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This meeting took place in 2006



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Pancreatic Islets: From Development to Transplantation (X2)


Organizer(s) Alvin C. Powers, David M. Harlan, Christopher V.E. Wright and Michael German
February 23—28, 2006
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 24, 2005
Late Abstract Deadline: Nov 16, 2005
Scholarship Deadline: Oct 24, 2005
Early Registration Deadline: Dec 23, 2005

Supported by the Juvenile Diabetes Research Foundation


Summary of Meeting:
The meeting will be an integrated program on pancreatic islet developmental biology and pancreatic islet transplantation. Both areas are on the forefront of several scientific disciplines (developmental biology, stem cells, transcription factors, transplantation, cell biology, gene regulation, and diabetes) and are the subject of intense scientific investigation. Islet transplantation, an emerging therapy for diabetes, is severely hampered by the lack of a sufficient number of islets for transplantation. A major goal of work to understand pancreatic islet development is the generation of new islets from stem cells (adult or embryonic). Challenges relevant to both fields are an incomplete understanding of the mechanisms controlling normal islet development and function and lack of information about islet cell differentiation, survival, and function after transplantation. The program will focus on these scientific challenges by reviewing progress in these rapidly expanding fields and discussing strategies to overcome these obstacles. The planning committee has structured the program to foster interaction between scientists interested in islet transplantation and those interested in pancreatic islet development.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 23

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom
* Lydia Aguilar-Bryan, Pacific Northwest Research Institute, USA

* Alvin C. Powers, Vanderbilt University School of Medicine, USA

Philip F. Smith, NIDDK, National Institutes of Health, USA
The NIDDK Agenda for Research on Islet Development, Biology and Transplantation

Philippe A. Halban, Geneva University, Switzerland
Connecting Beta Cell Biology to Effective Therapies for Type 1 and Type 2 Diabetes


FRIDAY, FEBRUARY 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Joint Session with the Pancreatic Islet Biology Meeting
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom
* Chris Wright, Vanderbilt University Medical Center, USA

* Christopher B. Newgard, Duke University Medical Center, USA
Metabolic networks of the mature beta-cell

Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Molecular Mechanism of Food Intake-Dependent Fluctuations in the Functional Beta Cell Mass

Markus Stoffel, ETH Zürich, Switzerland
Role of Micro RNAs in Islet Function

Roger H. Unger, University of Texas Southwestern Medical Center, USA
Metabolic “Rejection” of Intraportal Islet Transplants: Evidence for Lipotoxic Destruction of Islets by Hepatic Lipids and its Prevention by Leptinization

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Challenges for Islet Transplantation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Gordon C. Weir, Joslin Diabetes Center, USA

David M. Harlan, National Institutes of Health, NIDDK, USA
Immune Aspects of Type 1 Diabetes and Islet Transplantation

R. Paul Robertson, Pacific Northwest Research Institute, USA
What is a "Successful" Islet Transplant?

Daniel Nyqvist, Karolinska Institute, Sweden
Short Talk: 3D Visualization and Quantification of the Intact Islet Graft Vasculature

Francis C. Lynn, University of British Columbia, Canada
Short Talk: MicroRNA Expression is Necessary for Normal Pancreas Development.

Olle Korsgren, Uppsala University, Sweden
Inflammatory Events after Islet Transplantation


Following Session is for Toward Understanding Islet Biology (X1)

17:00—19:15
Regulation of Insulin Secretion I
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Christopher J. Rhodes, MedImmune, USA

Kenneth S. Polonsky, Washington University School of Medicine, USA
Pancreatic beta cell survival: critical roles of pdx-1 and insulin

Jean Claude Henquin, University of Louvain, Belgium
Triggering and amplifying pathways of glucose-stimulated insulin secretion: how and when?

