Beaver Run Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2006



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tolerance, Autoimmunity and Immune Regulation (D1)


Organizer(s) David W. Scott, Rachel R. Caspi, Matthias G. von Herrath and Terry L. Delovitch
March 21—26, 2006
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Nov 21, 2005
Late Abstract Deadline: Dec 14, 2005
Scholarship Deadline: Nov 21, 2005
Early Registration Deadline: Jan 20, 2006

Supported by The Director's Fund

Summary of Meeting:
Self versus non-self discrimination is one of the basic tenets of immunology. The pathways by which tolerance is established are complex but recent work has provided greater insight into this important process. Understanding how tolerance is induced and “broken” is critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to tissue target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown, and bridging the gap between basic, pre-clinical and clinical studies. While there will be an emphasis on basic studies, disease models for dissecting pathogenesis and examining novel therapies in a variety of autoimmune diseases (e.g., diabetes, multiple sclerosis, IBD, uveitis, as well as hemophilia), which will provide a major focus. Thus, a major theme will be the underlying tolerance pathways, as well as how they are subverted. The establishment of new models and therapies, including human clinical trials, will be included. Sessions to be covered include studies of the genes and signals involved in tolerance and autoimmunity, the interaction of the innate and adaptive immune systems, novel approaches for tolerance induction in autoimmune models, and translation of these to human clinical trials. Proof of principle studies and new biotechnology approaches will also be emphasized. The goals of the meeting are the following: • To provide an understanding of the mechanisms of immune tolerance and its breakdown • To update the audience on autoimmune models and clinical trials. • To stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry, from around the globe to collaborate to respond to the challenges in this area. A novel feature this year is the addition of a formal debate session in the evening of the second day, as well as the presentation of the Lifetime Achievement Awards, with a brief historical overview. Workshops will be designed to be interactive rather than shorter plenary-type talks.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 21

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Diane Mathis, Harvard Medical School, USA
Immunogenetics of Autoimmunity


WEDNESDAY, MARCH 22

07:00—08:00
Breakfast

Peaks 6-12
08:00—12:00
Genes and Signals in Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Transciptional Programs in T Cells: FoxP3 Controls T Regulatory Functions through Cooperation with NFAT

Kristin A. Hogquist, University of Minnesota, USA
Genetic Changes Underlying Positive Selection: KLF2 and Thymus Emigration

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: What is the TCR Signaling Strength Required to Induce Tolerance and Functions

Signe J. Hässler, Uppsala University, Sweden
Short Talk: The Function of Aire in Dendritic Cells and Peripheral Tolerance

Elizabeth A. Wohlfert, NIAID, National Institutes of Health, USA
Short Talk: Regulatory T Cells Represent a Novel Target for the Immunoregulatory Effects of PPAR-gamma Ligands

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
FoxP3 and Regulatory T Cells in Mice and Men

09:40—10:00
Coffee Break

Foyer
12:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—18:30
Genes and Signals in Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
TIM Family of Genes: Role in T Cell Differentiation, Autoimmunity and Tolerance

Doron Melamed, Technion, Faculty of Medicine, Israel
Short Talk: Activation Competence of Developing Bone Marrow B Cells is a Novel Pathway for Initiation of B Cell Autoimmunity

Dale T. Umetsu, Harvard Medical School, Children's Hospital Boston, USA
TIM-1, Hygiene and Allergic Disease

18:30—19:30
Social Hour with Lite Bites

Peaks 14-17
19:00—22:00
Poster Session 1

Peaks 14-17
20:00—21:30
Workshop A: Apoptosis vs. Anergy Signals in Tolerance

Peaks 1-4
* Richard M. Siegel, NIAMS, National Institutes of Health, USA

* Jonathan D. Powell, Johns Hopkins University School of Medicine, USA

Georgia Fousteri, University of Crete, Greece
A Novel in vivo Role of TNF on Peripheral CD8 T Cell Tolerance: TNF Deficiency Leads to Development of Autoimmune Diabetes in a TCR/Antigen Mouse Model

Brian T. Fife, University of Minnesota, USA
The Programmed Death-1 (PD-1) Pathway Regulates the Induction and Maintenance of Peripheral T Cell Tolerance during Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

Paul E. Zarek, Johns Hopkins University, USA
A2a Receptor Engagement on T Cells Promotes T Cell Tolerance

