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This meeting took place in 2006



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Epigenetics and Chromatin Remodeling in Development (A7)


Organizer(s) Renato Paro and Peter Fraser
January 19—24, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 19, 2005
Late Abstract Deadline: Oct 12, 2005
Scholarship Deadline: Sep 19, 2005
Early Registration Deadline: Nov 18, 2005

Supported by The Director's Fund

Summary of Meeting:
The stability of gene expression patterns, which define different cellular states, is highly dependent on chromatin structure and function. Regulatory features invoked by, for example, particular histone modifications or nuclear architecture greatly influence the way genetic information is interpreted during developmental processes. Such an epigenetic constitution of the nucleus is heritable, providing the basis for mechanisms like the permanent inactivation of an X chromosome or genomic imprinting in mammalian cells. The recent identification of many components of epigenetic regulation has created enormous excitement in the field, not only because we foresee a better understanding of the basic mechanisms on how developmental decisions are maintained, but also because we might learn how aberrant cases, like cancer cells, change their epigenetic hallmarks. Epigenetic gene control also needs to be considered to better understand and approach more applied topics like nuclear cloning, stem cells and tissue engineering. This meeting will bring together scientists who have identified epigenetic constituents and studied their regulatory contributions at the molecular level, with scientists who study, in more complex organisms, epigenetic programming of cellular fates during normal developmental and in the disease case.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 19

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Azim Surani, University of Cambridge, UK
Epigenetic Programming of the Genome in the Embryo and Germ Cells


FRIDAY, JANUARY 20

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
Chromatin Structure and Function
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Reading and Writing the 'Histone Code'

* Peter B. Becker, University of Munich, Germany
Site-Specific Acetylation Defines an Embryonic form of ISWI Associated with Mitotic Chromatin

Zhiguo Zhang, Mayo Clinic, USA
Short Talk: Rtt106p is a Novel Histone Chaperone Involved in Epigenetic Silencing

Stefan Kubicek, Austrian Academy of Sciences, Austria
Epigenetic Control by Histone Methylation

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Regulation of Histone Methylation Patterns by RNAi in Plants and Fission Yeast

Kevin V. Morris, Center for Gene Therapy, City of Hope, USA
Short Talk: The Antisense Strand of Small Interfering RNAs Directs Histone Methylation and Transcriptional Gene Silencing in Human Cells

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys 1-4
13:00—22:00
Poster Viewing

Torreys 1-4
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Establishing Epigenetic Marks
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Epigenetic Patterns Generated by Assembly of Histone Variants into Nucleosomes

Caline Karam, Columbia University Medical Center, USA
Short Talk: The Role of JIL-1 Mediated Histone H3 Phosphorylation in Transcriptional Activation

En Li, China Novartis Institutes for BioMedical Research, China
Role of DNA Methyltransferases in Mammalian Development

Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
A New Role of Genome Organizer SATB1 in Breast Cancer Mestastasis

19:00—20:00
Social Hour with Lite Bites

Torreys 1-4
19:30—22:00
Poster Session 1

Torreys 1-4

SATURDAY, JANUARY 21

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
Chromatin-Controlled Gene Regulation in Development
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Vicki L. Chandler, Minerva Schools at Keck Graduate Institute, USA
Heritable Chromatin Structures are Established through Trans-Interactions between Tandem Repeats

Jeannie T. Lee, Massachusetts General Hospital, USA
Cis-Regulatory Chromatin Dynamics at the X-Inactivation Center

Dominic John Ciavatta, University of North Carolina at Chapel Hill, USA
Short Talk: DNA Insulators Prevent Repression of a Targeted X-linked Transgene but not Its Random or Imprinted X-Inactivation

Kami Ahmad, Harvard Medical School, USA
Replication-Independent Histone Replacement, Histone Variants and Maintaining Epogenetic States

Laurie Jackson-Grusby, Harvard Medical School, USA
Reprogramming Epigenetic Imprinting

Nora I. Engel, Temple University School of Medicine, USA
Insulators, Mathylation and Transcriptional Regulation: Complesities of Imprinting Control

