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This meeting took place in 2006
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Cell Biology of Virus Entry, Replication and Pathogenesis (C4)
Organizer(s) Herbert W. Virgin, Robert A. Lamb, Richard W. Compans, Robert W. Doms and Michael B.A. Oldstone
February 24—March 1, 2006
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Oct 25, 2005
Late Abstract Deadline: Nov 17, 2005
Scholarship Deadline: Oct 25, 2005
Early Registration Deadline: Dec 23, 2005
Supported by The Director's Fund
Summary of Meeting:
The elucidation of the molecular interactions between viral components and cells, and how this determines the outcome of infection is the most exciting area of modern virology. New advances in structural biology, genetics, and molecular virology have speeded the pace of discovery in this area and led to significant insights into virology, immunology and cell biology. The new NIH emphasis on mechanisms of viral infection provides new support and excitement for this already fertile area. The pivotal areas to be covered are (i) the cell biology of virus entry, uncoating, protein traffic, assembly, budding and release, (ii) the defensive mechanisms that cells and organisms use to combat viruses, (iii) strategies of viral immune evasion. These areas impact significantly on fundamental issues in cell biology, cell and species tropism, and pathogenesis of viral diseases. The meeting will once again provide a cross disciplinary forum for discussing novel insights into cell biology of virus infection and the relationship of these findings to pathogenesis and defense. Each session covers a topic rather than a virus family in order to foster discussion across virus family-boundaries. Our topic oriented program has been very successful in the many successful meetings organized since 1988.
View Scholarships/Awards
The elucidation of the molecular interactions between viral components and cells, and how this determines the outcome of infection is the most exciting area of modern virology. New advances in structural biology, genetics, and molecular virology have speeded the pace of discovery in this area and led to significant insights into virology, immunology and cell biology. The new NIH emphasis on mechanisms of viral infection provides new support and excitement for this already fertile area. The pivotal areas to be covered are (i) the cell biology of virus entry, uncoating, protein traffic, assembly, budding and release, (ii) the defensive mechanisms that cells and organisms use to combat viruses, (iii) strategies of viral immune evasion. These areas impact significantly on fundamental issues in cell biology, cell and species tropism, and pathogenesis of viral diseases. The meeting will once again provide a cross disciplinary forum for discussing novel insights into cell biology of virus infection and the relationship of these findings to pathogenesis and defense. Each session covers a topic rather than a virus family in order to foster discussion across virus family-boundaries. Our topic oriented program has been very successful in the many successful meetings organized since 1988.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
FRIDAY, FEBRUARY 24
SATURDAY, FEBRUARY 25
SUNDAY, FEBRUARY 26
MONDAY, FEBRUARY 27
TUESDAY, FEBRUARY 28
WEDNESDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
FRIDAY, FEBRUARY 24
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.
Stephen C. Harrison,
Harvard Medical School, USA
Viral Membrane Fusion: The Converging Paradigms
Viral Membrane Fusion: The Converging Paradigms
08:00—11:00
Viral Receptor Binding and Entry (a)
Meeting has ended...abstracts no longer viewable online.
*
Theodore S. Jardetzky,
Stanford University, USA
Terence S. Dermody,
Vanderbilt University School of Medicine, USA
Reovirus Cell Entry and Activation of Innate Immune Response Signaling
Reovirus Cell Entry and Activation of Innate Immune Response Signaling
Yusuke Yanagi,
Kyushu University, Japan
Measles Virus Receptors: Their Roles in Tropism and Signal Transduction
Measles Virus Receptors: Their Roles in Tropism and Signal Transduction
John A. T. Young,
F.Hoffmann-La Roche Ltd, Switzerland
Early Steps of Retroviral Replication
Early Steps of Retroviral Replication
Susan R. Ross,
University of Pennsylvania, USA
MMTV Interaction with Toll-like Receptors and Other Immunological Signaling Pathways
MMTV Interaction with Toll-like Receptors and Other Immunological Signaling Pathways
14:30—16:30
Workshop 1: Viral Receptors and Entry
*
Frederic S. Cohen,
Rush Medical College, USA
Christopher Aiken,
Vanderbilt University School of Medicine, USA
Inside-Out Regulation of HIV-1 Particle Fusion
Inside-Out Regulation of HIV-1 Particle Fusion
Carolyn B. Coyne,
University of Pittsburgh, USA
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions
Kimberly A. Bishop-Lilly,
Naval Medical Research Center, USA
Characterization of the EphrinB2-Binding Site on the Henipavirus G Glycoprotein
Characterization of the EphrinB2-Binding Site on the Henipavirus G Glycoprotein
Robert A. Davey,
Texas Biomedical Research Institute, USA
siRNA Screening for Cellular Factors Required for Infection by Human Respiratory Syncytial Virus Reveals Important Role for Clathrin-Mediated Endocytosis
siRNA Screening for Cellular Factors Required for Infection by Human Respiratory Syncytial Virus Reveals Important Role for Clathrin-Mediated Endocytosis
Karin Stiasny,
Medical University of Vienna, Austria
Structural and Functional Dissection of the Flavivirus Membrane Fusion Pathway
Structural and Functional Dissection of the Flavivirus Membrane Fusion Pathway
Oscar Negrete,
Sandia National Labs, USA
EphrinB3 is an Alternate Receptor for Nipah Virus
EphrinB3 is an Alternate Receptor for Nipah Virus
Lily Y. Lee,
Harvard Medical School, USA
Poliovirus Entry and RNA Release: A Multidisciplinary Study
Poliovirus Entry and RNA Release: A Multidisciplinary Study
Roy Duncan,
Dalhousie University, Canada
Simplified Fusion Machines: The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins.