Joseph Bryan, Pacific Northwest Research Institute, USA
Alpha-/Beta-cell Crosstalk

Thomas C. Becker, Duke University Medical Center, USA
Short Talk: Micro RNA ad B Cell Function

Savita Dhanvantari, Lawson Research Health Institute, Canada
Short Talk: Cellular and Molecular Imaging of Pancreatic Islet Cells

19:00—20:00
Social Hour with Lite Bites

Chamisa Lobby
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

SATURDAY, FEBRUARY 25

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Pancreas and Islet Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA

Michael German, University of California, San Francisco, USA
Gene Expression Cascades in Islet Development

Chris Wright, Vanderbilt University Medical Center, USA
Pdx-1 Level is Instructive for Pancreatic Differentiation

Paul E. Harris, Columbia University, USA
Short Talk: Targeting Vesicular Monoamine Transporter Type 2 for Non-Invasive Longitudinal P.E.T. Studies of Beta Cell Mass Change

Lori Sussel, University of Colorado, USA
Pathways of Islet Cell Differentiation and Development

Jared S. Burlison, Vanderbilt University School of Medicine, USA
Short Talk: Genetic Labelling of PtF/a Expressing Cells

Kenneth S. Zaret, University of Pennsylvania, USA
Specifying Pancreas and Liver Cells in Development


Following Session is for Toward Understanding Islet Biology (X1)

08:00—11:15
Regulation of Insulin Secretion II
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Joseph Bryan, Pacific Northwest Research Institute, USA

Christopher J. Rhodes, MedImmune, USA
Trafficking ß-Granule Trafficking

Franz M. Matschinsky, University of Pennsylvania, USA
Glutamine metabolism and Insulin Release

Marc Prentki, , Canada
Glucose and Fuel-Stimulated Lipolysis, TG/FFA Cycling and Lipid Signaling for Insulin Secretion in Pancreatic B Cells

Celia Briscoe, Johnson and Johnson, USA
Fatty Acids as Extra-cellular Regulators of Insulin Secretion

Hassan Mziaut, Medical School TU Dresden, Germany
Short Talk: Synergy of Glucose and GH Signaling in Islet B Cells via ICA5/2

Alan D. Attie, University of Wisconsin-Madison, USA
Short Talk: Positional Cloning of a Type 2 Diabetes Quantitative Trait Gene

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Stem Cells and Pancreatic Islets
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Michael German, University of California, San Francisco, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Commitment of ES Cells to Endoderm

Sarah L. Londrigan, University of Melbourne, Australia
Short Talk: Prolonged Islet Allograft Survival by Modification Using Immunomodulatory Adenoviruses

Laura Crisa, The Scripps Research Institute, USA
Short Talk: Enhaced Engraftment and Function of Pancreatic Islet Cell Transplants by Bone Marrow-Derived Blood Vessels

Alan Colman, ES Cell International and A*STAR Center for Molecular Medicine, Singapore
Making Clinically Useful beta-Like Cells from Human Embryonic Stem Cells

Norris Ray Dunn, ES Cell International Pte Ltd, Singapore
Diabetes Cell Therapy from ES Cells


Following Session is for Toward Understanding Islet Biology (X1)

17:00—19:15
Role of Mitochondrial Metabolism in Health and Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jack Leahy, University of Vermont, USA

John A. Corbett, Medical College of Wisconsin, USA
A Transgenic Approach to Study the Role of mtDNA Mutations in Pancreatic b-cell Failure

Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Defective Beta-Cell Mitochondrial Signalling is Restored by the Nuclear Factor TFAM or by Matrix Calcium Elevation.

Donalyn Scheuner, University of Michigan, USA
Signaling the Unfolded Protein Response Protects the Endoplasmic Reticulum Compartment and Prevents Beta Cell Failure

Cedric Le May, Baylor College of Medicine, USA
Short Talk: Estrogens Protect Pancreatic Beta-Cells From Apoptosis via Activation of the Estrogen Receptor-alpha and Prevent Insulin-Deficient Diabetes

Christine Bruun, Novo Nordisk A/S, Denmark
Short Talk: Proliferative and Anti-Apoptotic Signalling Pathways in Human Beta-Cells

19:15—20:15
Social Hour with Lite Bites

Chamisa Lobby
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

SUNDAY, FEBRUARY 26

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Current Status of Human Islet Transplantation

Chamisa Ballroom 2
* Robert A. Rizza, Mayo Clinic and Foundation, USA

Mathias Brendel, University of Giessen, Germany
How do we Evaluate Islets prior to Transplantation?