Nikolay P. Nikolov, National Institutes of Health, USA
Autoimmunity and Impaired T Cell Apoptosis in Wiskott-Aldrich Syndrome Protein Deficiency: A FasL Connection

Carrie D. Beal, Cleveland Clinic Foundation, USA
SHP-1 Regulates Anergy Induction in Autoimmune T Cells in Experimental Autoimmune Encephalomyelitis

Shiang-Jong Tzeng, National Taiwan University, Taiwan
C-Abl Family Kinases Mediate Apoptosis in B Cells in Response to Fc Receptor Stimulation

Yuanyuan Zha, University of Chicago, USA
Established T Cell Anergy is Reversed by Active Ras and Partially Regulated by Diacylglycerol Kinase

Jonathan A. Lindquist, Otto-von-Guericke University, Germany
Signaling in Anergy: From Fyn to PAG to Ras

Fernando Macian, Albert Einstein College of Medicine, USA
Active Transcriptional Repression Controls IL-2 Expression in Anergic T Cells

20:00—21:30
Workshop B: How Many Suppressors Are There?

Peak 5
* Rachel R. Caspi, NEI, National Institutes of Health, USA

Danielle M. Nast, University of Missouri, USA
Loss of Membrane-Bound TGFbeta during the Onset of Insulitis Disables Treg Function Leading to Diabetes

Geoffrey L. Stephens, Cellcion, LLC, USA
A Distinct Subset of MHC-Independent FoxP3+ T Cells Participates in the Control of Adaptive Immune Responses in vivo

Mindi R. Walker, Johnson and Johnson, USA
Generation of Autoantigen-Specific CD4+CD25+ Regulatory T Cells from Human CD4+CD25- Cells

Vanessa A.G. Oliveira, Instituto de Medicina Molecular, Portugal
CD62L+CD25+CD4+ Regulatory T Cells Generated in vitro by Anti-CD4 Treatment Express FoxP3 and Can Prevent Rejection of Allogeneic Skin Transplants

Judith A. Kapp, University of Alabama at Birmingham, USA
TCR Transgenic CD8+ T Cells Activated in the Presence of TGFbeta1 Express FoxP3 and Mediate Linked-Suppression of MLR Responses and Cardiac Rejection

Sylvain Fisson, University of Evry Val d'Essonne, France
Therapeutic Potential of Self Antigen-Specific CD4+CD25+ Regulatory T Cells Selected in vitro from a Polyclonal Repertoire

Richard J. DiPaolo, NIAID, National Institutes of Health, USA
Polyclonal and Organ Specific CD4+CD25+Foxp3+ Regulatory T Cells (nTregs): Different Mechanisms of Suppressing Organ Specific Autoimmunity in vivo

Rafael S. Grajewski, National Eye Institute, National Institutes of Health, USA
Endogenous Expression of IRBP is Dispensable for Generation of CD4+CD25+ Regulatory T Cells that Protect against IRBP-Induced Experimental Autoimmune Uveitis (EAU)

Yuelei Shen, New York University School of Medicine, USA
Depletion of FoxP3+ Regulatory T Cells Enhances Primary CD8 T Cell Responses, but Impairs Generation of Memory T Cells

Santiago Pablo Zelenay, Cancer Research UK, London Research Institute, UK
Regulatory T Cells Control Early Innate Immune Responses


THURSDAY, MARCH 23

07:00—08:00
Breakfast

Peaks 6-12
08:00—12:00
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
A Novel Combinatorial Treatment of Recent-Onset Type 1 Diabetes: Synergy between Islet-Antigen Specific Tregs and Non-Mitogenic Anti-CD3

Joan Goverman, University of Washington, USA
The Dynamic State of Peripheral Tolerance In Myelin Basic Protein-Specific T Cells

Daniel J. Cua, Merck Research Laboratories, USA
Role of IL-23 in Autoimmune Disease Pathogenesis

Silvia Bolland, NIAID, National Institutes of Health, USA
Short Talk: TLR7/8 Gene Duplication in the Pseudoautosomal Region of Y-Linked Autoimmune Accelerating (Yaa) Mice

Stephen D. Miller, Northwestern University Medical School, USA
Epitope Spreading in Relapsing EAE: The CNS as a Neo-lymphoid Organ

Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of Apoptosis in the Induction of Tolerance versus Autoimmunity

