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This meeting took place in 2006



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Viral Immunity: From Basic Mechanisms to Vaccines (X7)


Organizer(s) Marcia A. Blackman, Peter C. Doherty and Ralph A. Tripp
March 28—April 2, 2006
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 30, 2005
Late Abstract Deadline: Dec 21, 2005
Scholarship Deadline: Nov 30, 2005
Early Registration Deadline: Jan 27, 2006

Supported by The Director's Fund


Summary of Meeting:
Most human viruses lack an effective vaccine, and the problems posed by emerging viruses and the use of exotic viruses in acts of terrorism are extremely complex. Recent advances in basic and applied research have provided an unparalleled opportunity to understand the interplay between the virus and the immune system. This meeting will bring together basic and applied viral immunologists from academia, government, and industry to foster collaborative efforts to take advantage of recent progress in understanding basic mechanisms in the generation and long-term maintenance of anti-viral immunity for the development of effective anti-viral strategies. Experts in the field will present plenary talks on the latest breakthroughs in key areas of viral immunology, including molecules and immune cells involved in the initiation of immunity, cellular and humoral effector mechanisms, and mechanisms involved in establishing and maintaining protective memory responses. Workshops will provide a more interactive format for discussion of cutting-edge results. The overall emphasis of the meeting is to discuss how to exploit advances made in fundamental concepts to make vaccines. The goal of the meeting is to accelerate vaccine development for existing viruses, and to facilitate a rapid response to the threat of emerging viruses and bioterrorism.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 28

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine / Mt. Werner / Storm Peak
* Kanta Subbarao, NIAID, National Institutes of Health, USA
Introduction of Influenza Meeting

* Ralph A. Tripp, University of Georgia, USA

Peter C. Doherty, University of Melbourne, Australia
Structure-Function Relationships in the Influenza Virus-Specific CD8+ T Cell Response


WEDNESDAY, MARCH 29

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:15
Emerging and Re-Emerging Respiratory Virus Infections (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine / Mt. Werner / Storm Peak
* Ralph A. Tripp, University of Georgia, USA

Malik Peiris, University of Hong Kong, Hong Kong
Human Infections with Avian Influenza Viruses

Jeffery K. Taubenberger, NIAID, National Institutes of Health, USA
Lessons from the 1918 Pandemic

Paul A. Rota, Centers for Disease Control, USA
The Emergence of Two Novel Respiratory Viruses: Nipah Virus and SARS-CoV

Jason W. Botten, The Scripps Research Institute, USA
Short Talk: Identification of Protective HLA-A2 Supertype-Restricted CD8+ T Lymphocyte Epitopes in Lassa Virus

Coreen M. Beaumier, Walter Reed Army Institute of Research, USA
Short Talk: Kinetics and Specificity of CD8+ T Cell Responses to Sequential Dengue Virus Infections

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Rainbow / Twilight / Sunset / Skyline
13:00—22:00
Poster Viewing

Rainbow / Twilight / Sunset / Skyline
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Alerting the Immune System
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
Evelyn A. Kurt-Jones, University of Massachusetts Medical School, USA
PAMPS and Viral Infections - Gathering Evidence

Amaya Wolf, Wistar Institute, USA
Short Talk: Overlapping and Distinct Transcriptional Programs of Murine Plasmacytoid Dendritic Cells in Response to TLR7 and TLR9 Engagement

* Christine A. Biron, Brown University, USA
Innate Signaling of Effective Antiviral Immunity

Maureen C. Howard, Trudea Institute, Inc., USA
Cytokine and Chemokine Signaling of Effective Antiviral Immunity

17:00—19:00
Influenza Viruses that Jump the Species Barrier
Meeting has ended...abstracts no longer viewable online.

Sunshine
Ian A. Wilson, The Scripps Research Institute, USA
Receptor Specificity of H1, H3 and H5 Hemagglutinins

Mikhail Matrosovich, Philipps University, Germany
Influenza Virus Infection in Cultures of Human Airway Epithelium

* Jacqueline M. Katz, Centers for Disease Control and Prevention, USA
Avian Influenza Virus Pathogenesis in Animal Models

Urban R.J. Kumlin, Umeå University, Sweden
Short Talk: The Human Eye as a Portal of Entry for Influenza

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 1

Rainbow / Twilight / Sunset / Skyline

THURSDAY, MARCH 30

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:15
Induction of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
Anne B. Krug, Technical University Munich, Germany
The Two Faces of Nucleic Acid Recognition in Dendritic Cells – Induction of Antiviral Responses and Autoimmunity

Francis R. Carbone, University of Melbourne, Australia
DC Subsets in T Cell Immunity to Peripheral Viral Infection

