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This meeting took place in 2005



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Diverse Roles of RNA in Gene Regulation (A5)


Organizer(s) Gregory Hannon and Timothy W. Nilsen
January 8—14, 2005
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 30, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 9, 2004

Supported by The Director's Fund

Summary of Meeting:
The role of non-coding RNAs in regulating gene expression and genome stability has become a topic of intense interest. In part, this is fueled by the realization that non-coding RNAs are much more common than previous thought, and emerging evidence suggests fundamental roles for these transcripts. Furthermore, engineered versions of one class of non-coding RNAs, namely microRNAs and their cousins siRNA, are being widely used for experimental manipulation of gene expression, and an understanding of other additional classes may lead to similarly powerful biological tools. Numerous recent meetings have focused on the mechanism and applications of RNA interference and the characterization of naturally occurring triggers of this process. However, no forum has yet been provided to bring together a wider group focused on the roles of non-coding RNAs in gene regulation. Such a meeting is essential to promote interactions and communication between fields that may lead to an understanding of the relationship between RNAi, imprinting, X-chromosome inactivation, widespread transcription of the genome in “non-genic” regions and prevalent, naturally occurring antisense transcripts.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 8

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Timothy W. Nilsen, Case Western Reserve University School of Medicine, USA

John Abelson, University of California, San Francisco, USA
RNAi Perspective: Early Research on Small RNAs


SUNDAY, JANUARY 9

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Classes of Non-Coding RNAs and their Biological Roles
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* David P. Bartel, HHMI, MIT and Whitehead Institute, USA

Todd M. Lowe, University of California, Santa Cruz, USA
Screening for Novel Non-Coding RNAs with Comparative Genomics and Arrays

Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
Empirical Analysis of Sites of RNA Transcription for 30% of the Human Genome: The Changing Landscape of the Human Genome Annotations

Carin K. Vanderpool, National Cancer Institute, National Institutes of Health, USA
Small RNAs as Critical Regulators in Bacteria

Aixia Zhang, NICHD, National Institutes of Health, USA
Short Talk: Role of the Hfq Protein in Facilitating Non-Coding RNA Function

Isaac Bentwich, Rosetta Genomics, Israel
Short Talk: The Number of Human microRNAs is Significantly Underestimated

Xiaoqin Fu, Henry Jackson Foundation, USA
Short Talk: Cellular Functions and Pathways Affected by PCGEM1, A Prostate Specific Non-Coding RNA Gene

Victoria L. Buettner, City of Hope National Medical Center, USA
Short Talk: Novel Paternally Expressed Non-Coding RNA Transcripts within the Prader-Willi/Angelman Syndrome Imprinted Domain

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:15—16:30
Coffee & Snacks Available

Foyer
16:30—19:00
Monoallelic Expression I: X-Chromosome Inactivation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Shiv I. S. Grewal, NCI, National Institutes of Health, USA

Mitzi I. Kuroda, Harvard Medical School, USA
Regulation of roX RNAs and Dosage Compensation in Drosophila

Hervé Seitz, CNRS, France
Short Talk: Imprinted Small RNA Genes

Stefan Schoenfelder, University of Heidelberg, Germany
Short Talk: RNA Mediated Gene Silencing at a Drosophila Transgene Containing the Mouse H19 Imprinting Control Region

Takashi Sado, National Institute of Genetics, Japan
Short Talk: Antisense Regulation at the Xist Locus Involves Changes in Epigenetic Modification Mediated by Tsix

Claire Rougeulle, Epigenetics and Cell Fate, France
Short Talk: Tsix Transcription Controls the Chromatin Structure of the Xist/Tsix Locus: Implications for Imprinted and Random X-Inactivation

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

MONDAY, JANUARY 10

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Regulation of the Genome by RNA
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Mitzi I. Kuroda, Harvard Medical School, USA

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Transposable Elements Heterochromatin and RNAi

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi or Chromatin

Renato Paro, ETH Zurich, Switzerland
The Role of Non-Coding RNAs in Transcriptional Memory

Robin C. Allshire, University of Edinburgh, UK
RNA Interference, Heterochromatin and Centromere Architecture

Emily Bernstein, Mount Sinai School of Medicine, USA
Linking Heterochromatin and RNA in Tetrahymera and Mammals

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:15—16:30
Coffee & Snacks Available

Foyer
16:30—19:00
Emerging Topics in the Application of RNAi in Mammals
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Phillip D. Zamore, University of Massachusetts Medical School, USA

John J. Rossi, Beckman Research Institute of the City of Hope, USA
Dicer Substrate RNAs are More Potent than siRNA

Kazunari Taira, University of Tokyo, Japan
Rapid Identification of Functional Genes by Ribozyme and Sirna Libraries that would not Induce Interferon Responses

David J. Looney, University of California, San Diego, USA
siRNA-Mediated Transcriptional Silencing

Lee Lim, Sirna/Merck, USA
Microarray Analysis Shows that Some MicroRNAs Downregulate Large Numbers of Target mRNAs

19:15—20:15
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

TUESDAY, JANUARY 11

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
RNA Interference: Mechanisms - 1
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands

Gregory J. Hannon, University of Cambridge, UK
Argonaughty: The Secret Life of Slicer

Phillip D. Zamore, University of Massachusetts Medical School, USA
A Protein Sensor for siRNA Asymmetry

Thomas Tuschl, HHMI/Rockefeller University, USA
Mechanism and Natural Function of Small dsRNA-Triggered Gene Silencing in Mammalian Systems