Simplified Fusion Machines: The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins.
17:00—19:00
Receptor Binding and Entry (b)
Meeting has ended...abstracts no longer viewable online.
*
Robert A. Lamb,
Northwestern University, USA
Theodore S. Jardetzky,
Stanford University, USA
Structural Insights into Paramyxovirus Fusion Protein Folding and Function
Structural Insights into Paramyxovirus Fusion Protein Folding and Function
Robert P. Blumenthal,
NCI, National Institutes of Health, USA
Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins
Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins
Richard W. Compans,
Emory University, Rollins Research Center, USA
Specific Inhibition of Paramyxovirus F-Mediated Membrane Fusion
Specific Inhibition of Paramyxovirus F-Mediated Membrane Fusion
08:00—11:00
Viral Movement and Trafficking
Meeting has ended...abstracts no longer viewable online.
Ari Helenius,
ETH Zurich, Switzerland
How Viruses Enter Animal Cells
How Viruses Enter Animal Cells
Thomas J. Hope,
Northwestern University, USA
Virus Interactions with Dendritic Cells: Moving to the Synapse
Virus Interactions with Dendritic Cells: Moving to the Synapse
Geoffrey L. Smith,
University of Cambridge, UK
Ligand-Induced and Non-Fusogenic Dissolution of a Virus Membrane
Ligand-Induced and Non-Fusogenic Dissolution of a Virus Membrane
Xiaowei Zhuang,
Harvard University, USA
Entry and Trafficking of Influenza Viruses by Single-Virus Tracking
Entry and Trafficking of Influenza Viruses by Single-Virus Tracking
14:30—16:30
Workshop 2: Immunity, Antivirals and Vaccines
*
Mary K. Estes,
Baylor College of Medicine, USA
Sheri L. Hanna,
University of Pennsylvania, USA
Contribution of WNV Envelope N-linked Glycosylation to Assembly, Infectivity and Tropism
Contribution of WNV Envelope N-linked Glycosylation to Assembly, Infectivity and Tropism
Grant E. Nybakken,
Washington University, USA
Mechanistic Correlates of Antibody-Mediated Protection against West Nile Virus Infection
Mechanistic Correlates of Antibody-Mediated Protection against West Nile Virus Infection
Christian D.S. Nelson,
Cornell University, USA
Antibody Neutralization Mechanisms: Different Responses to Antibody Binding at the Same Site in a Virus Capsid
Antibody Neutralization Mechanisms: Different Responses to Antibody Binding at the Same Site in a Virus Capsid
Rebecca K. Holmes,
King's College London, UK
Unravelling the Importance of Cytidine Deamination for the Anti-Viral Activity of APOBEC3G and APOBEC3F
Unravelling the Importance of Cytidine Deamination for the Anti-Viral Activity of APOBEC3G and APOBEC3F
Dapeng Zhou,
MD Anderson Cancer Center, USA
A Natural Glycolipid Ligand of NKT Cells: Implications for Anti-Viral Immunity
A Natural Glycolipid Ligand of NKT Cells: Implications for Anti-Viral Immunity
Byeongwoon Song,
Emory University, USA
TRIM5alpha: Retroviral Restriction and Subcellular Localization
TRIM5alpha: Retroviral Restriction and Subcellular Localization
Xiuyan Wang,
Yale University School of Medicine, USA
A Novel Antiviral Mechanism Mediated by the Interferon-Inducible Protein Viperin
A Novel Antiviral Mechanism Mediated by the Interferon-Inducible Protein Viperin
Michael S. Kay,
University of Utah School of Medicine, USA
Steric Accessibility of the HIV-1 gp41 N-Trimer Region
Steric Accessibility of the HIV-1 gp41 N-Trimer Region
17:00—19:00
Virus Assembly and Release
Meeting has ended...abstracts no longer viewable online.
