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This meeting took place in 2006



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Metabolomics: From Bioenergetics to Apoptosis (G5)


Organizer(s) Craig B. Thompson, David G. Nicholls and Anne N. Murphy
April 2—7, 2006
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 1, 2005
Late Abstract Deadline: Dec 27, 2005
Scholarship Deadline: Dec 1, 2005
Early Registration Deadline: Feb 2, 2006

Supported by The Director's Fund

Summary of Meeting:
The bioenergetic status of a cell plays a critical role in determining its ability to survive. Cells unable to maintain sufficient ATP production to support essential cellular processes die passively by necrosis. In contrast, apoptosis is an organized and energy-dependent form of cell death. Recently, genes involved in bioenergetic control and/or mitochondrial function have been implicated in the regulation of apoptosis. The purpose of this meeting is to define the role of bioenergetics in determining a cell's susceptibility to apoptosis. Among the issues to be considered are the following: the contribution of metabolic regulators (Akt, PGC-1, and HIF-1a) to mitochondrial function and apoptotic susceptibility, the role of bioenergetic sensing pathways (AMPK, TOR, autophagy) in modulating apoptotic sensitivity, and how mitochondrial function influences the contributions of calcium, oxidative stress, and Bcl-2 family proteins to apoptotic regulation. The meeting will focus on how these relationships may contribute to understanding the pathogenesis and improving the treatment of a wide variety of disorders including neurodegenerative syndromes, cancer, and cardiovascular disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 2

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Mezzanine & Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Douglas C. Wallace, Children's Hospital of Philadelphia, USA
Mitochondrial and Evolutionary Medicine: A Paradigm of Metabolic and Degenerative Diseases, Cancer and Aging


MONDAY, APRIL 3

07:00—08:00
Breakfast

Wasatch / Superior Lobby
08:00—11:15
Metabolic Regulation of Mitochondrial Function and Apoptosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Morris J. Birnbaum, Pfizer Inc., USA
Akt Control of Glucose Metabolism and Apoptosis

Don W. Cleveland, University of California, San Diego, USA
Mechanisms and Treatment of ALS: Selective Mitochondrial Targeting of Misfolded Mutant Protein

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient-Regulated Transcriptional Responses Linked to Glucose and Lipid Metabolism

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Bcl-xL Modulates Mitochondrial Structure and Energetics

Qiang Tong, Baylor College of Medicine, USA
Short Talk: Metabolic Regulation of SIRT3, A Mitochondrial NAD-Dependent Deacetylase

Ioanna Papandreou, Ohio State University, USA
Short Talk: Hif-1 Down-Regulates Mitochondrial Oxygen Consumption in Tumors, Modifying Sensitivity to Oxygen-Dependent Therapies

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:15—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:15
Bioenergetic Sensing Pathways
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
George Thomas, University of Cincinnati, USA
The Role of Nutrients in TSC1/2-RHEB Mediated mTOR Pathway

* Lewis C. Cantley, Weill Cornell Medicine, USA
LKB1 and AMP Kinase Link Bioenergetic Status to Apoptosis and Growth

Narayan G. Avadhani, University of Pennsylvania, USA
Signaling from Mitochondria to Nucleus: A Mitochondrial Stress Response

Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy, Cell Death and Bioenergetics

19:15—20:15
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Maybird

TUESDAY, APRIL 4

07:00—08:00
Breakfast

Wasatch / Superior Lobby
08:00—11:15
Mitochondrial Bioenergetics and the Induction of Apoptosis
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Martin Crompton, University College London, UK
The Mitochondiral Transition Pore and its Role in Cell Death

Rosario Rizzuto, University of Padua, Italy
Mitochondrial/ER Ca++ Communication during Apoptosis

Pierluigi Nicotera, University of Leicester, UK
Transduction of Cellular and Mitochondrial Calcium Signals to the Neuronal Death Machineries

Paolo Bernardi, University of Padova Medical School, Italy
Properties of the Permeability Transition in Mitochondria from VDAC1-/- and Ppif-/- mice

Roman A. Eliseev, University of Rochester Medical Center, USA
Short Talk: The Role of Cyclophilin D in the Resistance of Brain Mitochondria to the Ca2+ Induced MPT

J. Kevin Foskett, University of Pennsylvania, USA
Short Talk: The ImsP3 Receptor Ca2+ release Channel and the Endoplasmic Reticulum Gateway to Apoptosis

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:15—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:00
The Role of Macroautophagy in Cell Death and Bioenergetics
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Autophagy and Aerobic Gycolysis Represent the Extremes of Intermediate Metabolism in Cells Dependent on Receptor-Directed Nutrient Uptake

Devrim Gozuacik, Sabanci University, Turkey
The DAP-Kinase Family of Proteins: Analysis of their Structure and Function at the Apoptosis/Autophagic Cell Death Junction

Stéphen Manon, Centre National de la Recherche Scientifique, France
Short Talk: Mitochondria-Selective Autophagy (Mitophagy) in Yeast

Li Yu, Tsinghua University, China
Short Talk: Autophagic Programmed Cell Death by Selective Catalase Degradation

