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This meeting took place in 2006



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Gut Hormones and Other Regulators of Appetite, Satiety and Energy Expenditure (F1)


Organizer(s) Stephen R. Bloom and Roger D. Cone
March 2—7, 2006
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Nov 2, 2005
Late Abstract Deadline: Nov 23, 2005
Scholarship Deadline: Nov 2, 2005
Early Registration Deadline: Jan 3, 2006

Sponsored by Lilly Research Laboratories

Summary of Meeting:
Circulating factors are important in regulating energy balance. It has long been recognized that the adipose hormone, leptin, reduces food intake by specific CNS pathways. Gut hormones have also been shown to be major regulators of appetite, acting both in the brainstem and hypothalamus. In addition, they have been found to markedly influence energy expenditure. Obesity is associated with a reduced gut hormone release but the mechanism is unknown. In man, this change may perpetuate or contribute to obesity. This meeting will address the physiological importance of circulating hormones in the regulation of energy balance. We will explore the mechanisms involved, their disturbance in obesity, and therapeutic possibilities.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 2

15:00—19:00
Registration

South Concourse
18:30—19:30
Refreshments

Eldorado Court/Sunset Room
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Roger D. Cone, University of Michigan, USA
Introductory Remarks

Stephen O'Rahilly, University of Cambridge, UK
Genetic Disorders of Energy Balance


FRIDAY, MARCH 3

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
CNS Appetite Circuits
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Andrew D. Howard, Merck Research Laboratories, USA

Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Brainstem Integration of Short- and Long-Term Satiety Signals

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Circuits Underlying the Coordinated Control of Body Weight and Glucose Homeostasis

Roger D. Cone, University of Michigan, USA
Development of the Zebrafish as a System for the Genetic Analysis of Energy Homeostasis

Maribel Rios, Tufts University School of Medicine, USA
Short Talk: Brain-derived Neurotrophic Factor as a Regulator of Energy Balance

William F. Colmers, University of Alberta, Canada
Short Talk: Development of Energy-Balance-Sensitive Parvocellular eurons in Rat Paraventricula Hypothalamus (PVN)

09:20—09:40
Coffee Break

South Concourse
11:00—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

South Concourse
17:00—19:00
Ghrelin
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Yvette Taché, University of California, Los Angeles, USA

David E. Cummings, University of Washington, USA
Roles for Ghrelin in the Regulation of Energy Balance and Glucose Homeostasis

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Ghrelin

Andrew D. Howard, Merck Research Laboratories, USA
Pharmacology of Ghrelin

Yukari Date, University of Miyazaki, Japan
Short Talk: Stomach-Derived Ghrelin’s Communication with the Brain

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

SATURDAY, MARCH 4

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
GLP-1 and Oxyntomodulin
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* David E. Cummings, University of Washington, USA

Jens Juul Holst, University of Copenhagen the Panum Institute, Denmark
Glucagon-Like Peptide 1: Effects in Diabetes and on Body Weight

Nazneen Aziz, Point Therapeutics, USA
Short Talk: Glucose, Triglyceride Lowering and Other Antidiabetic Activity Of PT-630, a Long-Acting DPP-4 Inhibitor, in Acute and Chronic Studies

Andrew A. Young, Intarcia Therapeutics Inc, USA
Exenatide for Diabetes

Stephen R. Bloom, Imperial College London, UK
Oxyntomodulin

Carolyn M. Jodka, Amylin Pharmaceuticals Inc., USA
Short Talk: Anti-Obesity Effects of Peripherally Administered Oxyntomodulin in High Fat-Fed Mice

Yvette Taché, University of California, Los Angeles, USA
Nibbling at CRF Receptor Control of Feeding and Gastric Emptying in Rodents

09:20—09:40
Coffee Break

South Concourse
11:15—13:00
Poster Setup

Sunset Room
13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

South Concourse
17:00—19:00
Other Hormones
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* I. Sadaf Farooqi, University of Cambridge, UK

Rachel L. Batterham, University College London, UK
Macronutrients and Satiety

Thue W. Schwartz, University of Copenhagen, Denmark
Obestatin a Peptide Fragment From the Ghrelin Precursor And GPR39 a Constitutively Active Member of the Ghrelin Family of 7TM Receptors