09:40—10:00
Coffee Break

Foyer
12:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—18:30
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada

Brigitta Stockinger, Francis Crick Institute, UK
Homeostasis,Competition and Regulation of the Peripheral T Cell Pool

Anne Cooke, University of Cambridge, UK
Perturbing the Balance Between Infection and Immunity: Consequences for Autoimmunity

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Short Talk: Toll Like Receptors Control Autoantibody Specificities and Regulate Systemic Autoimmunity

18:30—19:30
Social Hour with Lite Bites

Peaks 14-17
19:00—22:00
Poster Session 2

Peaks 14-17
20:00—21:30
Town Hall Debate - Friendly or Dangerous Signals?

Peaks 1-5
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA

Polly Matzinger, NIAID, National Institutes of Health, USA

Eyal Raz, University of California, San Diego, USA

Neil S. Greenspan, Case Western Reserve University, USA

Rolf M. Zinkernagel, University Hospital Zurich, Switzerland
Credo 2006


FRIDAY, MARCH 24

07:00—08:00
Breakfast

Peaks 6-12
08:00—12:00
Suppression and Regulation of the Immune Response
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada
Regulation of Type 1 Diabetes by iNKT Cells, Cytokines and Chemokines

* Rachel R. Caspi, NEI, National Institutes of Health, USA
Generation of Pathogenic and Regulatory T Cells in a Model of Retinal Autoimmunity: Dependency on Innate Immune Responses

Joan Stein-Streilein, Schepens Eye Research Institute, USA
Privilege, Deviation and Regulatory Cell Circuits: Assembling the Puzzle

Michele M. Kosiewicz, University of Louisville, USA
Short Talk: Androgen-Driven Expression of CD103 by CD4+CD25+ Regulatory Cells is Associated with Increased Regulatory Function and Prevention of Autoimmune Disease

Habib Zaghouani, University of Missouri School of Medicine, USA
Tregs For or Against Autoimmunity

Andrew L. Mellor, Georgia Regents University, USA
Regulation of T Cell Responses by Indoleamine 2,3 Dioxygenase (IDO)

09:40—10:00
Coffee Break

Foyer
12:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—18:30
Suppression and Regulation of the Immune Response
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Anne Cooke, University of Cambridge, UK

Shimon Sakaguchi, Osaka University, Japan
Natural Tregs and Autoimmune Diseases

Joshua D. Milner, NIAID, National Institutes of Health, USA
Short Talk: Reconstitution of Lymphopenic Mice with Limited T-Cell Repertoire Results in Severe Multiorgan Eosinophilic Disease

Kathryn J. Wood, University of Oxford, UK
Transplantation Tolerance - Control of Rejection by Alloantigen Reactive Regulatory T Cells

18:30—19:30
Social Hour with Lite Bites

Peaks 14-17
19:00—22:00
Poster Session 3

Peaks 14-17
20:00—21:30
Workshop C: Genetics of Autoimmunity

Peaks 1-4
* Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Genomic Analysis of the NOD Idd4 Locus in Type 1 Diabetes: Candidate Genes and Complex Genetic Architecture

* Bhagirath Singh, University of Western Ontario, Canada

Stephan Kissler, Joslin Diabetes Center, USA
In vivo RNA Interference Demonstrates Nramp1 is a Type 1 Diabetes Gene

Mehmet L. Guler, Johns Hopkins University, USA
Two Autoimmune Disease Loci Influencing T Cell Apoptosis Control Susceptibility to Experimental Autoimmune Myocarditis

Robert H. Wallis, Sunnybrook & Women's College Health Sciences Centre, Canada
A Novel Type 1 Diabetes Susceptibility Locus Identified Using the BB/WOR Rat Model

Zhibin Chen, University of Miami, USA
Modeling CTLA-4-Associated Human Autoimmune Diseases with Transgenic RNA Interference in Mice

Emma E. Hamilton-Williams, University of Queensland, Australia
Loss of CD8 Self-Tolerance in the NOD Mouse is Controlled by Genes Encoded Within the Idd9 Locus

20:00—21:30
Workshop D: Novel Therapies for Tolerance

Peak 5
* David W. Scott, Uniformed Services University of Health Sciences, USA

* Anne Cooke, University of Cambridge, UK

Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Mucosal Anti-CD3 Antibody Suppresses EAE, Collagen Crthritis, Diabetes and Prolongs Cardiac Allograft Survival by Inducing CD4+CD25-LAP+ Regulatory T Cells

