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This meeting took place in 2006



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Lymphocyte Activation and Signaling (A1)


Organizer(s) Susan K. Pierce, Gary A. Koretzky, Pamela L. Schwartzberg and Jason G. Cyster
January 6—11, 2006
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 13, 2005
Late Abstract Deadline: Oct 5, 2005
Scholarship Deadline: Sep 13, 2005
Early Registration Deadline: Nov 7, 2005

Supported by The Director's Fund

Summary of Meeting:
The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. We propose to bring together distinguished scientists working at the cutting edge of immune cell signaling to describe their new findings and to address how these issues relate to human disease. This meeting will provide a view of 1) how the initial encounter of immune cell signaling receptors with their ligands ultimately leads to the biological response, be it activation, differentiation, movement, or cell death and 2) how this knowledge is being translated to important clinical problems in autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 6

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Lewis L. Lanier, University of California, San Francisco, USA
Immunoreceptor Tyrosine-Based "Ambiguos" Motif (ITAM) Signaling


SATURDAY, JANUARY 7

07:00—08:00
Breakfast

3 Saddles / Sevens
08:00—11:00
Early Events in Immune Cell Signaling
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Lawrence E. Samelson, National Institutes of Health, USA
Signaling via the T Cell Antigen Receptor

* Andrey S. Shaw, Genentech, Inc., USA
Complex Roles of the Immunological Synapse

Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function

Susan K. Pierce, NIAID, National Institutes of Health, USA
Viewing the Initiation of B Cell Receptor Signaling in Living Cells by FRET

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Short Talk: RasGRP3, A Key Molecule for Ras Activation in B Lymphocytes

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Regulation of Signaling in the Adaptive and Innate Immune Systems
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
* Arthur Weiss, University of California, San Francisco, USA
Regulating Antigen Receptor Signal Transduction

Pamela L. Schwartzberg, NIAID, NHGRI, USA
Development of a Novel CD8+ T Cell Image in Mice Deficient in the Tec Kinases Itk and RIK

Silvia Bolland, NIAID, National Institutes of Health, USA
Short Talk: Autoimmune Acceleration by Genomic Duplication of TLR Genes

Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Short Talk: Newly Generated TCR Microclusters Initiate and Sustain T Cell Activation

Christopher E. Rudd, University of Montreal, Canada
Short Talk: SKAP-55 and T Cell Imaging

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 1

Sunshine Peak

SUNDAY, JANUARY 8

07:00—08:00
Breakfast

3 Saddles / Sevens
08:00—11:00
Signaling and Cell Activation Imaged in Living Cells and in Vivo
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Akihiro Kusumi, Kyoto University, Japan
Ligand-Induced Stabilized Raft as a Signaling Platform for GPI-Anchored Receptors: A Single-Molecule Tracking Study

Ellen A. Robey, University of California, Berkeley, USA
Imaging the Dynamic Behavior of T Cells and Thymocytes in Tissues

* Michael L. Dustin, University of Oxford, UK
Imaging Immunity Near to Far- T Cell Activation from Molecules to Mice

Nicholas R. J. Gascoigne, National University of Singapore, Singapore
Short Talk: Imaging Molecular Interactions during T Cell Recognition Using FRET Microscopy: Endogenous Peptides, Apls and the TCR-CD8 Interaction

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
A New Role for Ca++ Signaling In Regulating Lymphocyte Growth and Survivial

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:30—16:30
Workshop 1: Regulation of Signaling in the Adaptive System

Storm Peak / Mt. Werner
* Pamela L. Schwartzberg, NIAID, NHGRI, USA

Andrew D. Wells, University of Pennsylvania, USA
Foxp3 Binds to the IL-2 And IFNgamma Genes in T Cells and Promotes Histone Deacetylation in a TCR-Dependent Manner

Jian Zhang, University Of Chicago, USA
Cbl-B Negatively Regulates Antigen Receptor-Induced NF-KappaB Activation via Controlling the Assembly of PKC-Theta/CARMA1/Bcl10/MALT1/IKK Signaling Complex in T Cells

Jennifer L. Cannons, National Institutes of Health, USA
T Cell-mediated Regulation of Humoral Immunity by SAP

Haewon Sohn, NIAID, National Institutes of Health, USA
Short Talk: FRET Imaging in Living Cells Reveals the Dynamics of Membrane Changes in Initiation of B Cell Receptor Signaling

Donna L. Farber, Columbia University Medical Center, USA
Divergent Generation of Heterogeneous Memory CD4 T cells

Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The Hedgehog Signaling Network Controls Lymphoid Progenitor Homeostasis and Differentiation in the Thymus

Amanda L. Prince, University of Massachusetts, USA
Alternative Differentiation of CD4 T Cells in the Absence of Jak3

Jim Miller, University of Rochester, USA
T Cell Costimulation through the Immunological Synapse

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Integration of Signaling in the Adaptive and Innate Immune Systems
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
* Juan Rivera, , USA
Integrating Signaling In Mast Cells: IgEIAg-Mediated Response

Mark R. Philips, New York University Cancer Institute, USA
Compartment Specific Ras Signaling in T Cells

Sarah Russell, Swinburne University of Technology, Australia
Short Talk: T Cell Shape and Function is Orchestrated by a Network of T Polarity Proteins.