* Thomas J. Braciale, University of Virginia, USA
Early Events in the T cell Response to Respiratory Virus Infection

Jack R. Bennink, NIAID, National Institutes of Health, USA
Immunodominance Rules

Misty Jenkins, University of Melbourne, Australia
Short Talk: Diversity of Granzyme and Perforin Co-Expression in Effector and Memory Influenza-Specific CD8+ T Cells

Heath Guay, Wyeth, USA
Short Talk: MyD88 is Required to Generate Long-Term Humoral Immunity to Virus Infection

08:00—11:30
New Advances in Influenza Virus Biology
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Paul Digard, University of Cambridge, UK
A Second Requirement for RNA Pol II in the Influenza Virus Lifecycle

Peter M. Palese, Icahn School of Medicine at Mount Sinai, USA
Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1

George G. Brownlee, University of Oxford, UK
Different de novo Initiation Strategies are used by Influenza Virus RNA Polymerase on its cRNA and vRNA Promoters during Viral RNA Replication

Robert A. Lamb, Northwestern University, USA
Assembly of Influenza Viruses

Yuying Liang, University of Minnesota, Twin Cities, USA
Short Talk: Packaging Signals in the Influenza Virus PB1, PB2, and PA Segments

Andrew S. Pekosz, Johns Hopkins University, USA
Short Talk: The Influenza A Virus M2 Protein Cytoplasmic Tail Contains Sequences that Affect Virus Budding and Genome Incorporation

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Blood Leukocyte Transcriptional Fingerprints as Novel Diagnostic and Prognostic Indicators

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Rainbow / Twilight / Sunset / Skyline
13:00—22:00
Poster Viewing

Rainbow / Twilight / Sunset / Skyline
14:30—15:30
Workshop 1A: Immune Modulation

Sunshine
* Joan Durbin, New York University, USA

Nancy A. Jewell, Lovelace Respiratory Research Institute, USA
Type I Interferon Induction by Respiratory Viruses in vivo

Kapil Bahl, Yale University School of Medicine, USA
Interferon-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections

Ulf Dittmer, University of Duisburg-Essen, Germany
Kinetics of the Development of CD8+ Effector T Cells and CD4+ Regulatory T Cells during Friend Retrovirus Infection

Peter Johannes Holst, Laboratory of Experimental Vaccinology, Denmark
Prompt Protection Against Lethal Viral Disease Induced by an Improved Adenoviral Vaccine

14:30—16:30
Workshop: Host Range and Virulence Determinants in Highly Pathogenic Influenza Viruses

Sunshine
* Terrence Tumpey, Centers for Disease Control and Prevention, USA

* Hualan Chen, Chinese Academy of Agriculture Sciences, China
Molecular Basis for the Host Range of H5N1 Avian Influenza Viruses

Jessica A. Belser, Centers for Disease Control and Prevention, USA
Characterization of H7 Influenza A Viruses in Mammalian Models

Sandra Ewald, Auburn University, USA
Mx Gene Polymorphism Determining Differential Antiviral Activity in Commercial Meat-Type Chicken Lines

Aeron C. Hurt, World Health Organization Collaborating Centre for Influenza, Australia
Isolation of Avian Influenza Viruses from Two Different Transhemispheric Migratory Shorebird Species in Australia

Kathy E. Magor, University of Alberta, Canada
Immunogenetic Clues to Why Ducks are the Reservoir of Influenza Viruses

Josephine M. McAuliffe, National Institutes of Health, USA
Antigenic Relatedness Among Avian Influenza A H7 Subtype Viruses with Post Infection Mouse Sera

Rachelle Salomon, St. Jude Children's Research Hospital, USA
Multiple Genes Contribute to the High Virulence of the H5N1 Influenza Virus Isolate A/Vietnam/1203/04

Katharine Marie Sturm-Ramirez, St Jude Children's Research Hospital, USA
Interspecies Transmission of H5N1 Influenza Viruses Among Ducks and Chicken

15:30—16:30
Workshop 1B: Disease and Pathogenesis

Sunshine
* Stanley Perlman, University of Iowa, USA
Pathogenic Role for Virus-Specific CD4 T cells in Mice with Coronavirus-induced Acute Encephalitis

Richard I. Enelow, Dartmouth Medical School, USA
NKG2A Expression by Influenza-Specific Effector CD8+ T Cells Regulates Pulmonary Immunopathology

Fei Liu, Affymetrix, USA
Peptide Vaccination of a Virus-Immune Recipient May Cause Serious CD8+ T Cell Mediated, TNF-Dependent, Immunopathology

