Fairmont Empress Victoria Floorplan

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This meeting took place in 2006



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The Molecular and Integrative Basis for Toxic Responses (Z4)


Organizer(s) Roger G. Ulrich and Robert A. Roth
May 7—11, 2006
Fairmont Empress Victoria • Victoria, British Columbia Canada
Abstract Deadline: Jan 5, 2006
Late Abstract Deadline: Mar 17, 2006
Scholarship Deadline: Jan 5, 2006
Early Registration Deadline: Mar 17, 2006

Sponsored by ICOS Corporation


Summary of Meeting:
Drug toxicity continues to be an important human health problem and a major economic issue for the pharmaceutical industry, since it results in many failed candidates and drug recalls. It is widely recognized that knowledge of toxic mechanisms can aid in the design of safer drugs, and recent advances in molecular and genomic biology hold promise for increasing such mechanistic understanding. Determining untoward effects of drug exposure on cellular signaling pathways that result in altered RNA transcription, protein expression and activity along with the consequent impact on cell and tissue function has become an intense focus in toxicological research. This conference will bring together key scientists to discuss important organ targets for drug toxicity, emphasizing pathways and mediators of cell and tissue injury and the contribution of environmental and genetic factors that determine individual susceptibility.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 7

15:00—19:30
Registration

Victoria Conference Center Foyer
18:30—19:30
Refreshments

Victoria Conference Center Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Victoria Conference Center Lecture Theatre
Neil Kaplowitz, University of Shouther California Liver Transplant Program, USA
Adverse Drug Reactions in the Liver


MONDAY, MAY 8

07:00—08:00
Breakfast

Tea Lobby
08:00—11:00
Endogenous Susceptibility Factors in Toxic Responses
Meeting has ended...abstracts no longer viewable online.

Salon C
Robert S. McCuskey, University of Arizona, USA
Hepatic Microvascular Responses to Toxicants

Robert A. Roth, Michigan State University, USA
Influence of Inflammatory Stress on Drug Hepatotoxicity

Peter J. O'Brien, University of Toronto, Canada
Antioxidant Prevention of Drug Induced Oxidative Stress (Inflammation Model)

Wen Xie, University of Pittsburgh, USA
Short Talk: Orphan Nuclear Receptor-Mediated Gene Regulation in Xeno- and Endobiotic Toxic Responses

08:00—11:00
Sub-Typing Human Diseases
Meeting has ended...abstracts no longer viewable online.

Salon A
Allen D. Roses, Duke University, Drug Discovery Institute, USA
Susceptibility Genes and Drug Development in Alzheimer's Disease and Other Complex Diseases

Eric Schadt, Mount Sinai School of Medicine, USA
An Integrative Genomics Approach to Elucidating the Genetics of Drug Response

Speaker to be Announced

09:20—09:40
Coffee Break

Victoria Conference Center Foyer
11:00—13:00
Poster Setup

Salon B
13:00—22:00
Poster Viewing

Salon B
16:30—17:00
Coffee Available

Victoria Conference Center Foyer
17:00—19:00
Receptors and Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Salon C
Frank J. Gonzalez, National Institutes of Health, USA
Role of Nuclear Receptors in Chemical Toxicity and Carcinogenicity

Mark J. Czaja, Albert Einstein College of Medicine, USA
Regulation of Toxic Liver Injury by Cell Signaling

Serrine S. Lau, University of Arizona, USA
Prostanoid Receptor-Mediated Cytoprotective Signaling Pathways

17:00—19:00
Economic Considerations of Biomarkers
Meeting has ended...abstracts no longer viewable online.

Salon A
Gary E. Marchant, Arizona State University, USA
Legal, Ethical and Policy Issues with Biomarkers

M. J. Finley Austin, Hoffman-La Roche, USA
An Economic Perspective on Biomarkers and Personalized Medicine: Regulatory and Science Policy Implications

Phillip G. Febbo, Genomic Health, Inc., USA
Genomic Strategies for Individualizing Therapy in Oncology

19:00—20:00
Social Hour with Lite Bites

Salon B
19:30—22:00
Poster Session 1

Salon B

TUESDAY, MAY 9

07:00—08:00
Breakfast

Tea Lobby
08:00—11:00
Bioactivation and Macromolecular Adducts
Meeting has ended...abstracts no longer viewable online.