Breay W. Paty, University of Alberta, Canada
Islet Transplantation: Learning from the Edmonton Experience

Camillo Ricordi, University of Miami School of Medicine, USA
Miami Initiatives for Improving Islet Transplantation

Bernhard J. Hering, University of Minnesota, USA
Single-Donor Islet Transplants

Lorna W. Harries, Peninsula Medical School, UK
Short Talk: Alternate mRNA Processing of the Hepatocyte Nuclear Factor –1 alpha (HNF-1alpha) Gene Impacts on Clinical Phenotype

David D. Lee, University of Chicago, USA
Short Talk: An Indirect Role for the Spleen in Functional Islet beta-Cell Regeneration


Following Session is for Toward Understanding Islet Biology (X1)

08:00—11:15
Pathways for Development of Beta Cell Dysfunction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Frans C. Schuit, Katholieke Universiteit Leuven, Belgium

Jack Leahy, University of Vermont, USA
Mitochondrial Metabolism and Beta Cell Dysfunction

Vincent Poitout, Montreal Diabetes Research Center, Canada
Fatty-Acid Inhibition of Insulin Gene Expression.

Michele Solimena, Dresden University of Technology, Germany
Insulin Secretory Granule Biogenesis and Signaling

Michael J. MacDonald, University of Wisconsin-Madison, USA
Roles Of Mitochondrially Synthesized Products In Insulin Secretion

Jonathan C. Schisler, Duke University Medical Center, USA
Short Talk: The Transcription Factor Nkx6.1 Regulates Mature Beta-Cell Proliferation Through Control of Multiple Cell Cycle Genes

Helle Frobøse, Steno Diabetes Center, Denmark
Short Talk: IL-1 Signalling is Inhibited by Suppressor of Cytokine Signalling (SOCS)-3 Targeting The TRAF-6/TAK1 Complex

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Beta Cell – Birth and Death
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Kevin Docherty, University of Aberdeen, UK

Ray MacDonald, University of Texas Southwestern Medical Center, USA
Islet Formation at the Secondary Transition

Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Turnover in Humans

Jake A. Kushner, Baylor College of Medicine, USA
Beta Cell Turnover in Mice

Maike Sander, University of California, San Diego, USA
Transcriptional Control of Pancreatic Cell Fate Determination

Lorella Marselli, Joslin Diabetes Center, USA
Short Talk: Evidence for Arrested Regeneration in Islets of Human Type 2 Diabetes


Following Session is for Toward Understanding Islet Biology (X1)

17:00—19:15
Autonomic Regulation of Insulin Release
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Gary J. Schwartz, Albert Einstein College of Medicine, USA
Integrated Neural Control of Glucose Homeostasis

* Gerald J. Taborsky, Jr., Seattle VA Puget Sound Health Center, USA
Neural Control of Islet Function

* Bo Ahrén, Lund University, Sweden
Neuropeptides and Islet Function

Maria L. Golson, University of Pennsylvania, USA
Short Talk: Jagged1 is Required for Normal Cell Lineage Allocation in the Endocrine Pancreas

Nada Nekrep, University of California, San Francisco, USA
Short Talk: Target Genes of Nkx2.2 During Pancreatic Development and in Mature Beta Cells

19:15—20:15
Social Hour with Lite Bites

Chamisa Lobby
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

MONDAY, FEBRUARY 27

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Moving from the Laboratory to Humans
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* David M. Harlan, National Institutes of Health, NIDDK, USA

Daniel Pipeleers, Vrije Universiteit Brussel, Belgium
From Beta Cell Biology to Beta Cell Therapy - and Back

David W. Scharp, Prodo Laboratories, USA
Immunoisolation of Islets by Encapsulation

Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Identification of a Factor that Supports Differentiation of Pancreatic Endocrine Cells Mediated by a Negative Feed Back Regulation of Ngn3