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys 1-4
13:00—22:00
Poster Viewing

Torreys 1-4
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Nuclear Positioning
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Peter Fraser, Florida State University, USA
Nuclear Organization of Transcription

Giacomo Cavalli, Institute of Human Genetics, France
Association of Polycomb Group Response Elements in the Nuclear Space

Wendy A. Bickmore, University of Edinburgh, UK
Nuclear Re-Organization during Embryonic Development

Daryl Gohl, Princeton University, USA
Short Talk: Analyzing Boundary Element Pairing and Competiton

19:00—20:00
Social Hour with Lite Bites

Torreys 1-4
19:30—22:00
Poster Session 2

Torreys 1-4

SUNDAY, JANUARY 22

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
Mechanisms of Cellular Memory
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Renato Paro, ETH Zurich, Switzerland
Epigenetic Control of Tissue Regeneration in Drosophila

Maxim Nekrasov, Australian National University, Australia
Short Talk: Characterization of the Drosophila PRC2 HMTase

Alexander Tarakhovsky, Rockefeller University, USA
Protein Lysine Methylation and Signal Transduction

Keji Zhao, NHLBI, National Institutes of Health, USA
Short Talk: Identification and Characterization of Human Polycomb Response Elements

* Ueli Grossniklaus, University of Zürich, Switzerland
Epigenetic Inheritance during Arabidopsis Seed Development

Peter Verrijzer, Erasmus University Medical Center, Netherlands
PREs are CIS-Regulatory Elements That Mediate Function of PcG and TRXG Proteins

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys 1-4
13:00—22:00
Poster Viewing

Torreys 1-4
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Cellular Plasticity and Tissue Reprogramming
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Eric N. Olson, University of Texas Southwestern Medical Center, USA
Signfalling to the Genome: Lessons from the Heart

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of B Cell Identity by Pax5

Jiang Wu, University of Texas Southwestern Medical Center, USA
Short Talk: An Essential Epigenetic Switch for Progenitor-to-Post-Mitotic Neural Development

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Molecular Control of Pluripotency and Self-Renewal

19:00—20:00
Social Hour with Lite Bites

Torreys 1-4
19:30—22:00
Poster Session 3

Torreys 1-4

MONDAY, JANUARY 23

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
Cancer Epigenetics
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Peter A. Jones, Van Andel Research Institute, USA
DNA Footprinting of CpG Islands at Single Molecule Resolution

Tom Latham, Westerb General Hospital, UK
Short Talk: Transgenic Mice Overexpressing DNA Methyltransferase Dnmt3b Develop Abnormal Cpg Island Methylation and Increased Progression of Apc min Intestinal Tumours

Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Epigenetic Control of Cancer or Questions of Epigenetic Networks Gone Wrong

Michael J. Boland, University of Nebraska Medical Center, USA
Short Talk: Initial Characterization of an Interaction between C5-DNA Methyltransferase, Dnmt3b, and Thymine DNA Glycosylase

Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Trang Hoang, Université de Montréal, Canada
Integration of Proliferative Signals from EED and BMI1 Proteins

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee Available

Shavano Peak Foyer
17:00—19:00
Stem Cell Programming
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Allan C. Spradling, HHMI/Carnegie Institute, USA
The Lighten-up/p68 RNA Helicase Regulates Transcriptional Deactivation by Promoting RNA Release from Chromatin

* Emma Whitelaw, Queensland Institute of Medical Research, Australia
An ENU Screen for Modifiers of Epigenetic Gene Silencing in the Mouse

David J. Katz, Emory University, USA
Short Talk: Histone H3 Lysine 4 Methylation Guards the Germ Cell Lineage

Wolf Reik, Babraham Institute, UK
Imprinting and Epigenetic Reprogramming in Mammalian Development

19:00—20:00
Social Hour with Lite Bites

Torreys 1-4
20:00—23:00
Entertainment

Torreys 1-4

TUESDAY, JANUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA117385-01




We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies Invitrogen Corporation
March of Dimes Foundation Novartis Institutes for BioMedical Research

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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