Yarrow Resort Hotel Floorplan

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This meeting took place in 2006



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Eicosanoids in Inflammation and Chronic Diseases (A3)


Organizer(s) K. Frank Austen, Roy J. Soberman and Jilly F. Evans
January 10—15, 2006
Yarrow Resort Hotel • Park City, Utah USA
Abstract Deadline: Sep 14, 2005
Late Abstract Deadline: Oct 6, 2005
Scholarship Deadline: Sep 14, 2005
Early Registration Deadline: Nov 10, 2005

Supported by The Director's Fund

Summary of Meeting:
The consideration of eicosanoids in chronic inflammatory disease will provide a molecular and structural background that will integrate basic, translational, clinical and therapeutic findings. To focus on eicosanoids as elements in chronic inflammation, it appears instructive to examine three clinical entities in which inflammation is superimposed on pathobiology modulated by genetic and environmental susceptibilities. These entities -- atherosclerosis, rheumatoid arthritis, and bronchial asthma with remodeling -- involve different organ systems, yet share the cellular events of chronicity and evidence for involvement of eicosanoids. Various eicosanoids have been implicated in chronic inflammatory diseases by identification of eicosanoid producing cells within clinical lesions, positional cloning of disease associated candidate genes within the eicosanoid generating pathway, and targeted mutations within the eicosanoid generating pathway that interrupt surrogate animal models of a clinical entity. The identification of two or more receptors for a particular eicosanoid at the cellular membrane of bone marrow-derived inflammatory cells has expanded the role of eicosanoids to all aspects of the innate and adaptive immune host inflammatory responses. The generation of eicosanoids by leukocytes is regulated during cell differentiation and after maturation by local peripheral tissue-derived growth factors and cytokines. Finally, particular eicosanoids can have opposing cellular functions uncovered through the time course of their appearance or the profile of receptor expression on the target cell.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 10

15:00—19:30
Registration

Lobby
18:30—19:30
Refreshments

Summit C
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Summit A-B
Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Cardiovascular Biology


WEDNESDAY, JANUARY 11

07:00—08:00
Breakfast

Ivers/Hearst/Kearns & Mountain View
08:00—11:00
The Biology and Biochemistry of Phospholipases
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* Christina C. Leslie, National Jewish Health, USA
Regulation of Cytosolic Phospholipase A2 Activation and COX2 Expression in Macrophages by the Beta-Glucan Receptor

Michael H. Gelb, University of Washington, USA
The Role of Phospholipases A2 in Eicosanoid Generation and Airway Inflammation

Jonathan P. Arm, Harvard Medical School, USA
How Group V Phospholipase A2 Amplifies Inflammation

Dieter Steinhilber, University of Frankfurt, Germany
Pathways Involved in Cellular 5-Lipoxygenase Activation

Peter F. Weller, Beth Israel Deaconess Medical Center, USA
Short Talk: 5-Lipoxygenase Localization to Cytosolic Lipid Bodies in Rat Basophil Leukemia Cells

09:20—09:40
Coffee Break

Summit Hallway
11:00—13:00
Poster Setup

Summit C
13:00—22:00
Poster Viewing

Summit C
16:30—17:00
Coffee Available

Summit Hallway
17:00—19:00
Structural Biology of Proteins in the Eicosanoid Pathways
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* William L. Smith, University of Michigan, USA
Omega-3 and Omega-6 Essential Fatty Acids, COX-1 and COX-2, and TP and IP Receptors

Ingeborg Schmidt-Krey, Georgia Institute of Technology, USA
Structure Determination of LTC4 Synthase by Electron Crystallography

Daniel J. Müller, ETH Zurich, Switzerland
Observing Folding Kinetics, Ligand Binding and Activation of a Single Antiporter

19:00—20:00
Social Hour with Lite Bites

Summit C
19:30—22:00
Poster Session 1

Summit C

THURSDAY, JANUARY 12

07:00—08:00
Breakfast

Ivers/Hearst/Kearns & Mountain View
08:00—11:00
Integrative Biology of Leukotriene Synthesis
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* Roy J. Soberman, Harvard Medical School, USA
The Membrane Organization of Leukotriene and Prostaglandin Formation