Salon C
Robert P. Hanzlik, University of Kansas, USA
Tissue Injury by Reactive Metabolites: Chemistry, Proteomics and Beyond

Daniel C. Liebler, Vanderbilt University Medical Center, USA
What are Protein Targets of Reactive Electrophiles?

Wei Tang, Merck & Co., Inc., USA
Metabolic Bioactivation and Drug Toxicity: Managing Safety Issues Proactively in the Drug Discovery Phase

Kiyoto Motojima, Meiji Pharmaceutical University, Japan
Short Talk: Peroxisome Proliferator-Activated Receptor รก is Essential for the Induction of a Detoxification System against Plant Compounds in the Mouse Intestine and Liver

08:00—11:00
Detection of Early Disease
Meeting has ended...abstracts no longer viewable online.

Salon A
Emanuel F. Petricoin, George Mason University, USA
Diagnostics and Theranostics: Applications of Proteomics for Disease Detection and Tailored Therapy

Howard Schulman, Pharmaceutical Product Development, Inc., USA
Biomarker Discovery in Proteomes and Sub-Proteomes

Amanda Paulovich, Fred Hutchinson Cancer Research Center, USA
Evaluating Technologies for Protein Biomarker Discovery and Validation

Dieter Deforce, Ghent University, Belgium
Title to be Determined

09:20—09:40
Coffee Break

Victoria Conference Center Foyer
16:30—17:00
Coffee Available

Victoria Conference Center Foyer
17:00—19:00
Metabolic Dysfunction
Meeting has ended...abstracts no longer viewable online.

Salon C
Kendall B. Wallace, University of Minnesota, USA
Adriamycin-Induced Mitochondrial Cardiomyopathy and the Compensated Metabolic State

Greg Slatter, Amgen Inc., USA
Dose-Related Hepatic Effects of NSAIDS in Rodents: Covalent Binding Measurements and Microarray-Based Determination of Gene Expression Changes

Eric P. Brass, Harbor UCLA Medical Center, USA
Metabolic Basis for Drug and Nutraceutical Toxicity in Humans

17:00—19:00
Identifying Drug Responders from Non-Responders
Meeting has ended...abstracts no longer viewable online.

Salon A
John J. Sninsky, consultant, USA
Identifying Patients Responsive to Interferon

Nicholas C. Dracopoli, Janssen R&D Inc., USA
Predicting Drug Response: Molecular Profiles to Enrich Efficacy and Reduce Risk of Adverse Events

19:00—20:00
Social Hour with Lite Bites

Salon B

WEDNESDAY, MAY 10

07:00—08:00
Breakfast

Tea Lobby
08:00—11:00
Biomarkers to Monitor the Safety/Toxicity of Compounds (Joint)
Meeting has ended...abstracts no longer viewable online.

Victoria Conference Center Lecture Theatre
Michael Lawton, Pfizer Global Research & Development, USA
A Systems Biology Approach to Identification of Candidate Biomarkers of Drug-induced Vascular Injury

Joseph V. Bonventre, Brigham and Women's Hospital, Harvard Medical School, USA
Mechanistic Basis and Biomarkers for Cytotoxic Renal Injury

Roger G. Ulrich, RUC Pharmaceutical Development Specialists, USA
Risk Factors and Differentiating Biomarkers for Liver- and Muscle-Related Adverse Drug Effects

09:20—09:40
Coffee Break

Victoria Conference Center Foyer
16:30—17:00
Coffee Available

Victoria Conference Center Foyer
17:00—19:00
Panel Discussion: Biomarkers into Clinical Practice (JOINT)
Discuss the paradigm shift on how biomarkers can be used by a consortium of industry, govenment and acedemic scientist to solve toxicology/health issues.

Victoria Conference Center Lecture Theatre
Stephen H. Friend, Sage Bionetworks, USA

Daniel K. Burns, GlaxoSmithKline, USA

Katharine Yen, Agios Pharmaceuticals, USA

19:00—20:00
Social Hour with Lite Bites

Palm Court & Crystal Ballroom
20:00—23:00
Entertainment

Palm Court & Crystal Ballroom

THURSDAY, MAY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 ES014763-01




We gratefully acknowledge additional support for this conference from:

ICOS Corporation Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Merck Research Laboratories


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