Granlibakken Tahoe Floorplan

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This meeting took place in 2006



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Molecular Targets for Cancer Prevention (C7)


Organizer(s) Scott M. Lippman, Nancy H. Colburn and Andrew J. Dannenberg
March 6—10, 2006
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 7, 2005
Late Abstract Deadline: Nov 29, 2005
Scholarship Deadline: Nov 7, 2005
Early Registration Deadline: Jan 6, 2006

Supported by The Director's Fund

Summary of Meeting:
The most promising directions in cancer prevention lie in the early identification of high-risk individuals and the development of targeted interventions to prevent or delay carcinogenesis. A revolution in molecular studies and drug development has blurred the distinction between malignancy and pre-malignancy and between cancer therapy and prevention. Molecular targeted agents have produced major clinical advances in randomized controlled cancer prevention trials. Inflammation and obesity have emerged as important risk factors and provide new molecular targets for prevention such as HIF-1 and IGF-1. Molecular studies of fatty acid metabolism and stromal-epithelial interactions in carcinogenesis have identified targets such as cyclooxygenases, lipoxygenases, ECM proteases, and TGF-beta. Translation joins transcription as a new gene-regulation target for interventions; translationally regulated targets include c-myc and ODC. Imaging and proteomics have revealed new biomarkers that enable the early detection of cancer and enable more effective monitoring of drug effects in cancer prevention trials.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 6

15:00—19:30
Registration

Pre-Function
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Waun Ki Hong, University of Texas MD Anderson Cancer Center, USA
Convergence of Molecular Targets for Cancer Therapy and Prevention


TUESDAY, MARCH 7

07:00—08:00
Breakfast

Granhall
08:00—11:15
Inflammation, Immune Response and Cancer Risk
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Madhav V. Dhodapkar, Yale School of Medicine, USA
Harnessing Host Immune Response to Preneoplasia

Steven M. Dubinett, University of California, Los Angeles, USA
COX-2, Immune Modulation and Lung Cancer

Angelo De Marzo, Johns Hopkins School of Medicine, USA
Inflammation, Atrophy and Prostate Carcinogenesis

Claire E. Lewis, University of Sheffield Medical School, UK
The Hypoxic Macrophage: A Driving Force in Tumor Progression

Connie P. Matthews, National Cancer Institute at Frederick, USA
Short Talk: Cox-2 and Other Inflammatory Response Proteins Mediate Prevention of Human Papilloma Virus (HPV) E7-Driven Tumorigenesis by Dominant Negative cJun (TAM67)

Ling-Min Lu, McMaster University, Canada
Short Talk: Cigarette Smoke Impairs NK-Dependent Tumor Immune Surveillance and Immune-Based Intervention

09:20—09:40
Coffee Break

Pre-Function
11:15—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
14:30—16:30
Workshop 1

Mountain/Lake Rooms
* John M. Pezzuto, , USA
Molecular Targeting by Natural Preventive Agents

Chinthalapally V. Rao, University of Oklahoma Health Sciences Center, USA
Molecular Targets for Colon Cancer Prevention

David S. Franklin, Purdue University, USA
RET2A / Cell Cycle Signaling during MEN2 Tumorigenesis: Implication in Novel Molecular Targets for Cancer Treatment

Katie M. Ruocco, National Cancer Institute, National Institutes of Health, USA
Targeting Transcription Factors: A High Throughput Screen to Identify Natural Product Inhibitors of AP-1

Jing Y. Han, St. John's University, USA
Role of GADD Genes in the ER-stress-induced Apoptotic Response of C33A Human Cervical Carcinoma Cells exposed to 3,3’-Diindolylmethane

Emmanuelle J. Meuillet†, University of Arizona, USA
Selenium Increases the Activity of the Tumor Suppressor Protein, PTEN via the Thioredoxin-Thioredoxin Reductase System by Decreasing Phospho-Thr382/383PTEN in Prostate Cancer Cells

Daniel Sliva, Methodist Research Institute, USA
Suppression of Cancer Proliferation and Invasiveness by Natural Terpenoids

Satoko Aoki, Tokyo University of Science, Japan
Screening of The Target Molecule for Sulfoquinovosylacylglycerol., Novel Anti-Tumor Agents

Fuzhi Lian, JM USDA Human Nutrition Research Center on Aging, USA
Beta-Cryptoxanthin Inhibits The Growth of Immortalized Human Bronchia Epithelial Cells and Non-Small Cell Lung Cancer Cells and Up-Regulates Retinoic Acid Receptor beta Expression

16:30—17:00
Coffee Available

Pre-Function
17:00—19:00
Targeting Translation Initiation
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Nahum Sonenberg, McGill University, Canada
How Does eIF4E Transform Cells?

