Swissotel The Stamford Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2005



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Stem Cells, Senescence and Cancer (D5)


Organizer(s) Edison T. Liu, Alan Colman, Curtis C. Harris, Shin-Ichi Nishikawa and Roger R. Reddel
October 25—30, 2005
Swissotel The Stamford • Singapore, Singapore
Abstract Deadline: Jul 25, 2005
Late Abstract Deadline: Aug 8, 2005
Scholarship Deadline: Jul 25, 2005
Early Registration Deadline: Aug 25, 2005

In collaboration with Agency for Science, Technology and Research (A*STAR) and Sponsored by GlaxoSmithKline Singapore

Summary of Meeting:
Stem cells represent a cellular compartment that is partially characterized by regenerative capacity and multipotential differentiation capabilities. In these characteristics, they resemble cancer cells and it is thought that these self-renewing stem cells are at risk for neoplastic transformation by oncogenic mutations. Recently, the same repair, apoptotic and senescence effector mechanisms involved in limiting normal stem cell life span have also been found to be involved in aging and in cancer susceptibility. Studies in Drosophila and Caenorhabditis elegans have implicated free radical production, the rate of cellular metabolism, and DNA repair in the aging of these species which have been corroborated by investigations of mammalian cells and animal models. Further association between stem cell and cancer biology have been buttressed by the identification of putative cancer stem cells in human carcinoma. An in depth discussion of the intersect between stem cell biology, cancer, and senescence is therefore timely. A goal of this symposium is to explore the cancer stem cells in the context of the rapidly advancing understanding of stem cell biology and aging. Activation of telomerase and more rarely a recombinogenic mechanism (Alternative Lengthening of Telomeres; ALT) can maintain telomeres allowing cancer cells to escape senescence. The targeting of cancer stem cells and other telomerase positive cancer cell populations to either die by apoptosis or undergo induced “premature” senescence will a major theme during the last two days of the conference.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, OCTOBER 25

15:00—19:00
Registration

Bencoolen Foyer
18:00—19:00
Refreshments

Stamford/Bencoolen Foyer
19:00—19:15
Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Sophia/Olivia
Vivian Balakrishnan, Second Minister for Trade and Industry, Singapore

19:15—20:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sophia/Olivia
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Nuclear Cloning, Stem cells and Reprogramming of the Genome


WEDNESDAY, OCTOBER 26

07:30—08:30
Breakfast

Matrix Foyer, Biopolis
08:30—11:30
A Focus on Stem Cells I
Meeting has ended...abstracts no longer viewable online.

Matrix Auditorium, Biopolis
* Alan Colman, ES Cell International and A*STAR Center for Molecular Medicine, Singapore

* Shin-Ichi Nishikawa, RIKEN Center for Developmental Biology, Japan

Azim Surani, University of Cambridge, UK
Epigenetic Programming of the Genome in The Embryo and Germ Cells

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Balancing Quiescence, Activation and Differentiation of Stem Cells in Skin

Haifan Lin, Yale University, USA
Self-Renewing Mechanisms of Stem Cells in the Germline

Kenneth R. Chien, Karolinska Institutet, Sweden
Islet-1 Cardiovascular Progenitors and Pathways for Heart Cell Lineage Diversification

Alexander Meissner, Max Planck Institute for Molecular Genetics, Germany
Short Talk: Altered Nuclear Transplantation Allows Generation of Pluripotent ES Cells from Inherently Defective Cloned Blastocysts

Alexey Terskikh, Sanford-Burnham Medical Research Institute, USA
Short Talk: Generation of Homogenous Neural Precursors from Human ES Cells

09:45—10:00
Coffee Break

Matrix Foyer, Biopolis
12:00—13:00
Poster Setup

Sophia/Olivia
15:30—17:30
Poster Session 1

Sophia/Olivia
16:30—17:30
Coffee & Snacks Available

Stamford/Bencoolen Foyer
17:30—19:30
A Focus on Stem Cells II
Meeting has ended...abstracts no longer viewable online.

Sophia/Olivia
* Alan Colman, ES Cell International and A*STAR Center for Molecular Medicine, Singapore

* Shin-Ichi Nishikawa, RIKEN Center for Developmental Biology, Japan

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Adult Neural Stem Cell Plasticity

Phillip A. Newmark, HHMI/University of Illinois at Urbana-Champaign, USA
Stem Cells, Germ Cells, and Regeneration in Planarians

Tara L. Huber, Genome Institute of Singapore, Singapore
Short Talk: Hemangioblasts and the Establishment of Hematopoietic Programs

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
The Stem Cell Niche, a Druggable Target?


