Beaver Run Resort Floorplan

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This meeting took place in 2006



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Allergy, Allergic Inflammation and Asthma (D7)


Organizer(s) Donata Vercelli, Stephen J. Galli, Paul B. Rothman
April 6—11, 2006
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Dec 6, 2005
Late Abstract Deadline: Dec 29, 2005
Scholarship Deadline: Dec 6, 2005
Early Registration Deadline: Feb 6, 2006

Sponsored by Sanofi Aventis Pharmaceuticals, Inc.

Summary of Meeting:
Much of the morbidity of asthma and other allergic disorders is now thought to reflect the consequences of the inflammation that develops in these settings. Accordingly, understanding the origins, expression and tissue effects of allergic inflammation is a rapidly developing field at the interface between basic and clinical research. Exciting work currently focuses on the following: • the genetic basis of allergic inflammation, and how genetic and environmental factors interact to shape the pathogenesis of this process; • the interface between innate and adaptive immunity as a regulator of Th2 responses, and the role of T regulatory cells; • the regulation of Th2 signaling. However, some major problems remain unsolved, particularly: • the developmental origins of allergic inflammation; • the relative contributions of distinct molecules and/or cells to the pathogenesis of allergic inflammation in the lung; • the heterogeneity of human asthma phenotypes and responses to treatment. The main goal of this meeting is to advance understanding of allergic inflammation by assembling field leaders to discuss the most exciting areas of current research and to suggest potentially fruitful directions for future work. Dedicated sessions and/or workshops will address the major problems still unsolved in an attempt to facilitate their solution.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, APRIL 6

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—19:45
Opening Remarks

Donata Vercelli, University of Arizona, USA
Welcome to the Conference and Introduction of Keynote Speaker

19:45—20:45
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
William E. Paul, NIAID, National Institutes of Health, USA
IL4 and Th2 Cells: Regulation and Homeostasis


FRIDAY, APRIL 7

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Impact of Genes and Environment on Allergy and Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Erika von Mutius, University Children's Hospital, Munich, Germany
Epidemiology and the Environment

William O.C. Cookson, Wellcome Trust Centre for Human Genetics, UK
The Genes of Allergic Inflammation

Carole Ober, University of Chicago, USA
Sex-Specific Genetic Architecture of Asthma-Associated Quantitative Trait Loci in the Hutterites

Donata Vercelli, University of Arizona, USA
Functional Genomics in an Evolutionary Framework: IL13 and Allergic Inflammation

Matthew E. Poynter, University of Vermont, USA
Short Talk: Toll-Like Receptor (TLR)2 is Necessary for Nitrogen Dioxide (NO2)-Induced Allergic Sensitization to Inhaled Antigen

Mayumi Tamari, RIKEN, SNP Research Center, Japan
Short Talk: Functional Haplotypes of IL-12B are Associated with Childhood Atopic Asthma

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Pharmacological Targets in Allergic Inflammation and Asthma
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* K. Frank Austen, Harvard Medical School, USA
Innate and Adaptive Immune Functions of the Cysteinyl Leukotrienes (CyslTs)

Roland W. Kolbeck, MedImmune, LLC, USA
Targeting Chemokine Receptors for the Treatment of Asthma: Critical Role for Mast Cell-Derived CCL1 and CCR8+ T-Helper 2 (Th2) Effector Cells?

Fernando D. Martinez, University of Arizona, USA
Genetics of Response to Asthma Therapy: Which are the Right Phenotypes to Study?

William M. Gwinn, George Washington University Medical Center, USA
Short Talk: Blocking Extracellular Cyclophilin-CD147 Interactions Significantly Inhibits Asthma-Mediated Lung Inflammation

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

SATURDAY, APRIL 8

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Role of Innate Immunity in the Pathogenesis of Allergy and Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Kim Bottomly, Yale University School of Medicine, USA
Innate Control of CD4 T Cell Responses to Inhaled Antigen

Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cells in Allergic Inflammation

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Parasites and Immune Regulation: The Link to Allergy

Graham A.W. Rook, Royal Free and University College Medical School, UK
How Broad is the Role of the Microbial Environment in Mammalian Homoeostasis?

Sonja Kierstein, University of Pennsylvania, USA
Short Talk: Local Gene Expression Profiling Suggests Altered Dendritic Cell (DC) Function in Surfactant Protein D (SP-D) Deficient Mice

Toshinori Nakayama, Chiba University, Japan
Short Talk: Regulation of Allergic Airway Inflammation through Toll Like Receptor 4-Mediated Modification of Mast Cell Function

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:30
Workshop 1: Genetic, Developmental and Environmental Factors in Allergic Inflammation

Peaks 4-5
* Donata Vercelli, University of Arizona, USA

Miriam F. Moffatt, University of Oxford, UK
A Pan-European Study of Genetic Asthma Susceptibility in the ISAAC II Survey

Alexey V. Fedulov, Harvard School of Public Health, USA
Environmental Particle Exposures During Pregnancy Cause Increased Allergic Susceptibility In Offspring

Maike K. Knackstedt, Charité, Germany
Exposure to Stress during Pregnancy Increases Susceptibility of Murine Offspring Towards Allergic Diseases

Wayne G. Shreffler, Massachusetts General Hospital/Harvard Medical School, USA
The Major Glycoprotein Allergen from Arachis hypogaea, Ara h 1, May Facilitate Th2 Priming through its Specific Recognition by DC-SIGN

Hermelijn H. Smits, Leiden University Center, Netherlands
Experimental Chronic Schistosoma mansoni Infection Protects Mice from the Development of Allergic Asthma