Kerstin Luhn, Weatherall Institute of Molecular Medicine, UK
Increased Frequencies of CD4+CD25high Regulatory T Cells in Acute Dengue Infection

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Memory to Virus Infections
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA
Unique Aspects of T Cell Memory in the Respiratory Tract

Liisa K. Selin, University of Massachusetts Medical School, USA
Heterologous Immunity and CD8 T Cell Cross-Reactivity during Viral Infections

Hao Shen, University of Pennsylvania, USA
Epigenetic Modification of the IL-2 and IFN-gamma Genes in Memory CD8+ T Cells is Influenced by CD4+ T Cell Help

David Masopust, University of Minnesota, USA
Short Talk: Antigen Experience Dictates Central and Effector Memory CD8 T Cell Differentiation: Implications for Heterologous Prime-Boost Vaccination

17:00—19:00
Molecular Pathogenesis: Interactions of the Virus and Host
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
PB1-F2: What Does It Do and How Does It Do It?

Zahra F. Zakeri, Queens College of City University of New York, USA
Short Talk: Influenza Virus Uses Several Cell Death Pathways

Stephan Ludwig, University of Münster, Germany
Influenza Viruses and Cell Signaling

Adolfo García-Sastre, Mount Sinai School of Medicine, USA
How Influenza Virus Counteracts the Type I Interferon Response

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 2

Rainbow / Twilight / Sunset / Skyline

FRIDAY, MARCH 31

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:00
Challenges Presented by Persistent Viruses
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
* Ralph A. Tripp, University of Georgia, USA
Respiratory Syncytial Virus Manipulation of the Anti-Viral Cytokine Response Facilitates Infection and Contributes to Persistence

Alan B. Rickinson, University of Birmingham, UK
Immunity to Epstein-Barr Virus

Marcia A. Blackman, Trudeau Institute, USA
Gamma-Herpesvirus Latency: Lessons from the Mouse

Alfredo Nicosia, Instituto di Ricerche di Biologia Molecolare, Italy
Prospects for T-Cell Based HCV Vaccine

Neil Blake, University of Liverpool, UK
Short Talk: The Role of the Large Acidic Repeat Domain of Herpesvirus saimiri ORF73 in Immune Evasion

Erin M. Buckingham, University of Colorado Health Sciences Center, USA
Short Talk: Tracking Immune Control of Virus Reactivation in vivo

08:00—11:15
Immunity to Influenza: Basic Mechanisms
Meeting has ended...abstracts no longer viewable online.

Sunshine
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA

Troy D. Randall, University of Alabama at Birmingham, USA
Role of Lung Lymphoid Structures in the Immune Response to Influenza Virus

Guus Rimmelzwaan, Erasmus MC, Netherlands
Human Cytotoxic T-Lymphocyte Mediated Immunity to Influenza A Viruses

Tania H. Watts, University of Toronto, Canada
Costimulating the Immune Response to Influenza Virus

Walter Gerhard, Wistar Institute, USA
Cooperative Interactions in Antibody-Mediated Protection in vivo.

Frances E. Lund, University of Alabama at Birmingham, USA
Short Talk: CD4 T Cell-Independent Antibody Response Promotes Resolution of Primary Influenza Infection and Helps to Prevent Reinfection

Nicole Baumgarth, University of California, Davis, USA
Short Talk: Innate Regulation of B Cell Responses to Influenza

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Rainbow / Twilight / Sunset / Skyline
13:00—22:00
Poster Viewing

Rainbow / Twilight / Sunset / Skyline
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Humoral Immunity and Viruses
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
* Dennis R. Burton, The Scripps Research Institute, USA
Anti-HIV Activities of Antibodies in vitro and in vivo

Jenny M. Woof, University of Dundee, UK
Mucosal Immunoglobulins in Viral Immunity

Robert G. Whalen, Altravax, Inc., USA
Creating Improved Viral Immunogens by Directed Molecular Evolution

HyeMee Joo, Baylor Institute Research, USA
Short Talk: Distribution of Virus-Specific Memory B Cells Following Influenza Infection of the Respiratory Tract

17:00—19:00
Immunity to Influenza: Vaccine Issues
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Robert B. Couch, Baylor College of Medicine, USA
Correlates of Immunity to Influenza

George Kemble, 3-V BioSciences, USA
Live Attenuated Influenza Vaccines

Donna M. Murasko, Drexel University, USA
The Challenge of Vaccinating the Elderly

Derek T. O'Hagan, GSK Vaccines, USA
Short Talk: Combination Adjuvants for Optimal Potency of Influenza Vaccines

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 3

Rainbow / Twilight / Sunset / Skyline

SATURDAY, APRIL 1

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:15
Novel Developments in Antiviral Immunity
Meeting has ended...abstracts no longer viewable online.