Claudia Mauri, University College London, UK
Anti TNF-alpha Therapy in Rheumatoid Arthritis Promotes the Differentiation of Regulatory T Cells with a Memory-Like Phenotype

Sayuri Yamazaki, Rockefeller University, USA
Effective Expansion of Alloantigen-Specific Foxp3+ CD25+ CD4+ Regulatory T Cells by Dendritic Cells during the Mixed Leukocyte Reaction

David J. Kahler, Medical College of Georgia, USA
Type I Interferon Mediates T Cell Suppression By Inducing Indoleamine 2,3 Dioxygenase Expression in Dendritic Cells

Ivan Zanoni, University of Milano Bicocca, Italy
Induction of Peripheral T Cell Tolerance by Antigen Presenting B Cells: The Activation state of Antigen Presenting Cells is Not Relevant for Tolerization when the Antigen is Chronically Presented

Manuela Battaglia, TIGET, Telethon Institute for Gene Therapy, Italy
Rapamycin Promotes Expansion of CD4+CD25+ Tr Cells from NOD Mice

Alan R. Anderson, , USA
Significant Expansion and Suppressive Function of Rhesus Macaque Regulatory T Cells

Sarah E. Allan, Elsevier, UK
Generation of Human T Regulatory Cells by FOXP3 Transduction in vitro

Carsten Wiethe, University of Erlangen, Germany
Interdependency of MHC II/Self-Peptide and CD1D/Self-IGB3 Presentation for Autoimmune Disease Protection Induced by TNF-Stimulated Dendritic Cells

Andre I. David, University of Miami, USA
Bone Marrow Derived Mesenchymal Cells Delay Allogeneic Rejection

Ehud Hauben, San Raffaele Hospital, Italy
A Novel Low Molecular Weight Compound Promotes Islets Allograft Acceptance and Induces Long-Term Active Tolerance

Michael R. Ehrenstein, University College London, UK
B Cell Depletion for Autoimmunity


SATURDAY, MARCH 25

07:00—08:00
Breakfast

Peaks 6-12
08:00—12:00
Translating Tolerance to the Clinic
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* David W. Scott, Uniformed Services University of Health Sciences, USA
B-Cell Induced Tolerance for Autoimmunity and Hemophilia

Jean-Marie Saint-Remy, University of Leuven, Belgium
Cytolytic regulatory T cells in experimental allergic asthma

Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Treatment of Type 1 Diabetes by Restoration of Self-Tolerance

David H. Wagner, Jr., University of Colorado Health Sciences Center, USA
Short Talk: Of Mice and Man: Identification of Auto-Aggressor T Cells and Breach of Self-Tolerance in Type 1 Diabetes

Clare M. Baecher-Allan, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Functionally Distinct Subsets of Human Natural Regulatory T cells

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Human Suppressor T Cells in Clinical Application

09:40—10:00
Coffee Break

Foyer
12:00—13:00
Lunch

Peaks 14-17
12:00—13:00
Poster Setup

Peaks 14-17
13:00—17:00
Poster Viewing

13:00—15:00
Poster Session 4

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—18:00
Translating Tolerance to the Clinic
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* David W. Scott, Uniformed Services University of Health Sciences, USA

* Rachel R. Caspi, NEI, National Institutes of Health, USA

Sergio A. Quezada, University College London, UK
Short Talk: CTLA-4 Blockade and GMCSF Combination Immunotherapy Alters the Intra-Tumor Balance of Effector and Regulatory T Cells Without Directly Interfering with Regulatory T Cell Activity

Jeffrey A. Bluestone, University of California, San Francisco, USA
Intrinsic and Extrinsic Regulation of Autoimmune Diabetes

18:00—19:00
Lifetime Achievement Awards
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
Eli E. Sercarz, Torrey Pines Institute for Molecular Studies, USA
Repertoires, Drivers and Passengers in a Lifetime Sojourn

Noel R. Rose, Johns Hopkins University, USA
Environmental Triggers of Autoimmunity: We’ve Come to This!

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
20:00—23:00
Entertainment

Peaks 14-17

SUNDAY, MARCH 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068401-01




We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen JDRF
National Multiple Sclerosis Society Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676