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This meeting took place in 2005
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Stem Cells, Senescence and Cancer (D5)
Organizer(s) Edison T. Liu, Alan Colman, Curtis C. Harris, Shin-Ichi Nishikawa and Roger R. Reddel
October 25—30, 2005
Swissotel The Stamford • Singapore, Singapore
Abstract Deadline: Jul 25, 2005
Late Abstract Deadline: Aug 8, 2005
Scholarship Deadline: Jul 25, 2005
Early Registration Deadline: Aug 25, 2005
In collaboration with Agency for Science, Technology and Research (A*STAR) and Sponsored by GlaxoSmithKline Singapore
Summary of Meeting:
Stem cells represent a cellular compartment that is partially characterized by regenerative capacity and multipotential differentiation capabilities. In these characteristics, they resemble cancer cells and it is thought that these self-renewing stem cells are at risk for neoplastic transformation by oncogenic mutations. Recently, the same repair, apoptotic and senescence effector mechanisms involved in limiting normal stem cell life span have also been found to be involved in aging and in cancer susceptibility. Studies in Drosophila and Caenorhabditis elegans have implicated free radical production, the rate of cellular metabolism, and DNA repair in the aging of these species which have been corroborated by investigations of mammalian cells and animal models. Further association between stem cell and cancer biology have been buttressed by the identification of putative cancer stem cells in human carcinoma. An in depth discussion of the intersect between stem cell biology, cancer, and senescence is therefore timely. A goal of this symposium is to explore the cancer stem cells in the context of the rapidly advancing understanding of stem cell biology and aging. Activation of telomerase and more rarely a recombinogenic mechanism (Alternative Lengthening of Telomeres; ALT) can maintain telomeres allowing cancer cells to escape senescence. The targeting of cancer stem cells and other telomerase positive cancer cell populations to either die by apoptosis or undergo induced “premature” senescence will a major theme during the last two days of the conference.
View Scholarships/Awards
Stem cells represent a cellular compartment that is partially characterized by regenerative capacity and multipotential differentiation capabilities. In these characteristics, they resemble cancer cells and it is thought that these self-renewing stem cells are at risk for neoplastic transformation by oncogenic mutations. Recently, the same repair, apoptotic and senescence effector mechanisms involved in limiting normal stem cell life span have also been found to be involved in aging and in cancer susceptibility. Studies in Drosophila and Caenorhabditis elegans have implicated free radical production, the rate of cellular metabolism, and DNA repair in the aging of these species which have been corroborated by investigations of mammalian cells and animal models. Further association between stem cell and cancer biology have been buttressed by the identification of putative cancer stem cells in human carcinoma. An in depth discussion of the intersect between stem cell biology, cancer, and senescence is therefore timely. A goal of this symposium is to explore the cancer stem cells in the context of the rapidly advancing understanding of stem cell biology and aging. Activation of telomerase and more rarely a recombinogenic mechanism (Alternative Lengthening of Telomeres; ALT) can maintain telomeres allowing cancer cells to escape senescence. The targeting of cancer stem cells and other telomerase positive cancer cell populations to either die by apoptosis or undergo induced “premature” senescence will a major theme during the last two days of the conference.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, OCTOBER 25
WEDNESDAY, OCTOBER 26
THURSDAY, OCTOBER 27
FRIDAY, OCTOBER 28
SATURDAY, OCTOBER 29
SUNDAY, OCTOBER 30
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, OCTOBER 25
19:00—19:15
Opening Remarks
Meeting has ended...abstracts no longer viewable online.
Vivian Balakrishnan,
Second Minister for Trade and Industry, Singapore
19:15—20:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
Nuclear Cloning, Stem cells and Reprogramming of the Genome
Nuclear Cloning, Stem cells and Reprogramming of the Genome
08:30—11:30
A Focus on Stem Cells I
Meeting has ended...abstracts no longer viewable online.
*
Alan Colman,
ES Cell International and A*STAR Center for Molecular Medicine, Singapore
Azim Surani,
University of Cambridge, UK
Epigenetic Programming of the Genome in The Embryo and Germ Cells
Epigenetic Programming of the Genome in The Embryo and Germ Cells
Elaine V. Fuchs,
HHMI/Rockefeller University, USA
Balancing Quiescence, Activation and Differentiation of Stem Cells in Skin
Balancing Quiescence, Activation and Differentiation of Stem Cells in Skin
Kenneth R. Chien,
Karolinska Institutet, Sweden
Islet-1 Cardiovascular Progenitors and Pathways for Heart Cell Lineage Diversification
Islet-1 Cardiovascular Progenitors and Pathways for Heart Cell Lineage Diversification
Alexander Meissner,
Max Planck Institute for Molecular Genetics, Germany
Short Talk: Altered Nuclear Transplantation Allows Generation of Pluripotent ES Cells from Inherently Defective Cloned Blastocysts
Short Talk: Altered Nuclear Transplantation Allows Generation of Pluripotent ES Cells from Inherently Defective Cloned Blastocysts
Alexey Terskikh,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Generation of Homogenous Neural Precursors from Human ES Cells
Short Talk: Generation of Homogenous Neural Precursors from Human ES Cells
17:30—19:30
A Focus on Stem Cells II
Meeting has ended...abstracts no longer viewable online.