Mt. Werner / Storm Peak
* Barry T. Rouse, University of Tennessee, USA
Regulatory T Cells and Control of Viral Immunity and Immunopathology

Janko Nikolich-Zugich, University of Arizona College of Medicine, USA
Aging and anti-viral Immunity to Acute and Chronic Infections

Ann M. Arvin, Stanford University, USA
Infant and Maternal Immunization and Passive Antibodies: New Insights from Investigations of Measles Vaccination

Dennis M. Klinman, U.S. Food and Drug Administration, USA
Use of CpG Oligonucleotides to Improve Host Protection from Infectious Pathogens

Maya Kotturi, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Defining the Spectrum of CD8+ T Cell Responses to LCMV

Michael A. Brehm, University of Massachusetts Medical School, USA
Short Talk: Naïve Virus-Specific CD8 T Cells Rapidly Produce TNF-alpha in vivo following TCR-Engagement

08:00—11:15
Strategies to Control Avian Influenza Infections in Humans
Meeting has ended...abstracts no longer viewable online.

Sunshine
William G. Dundon, Istituto Zooprofilattico delle Venezie, Italy
Strategies for the Control of Avian Influenza in Poultry in an Evolving Scenario

Maria Zambon, Health Protection Agency - Centre for Infections, UK
Lessons from Clinical Trials of Inactivated Pandemic Vaccines in Humans

* Kanta Subbarao, NIAID, National Institutes of Health, USA
Evaluation of Live Attenuated Pandemic Vaccines

Penelope A. Robbins, California Department of Health Services, USA
Short Talk: T-Cell Immunity to Influenza H3N2 A/CA/7/2004 and Cross Recognition of Avian H5N1 A/VN/1203/2004

Suzanne L. Epstein, Center for Biologics Evaluation and Research, FDA, USA
Small Interfering RNAs and Vaccines: Protection against Influenza by Targeting Conserved Components

Christina E. Mills, Harvard School of Public Health, USA
Short Talk: Pandemic Infuenza: Risk of Multiple Introductions and the Need to Prepare for Them

09:20—09:40
Coffee Break

Foyer
14:30—15:30
Workshop 2A: Antigen Presentation

Sunshine
* Kevin L. Legge, University of Iowa Carver College of Medicine, USA
Elimination of Respiratory APCs Inhibits Pulmonary Influenza-Specific CD8 T Cell Responses

Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research, Australia
Preactivation of Dendritic Cells and TLR Ligands or Malaria Infection Impairs Cross-Priming

Brian P. Dolan, NIAID, National Institutes of Health, USA
Dendritic Cells Cross-Dressed with Peptide-MHC Class I Complexes from Necrotic Cells Activate CD8+ T Cells

W. L. William Chang, University of California, Davis, USA
Tissue Macrophages are a Main Population of Antigen-Presenting Cells during Early Influenza Virus Infection

15:30—16:30
Workshop 2B: Immune Recall

Sunshine
* David J. Topham, University of Rochester Medical Center, USA

Timothy J. Chapman, University of Rochester, USA
Central Memory CD4 T Cells can Mediate Protection Against Secondary Influenza Infection

Scott N. Mueller, University of Melbourne, Australia
Qualitatively Different Memory Cells are Generated Following LCMV or Influenza Virus Infection

Emilio Flaño, Ohio State University, USA
Generation of CD8+ T Cell Memory to Latent Viral Infections

Luis J. Sigal, Fox Chase Cancer Center, USA
Long-Lived Memory CD8+ T Cells Protect from a Lethal Viral Disease by Limiting Virus Spread from the Lymph Node Draining the Site of Primary Infection

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Exploring Fundamental Concepts to Make Vaccines (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine / Mt. Werner / Storm Peak
Stanley A. Plotkin, Vaxconsult, LLC, USA
Old and New Vaccine Strategies

* Yoshihiro Kawaoka, University of Wisconsin/University of Tokyo, USA
Application of Reverse Genetics to Vaccine Development

Mark K. Slifka, Oregon National Primate Research Center, Oregon Health & Science University, USA
Smallpox, Smallpox Vaccination, and the Question of Long-Term Immunity

Stephen Mark Tompkins, University of Georgia, USA
Short Talk: M2-DNA Immunization Induces Broad Protection against Influenza Virus Challenge, Including Potentially Pandemic H5N1 Isolates

19:00—20:00
Social Hour with Lite Bites

Foyer
20:00—23:00
Entertainment

Sunshine

SUNDAY, APRIL 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 U13 AI60000-01




National Institutes of Health

Grant No. 1R13 AI068316-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Maxygen, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676