Zheng Tan, University of Chicago, USA
A Polymorphism in the HLA-G 3’-UTR Influences Targeting of miR-148a, -148b and -152 and is Associated with Asthma

Valerie Verhasselt, INSERM, France
Breast-Feeding Induced Tolerance in a Murine Model of Asthma

Robin B. Webster, University of Arizona, USA
The Human IL-13 Locus in Neonatal CD4 T cells is Refractory to the Acquisition of a Repressive Chromatin Architecture

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regulatory Cells in Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Molecular Regulation of Regulatory CD4 T Cell Development and Maintenance

* Dale T. Umetsu, Harvard Medical School, Children's Hospital Boston, USA
The Regulation of Asthma by NKT Cells

Mubeccel Akdis, Swiss Institute of Allergy and Asthma Research, Switzerland
Fine Tuning of Allergen-Specific Human T Regulatory Responses

Mark S. Wilson, Genentech, Inc., USA
Short Talk: Protection from Allergy and Autoimmunity by Helminth-Induced B Cells

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

SUNDAY, APRIL 9

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Th2 Differentiation and Th2 Effector Responses
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
T Cell Differentiation and microRNAs

* Paul B. Rothman, University of Iowa, USA
The Role of SOCS Proteins in Regulating Allergic Immune Responses

Mark H. Kaplan, Indiana University School of Medicine, USA
Short Talk: PU.1 Expression Defines Heterogeneity in Primary Th2 Cultures

Benjamin D. Medoff, Massachusetts General Hospital, USA
Short Talk: CARMA1 is Critical for the Development of Allergic Airway Inflammation in a Murine Model of Asthma

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
Short Talk: TSLP is Necessary and Sufficient for the Development of Asthma

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:30
Workshop 2: Mouse Models for Investigating Allergic Inflammation and its Treatment

Peaks 4-5
* Stephen J. Galli, Stanford University, USA

Bryan S. Clay, University of Chicago, USA
Genetic Predisposition to Express Higher Surface Levels of ICOS on T Cells Regulates the Magnitude of Th2-Mediated Airway Inflammation in a Murine Model of Asthma

John R. Gordon, University of Saskatchewan, Canada
Dendritic Cell Therapy Abrogates Local and Systemic Asthma Responses Via Initiation of Infectious Tolerance

James G. Karras, Janssen R&D, USA
Combination Studies of Topically Administered Interleukin-4 Receptor-alpha Antisense Oligonucleotide and Budesonide in Mouse Models of Allergic Inflammation

Mirjam Kool, Erasmus MC, Netherlands
Plasmacytoid Dendritic Cells Dampen Eosinophilic Airway Inflammation in a Mouse Model for Asthma

Erika Rickel, Amgen Inc., USA
TH2-Associated Effects of Intranasal Murine IL-17E can be Antagonized by Murine IL-17RB Fc

Erdyni N. Tsitsikov, Harvard Medical School, USA
Non-T Cell TRAF1 is Required for Allergic Lung Inflammation in Mice

Nicholas van Panhuys, NIAID, National Institutes of Health, USA
The Role of IL4 and STAT6 in Th2 Immune Responses and Protective Immunity

Tomohiro Yoshimoto, Hyogo College of Medicine, Japan
Role of IL-18-Induced Mucosal Mast Cells in Nematode Expulsion

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regulation of Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Hannah J. Gould, King's College London, UK
IgE Switching and Somatic Hypermutation in Tissues

Raif S. Geha, Harvard Medical School, USA
Molecular Mechanisms of IgE Isotype Switching

Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Short Talk: Basophils Play a Critical Role in the Development of IgE-Mediated Chronic Allergic Inflammation Independently of T Cells and Mast Cells

Tiffany A. Reese, University of Texas Southwestern Medical Center, USA
Short Talk: Acidic Mammalian Chitinase (AMCase) Negatively Regulates Lung Inflammation

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

MONDAY, APRIL 10

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Effector Mechanisms of Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA
Novel Effector Molecules in Allergic Inflammation

Stephen J. Galli, Stanford University, USA
Mast Cells: "Tunable" Regulators of Acute, Late Phase and Chronic Components of Allergic Inflammation

Angela Haczku, UC Davis, USA
Epithelial Cell Derived Innate Immune Molecules in Allergic Airway Inflammation

* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Identification of Comliment Factor 5 as an Asthma Susceptibility Gene

Pierre Bruhns, Institut Pasteur, France
Short Talk: FcgammaRIV: A Novel Murine IgE Receptor

John T. Pesce, Henry M. Jackson Foundation, USA
Short Talk: The IL-21 Receptor Augments TH2 Effector Functions and Alternative Macrophage Activation

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Targeting the Pathogenetic Mechanisms of Allergic Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Patrick G. Holt, University of Western Australia, Australia
Drug Development Strategies in Asthma: In Search of a New Paradigm

Robert L. Coffman, Dynavax Technologies, USA
Redirecting the Immune Response with Immunostimulatory DNA

Rudolf Valenta, University of Vienna, Austria
From allergen structure to new forms of diagnosis and therapy of allergy

Katinka A. Vigh, University of Chicago, USA
Short Talk: Phenotyping Allergen Sensitization Using Protein Arrays

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
20:00—23:00
Entertainment

Peaks 1-3

TUESDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068367-01




We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Novartis Institutes for BioMedical Research
Sanofi US
GlaxoSmithKline Research & Development, Ltd.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Dynavax Technologies Corporation


Nuvelo


Peptimmune, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676