* Arthur M. Krieg, Checkmate Pharmaceuticals, USA
G/U-rich RNAs, CpGs, TLRs, and Anti-Viral Defense

Franck J. Barrat, Hospital for Special Surgery, USA
Oligonucleotide-Based Inhibitors of Toll-Like Receptors -7, -8 and -9 and their Potential for the Treatment of Systemic Lupus Erythematosis

09:20—09:40
Coffee Break

Foyer
11:00—12:00
Poster Setup

Sunshine Peak
11:00—12:00
Lunch

Sunshine Peak
11:30—14:00
Poster Session 2

Sunshine Peak
14:00—16:00
Workshop 2: Recognition of Pathogens and Regulation of Host Responses

Storm Peak/Mt Werner
* Gordon D. Brown, University of Aberdeen, UK
Short Talk: Dectin-1 Immunobiology

Robert T. Wheeler, Whitehead Institute for Biomedical Research, USA
Innate Immune Recognition of Fungal Pathogens

Jennifer Philips, Washington University School of Medicine, USA
Genome-Wide RNAi Screen in Drosophila Identifies a CD36 Family Member Required for Mycobacterial Infection

Jin Seon S. Im, MD Anderson Cancer Center, USA
A Novel Mechanism for Modulation of CD1d-restricted NK T Cell Functions by Th2 Cytokine Skewing alpha Galactosyl Ceramide Analogs

Masahiro Yamamoto, Osaka University, Japan
An Inducible Nuclear Protein, I kappa B zeta Regulates TLR-Mediated Gene Expression in a Two-Step Fashion

Ashley Mansell, Monash Institute of Medical Research, Australia
SOCS-1 Targets Mal/TIRAP for Degradation to Regulate TLR-mediated Signaling.

Senad Divanovic, Cincinnati Children's Hospital Medical Center, USA
Negative Regulation of TLR4 Signaling by RP105

Kui Li, University of Texas Medical Branch, USA
Hepatitis C Virus NS3/4A Protease Limits TLR3-Mediated Antiviral Signaling by Specifically Targeting its Adaptor Protein, TRIF, for Proteolysis

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Viral and Microbial Interactions with Innate Immune Cells I
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Stefanie N. Vogel, University of Maryland, USA
Innate Immune Responses to Microbes Initiated by Toll-Like Receptors

* Marian R. Neutra, Children's Hospital Boston, USA
Innate Immunity in Organized Mucosal Lymphoid Tissues: Collaboration of Epithelial and Dendritic Cells


TUESDAY, JANUARY 11

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Viral and Microbial Interactions with Innate Immune Cells II
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Dana Philpott, University of Toronto, Canada
NOD Proteins and Bacterial Infections

Olivier Lantz, Institut Curie, France
Mucosal-Associated Invariant T (MAIT) Cell Selection

Albert S. Bendelac, University of Chicago, USA
CD1-Restricted NKT Cells in Innate Recognition

* Alan Sher, NIAID, National Institutes of Health, USA
Parasites Trigger Dendritic Cells to Activate and Polarize CD4 +T Cells by Two Distinct Pathways

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:00—16:00
Workshop 3: Host-Pathogen Interactions

Storm Peak/Mt Werner
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany

Abdul Basit, Yale, USA
Essential Role of ICAM-1 and LFA-1 in LPS-Induced Neutrophil Recruitment into the Alveolar Space

Krischan J. Hudson, University of Virginia, USA
Distinct beta 1 Integrin-binding Mechanisms of Yersinia pseudotuberculosis Adhesins Differentially Regulate Phagocytic Signaling Events in Macrophages

Werner Solbach, University of Luebeck, Germany
Chlamydia pneumoniae Multiply in Neutrophil Granulocytes and Delay their Spontaneous Apoptosis

Katherine C. Brittingham, US Army Medical Research Institute of Infectious Diseases, USA
Dendritic Cell Uptake of Bacillus anthracis Spores: Implications for Anthrax Pathogenesis

Sergio Lopez-Briones, Universidad de Guanajuato, Mexico
Identification and Characterization of a Novel CD8 alpha beta + TCR gamma delta + iIEL Subset that Expands following Enteric Bacterial Infection

Rebekah T. Taylor, Emory University, USA
The Role of Enteric Flora-Stimulated TLR Signaling in the Maturation of Isolated Lymphoid Follicles (ILF) in the Murine Small Intestine

Christine McDonald, Cleveland Clinic, USA
Identification of a Novel Regulator of Nod2 Signaling

Heidi Cheung, University of Toronto, Canada
AcPL is Essential for IL-18-Mediated Signaling

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Innate Immune Evasion by Pathogens
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
* Wayne M. Yokoyama, Washington University School of Medicine, USA
Natural Killer Cell Control of Viral Infection

Anthony R. French, Washington University, USA
Short Talk: Escape of Mutan Double Strad DIVA Virus from NIC cell Medicated Control

Stipan Jonjic, University of Rijeka, Faculty of Medicine, Croatia
Multiple Strategies to Evade NKG2D by MCMV

David H. Margulies, National Institutes of Health, USA
Short Talk: X-Ray Crystallographic Structure of the Murine Cytomegalovirus Immuno-Evasion MHC-1 Homolog m144: A Disordered Region Suggests a Natural Killer (NK) Cell Recognition Site

19:00—20:00
Social Hour

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak

WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Innate Control of Acquired Immunity I
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Laurence Zitvogel, Institut Gustave Roussy, France
Regulation of NK Cell Priming by Dendritic Cells

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Control of T Cell Immunity by Dendritic Cells

Jonathan Sprent, Garvan Institute, Australia
Innate Control of Memory T Cell Responses

* Bana Jabri, University of Chicago, USA
IL-15 and NKG2 Receptors: Linking Adaptive and Innate Immunity

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Innate Control of Acquired Immunity II
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt Werner
Thomas A. Wynn, Pfizer, USA
Role of IL-13 Receptor alpha 2 in Innate Control of Acquired Immunity

* Richard M. Locksley, HHMI/University of California, San Francisco, USA
Activating the Components of Type 2 Immunity

Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Innate Response to Mycobacteria and Control of Acquired Immunity

19:00—20:00
Social Hour

Foyer
20:00—23:00
Entertainment

Sunshine Peak

THURSDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 U13 AI60000-01




National Institutes of Health

Grant No. 1R13-AI063644-01




We gratefully acknowledge additional support for this conference from:

Burroughs Wellcome Fund

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Coley Pharmaceutical Group, Inc.


Dynavax Technologies Corporation


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