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This meeting took place in 2006



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Regulation of Eukaryotic Transcription: From Chromatin to mRNA (E3)


Organizer(s) James A. Goodrich, Laszlo Tora and Karolin Luger
April 21—26, 2006
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Dec 21, 2005
Late Abstract Deadline: Jan 13, 2006
Scholarship Deadline: Dec 21, 2005
Early Registration Deadline: Feb 21, 2006

Supported by The Director's Fund

Summary of Meeting:
This meeting will encompass the most exciting current research on eukaryotic mRNA transcription and its regulation. Sessions will address the following pivotal topics in the field: how chromatin and its modification actively sets levels of gene-specific transcription; promoter recognition complexes and their function in directing transcription initiation; the structure and organization of large macromolecular transcription complexes as revealed by X-ray crystallography and electron microscopy; transcriptional coregulatory complexes and their roles as mediators of transcriptional regulation during differentiation and development; the steps in the transcript synthesis reaction; and the application of emerging imaging techniques to the real time analysis of transcription in living cells. The goals of this meeting are to report the most recent progress on these topics, as well as to provide an understanding of both detailed transcriptional regulatory mechanisms and how transcriptional regulation integrates with other cellular and developmental processes.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 21

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Roger D. Kornberg, Stanford University, USA
RNA Polymerase II Transcription: Structure, Mechanism and Regulation


SATURDAY, APRIL 22

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Structure of Transcription Complexes
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Christoph W. Müller, EMBL / Grenoble Outstation, France

Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
From the Complete RNA Polymerase II Structure to Transcription Regulation

Patrick Schultz, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
The 3-D structures of yeast TFIID and human TFIIE revealed by cryo EM

Eva Nogales, University of California, Berkeley, USA
Electron Microscopy Studies of Multi-Subunit Transcription Factors

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
The Chemistry of Sir2 Enzymes

Eric A. Galburt, Max Planck Institute of Cellular Biology and Genetics, Germany
Short Talk: Single Molecule Transcription of Eukaryotic RNA Polymerase II

Raymond C. Trievel, University of Michigan, USA
Short Talk: Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 1: Mysteries of Intergenic Transcription

Chamisa Ballroom 1
* Jerry L. Workman, Stowers Institute for Medical Research, USA

Ann Dean, NIDDK, National Institutes of Health, USA
LCRs, Extragenic Transcription and Histone Modifications

David J. McBride, Medical Research Council Human Genetics Unit, UK
Control of Transcription at the Pax6 Locus

Henrietta Szutorisz, Mount Sinai School of Medicine, USA
The Proteasome Suppresses Transcription at Tissue-Specific Gene Loci in Embryonic Stem Cells

Yugong Ho, University of Pennsylvania School of Medicine, USA
A Role for Intergenic Transcription in Long-Range Gene Activation

Tae Hoon Kim, University of Texas at Dallas, USA
Identification and Analysis of Boundary Elements in the Human Genome

Catherine M. Farrell, National Library of Medicine, National Institutes of Health, USA
Long-Range Genetic Interactions in the Human Genome

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Transcript Synthesis - From Initiation through Elongation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Joan W. Conaway, Stowers Institute for Medical Research, USA

Donal S. Luse, Cleveland Clinic Foundation, USA
Promoter Clearance and the Transition from Initiation to Elongation by RNA Polymerase II

James A. Goodrich, University of Colorado, USA
The Regulation of the Early Steps of Transcription by Noncoding RNAs

Katherine A. Jones, The Salk Institute, USA
Spt6 Binds the Ser2P-RNAPII to Facilitate mRNA Processing and Nuclear Export

Keiko Ozato, NICHD, National Institutes of Health, USA
Short Talk: The Chromatin Binding Protein Brd4 Interacts with P-TEFb and Stimulates RNA Polymerase II Dependent Transcription in vivo

Robert C. Landick, University of Wisconsin-Madison, USA
Short Talk: Regulation of Transcriptional Pausing by RNA Polymerase II

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

SUNDAY, APRIL 23

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
General Factors and Transcription Initiation
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* John T. Lis, Cornell University, USA

James T. Kadonaga, University of California, San Diego, USA
Studies of the RNA Polymerase II Core Promoter

Bing Ren, Ludwig Institute for Cancer Research, USA
Genome-Wide Location Analysis of the RNA Polymerase II Pre-Initiation Complex in Mouse Embryonic Stem Cells and Adult Tissues

Laszlo Tora, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
Regulation of RNA Polymerase II Transcription Initiation at Core Promoters by the Diversity in Initiation Complex Formation and Function

Kevin Struhl, Harvard Medical School, USA
Regulation of Transcription Initiation in Yeast

Gail Miller, , USA
Short Talk: A DNA-Tethered Hydroxyl Radical Cleavage Probe Reveals the Path for Promoter DNA in the Yeast Preinitiation Complex

Mariana Fregoso-Lomas, Instituto de Biotecnología, Mexico
Short Talk: Characterization of p52 in Drosophila melanogaster

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop 2: New and Noteworthy

Chamisa Ballroom 1
* Marc Timmers, University Medical Centre Utrecht, Netherlands

Chase T. Archer, University of Texas Southwestern Medical Center, USA
Understanding how Mono-Ubiquitylation of Transactivators Protects Transactivator-DNA Complexes from Destabilization by 26S Proteasome Subcomplexes