Kai-Christian Sonntag, Harvard Medical School, USA
Embryonic Stem Cells as Cell Therapy for Parkinson’s Disease

Hsun Teresa Ku, Mount Sinai School of Medicine, USA
Short Talk: Insulin-Expressing Colonies Developed from Murine Embryonic Stem Cell-Derived Pancreatic beta-Cell Progenitors

Juan L. Contreras, University of Alabama at Birmingham, USA
Approaches to Improve Survival of Transplanted Islets


Following Session is for Toward Understanding Islet Biology (X1)

08:00—11:15
Emerging Technologies for Beta Cell Research
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Christopher B. Newgard, Duke University Medical Center, USA

Mark A. Magnuson, Vanderbilt School of Medicine, USA
Multi-Allelic Gene Targeting Strategies and Their Application to Studies of Pancreas Development and Beta Cell Function

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Orthogonal Analysis of Transcriptional Programs in the Endocrine Pancreas: A Novel Role for the MODY1 Gene HNF4alpha

Dean Sherry, University of Texas at Dallas, USA
13C NMR Isotopomer Analysis Reveals Metabolic Details of Beta Cell Function

Anna Moore, Massachusetts General Hospital, USA
Strategies for Molecular Imaging of Diabetic Pancreas

Kazuaki Ohtsubo, Kumamoto University, Japan
Short Talk: A Dietary and Genetic Mechanism of Pancreatic Beta Cell Failure in the Pathogenesis of Type 2 Diabetes

James Herrington, Merck & Co., Inc., USA
Short Talk: Inhibitors of the Pancreatic Beta-Cell Delayed Rectifier Potassium Current Enhance Insulin Secretion

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Islet Proliferation, Growth and Survival
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Fred Levine†, Sanford-Burnham Medical Research Institute, USA

Marvin C. Gershengorn, National Institutes of Health, USA
Human Islet Precursors from Mature Islet Cells

Rennian Wang, University of Western Ontario, Canada
Short Talk: Temporal Gene Expression Patterns during Human Fetal Pancreas Development

Andrew F. Stewart, Mount Sinai School of Medicine, USA
Moleclar Control of Pancreatic B Cell Replication: Implications for Diabetes Therapy

Toshihiko Masui, University of Texas Southwestern Medical Center, USA
Short Talk: A Suppressor of Hairless is a Critical Component of the Pancreatic Acinar Complex PTF1 during Pancreatic Development

Alvin C. Powers, Vanderbilt University School of Medicine, USA
Pancreatic Islets: Vascularization and Revascularization


Following Session is for Toward Understanding Islet Biology (X1)

17:00—19:15
Targets for Improving Beta Cell Function
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Joseph Bryan, Pacific Northwest Research Institute, USA

Nancy A. Thornberry, Kallyope, Inc., USA
New Agents for the Treatment of Type 2 Diabetes

Rebecca A. Taub, VIA Pharmaceuticals, Inc, USA
Potential Novel Therapy for Type 2 Diabetes

Shinsaku Aramata, Nara Institute of Science and Technology, Japan
Short Talk: Synergistic Activation of the Insulin Promoter by the Beta-Cell Enriched Transcription Factors Mafa, Beta2, And Pdx1

Gary W. Cline, Yale University, USA
Short Talk: 13C Isotopomer Analysis of Impaired Insulin Secretion following siRNA Knockdown of Cytosolic and Mitochondrial Malic Enzyme Isoforms in INS-1 Cells

Claudia E. Robert, University of Pennsylvania, USA
Short Talk: Transgenic Mice Overexpressing the Novel Islet Specific Cytokine, PANDER, Exhibit Glucose Intolerance and Decreased beta Cell Mass

19:15—20:15
Social Hour

Sagebrush Lounge
20:15—21:15
Dinner

Chamisa Ballroom
20:00—23:00
Entertainment

Chamisa Ballroom

TUESDAY, FEBRUARY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 DK074311-01




We gratefully acknowledge additional support for this conference from:

JDRF

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



ViaCyte, Inc.


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