*
Alan Colman,
ES Cell International and A*STAR Center for Molecular Medicine, Singapore
Fred (Rusty) H. Gage,
The Salk Institute for Biological Studies, USA
Adult Neural Stem Cell Plasticity
Adult Neural Stem Cell Plasticity
Phillip A. Newmark,
HHMI/University of Illinois at Urbana-Champaign, USA
Stem Cells, Germ Cells, and Regeneration in Planarians
Stem Cells, Germ Cells, and Regeneration in Planarians
Tara L. Huber,
Genome Institute of Singapore, Singapore
Short Talk: Hemangioblasts and the Establishment of Hematopoietic Programs
Short Talk: Hemangioblasts and the Establishment of Hematopoietic Programs
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
The Stem Cell Niche, a Druggable Target?
The Stem Cell Niche, a Druggable Target?
08:30—11:30
Senescence
Meeting has ended...abstracts no longer viewable online.
*
Suzanne Cory-Adams,
Walter & Eliza Hall Institute of Medical Research, Australia
Elizabeth H. Blackburn,
The Salk Institute, USA
The End Game: Telomeres and Telomerase in Health and Disease
The End Game: Telomeres and Telomerase in Health and Disease
Yosef Yarden,
Weizmann Institute of Science, Israel
Oncogenic Receptors for Growth Factors: Signaling Mechanisms and Targets for Cancer Therapy
Oncogenic Receptors for Growth Factors: Signaling Mechanisms and Targets for Cancer Therapy
Roger R. Reddel,
Children’s Medical Research Institute, Sydney, Australia
Alternative Lengthening of Telomeres: A Target for Cancer Treatment?
Alternative Lengthening of Telomeres: A Target for Cancer Treatment?
Caleb E. Finch,
University of Southern California, USA
The Environment of the Aging Brain and Neuronal Stem Cell Survival and Differentiation: An in vitro Model
The Environment of the Aging Brain and Neuronal Stem Cell Survival and Differentiation: An in vitro Model
Cynthia Wetmore,
St. Jude Children's Research Hospital, USA
Short Talk: Modulation of Sonic Hedgehog Signaling in Normal and Tumor-Derived Neural Stem Cells
Short Talk: Modulation of Sonic Hedgehog Signaling in Normal and Tumor-Derived Neural Stem Cells
13:30—15:30
Workshop 1
*
Roger R. Reddel,
Children’s Medical Research Institute, Sydney, Australia
*
Elizabeth H. Blackburn,
The Salk Institute, USA
Arun Balakumaran,
NHLBI, National Institutes of Health, USA
Histopathological Improvement of Severe Acute Graft Versus Host Disease of the Gut with Unrelated Mesenchymal Stem Cells
Histopathological Improvement of Severe Acute Graft Versus Host Disease of the Gut with Unrelated Mesenchymal Stem Cells
Tae Hoon Kim,
University of Texas at Dallas, USA
Decoding the WNT Signaling Pathway
Decoding the WNT Signaling Pathway
Koen Schepers,
Leiden University Medical Center, Netherlands
Dissecting Cellular Differentiation by Genetic Barcoding
Dissecting Cellular Differentiation by Genetic Barcoding
Kee-Yew Wong,
Genome Institute of Singapore, Singapore
Screening for Key Transcription Factors in the Regulation of Stem Cell Pluripotency and Differentiation
Screening for Key Transcription Factors in the Regulation of Stem Cell Pluripotency and Differentiation
Huck-Hui Ng,
Genome Institute of Singapore, Singapore
Transcription Regulatory Circuitry in Embryonic Stem Cells: Global Mapping of Transcription Factor Binding Sites
Transcription Regulatory Circuitry in Embryonic Stem Cells: Global Mapping of Transcription Factor Binding Sites
17:30—19:30
Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.
*
Suzanne Cory-Adams,
Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 family: Making Life and Death Decisions
The Bcl-2 family: Making Life and Death Decisions
Irving L. Weissman,
Stanford University, USA
The Cancer Stem Cell
The Cancer Stem Cell
Hans C. Clevers,
Hubrecht Institute, Netherlands
Wnt and Notch Cooperate to Maintain Proliferative Compartments in Crypts and Intestinal Neoplasia
Wnt and Notch Cooperate to Maintain Proliferative Compartments in Crypts and Intestinal Neoplasia
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal and the Repression of Senescence
Stem Cell Self-Renewal and the Repression of Senescence
Jeffrey M. Rosen,
Baylor College of Medicine, USA
Stem/progenitor cells in the etiology and treatment of breast cancer
Stem/progenitor cells in the etiology and treatment of breast cancer
08:30—11:30
Cancer I
Meeting has ended...abstracts no longer viewable online.
