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This meeting took place in 2006



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Biology of the Vasculature (Z2)


Organizer(s) Michael E. Mendelsohn and Bradford C. Berk
April 2—7, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Dec 1, 2005
Late Abstract Deadline: Dec 28, 2005
Scholarship Deadline: Dec 1, 2005
Early Registration Deadline: Feb 2, 2006

Supported by The Director's Fund

Joint Meeting: Atherothrombosis (Z1)

Summary of Meeting:
Vascular diseases are the leading cause of morbidity and mortality in western society. The Molecular Biology of the Vasculature Keystone Symposium is intended to be the premier international meeting of molecular scientists studying vascular biology, with an emphasis on discussions of our current understanding of the molecular regulation and dysfunction of vascular cells in cardiovascular biology. The objective of this meeting is to promote lively interchange between the field's leading experts, younger scientists and trainees in a relaxed setting conducive to discussions, with an emphasis on the inclusion of under-represented groups. Leading scientists in molecular vascular biology will address critical issues in the field at present, and will share newly emerging and unpublished data in these areas, including the latest findings regarding vascular genetics and genomics, vascular function in health and disease, molecular endothelial and smooth muscle cell biology, molecular regulation of vascular tone, and vascular pathobiology. The Symposium is intended to provide participants with an integrated, state-of-the-art view of the molecular mechanisms regulating blood vessel functions in health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 2

15:00—19:30
Registration

Columbine Foyer
18:30—19:30
Refreshments

Columbine Foyer
19:30—19:45
Opening Remarks

Grays/Longs
Peter Libby, Brigham and Women's Hospital, USA

Shaun R. Coughlin, University of California, San Francisco, USA

Michael E. Mendelsohn, , USA

Bradford C. Berk, University of Rochester Medical Center, USA

19:45—20:45
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Long
Robert J. Lefkowitz, HHMI/Duke University Medical Center, USA
7TM Receptors: Brief History and New Signaling Paradigms


MONDAY, APRIL 3

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Vascular Genetics and Genomics (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Longs
Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Comparative Genomics at the Extremes

Peter F. Carmeliet, University of Leuven, VIB, Belgium
Functional Angiogenomics

* Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Genetic Protection from Coronary Atherosclerosis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Vascular Function in Health and Disease
Meeting has ended...abstracts no longer viewable online.

Longs
Thomas P. Stossel, Brigham and Women's Hospital, USA
Molecular Mechanisms of Vascular Cell Motility

Richard O. Hynes, Massachusetts Institute of Technology, USA
Contributions of Fibronectins to Vascular Development

* Monty Krieger, Massachusetts Institute of Technology, USA
The HDL Receptor SR-BI and a Model of Fatal Occlusive Coronary Heart Disease


Following Session is for Atherothrombosis (Z1)

17:00—19:00
Oxidative Stress
Meeting has ended...abstracts no longer viewable online.

Grays
* Kathy K. Griendling, Emory University School of Medicine, USA
Physiology and Pathophysiology of Vascular NADPH Oxidases

Jay W. Heinecke, University of Washington School of Medicine, USA
Production of Dysfunctional HDL by Myeloperoxidase

Anders Gabrielsen, Karolinska Institute, Sweden
Short Talk

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, APRIL 4

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Vascular Cell Biology I: Vascular Endothelium
Meeting has ended...abstracts no longer viewable online.

Longs
Guillermo Garcia-Cardena, Harvard Medical School, USA
Short Talk: KLF2: A Mechano-Activated Transcription Factor that Acts as an Integrator of Multiple Endothelial Functions

Mark L. Kahn, University of Pennsylvania, USA
Short Talk: Role of KLF2 in Cardiovascular Development and Function

Philip W. Shaul, University of Texas Southwestern Medical Center, USA
Atheroslerosis Risk Factors and Signaling Modules in Endothelial Cell Caveolae

William C. Sessa, Yale University School of Medicine, USA
Dynamics of Caveolae Function and eNOS Regulation