Ilia G. Halatchev, Vollum Institute, USA
Short Talk: Inhibition of Food Intake by PYY3–36 is Independent of NPY/AgRP and the Arcuate Nucleus

Aaron Hsueh, Stanford University, USA
Obestatin and its Receptor

Linda Rinaman, Florida State University, USA
Satiety vs. Nimiety: The Role of Central Oxytocin

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

SUNDAY, MARCH 5

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
CNS Pathways
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
AMPK

Rexford S. Ahima, University of Pennsylvania, USA
Role of Adiponectin in Energy and Glucose Homeostasis

Herbert Herzog, Garvan Institute, Australia
Lessons from NPY and Y-Receptor Knockout Mice

Gavin A. Bewick, Kings College London, UK
Short Talk: Phenotypic Characterisation of Mice Lacking AgRP Neurons

Sebastien G. Bouret, University of Southern California, USA
Short Talk: Development of Peptidergic Projection Pathways from the Arcuate Nucleus is Mediated Differentially through Activation of ObRb Signaling Pathways

Randy J. Seeley, University of Michigan, USA
A Novel Role for the Fuel-Sensitive Kinase mTOR in the Hypothalamic Regulation of Energy Balance

09:20—09:40
Coffee Break

South Concourse
16:30—17:00
Coffee Available

South Concourse
17:00—19:00
Short Talk Session
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Rachel L. Batterham, University College London, UK

Masoud Ghamari-Langroudi, Vanderbilt University, USA
Regulation of Firing Activity of Melanocortin 4 Receptor Expressing Neurons of Mouse Paraventricular Nucleus: Convergence of Signals of Adiposity

Kirsty L. Smith, Imperial College London, UK
Twenty Four Hour Metabolic Profiles of ICV Administered Hypothalamic Neuropeptides

Christian E. Elling, Lundbeck Foundation, Denmark
Short Talk: Selective Y2 Versus Selective Y4 And Combined Y2-Y4 Receptor Agonists for Treatment of Obesity

Ofer Reizes, Cleveland Clinic Foundation, USA
Ghrelin Antagonist is Efficacious in Lean but not Obese Rodents

Birgitte Sloth, Royal Veterinary and Agricultural University, Denmark
The Effect of PYY1-36 and PYY3-36 on Appetite, Energy Intake and Energy Expenditure in Obese and Lean Subjects

Judith Körner, Columbia University, USA
Differential Effects of Gastric Banding and Roux-en-Y Gastric Bypass on Fasting and Post-Prandial Plasma Peptide YY, Ghrelin, Leptin and Insulin Concentrations

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room

MONDAY, MARCH 6

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Novel Appetite Regulators
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA

Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1: From Metabolic Syndrome to Memory

Daniele Piomelli, University of California, Irvine, USA
Lipid Mediators that Regulate Feeding

Marie Björnholm, Karolinska Institutet, Sweden
Short Talk: Mice Lacking Inhibitory Leptin Receptor Signals are Lean with Normal Endocrine Function

Neel S. Singhal, University of Pennsylvania School of Medicine, USA
Short Talk: Divergent Effects of Resistin and Leptin on Energy and Glucose Homeostasis

Harvey J. Grill, University of Pennsylvania, USA
Contributions of Caudal Brainstem to Responses to GI Signals and to a Distributed Neural Control of Energy Homeostasis

I. Sadaf Farooqi, University of Cambridge, UK
Role of Neurotrophins in the Regulation of Human Appetite

09:20—09:40
Coffee Break

South Concourse
16:30—17:00
Coffee Available

South Concourse
17:00—19:00
Therapeutic Interest
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK

Colin T. Dourish, P1vital, UK
Serotonergic Circuits – Therapeutic Possibilities

Rick Costantino, Nastech Pharmaceutical Company Company Inc., USA
Peptides as Therapeutics – Novel Mechanisms for Delivery

Caroline Small, Imperial College London, UK
The Obesity Market – Do peptides such as PYY offer a viable approach?

20:00—21:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

TUESDAY, MARCH 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 DK074282-01




We gratefully acknowledge additional support for this conference from:

Diagnostics Systems Laboratories, Inc. (DSL) Lilly Research Laboratories
Novartis Institutes for BioMedical Research Research Diets, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Amylin Pharmaceuticals Inc.


P1vital


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