Randy Q. Cron, University of Pennsylvania, USA
Short Talk: Inhibition of NFAT2 Expression by FOXP3

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 2

Sunshine Peak

MONDAY, JANUARY 9

07:00—08:00
Breakfast

3 Saddles / Sevens
08:00—11:00
Late Events in Immune Cell Signaling: Fate Decisions
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
A Genome-Wide RNAi Screen in Drosophila Identifies Novel Regulators of the Ca2+ / Calcineurin/ NFAT Signaling Pathway

* Steven L. Reiner, Columbia University, USA
Programming of Effector and Memory T Cell Fate

Rafi Ahmed, Emory University School of Medicine, USA
Memory CD8 T Cell Differentiation during Acute versus Chronic Viral Infection

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Signals that Drive Immunological Memory

Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: The Role of Rac Gtpases and their Exchange Factors in Lymphocyte Activation and Development

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine Peak
13:00—22:00
Poster Viewing

Sunshine Peak
14:30—16:30
Workshop 2: Regulation of Signaling in the Adaptive and Innate Immune Systems

Storm Peak / Mt. Werner
* Lewis L. Lanier, University of California, San Francisco, USA

Peter C.L. Beverley, University of Oxford, UK
CD45 is Required for Type I IFN Production and Efficient Viral Antigen Presentation by Dendritic Cells

Nathalie Bonnefoy-Berard, INSERM U851, France
TLR2 Engagement on CD8 T Cells Lowers the Threshold for Optimal antigen-Induced T Cell Activation

Xingxing Zang, Memorial Sloan-Kettering Cancer Center, USA
B7x: A New B7-1/B7-2 Family Member that Regulates Immune Functions

Jeffrey C. Rathmell, Vanderbilt University, USA
Akt1 Preferentially Mediates Cytokine Regulated Glucose Uptake in Resting and Activated Lymphocytes

Lawrence Shiow, University of California, San Francisco, USA
CD69 Acts Downstream of IFNalpha/beta to Inhibit S1P1 and Lymphocyte Egress

Ilaria Tassi, Alector, USA
The Cytotoxicity Receptor CRACC (CS-1) Recruits EAT-2 and Activates the PI-3K and PLCgamma Signaling Pathways in Human NK Cells

Philip D. King, University of Michigan Medical School, USA
Short Talk: Essential Role of the T Cell-Specific Adapter Protein in the Activation of LCK in Peripheral T Cells

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
SAP Regulation of Follicular Helper CD4 T Cell Development is Independent of SLAM and Fyn Kinase

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell Death and Homeostasis
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Philippa C. Marrack, HHMI/National Jewish Health, USA
T Cell Life and Death is Controlled by Members of the Bcl-2 Family

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Lymphocyte Position Control by Activation Signals

* Michael J. Lenardo, NIAID, National Institutes of Health, USA
Apoptotic Signaling and Disease

Michael A. Farrar, University of Minnesota, USA
Short Talk: Interleukin-2 Receptor-dependent STAT5 Activation is Required for Regulatory T Cell Development

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 3

Sunshine Peak

TUESDAY, JANUARY 10

07:00—08:00
Breakfast

3 Saddles / Sevens
08:00—11:00
Signaling in Disease Processes
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Andre Veillette, Institut de Recherches Cliniques de Montreal, Canada
Signaling by SAP-Related Adaptors

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Determinants of Regulatory T Cell Development

* John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

Flavius Martin, Genentech, Inc., USA
Mechanisms of B Cell Targeted Immunotherapy: Contributions of Microenvironment and Effector Function

Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: TL1A/DR3 TNF Family Interactions in T cell Costimulation, Death and Differentiation

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Modeling Immune Cell Signaling
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Johannes Huppa, Stanford University, USA
Short Talk: Imaging T Cell Antigen Recognition by Single Molecule Microscopy

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Modeling T Cell Antigen Discrimination: The Key Role of Feedback Control Circuits

Arup K. Chakraborty, Massachusetts Institute of Technology, USA
How T Cells Hunt for Antigen

Aaron R. Dinner, University of Chicago, USA
Short Talk: Computational Model for Signaling in Dual TCR Cells

19:00—20:00
Social Hour with Lite Bites

Foyer
20:00—23:00
Entertainment

Sunshine

WEDNESDAY, JANUARY 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068311-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Educational donation provided by Amgen
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676