THURSDAY, OCTOBER 27

07:30—08:30
Breakfast

Matrix Foyer, Biopolis
08:30—11:30
Senescence
Meeting has ended...abstracts no longer viewable online.

Matrix Auditorium, Biopolis
* Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia

* Caleb E. Finch, University of Southern California, USA

Elizabeth H. Blackburn, The Salk Institute, USA
The End Game: Telomeres and Telomerase in Health and Disease

Yosef Yarden, Weizmann Institute of Science, Israel
Oncogenic Receptors for Growth Factors: Signaling Mechanisms and Targets for Cancer Therapy

Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia
Alternative Lengthening of Telomeres: A Target for Cancer Treatment?

Caleb E. Finch, University of Southern California, USA
The Environment of the Aging Brain and Neuronal Stem Cell Survival and Differentiation: An in vitro Model

Cynthia Wetmore, St. Jude Children's Research Hospital, USA
Short Talk: Modulation of Sonic Hedgehog Signaling in Normal and Tumor-Derived Neural Stem Cells

09:45—10:00
Coffee Break

Matrix Foyer, Biopolis
12:00—13:00
Poster Setup

Sophia/Olivia
12:00—13:30
Lunch

Stamford/Bencoolen Foyer
13:30—15:30
Workshop 1

Sophia/Olivia
* Roger R. Reddel, Children’s Medical Research Institute, Sydney, Australia

* Elizabeth H. Blackburn, The Salk Institute, USA

Arun Balakumaran, NHLBI, National Institutes of Health, USA
Histopathological Improvement of Severe Acute Graft Versus Host Disease of the Gut with Unrelated Mesenchymal Stem Cells

Tae Hoon Kim, University of Texas at Dallas, USA
Decoding the WNT Signaling Pathway

Koen Schepers, Leiden University Medical Center, Netherlands
Dissecting Cellular Differentiation by Genetic Barcoding

Kee-Yew Wong, Genome Institute of Singapore, Singapore
Screening for Key Transcription Factors in the Regulation of Stem Cell Pluripotency and Differentiation

Huck-Hui Ng, Genome Institute of Singapore, Singapore
Transcription Regulatory Circuitry in Embryonic Stem Cells: Global Mapping of Transcription Factor Binding Sites

15:30—17:30
Poster Session 2

Sophia/Olivia
16:30—17:30
Coffee & Snacks Available

Stamford/Bencoolen Foyer
17:30—19:30
Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.

Sophia/Olivia
* Caleb E. Finch, University of Southern California, USA

* Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 family: Making Life and Death Decisions

Irving L. Weissman, Stanford University, USA
The Cancer Stem Cell

Hans C. Clevers, Hubrecht Institute, Netherlands
Wnt and Notch Cooperate to Maintain Proliferative Compartments in Crypts and Intestinal Neoplasia

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Self-Renewal and the Repression of Senescence

Jeffrey M. Rosen, Baylor College of Medicine, USA
Stem/progenitor cells in the etiology and treatment of breast cancer


FRIDAY, OCTOBER 28

07:30—08:30
Breakfast

Matrix Foyer, Biopolis
08:30—11:30
Cancer I
Meeting has ended...abstracts no longer viewable online.

Matrix Auditorium, Biopolis
* Curtis C. Harris, NCI, National Institutes of Health, USA

* Yoshiaki Ito, Cancer Science Institute of Singapore, National University of Singapore, Singapore

Edison T. Liu, The Jackson Laboratory, USA
Expression Genomics and Cancer Biology

Andrew P. Feinberg, Johns Hopkins University School of Medicine, USA
The Epigenetics of Cancer Etiology

Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Damage Repair and the Balance Between Cancer and Ageing: Mouse Mutants and Human Syndromes

Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
The Bcl-2 Family: Making Life and Death Decisions

John E. Dick, Princess Margaret Cancer Centre, Canada
Short Talk: A Fully Experimental In Vivo Model of Human Leukemogenesis: Human Hematopoietic Cells Infected with MLL-ENL Induce Pro-B Acute Lymphoblastic Leukemia in NOD/SCID