Nancy H. Colburn, National Institutes of Health, USA
Pdcd4 Targets eIF4A to Inhibit Translation, Transcription Tumorigenesis, and Invasion

Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA
Signaling, RNA-Binding Proteins and Cancer

Hsin-Sheng Yang, University of Kentucky College of Medicine, USA
Short Talk: Pdcd4, a Novel Target for Colorectal Cancer Prevention

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay Room
20:00—21:00
Social Hour

Bay Room

WEDNESDAY, MARCH 8

07:00—08:00
Breakfast

Granhall
08:00—11:15
Bioactive Lipids and Cancer Prevention
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Scott M. Lippman, UC San Diego Moores Cancer Center, USA
Targeting 15-LOX-1 to Induce Apoptosis

Kenneth V. Honn, Wayne State University, USA
12-LOX, Angiogenesis and Cancer

Andrew J. Dannenberg, Weill Medical College of Cornell University, USA
The PGE2-Aromatase Connection

Masanobu Oshima, Kanazawa University, Japan
Stromal Eicosanoids and Gastric Tumorigenesis

Jason R. Mann, Vanderbilt University, USA
Short Talk: Repression of Prostaglandin Catabolism Disrupts the Epithelial Differentiation Program and Promotes Tumorigenesis

Dipti J. Mehta, University of Arizona, USA
Short Talk: 15-Deoxy-Delta12,14-Prostaglandin J2(15d-PGJ2) Mediated Apoptotic Signaling in Colon Cancer Cells

09:20—09:40
Coffee Break

Pre-Function
11:15—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
14:30—16:30
Roundtable Discussion: Clinical Challenges of Developing Preventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA

Mountain/Lake Rooms
* Powel H. Brown, Baylor College of Medicine, USA

Carl Barrett, AstraZeneca, USA

Ernest Hawk, National Cancer Institute, National Institutes of Health, USA

Leslie Ford, National Cancer Institute, National Institutes of Health, USA

Ann Farrell, U.S. Food and Drug Administration, USA

Pablo J. Cagnoni, Tizona Therapeutics, USA

Gary Gordon, Abbott Laboratories, USA

16:30—17:00
Coffee Available

Pre-Function
17:00—19:00
Stromal – Epithelial Interactions
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Thea D. Tlsty, University of California, San Francisco, USA
Genetic and Epigenetic Changes in Early Carcinogenesis

Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer Development

Harold L. Moses, Vanderbilt University, USA
Stromal TGF-beta Signaling in Cancer

Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Short Talk: Recruitment of Tumor Stromal Cells and Bone Marrow Support of Tumor Progression

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay Room
20:00—21:00
Social Hour

Bay Room

THURSDAY, MARCH 9

07:00—08:00
Breakfast

Granhall
08:00—11:00
Obesity and Cancer Risk
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Leslie Bernstein, University of Southern California, USA
Obesity, Physical Inactivity and Cancer Risk: Etiologic Insights

Michael Pollak, Jewish General Hospital, Canada
Insulin Resistance, IGFs and Cancer

Carl Barrett, AstraZeneca, USA
HIF-1, Obesity and Cancer

Helen Kim, University of Alabama at Birmingham, USA
Proteomics of Dietary Polyphenols on Brain Proteins: What it Predicts about Chemopreventive Activities of the Same Polyphenols

Lesley A. Mathews, NCI, USA
Short Talk: Effect of Insulin-like Growth Factor-I on Parity Induced Protection against Breast Cancer

Daqing Yang, University of South Dakota, Sanford School of Medicine, USA
Short Talk: The Identification of an Internal Ribosomal Entry Site in the p53 mRNA Provides a Novel Mechanism for the Regulation of its Translation Following DNA Damage

09:20—09:40
Coffee Break

Pre-Function
14:30—16:30
Workshop 2

Mountain/Lake Rooms
* Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA

* John V. Heymach, University of Texas MD Anderson Cancer Center, USA
Angiogenesis and Vascular Targeting in Early Tumorigenesis

Fabian Benencia, Ohio University, USA
Tumor-Associated Mature Dendritic Cells Show Express MMP9 and VEGF and Contribute to Tumor Angiogenesis

Matthew J. Rioth, Children's Hospital Boston, USA
Dysregulation of the Calcineurin-NFAT Pathway in DSCR1 -/- Mice Leads to Decreased Tumorigenesis and Impaired Endothelial Cell Function

Keisuke Ohta, Tokyo University of Science, Japan
Anti-Angiogenesis Activity of Sulfoquinovosylacylglycerols

16:30—17:00
Coffee Available

Pre-Function
17:00—19:15
Biomarkers in Cancer Detection and Prevention
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Biomarkers in Cancer Prevention

Harvey R. Herschman, University of California, Los Angeles, USA
"Molecular Imaging in Monitoring Cancer Initiation, Promotion and Progression."

David F. Ransohoff, University of North Carolina at Chapel Hill, USA
Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer

Ralph G. Zinner†, University of Texas MD Anderson Cancer Center, USA
Short Talk: Medicinal Algorithmic Combinatorial Screen (MACS): A Novel Approach to Identify New Therapeutic Regimens

Candy Lee, Angion Biomedica Corp, USA
Short Talk: Proteomic Analysis of Colon Adenocarcinoma Identified Novel Targets for Therapy

19:15—20:15
Social Hour

Granhall
20:15—21:15
Dinner

Mountain/Lake Rooms
20:00—23:00
Entertainment

Mountain/Lake Rooms

FRIDAY, MARCH 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676