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This meeting took place in 2005



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Chromatin Modification Pathways (C7)


Organizer(s) Tony Kouzarides and Shelley L. Berger
March 31—April 5, 2005
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Nov 30, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 31, 2005

Sponsored by Novartis Institutes for BioMedical Research and The Director's Fund

Summary of Meeting:
It has become apparent over the last few years that histone modifications mediate important biological functions. There is a plethora of these modifications and new ones are being discovered on a regular basis. These modifications are most commonly being studied in the context of transcriptional regulation, since classically modifications on histones were correlated with transcriptional state. However, it is now clear that any biological process involving DNA may be affected and regulated by histone modifications. As a result there are now indications that biological processes such as repair, replication and recombination are also under the control of histone modifications. Another recent development has been the mechanistic link between histone modifications and distinct processes involving nucleic acids such as DNA methylation and RNA interference. Each of these processes are under scrutiny in their own right, but the recent data suggests that each of these is intimately linked with histone modifications in the formation of heterochromatin structures which regulate transcription. Finally, data is now amassing that histone-modifying enzymes are linked to cancer. Inhibitors of deacetylases are now in phase I and II clinical trials and modifying enzymes are found over expressed, mutated and rearranged in cancer cells. The potential of these enzymes for radional drug discovery is therefore only now beginning to be realized. The aim of this meeting is to focus on basic research involving the normal biological functions relating to histone modifications and to highlight the pathways and enzymes that are deregulated in cancer cells.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 31

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Mezzanine & Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Genome Regulatory Networks in Living Cells


FRIDAY, APRIL 1

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:00
Histone and Factor Acetylation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Mary Ann Osley, University of New Mexico School of Medicine, USA

Michael Grunstein, University of California, Los Angeles, USA
Acetylation on the Histone Globular Core Regulates Gene Activity

Lorraine Pillus, University of California, San Diego, USA
Essential Functions for Chromatin Modifications

Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
New Functions for Histone Modifying Activities

Melanie M. Ott, University of California, San Francisco, USA
The “Yin and Yin” of HIV Tat Acetylation and Deacetylation

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Short Talk: Reversible NAD+-Dependent Modulation of Chromatin Structure and Transcription by Poly(ADP-ribose) Polymerase-1 (PARP-1)

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
14:30—16:30
Workshop 1

* Ramin Shiekhattar, University of Miami, USA

Ji-Joon Song, Korea Advanced Institute of Science and Technology, South Korea
Argonautica: Sclicer Revealed

Vincent Géli, Centre National de la Recherche Scientifique, France
Structure and Functional Characterization of the RNA Recognition Motif of the Histone H3 Lysine Methyltransferase Set1

Nevan J. Krogan, University of California, San Francisco, USA
Protein Complexes and Functional Pathways in Chromatin Metabolism

Ann Dean, NIDDK, National Institutes of Health, USA
Histone Modifications in Enhancer Activation and Enhancer Blocking

Xuetong Shen, University of Texas MD Anderson Cancer Center, USA
INO80 and gamma-H2AX Interaction Links ATP-dependent Chromatin Remodeling to DNA Damage Repair

Claudius Vincenz, University of Michigan, USA
Visualization of the Histon Code in Cells

Takashi Ito, Nagasaki University School of Medicine, Japan
Nucleosomal Histone Kinase-1 Phosphorylates H2A Thr 119 During Mitosis in the Early Drosophila Embryo


Analysis of the Substrate Specificity of a Protein Lysine Methyltransferase

Raymond C. Trievel, University of Michigan, USA
Structural Basis of Substrate Recognition by SET Domain Methyltransferase

16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Histone Ubiquitination
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Bradley R. Cairns, HHMI/University of Utah, USA

Shelley L. Berger, University of Pennsylvania, USA
Histone Ubiquitylation/Deupbiquitylation and Sumoylation Genomic Regulation

Mary Ann Osley, University of New Mexico School of Medicine, USA
H2B Ubuquitylation is Associated with Transcription Elongation

Ali Shilatifard, Northwestern University, USA
Yeast COMPASS Points the Way to Human MLL and its Role in Pathogens of Leukemia

Jaehoon Kim, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Human Homologue of Yeast BRE1 has Coactivator Function in Activator-Dependent Transcription

19:00—20:00
Social Hour

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Maybird

SATURDAY, APRIL 2

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:00
Histone Methylation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Ali Shilatifard, Northwestern University, USA

C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Writing and Reading the ‘Histone Code’

Tony Kouzarides, University of Cambridge, UK
Histone Methylation and Back

Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Dissecting the Junction of Histone Methylation

Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

David Y. Lee, University of New Mexico Cancer Center, USA
Short Talk: Identification and Characterization of a Coactivator Protein which Binds to Arginine-Methylated Histone H3