09:45—10:00
Coffee Break

Matrix Foyer, Biopolis
12:00—13:00
Poster Setup

Sophia/Olivia
12:00—13:30
Lunch

Stamford/Bencoolen Foyer
13:30—15:30
Workshop 2

Sophia/Olivia
* Irving L. Weissman, Stanford University, USA

* Edison T. Liu, The Jackson Laboratory, USA

* David P. Lane, Experimental Therapeutic Centre, Singapore

Takashi Nishimura, Hokkaido University, Japan
Adult Splenic Stem Cells Kinetics were Regulated by Inflammatory Cytokine, TGF-beta1

Lena Motoda, Institute of Molecular and Cell Biology, Singapore
Runx1 Inactivation Enhances Stemness and Supports a Clonal Maintenance of Leukemia Initiating Cells Carrying Oncogenic Ras

Mathijs Voorhoeve, Duke-NUS Graduate Medical School, Singapore
Identification of Oncogenic microRNAs using a Functional Genetic Screen

Sadhan Majumder, University of Texas MD Anderson Cancer Center, USA
Transcriptional Remodeling in Neural Stem Cells: Roles in Neuroregeneration and Cancer

William E. Lowry, Rockefeller University, USA
Operative Signaling Pathways in the Epidermal Stem Cell Niche

Arne N. Akbar, University College London, UK
The Exhaustion of Immunity by Telomere Erosion During Aging

15:30—17:30
Poster Session 3

Sophia/Olivia
16:30—17:30
Coffee & Snacks Available

Stamford/Bencoolen Foyer
17:30—19:30
Cancer II
Meeting has ended...abstracts no longer viewable online.

Sophia/Olivia
* Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA

* Edison T. Liu, The Jackson Laboratory, USA

David P. Lane, Experimental Therapeutic Centre, Singapore
Controlling p53, Aging and Cancer

David D.L. Bowtell, Peter MacCallum Cancer Institute, Australia
Intercellular Cross-Talk and Protein Degradation in Cancer

Roderick L. Beijersbergen, Netherlands Cancer Institute, Netherlands
Identification of Novel Drug Targets through Loss of Function Genetic Screens

Alea A. Mills, Cold Spring Harbor Laboratory, USA
Short Talk: p63 Links Cellular Senescence and Aging


SATURDAY, OCTOBER 29

07:30—08:30
Breakfast

Matrix Foyer, Biopolis
08:30—11:30
Cancer Biology
Meeting has ended...abstracts no longer viewable online.

Matrix Auditorium, Biopolis
* Jeffrey M. Rosen, Baylor College of Medicine, USA

* David D.L. Bowtell, Peter MacCallum Cancer Institute, Australia

Judith Campisi, Buck Institute for Research on Aging, USA
The Senescent Microenvironment: Implications for Cancer and Aging

Curtis C. Harris, NCI, National Institutes of Health, USA
p53, Senescence and Cancer

Yoshiaki Ito, Cancer Science Institute of Singapore, National University of Singapore, Singapore
The Tumor Suppressor RUNX3 Negatively Regulates the Wnt Pathway

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Executing Cellular Senescence

Chia-Lin Wei, Genome Institute of Singapore, Singapore
Short Talk: A Global Map of p53 Transcription Factor Binding Sites on Human Genome

09:45—10:00
Coffee Break

Matrix Foyer, Biopolis
15:00—16:00
Coffee Available

Stamford/Bencoolen Foyer
15:00—17:00
Perspectives

Sophia/Olivia
* Alan Colman, ES Cell International and A*STAR Center for Molecular Medicine, Singapore

John C. Reed, F. Hoffmann-La Roche AG, Switzerland
Endoplasmic Reticulum Stress and Cell Life-Death Decisions

Edison T. Liu, The Jackson Laboratory, USA

Elizabeth H. Blackburn, The Salk Institute, USA

Edward W. Holmes, Duke University Medical Center, USA

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA

John C. Reed, F. Hoffmann-La Roche AG, Switzerland

17:00—19:00
Social Hour with Lite Bites

Stamford/Bencoolen Foyer

SUNDAY, OCTOBER 30

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Affymetrix, Pte. Ltd. Agency for Science, Technology and Research (A*STAR)
Cell Signaling Technology, Inc. Chemicon International, Inc.

GlaxoSmithKline Cognition and Neurodegeneration Centre Singapore

Invitrogen Hong Kong, Ltd.

Lilly Singapore Centre for Drug Discovery Novartis Institutes for BioMedical Research
Research Instruments, Pte. Ltd
Viacell Singapore Pte Ltd


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



ES Cell International Pte Ltd


RIKEN, Center for Developmental Biology


Stem Cells - AlphaMed Press


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676