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Maybird

WEDNESDAY, APRIL 5

07:00—08:00
Breakfast

Wasatch / Superior Lobby
08:00—11:00
Metabolic Regulators of Mitochondrial Cell Death
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Nika N. Danial, Dana-Farber Cancer Institute, USA
Dual Role of the Pro-Apoptotic BCL-2 Protein BAD in Insulin Secretion and beta Cell Survival

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Regulation of Lipid and Glucose Metabolism and Cell Survival by Hypoxia-Inducible Factor 1

* Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA
Death and the Mitochondrion

Brian M. Polster, University of Maryland School of Medicine, USA
Mechanisms and Consequences of Mitochondrial Permeabilization

Kah Fei Wan, Institute of Molecular and Cell Biology, Singapore
Short Talk: Chelerythrine Confers Cytotoxicity on Mammalian Cells through a Bax-, Bak-Independent Apoptotic Pathway

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
14:30—16:30
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeabilization

Ballroom 2-3
* Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA

Salah Abu-Hamad, Ben-Gurion University of the Negev, Israel
Short Talk: The Expression Level of the Voltage-Dependent Anion Channel 1 Controls Life and Death of the Cell

Emilie Alirol, Venetian Institute of Molecular Medecine, Italy
Role of hFis1 in Mitochondrial Fission and Apoptosis

Jeffrey S. Armstrong, National University of Singapore, Singapore
Bax and the Mitochondrial Permeability Transition Cooperate in the Release of Cytochrome C during Thapsigargin Induced Apoptosis

Hubert Frédéric Arokium, , France
Molecular Mechanisms Underlying Bax/Mitochondria Interactions during Apoptosis: A Study in Yeast

Laurent Dejean, California State University Fresno, USA
The Mitochondrial Apoptosis-Induced Channel: From a Functional to a Molecular Definition

Francois Gonzalvez, Genentech, USA
Involvement of Cardiolipin in Apoptosis

Sergei A. Novgorodov, Medical University of South Carolina, USA
Long-Chain Ceramides Suppress Mitochondrial Permeability Transition at Physiologically Relevant Concentrations

Patrice X. Petit, Centre de Recherche des Saint-Pères, France
Short Talk: tBid Impaired Mitochondrial Bioenergetic via Cardiolipin Spatial Rearrangement and Favor Subsequent Bax Activity

Tatiana K. Rostovtseva, NICHD, National Institutes of Health, USA
Lipid Composition Regulates VDAC Channel Voltage Gating

Leah J. Siskind, Medical University of South Carolina, USA
Ceramide Channels Regulate the Permeability of the Mitochondrial Outer Membrane to Proapoptotic Proteins

16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:00
Bioenergetics and Neuronal Cell Death
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Natalia B. Pivovarova, NINDS, National Institutes of Health, USA
Not All Mitochondria are Created Equal: Calcium Accumulation and Excitotoxic Cell Death

David G. Nicholls, Buck Institute for Research on Aging, USA
Quantifying Mitochondrial Bioenergetics in Neurons During Excitotoxic and Apoptotic Cell Death

Robert M. Friedlander, Brigham and Women's Hospital, USA
Modulation of Mitochondrial Cell Death Pathways in Acute and Chronic Neurologic Diseases

Gregory J. Brewer, Southern Illinois University School of Medicine, USA
Short Talk: Age-Related Declines in Mitochondrial Membrane Potential, Respiratory Complexes, NAD(P)H and Glutathione Cause Catastrophic Redox Decline during Glutamate Treatment of Hippocampal Neurons

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Maybird

THURSDAY, APRIL 6

07:00—08:00
Breakfast

Wasatch / Superior Lobby
08:00—11:15
Oxidative Stress Regulation and Cell Death
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Jochen H.M. Prehn, RCSI Research Institute, Ireland
Oxidative Stress and Mitochondrial Bioenergetics During Apoptosis: Lessons from Real Time Single Cell Analyses

* Martin D. Brand, Medical Research Council, UK
Topology, Sites and Regulation of Mitochondrial Superoxide Production

Navdeep S. Chandel, Northwestern University, USA
Mitochondria Regulates Apoptosis and Gene Expression during Hypoxia

Paul S. Brookes, University of Rochester Medical Center, USA
Mitochondria: An End Point for NO Signaling in Ischemic Preconditioning

Gary L. Wright, Quillen College of Medicine, USA
Short Talk: The Prolyl Hydroxylase Oxygen-Sensor Confers Cytoprotection through Multiple Mechanisms that Include the Maintenance of Mitochondrial Membrane Potential during Metabolic Inhibition

Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Respiratory Chain Malfunction and TCA Cycle Defects Activate Hypoxia Response

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:00
Therapeutic Prevention of Mitochondrial Cell Death
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Poly(ADP-ribose) is a new messenger signaling life or death.

Michael P. Murphy, University of Cambridge, UK
Mitochondria-Targeted Antioxidants and Redox Probes

Gustav Mattiasson, Wallenberg Neuroscience Center, Sweden
UCP2-Mediated Neuroprotection Following Ischemia and Traumatic Brain Injury

Bruno Miroux, Centre National de la Recherche Scientifique, France
Short Talk: A Protective Role for Uncoupling Protein 2 (UCP2) in Experimental Autoimmune Encephalitis

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
20:00—23:00
Entertainment

Ballroom 2-3

FRIDAY, APRIL 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AG027645-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Metabolomics


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Phone:+1 970-262-2690

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