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Recruitment of Enzyme Complexes
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Robert E. Kingston, Massachusetts General Hospital, USA

Ramin Shiekhattar, University of Miami, USA
The histone demethylase complexes and their role in gene expression and cell fate

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin in Assembly Factors and Maintanance of Genome Organization

Danny F. Reinberg, HHMI/New York University, USA
Regulation of mRNA Biogenesis by the Coordinator Complex, which Binds to Methylated Lysine-4 of Histone H3

Yannick Doyon, Laval University, Canada
Short Talk: A Central Role for the Inhibitor of Growth Tumor Suppressor Family in Chromatin Modifying Complexes

19:00—20:00
Social Hour

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Maybird

SUNDAY, APRIL 3

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:00
ATP-Dependent Chromatin Remodeling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA

Toshio Tsukiyama, Fred Hutchinson Cancer Research Center, USA
Mechanism of Chramatin Interaction by Isw2 Complex in vivo

Jane Mellor, University of Oxford, UK
Isw1 ATPases in Transcription Elongation

Bradley R. Cairns, HHMI/University of Utah, USA
Chromatin Remodeling Involves Directional DNA Translocation from an Internal Nucleosomal Site

Robert E. Kingston, Massachusetts General Hospital, USA
Different Ways to Remodel Chromatin in an "Altered Function" APT-Dependent Remodeler

Blaine Bartholomew, University of Texas MD Anderson Cancer Center, USA
Short Talk: ATP-Dependent Nucleosome Mobilization Initiates Deep Within the Nucleosome

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
14:30—16:30
Workshop 2

* Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA

Keiko Ozato, NICHD, National Institutes of Health, USA
Mammalian Double Bromodomain Protein Brd4 Recognizes Acetylated Histone Codes and Remains on Chromatin during Mitosis

Catharine L. Smith, University of Arizona, USA
Regulation of Histone H3 Phosphorylation and Cell Cycle Depression through a Novel CAMP Signaling Pathway

Nick Barlev, NEMC-Tufts School of Medicine, USA
Regulation of p53 by Methyltransferase Set7/9

Hinrich Gronemeyer, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Epigenetic Modulation of Tumor-Selective Death Signaling

Keji Zhao, NHLBI, National Institutes of Health, USA
Acetylation Islands Revealed Genome-wide Mapping Are Functional Regulatory Elements

Masami Horikoshi, University of Tokyo, Japan
Toward Elucidating the Mechanism of DNA Mediated Reactions

Brent Brower-Toland, Monsanto Company, USA
Participation of RNA Interference in the Formation of Heterochromatin in Drosophila

André Verdel, Harvard Medical School, USA
Two RNAi Complexes Required for Heterochromatin Assembly, RITS and RDRC, Interact and are Recruited to Centromeric RNAs

16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Epigenetic Modifications and RNAi
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Geneviève Almouzni, Centre National de la Recherche Scientifique, France

Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
The Epigenome in the Context of the Post-Genomic Era

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Role of RNAi Machinery in Heterochromatin Assembly

Robin C. Allshire, University of Edinburgh, UK
RNA Interference, Heterochromatin and Centromere Architecture

Neil Brockdorff, University of Oxford, UK
Short Talk: Function of Polycomb-Group Complex PRC1 in H2A Ubiquitylation and X Inactivation

19:00—20:00
Social Hour

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Maybird

MONDAY, APRIL 4

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest
08:00—11:00
Chromatin in Transition: Histone Varients and Depletion
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Carl Wu, National Cancer Institute, NIH, USA
ATP-Dependent Chromatin Remodeling Complexes for Transcription

Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Chromatin States Distinguished by Histone H3 Variants

Jerry L. Workman, Stowers Institute for Medical Research, USA
Promotor and ORF Specific Rpd3 Complexes

Hiten D. Madhani, University of California, San Francisco, USA
Control of Gene Silencing by Chromatin Modifications in Euchromatin

Philippe E. Bouvet, Ecole Normale Superieure de Lyon, France
Short Talk: Structural and Functional Properties of macroH2A and H2ABbd Nucleosomes Variants

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine & Lobby
17:00—19:00
Histone Modifications and Cancer
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Lorraine Pillus, University of California, San Diego, USA

Victoria M. Richon, Sanofi, USA
Development of SAHA for the Treatment of Cancer

Andreas J. Ledl, , Germany
Short Talk: Viral Oncoproteins E1A and E7 and Cellular LxCxE Proteins Repress SUMO Modification of the Retinoblastoma Tumor Suppressor

Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA
Reading and Writing the Epigenome: Chromatin as a Drug Target

20:00—21:00
Social Hour

Ballroom 2-3
20:00—23:00
Entertainment

Ballroom 2-3

TUESDAY, APRIL 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck Research Laboratories


Sangamo BioSciences, Inc.


Merck Research Laboratories


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676