Jennifer F. Kugel, University of Colorado Boulder, USA
An 8 Nucleotide RNA Triggers a Rate-limiting Shift of RNA Polymerase II Complexes into Elongation

Masami Horikoshi, University of Tokyo, Japan
Structural and Functional Analyses on Chromatin-Related Transcription Regulated by Histone Chaperones

Yamini Dalal, NCI, National Institutes of Health, USA
Analysis of Centromeric Chromatin Reveals a Highly Unusual Structure in vivo

Jing-Yi Huang, National Taiwan University, USA
The Functional Interaction between FACT and PARP-1

Christian Muchardt, Institut Pasteur, France
The SWI/SNF Complex Regulates Alternative Splicing

Alexandre Akoulitchev, University of Oxford, UK
Regulatory Switch between Distinct Chromosomal Conformations of Active Transcriptional Units

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Imaging of Transcription in Vivo
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Eva Nogales, University of California, Berkeley, USA

Gordon L. Hager, NCI, National Institutes of Health, USA
Transcription Factor Mobility and Promoter Progression

John T. Lis, Cornell University, USA
Dynamics of Transcription Factors at Native Specific Gene Loci Examined by Multiphoton Imaging of Live Drosophila Salivary Glands

Marc Timmers, University Medical Centre Utrecht, Netherlands
Mobility of TBP and TBP-Complexes in Human Cells

Marco Emilio Bianchi, San Raffaele Scientific Institute, Italy
Short Talk: GR and HMGB1 Influence Each Other’s Residence Time on Chromatin

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

MONDAY, APRIL 24

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Chromatin - Structure and Remodeling
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* James T. Kadonaga, University of California, San Diego, USA

Karolin Luger, Colorado State University, USA
Nucleosome Assembly and Dynamics

Geeta J. Narlikar, University of California, San Francisco, USA
Mechanisms of ATP-Dependent Chromatin Remodeling

Carl Wu, National Cancer Institute, NIH, USA
and

Ed Luk, Stony Brook University, USA
Regulating Transcription by ATP-Dependent Chromatin Remodeling Complexes

Christoph W. Müller, EMBL / Grenoble Outstation, France
Structural Insight into Drosophila CHRAC Nucleosome Remodeling

Paul J. Laybourn, Colorado State University, USA
Short Talk: Tax-Dependent Displacement of Nucleosomes during Transcriptional Activation of Human T-Cell Leukemia Virus, Type 1

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Histone Modification
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Carl Wu, National Cancer Institute, NIH, USA

Jerry L. Workman, Stowers Institute for Medical Research, USA
Macromolecular Complexes that Modify Histones

Michael Grunstein, University of California, Los Angeles, USA
Acetylation of H2AZ Lysine 14 is Associated with Genome-Wide Gene Activity in Yeast

Ronen Marmorstein, Wistar Institute, USA
Chromatin Recognition by Enzymes that Regulate Gene Expression

Jane Mellor, University of Oxford, UK
Short Talk: The Spt6 Transcription Elongation Factor Maintains Co-Transcriptional Methylation of Lysine 36 on Histone H3 to Repress Transcription Initiation within Genes

Judd C. Rice, University of Southern California, Norris Cancer Center, USA
Short Talk: A Novel Methyl-Specific Trans-Tail Histone Code Defines Distinct Regions of Silent Chromatin

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

TUESDAY, APRIL 25

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Coregulatory Complexes
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Beverly M. Emerson, The Salk Institute, USA

Joan W. Conaway, Stowers Institute for Medical Research, USA
Transcriptional Regulatory Complexes

Michael T. Marr, University of California, Berkeley, USA
Dynamic Interaction and Differential Requirement for Transcriptional Coactivator Complexes

Danny F. Reinberg, HHMI/New York University, USA
Transcriptional Coregulators in Gene Expression

Sohail Malik, Rockefeller University, USA
Short Talk: Identification of an Accessory Factor for Human Mediator Function Delineates a Novel Aspect of its Mode of Action in RNA Polymerase II Transcription

Shigeaki Kato, University of Tokyo, Japan
Short Talk: Function of Co-Regulator Complexes for Nuclear Receptors

Michel Werner, CEA/Saclay, France
Short Talk: TFIIS RNA Polymerase II-Binding Domain and Med31 Subunit of Mediator Play a Redundant Role in Transcription Initiation

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Transcriptional Regulation during Differentiation and Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Katherine A. Jones, The Salk Institute, USA

Beverly M. Emerson, The Salk Institute, USA
Transcriptional Regulation by p53

Margaret T. Fuller, Stanford University, USA
Tissue Specific TAF Homologs Relieve Repression by Polycomb to Allow Differentiation

Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
In Vivo Functions of Histone Modifying Enzymes

Ferenc Müller, Forschungszentrum Karlsruhe, Germany
Short Talk: TBP is Required for Zygotic Activation of Develomentally Regulated Genes Rather than Constitutively Expressed Genes in the Zebrafish Embryo

Didier Devys, Institute of Genetics and Molecular and Cellular Biology, France
Short Talk: Abnormal Function of TFTC-Type Complexes and Chromatin Decondensation Induced by Polyglutamine-Expanded Ataxin-7

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

WEDNESDAY, APRIL 26

 
Departure

Chamisa Lobby

*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 CA119826-01




We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676