Douglas Kenneth Miller, Miller Associates, LLC, USA
The Structure/Function of FLAP

Susan P. C. Cole, Queen's University, Canada
Structure Function Studies of the LTC4 Transporter, MRP1 (ABCC1)

Robert C. Murphy, University of Colorado Denver, USA
Moving LTA4 Through and Between Cells: Transcellular Biosynthesis

Thomas G. Brock, University of Michigan, USA
Short Talk: Protein Kinase A Inhibits 5-Lipoxygenase Activity by Two Mechanisms

09:20—09:40
Coffee Break

Summit Hallway
11:00—13:00
Poster Setup

Summit C
13:00—22:00
Poster Viewing

Summit C
14:30—16:30
Workshop 1: Eicosinoids in Human Disease, Animal Models, and Mechanisms of Action

Summit A-B
* Shuh Narumiya, Kyoto University, Japan

Hans-Erik Claesson, Biolipox AB, Sweden
Evidence for a Pathophysiological Role of Cysteinyl Leukotrienes in Hodgkin Lymphoma

Nora A. Barrett, Brigham and Women's Hospital, USA
Short Talk: Cysteinyl Leukotriene-Dependent Th2 Pulmonary Inflammation

John-David H. Herlihy, University of Florida, USA
Alterations in Gene Expression in the Eicosanoid Pathway in a Mouse Model of Allergic Asthma in Normal and CFTR Knockout Mice

Irving C. Allen, Virginia Tech, USA
Thromboxane A2 Induces Airway Constriction Through An M3 Muscarinic Acetylcholine Receptor Dependent Mechanism

Charles D. Loftin, University of Kentucky, USA
Genetic or Pharmacological Inactivation of COX-2 Attenuates Abdominal Aortic Aneurysm Formation in Mice

Sylvain Dore, University of Florida College of Medicine, USA
Prostaglandin EP1 Receptor Contributes to Excitotocicity and Focal Ischemic Brain Damage

16:30—17:00
Coffee Available

Summit Hallway
17:00—19:00
Eicosanoids and Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Summit A-B
Gwendalyn J. Randolph, Washington University, USA
The Regulation of Langerhans Cell Migration by LTC4

Martin R. Hodge, Pfizer, USA
Regulation of Allergic Inflammation by CRTH2

* Bart N. Lambrecht, VIB, Ghent University, Belgium
Control of Dendritic Cell Function by Prostaglandin D2

Richard Breyer, , USA
Short Talk: The Role of PGD2 In Experimental Autoimmune Encephalomyelitis

19:00—20:00
Social Hour with Lite Bites

Summit C
19:30—22:00
Poster Session 2

Summit C

FRIDAY, JANUARY 13

07:00—08:00
Breakfast

Ivers/Hearst/Kearns & Mountain View
08:00—11:00
Eicosanoids and Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* Linda K. Curtiss, The Scripps Research Institute, USA
Atherosclerosis is a Chronic Inflammatory Disease

Colin D. Funk, Queen's University, Canada
5-Lipoxygenase in Vascular Disease and a New Knock-in Model (COX-1>COX-2) to Study Prostaglandin Function

Andreas J. R. Habenicht, Institute for Prophylaxis of Cardiovascular Diseases, Germany
LTD4-Induced Endothelial Cell Genes Indicate Roles of 5-Lipoxygenase in Vascular Inflammation

Margarete Mehrabian, University of California, Los Angeles, USA
5-Lipoxygenase: Pleiotropic Effects on Atherosclerosis, Obesity and Insulin Resistance

Kári Stefánsson, deCode Genetics, Iceland
The Role of the Leukotriene Pathway in the Risk of Myocardial Infarction

09:20—09:40
Coffee Break

Summit Hallway
16:30—17:00
Coffee Available

Summit Hallway
17:00—19:00
Eicosanoids in Arthritis: Human Disease and Animal Models
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* K. Frank Austen, Harvard Medical School, USA

Leslie J. Crofford, University of Kentucky, USA
Prostaglandins in Rheumatoid Arthritis: Can Safe Drugs be Developed?