* Peter F. Davies, University of Pennsylvania, USA
Site-Specific Phenotype Mapping of Endothelium from Patho-Susceptible and Resistant Locations in Vivo


Following Session is for Atherothrombosis (Z1)

08:00—11:00
New Pathways and Targets in Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Grays
Jorge Plutzky, Brigham and Women's Hospital, USA
Lipolytic Mechanisms of PPAR Activation

* Daniel J. Rader, University of Pennsylvania, USA
Molecular Regulation of Reverse Cholesterol Transport

Robert V. Farese Jr., Harvard School of Public Health, USA
The Enzymes of Neutral Lipid Synthesis: Sources of Some Fat Problems

Scott W. Altmann, Schering-Plough Research Institute, USA
Molecular Mechanisms of Intestinal Cholesterol Transport

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys

Following Session is for Atherothrombosis (Z1)

14:30—16:30
Roundtable Workshop on Development of Therapeutics

Grays
* Peter Libby, Brigham and Women's Hospital, USA

* Shaun R. Coughlin, University of California, San Francisco, USA

J. Anthony Ware, Eli Lilly and Company, USA
Development of Novel Drugs for Atherothrombotics

David R. Phillips, Portola Pharmaceuticals Inc., USA
Platelet Adhesion and Activation in Atherothrombosis

Roger S. Newton, Esperion Therapeutics, Inc., USA
Cholesterol Acceptors

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Vascular Cell Biology II: Vascular Smooth Muscle
Meeting has ended...abstracts no longer viewable online.

Longs
Peter Oettgen, Harvard Institutes of Medicine, USA
The Role of Ets-1 in Vascular Inflammation and Remodeling

Joachim Herz, University of Texas Southwestern Medical Center, USA
LRP1 and Vascular Wall Integrity

* Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Vascular Proliferation and Inflammation: Lessons Learned from Genetic Diseases


Following Session is for Atherothrombosis (Z1)

17:00—19:00
Cardiovascular Aspects of the Metabolic Syndrome/Diabetes
Meeting has ended...abstracts no longer viewable online.

Grays
* Jorge Plutzky, Brigham and Women's Hospital, USA

Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Mutations in Mitochondrial DNA and Metabolic Syndrome

Ann Marie Schmidt, New York University Langone Medical Center, USA
RAGE, Inflammatory Signaling & Atherosclerosis in Diabetes and Beyond

Douglas E. Vaughan, Vanderbilt University, USA
PAI-1, Obesity and Diabetes

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, APRIL 5

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Control of Vascular Tone I: Cyclic GMP
Meeting has ended...abstracts no longer viewable online.

Longs
Thomas M. Lincoln, University of South Alabama, USA
Cyclic GMP-Dependent Protein Kinases in Vascular Smooth Muscle: From the Regulation of Tone to Gene Expression

Joseph A. Beavo, University of Washington, USA
CGMP Phosphodiesterase in Vascular Smooth Muscle Cell Function

Chen Yan†, University of Rochester, USA
Short Talk: PDEIA in Vascular Smooth Muscle Function

Franz Hofmann, Technische Universität München, Germany
Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System: Insights from Genetically Modified Mice

* Michael E. Mendelsohn, , USA
Regulation of Vascular Smooth Muscle Cell Phenotype, Vascular Function and Blood Pressure by Cyclic GMP-dependent Protein Kinase Ialpha


Following Session is for Atherothrombosis (Z1)

08:00—11:00
Biomarkers/Imaging
Meeting has ended...abstracts no longer viewable online.