Alan J. Herr, University of Washington, USA
RNA Polymerase IV Directs Silencing of Transposons and Repetitive DNA in Plants

Christian Petersen, Massachusetts Institute of Technology, USA
Short Talk: The Mechanism of MicroRNA Silencing in Mammalian Cell

Leemor Joshua-Tor, HHMI/Cold Spring Harbor Laboratory, USA
Short Talk: Crystal structure of Argonaute: Slicer - Revealed

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:15—16:30
Coffee & Snacks Available

Foyer
16:30—19:00
RNA Interference: Mechanisms - 2
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Thomas Tuschl, HHMI/Rockefeller University, USA

Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands
RNAi and Transposon Silencing in C. elegans

Richard W. Carthew, Northwestern University, USA
Molecular Genetic Analysis of RNAi in Drosophila

Mo Motamedi, Harvard Medical School, USA
Short Talk: Two RNAi Complexes, RITs and RISC, Physically Interact and Localize to Noncoding Centromeric RNAs

Elisavet Maniataki, www.academcom.com, Greece
Short Talk: Human Mitochondrial tRNAMet is Exported to the Cytoplasm and Associates with the Argonaute2 Protein

Elena M. Gracheva, Washington University in St Louis, USA
Short Talk: RNAi Plays a Role in the Heterochromatin Formation in Drosophila

Craig C. Mello, University of Massachusetts Medical School, USA
RNAi in C. elegans

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

WEDNESDAY, JANUARY 12

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
MicroRNAs
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Gregory J. Hannon, University of Cambridge, UK

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNAs and Their Targets in Plants and Animals

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
miRNAs

Victor R. Ambros, University of Massachusetts, USA
Functions of MicroRNAs in Animal Development

James C. Carrington, Donald Danforth Plant Science Center, USA
Small RNA Functions in Plants

Antonio J. Giraldez, Yale University School of Medicine, USA
Short Talk: A Novel Family of MicroRNAs Regulates Brain Morphogenesis during Zebrafish Development


Short Talk: Pervasive Regulation of Drosophila Notch Target Genes by GY Box-, Brd Box-, and K Box-Class microRNAs

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:15—16:30
Coffee & Snacks Available

Foyer
16:30—19:00
Genome-Wide Applications of RNAi to Drug Target Discovery
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* John J. Rossi, Beckman Research Institute of the City of Hope, USA

Roderick L. Beijersbergen, Netherlands Cancer Institute, Netherlands
Unraveling Cellular Pathways in Human Cells Using RNAi Based Screening Methods

Andrew Fraser, Wellcome Trust Sanger Institute, UK
Exploring Genetic Interaction Networks in C. elegans Using RNAi

Norbert Perrimon, Harvard Medical School, USA
Applications of RNAi to Functional Genomic Studies

David Bumcrot, Editas Medicine, Inc., USA
Short Talk: Therapeutic Gene Silencing by Systemic Delivery of Short Interfering RNAs

Yuriy Fedorov, ThermoFisher Scientific, USA
Short Talk: Sequence-Specific siRNA Toxicity is Associated with Off-Target Activity

19:00—20:00
Social Hour

Peaks 1-3
19:30—22:00
Poster Session 4

Peaks 1-3

THURSDAY, JANUARY 13

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Classes of Non-Coding RNAs and Their Biological Roles
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Victor R. Ambros, University of Massachusetts, USA

James H. Eberwine, University of Pennsylvania School of Medicine, USA
Control of RNA Localization and Expression in Neurons

Ronald R. Breaker, Yale University, USA
Riboswitches

Qiang Zhou, University of California, Berkeley, USA
7SK-Dependent Modulation of P-TEFb Transcriptional Activity for Control of Cell Growth and Differentiation

R. Keith Slotkin, Ohio State University, USA
Short Talk: Heritable Transcriptional Silencing of the Mutator Transposable Element Family is Initiated by the Inverted Repeat Mu Killer

Gill Bejerano, Stanford University, USA
Short Talk: Candidate Non-Coding Functional RNAs among the Human Ultraconserved Elements and Related Genomic Regions

09:20—09:40
Coffee Break

Foyer
16:15—16:30
Coffee & Snacks Available

Foyer
16:30—19:00
Emerging Topics in the Biological Role of Small RNAs
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Timothy W. Nilsen, Case Western Reserve University School of Medicine, USA

Cheng Lu, Delaware Biotech Institute, USA
Short Talk: Deep Profiling of Small Rice RNAs by MPSS

Cristina Tufarelli, University of Nottingham, UK
Short Talk: Antisense-RNA Transcription through a Tissue Specific CpG Island Induces DNA Methylation and H3-K9 Trimethylation Specifically in cis

Vasilii V. Vagin, Cold Spring Harbor Laboratory, USA
Short Talk: Production and Function of rasiRNAs in Drosophila

Tom C. Evans, University of Colorado Denver Anschutz Med. Campus, USA
Short Talk: The Sm Complex Controls Germ Cell Fate during C. elegans Embryogenesis by a Process that may Involve Novel RNPs

Hannele Ruohola-Baker, University of Washington, USA
Short Talk: Dicer1, an Essential Component of the miRNA Pathway, is Required for Germline Stem Cell Division in Drosophila Melanogaster

19:00—20:00
Social Hour

Peaks 1-4
20:00—23:00
Entertainment

Peaks 1-4

FRIDAY, JANUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13-GM073291-01




We gratefully acknowledge additional support for this conference from:

Isis Pharmaceuticals, Inc. Promega Corporation
USB Corporation
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Affymetrix, Inc.


Rosetta Inpharmatics LLC


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