David M. Lee, F. Hoffmann-La Roche AG, Switzerland
Dissecting the 5-LO Pathway in Models of Arthritis

Ichiro Kudo, Showa University, Japan
Characterization of Mice Lacking Mircrosomal and Cytosolic Prostaglandin E Synthases

Eri Segi-Nishida, , USA
Short Talk: Prostacyclin Signaling Mediates Arthritic Inflammation by Promoting Synovial Cell Activation in Mouse Collagen-Induced Arthritis

19:00—20:00
Social Hour with Lite Bites

Summit C
20:00—22:15
Workshop 2: Eicosanoids in Human Disease and Relevant Animal Models

Summit A-B
* Jilly F. Evans, PharmAkea Therapeutics, USA
Technologies for Identifying and Designing Future Inhibitors of Enzymes and Receptors

* Takao Shimizu, University of Tokyo, Japan

Masataka Majima, Kitasato University School of Medicine, Japan
Stromal Prostaglandin Receptor Signaling Relevant to Tumor-Associated Angiogenesis: Role of Recruitment of Prostaglandin Receptor-Expressing Bone Marrow Cells

Yan Cheng, University of Pennsylvania, USA
Beyond Inhibition of COX-2: Differential Effects of PG/H and mPGE Synthase Disruption on Prostacyclin Biosynthesis and Cardiovascular Function in vivo

Christianne Bandeira-Melo, Universidade Federal do Rio de Janeiro, Brazil
PGD2 Controls LTC4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic Role of Endogenous Eotaxin

Pallavi R. Devchand, Harvard Medical School, USA
Chemical Probing in Rats to Understand Impact of Eicosonoids in Human Colitis-Induced Cancers

Annalisa Del Prete, University of Bari, Italy
Leukotriene B4 Receptors: Multiple Roles for LTB4 in Dendritic Cell Functions

Naonori Uozumi, Cincinnati Children's Hospital Medical Center, USA
Disease Model Studies on cPLA2alpha-deficient Mice


SATURDAY, JANUARY 14

07:00—08:00
Breakfast

Ivers/Hearst/Kearns & Mountain View
08:00—11:00
Eicosanoids, Asthma, and Airway Inflammation
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* Peter F. Weller, Beth Israel Deaconess Medical Center, USA

Larry Borish, University of Virginia Medical Center, USA
Cysteinyl Leukotriene Over-Production and Over-Responsiveness in Aspirin-Exacerbated Respiratory Disease

Marc Peters-Golden, University of Michigan, USA
Eicosanoids in Fibrotic Lung Disease: A Tale of Two Lipids

Alysia K. Lovgren, University of North Carolina at Chapel Hill, USA
Short Talk: COX-2 Mediated Protection against Pulmonary Fibrosis is Not Dependent on Prostaglandin E2 Production

Yoshihide Kanaoka, Harvard Medical School, USA
The Function of Cysteinyl Leukotriene Receptors in Lung Inflammation

Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Cysteinyl Leukotrienes and their Receptors as Autocrine Regulators of Mast Cell Function

09:20—09:40
Coffee Break

Summit Hallway
16:30—17:00
Coffee Available

Summit Hallway
17:00—19:00
Receptors for Leukotrienes and Prostaglandins
Meeting has ended...abstracts no longer viewable online.

Summit A-B
* Takao Shimizu, University of Tokyo, Japan
Biochemistry and Biology of Leukotriene B4 receptors

Shuh Narumiya, Kyoto University, Japan
Pro- and Anti-Inflammatory Actions of Prostanoids as Revealed by Receptor KO Mice Studies

* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Glyceryl Prostaglandins: Novel Bioactive Lipids Produced from Endocannabinoids

Hajime Yoshisue, Southampton General Hospital, UK
Short Talk: Cysteinyl-Leukotrienes Synergise with Receptor Tyrosine Kinase Growth Factors on Mitogenesis of Human Lung Fibroblasts

19:00—20:00
Social Hour with Lite Bites

Summit C
20:00—23:00
Entertainment

Summit C

SUNDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company


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