Grays
Thomas Hatsukami, University of Washington, USA
Magnetic Resonance Imaging of Atherosclerosis

João A.C. Lima, Johns Hopkins Medical Institutions, USA
Cardiovascular CT in Coronary Artery Disease

* Ralph Weissleder, Massachusetts General Hospital, USA
Molecular Imaging of Atherosclerosis

Jorge L. Durand, Albert Einstein College of Medicine, USA
Short Talk: A Novel Integration of Magnetic Resonance Imaging and Raman Spectroscopy of Atherosclerotic Mouse Aortas

Andreas Kalmes, Amgen Inc., USA
Short Talk: Use of Near-Infrared Protease-Activated Probes to Measure Anti-Inflammatory Treatment in a Mouse Model of Arterial Injury

Sander Leonard Wolters, Maastricht University and Hospital, Netherlands
Short Talk: Noninvasive Imaging of Inflammation/Apoptosis with 99mTc-Annexin A5 Reveals Plaque Instability in Patients with Significant Carotid Artery Stenosis

09:20—09:40
Coffee Break

Longs Peak Foyer

Following Session is for Atherothrombosis (Z1)

11:00—12:00
Optional Session: How to Navigate NIH Study Section and Program

Grays
Larry M. Pinkus, CSR, National Institutes of Health, USA
What You Need to Know about NIH Grant Applications

Eser Tolunay, NHLBI, National Institutes of Health, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Control of Vascular Tone II: EDHF and Ion Channels
Meeting has ended...abstracts no longer viewable online.

Longs
* Rudi Busse, Klinikum der J.W. Goethe-Universität, Germany
Endothelial Hyperpolarization: CYP’s, Trp’s, Gaps and the Rest

Michael J. Davis, University of Missouri-Columbia, USA
Signaling Mechanisms Underlying the Vascular Myogenic Response

Mark T. Nelson, University of Vermont, USA
Local Potassium Signaling Couples Astrocytic Activity to Cerebrovascular Function.


Following Session is for Atherothrombosis (Z1)

17:00—19:00
Immunity and Inflammation
Meeting has ended...abstracts no longer viewable online.

Grays
Peter Libby, Brigham and Women's Hospital, USA
Innate Immunity and Atherothrombosis

* Göran K. Hansson, Karolinska University Hospital, Sweden
Atherosclerosis – An Autoimmune Disease?

Cornelia M. Weyand, Emory University School of Medicine, USA
Mechanisms of Vasculitis

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys

THURSDAY, APRIL 6

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Vascular Pathobiology in Disease I
Meeting has ended...abstracts no longer viewable online.

Longs
* Bradford C. Berk, University of Rochester Medical Center, USA
Vascular Pathobiology of Oxidative Stress

Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Role of WNK Kinases in Human Hypertension

Marlene Rabinovitch, Stanford University, USA
Bone Morphogenetic Protein Mediated Signaling in the Pathobiology of Pulmonary Vascular Disease


Following Session is for Atherothrombosis (Z1)

08:00—11:00
Platelets/Thrombosis
Meeting has ended...abstracts no longer viewable online.

Grays
Kenneth G. Mann, University of Vermont, USA
Quantitative Modeling of the Tissue Factor Pathway of Coagulation

* Shaun R. Coughlin, University of California, San Francisco, USA
Thrombin signaling in hemostasis and thrombosis

Yale Nemerson, Mt. Sinai Medical School, USA
The Role of Phospholipid in Regulating Tissue Factor Activity: A Different Role for Lipid Surfaces in the Initiation of Coagulation.

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Intimal Cell Origins and Regulation/Vascular Pathobiology in Disease II (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays/Long
Ryozo Nagai, University of Tokyo, Japan
Significance of Krüppel-Like Transcription Factor 5 in Cardiovascular Disease

* Douglas W. Losordo, Caladrius Biosciences, Inc., USA
Autologous CD34+ Cells for Ischemic Tissue Repair: Scientific Basis and Early Results of Human Clinical Trials

Bruce Furie, Beth Israel Deaconess Medical Center, USA
Dynamics of Thrombus Formation in vivo

18:45—19:00
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Grays/Long
Michael E. Mendelsohn, , USA

Bradford C. Berk, University of Rochester Medical Center, USA

Peter Libby, Brigham and Women's Hospital, USA

Shaun R. Coughlin, University of California, San Francisco, USA

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

FRIDAY, APRIL 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 HL083680-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676