*
Yoshiaki Ito,
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Andrew P. Feinberg,
Johns Hopkins University School of Medicine, USA
The Epigenetics of Cancer Etiology
The Epigenetics of Cancer Etiology
Jan H. J. Hoeijmakers,
Erasmus MC, Netherlands
DNA Damage Repair and the Balance Between Cancer and Ageing: Mouse Mutants and Human Syndromes
DNA Damage Repair and the Balance Between Cancer and Ageing: Mouse Mutants and Human Syndromes
Suzanne Cory-Adams,
Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 Family: Making Life and Death Decisions
The Bcl-2 Family: Making Life and Death Decisions
John E. Dick,
Princess Margaret Cancer Centre, Canada
Short Talk: A Fully Experimental In Vivo Model of Human Leukemogenesis: Human Hematopoietic Cells Infected with MLL-ENL Induce Pro-B Acute Lymphoblastic Leukemia in NOD/SCID
Short Talk: A Fully Experimental In Vivo Model of Human Leukemogenesis: Human Hematopoietic Cells Infected with MLL-ENL Induce Pro-B Acute Lymphoblastic Leukemia in NOD/SCID
13:30—15:30
Workshop 2
*
Irving L. Weissman,
Stanford University, USA
*
David P. Lane,
Experimental Therapeutic Centre, Singapore
Takashi Nishimura,
Hokkaido University, Japan
Adult Splenic Stem Cells Kinetics were Regulated by Inflammatory Cytokine, TGF-beta1
Adult Splenic Stem Cells Kinetics were Regulated by Inflammatory Cytokine, TGF-beta1
Lena Motoda,
Institute of Molecular and Cell Biology, Singapore
Runx1 Inactivation Enhances Stemness and Supports a Clonal Maintenance of Leukemia Initiating Cells Carrying Oncogenic Ras
Runx1 Inactivation Enhances Stemness and Supports a Clonal Maintenance of Leukemia Initiating Cells Carrying Oncogenic Ras
Mathijs Voorhoeve,
Duke-NUS Graduate Medical School, Singapore
Identification of Oncogenic microRNAs using a Functional Genetic Screen
Identification of Oncogenic microRNAs using a Functional Genetic Screen
Sadhan Majumder,
University of Texas MD Anderson Cancer Center, USA
Transcriptional Remodeling in Neural Stem Cells: Roles in Neuroregeneration and Cancer
Transcriptional Remodeling in Neural Stem Cells: Roles in Neuroregeneration and Cancer
William E. Lowry,
Rockefeller University, USA
Operative Signaling Pathways in the Epidermal Stem Cell Niche
Operative Signaling Pathways in the Epidermal Stem Cell Niche
Arne N. Akbar,
University College London, UK
The Exhaustion of Immunity by Telomere Erosion During Aging
The Exhaustion of Immunity by Telomere Erosion During Aging
17:30—19:30
Cancer II
Meeting has ended...abstracts no longer viewable online.
David P. Lane,
Experimental Therapeutic Centre, Singapore
Controlling p53, Aging and Cancer
Controlling p53, Aging and Cancer
David D.L. Bowtell,
Peter MacCallum Cancer Institute, Australia
Intercellular Cross-Talk and Protein Degradation in Cancer
Intercellular Cross-Talk and Protein Degradation in Cancer
Roderick L. Beijersbergen,
Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens
Identification of Novel Drug Targets through Loss of Function Genetic Screens
Alea A. Mills,
Cold Spring Harbor Laboratory, USA
Short Talk: p63 Links Cellular Senescence and Aging
Short Talk: p63 Links Cellular Senescence and Aging
08:30—11:30
Cancer Biology
Meeting has ended...abstracts no longer viewable online.
*
David D.L. Bowtell,
Peter MacCallum Cancer Institute, Australia
Judith Campisi,
Buck Institute for Research on Aging, USA
The Senescent Microenvironment: Implications for Cancer and Aging
The Senescent Microenvironment: Implications for Cancer and Aging
Yoshiaki Ito,
Cancer Science Institute of Singapore, National University of Singapore, Singapore
The Tumor Suppressor RUNX3 Negatively Regulates the Wnt Pathway
The Tumor Suppressor RUNX3 Negatively Regulates the Wnt Pathway
Chia-Lin Wei,
Genome Institute of Singapore, Singapore
Short Talk: A Global Map of p53 Transcription Factor Binding Sites on Human Genome
Short Talk: A Global Map of p53 Transcription Factor Binding Sites on Human Genome
15:00—17:00
Perspectives
*
Alan Colman,
ES Cell International and A*STAR Center for Molecular Medicine, Singapore
John C. Reed,
F. Hoffmann-La Roche AG, Switzerland
Endoplasmic Reticulum Stress and Cell Life-Death Decisions
Endoplasmic Reticulum Stress and Cell Life-Death Decisions
Elizabeth H. Blackburn,
The Salk Institute, USA
Edward W. Holmes,
Duke University Medical Center, USA
John C. Reed,
F. Hoffmann-La Roche AG, Switzerland
*Session Chair †Invited, not yet responded.
We gratefully acknowledge additional support for this conference from:
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GlaxoSmithKline Cognition and Neurodegeneration Centre Singapore |
Invitrogen Hong Kong, Ltd. |
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Viacell Singapore Pte Ltd |
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