*
Richard W. Compans,
Emory University, Rollins Research Center, USA
Eric Hunter,
Emory University, USA
Cell Biology of Retroviral Assembly and Release
Cell Biology of Retroviral Assembly and Release
Robert A. Lamb,
Northwestern University, USA
Influenza Virus Assembly at the Viral Budozone
Influenza Virus Assembly at the Viral Budozone
08:00—11:00
Cellular Genes and Virus Infection
Meeting has ended...abstracts no longer viewable online.
*
Otto Haller,
University of Freiburg, Germany
Jeff Bergelson,
University of Pennsylvania, USA
Kinase Signals Permit Coxsackievirus Entry through Epithelial Type Junction
Kinase Signals Permit Coxsackievirus Entry through Epithelial Type Junction
Stephen P. Goff,
Columbia University, USA
Host Factors Involved in Retroviral Replication
Host Factors Involved in Retroviral Replication
Beth Levine,
University of Texas Southwestern Medical Center, USA
Autophagy in Innate Antiviral Immunity
Autophagy in Innate Antiviral Immunity
Daved Fremont,
Washington University School of Medicine, USA
Structural Mechanisms of Viral Immune Evasion
Structural Mechanisms of Viral Immune Evasion
14:30—16:30
Workshop 3: Intracellular Movement, Trafficking and Assembly of Viruses
*
Jeff Bergelson,
University of Pennsylvania, USA
Sara R. Cherry,
University of Pennsylvania School of Medicine, USA
COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication
COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication
Susana Guix,
Baylor College of Medicine, USA
Studies of Norwalk Virus RNA Encapsidation
Studies of Norwalk Virus RNA Encapsidation
Christopher T. Cornell,
The Scripps Research Institute, USA
Inhibition of Host Protein Secretion by Coxsackievirus b3 (CVB3): Multiple Gene Products Target a Common Organelle
Inhibition of Host Protein Secretion by Coxsackievirus b3 (CVB3): Multiple Gene Products Target a Common Organelle
Benjamin J. Chen,
Northwestern University, USA
Influenza Virus Hemagglutinin (H3) Requires Palmitoylation of its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in their Ability to Support Assembly
Influenza Virus Hemagglutinin (H3) Requires Palmitoylation of its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in their Ability to Support Assembly
Markus Thali,
University of Vermont, USA
Tetraspanin-Enriched Microdomains (TEMs) Function as Gateways for HIV-1
Tetraspanin-Enriched Microdomains (TEMs) Function as Gateways for HIV-1
Glenn F. Rall,
Fox Chase Cancer Center, USA
Neurokinin-1 Interacts with the Measles Virus Fusion Protein to Facilitate Trans-Synaptic Spread in Neurons
Neurokinin-1 Interacts with the Measles Virus Fusion Protein to Facilitate Trans-Synaptic Spread in Neurons
David C. Johnson,
Oregon Health & Science University, USA
Spread of Herpes Simplex Virus in Epithelial and Neuronal Tissues is Promoted by Membrane Proteins gE/gI and US9 which Sort Virions to Cell Junctions
Spread of Herpes Simplex Virus in Epithelial and Neuronal Tissues is Promoted by Membrane Proteins gE/gI and US9 which Sort Virions to Cell Junctions
Laura Burleigh,
Institut Pasteur, France
Long–Term Transfer of HIV from Immature Dendritic Cells to T Cells Occurs Exclusively through DC-SIGN-Mediated Cis Infection and not Intracellular Storage of Incoming Virus
Long–Term Transfer of HIV from Immature Dendritic Cells to T Cells Occurs Exclusively through DC-SIGN-Mediated Cis Infection and not Intracellular Storage of Incoming Virus
17:00—19:00
Viruses and Immunity
Meeting has ended...abstracts no longer viewable online.
Ira Mellman,
Genentech, Inc., USA
Dendritic Cells and Virus Infection
Dendritic Cells and Virus Infection
Raymond M. Welsh,
University of Massachusetts Medical School, USA
Privacy of T Cell-Dependent Heterologous Antiviral Immunity
Privacy of T Cell-Dependent Heterologous Antiviral Immunity
08:00—11:00
Control of Infection and Viral Vaccines
Meeting has ended...abstracts no longer viewable online.
*
Ann M. Arvin,
Stanford University, USA
Rafi Ahmed,
Emory University School of Medicine, USA
Mechanisms of T Cell Memory in Antiviral Immunity
Mechanisms of T Cell Memory in Antiviral Immunity
Nancy J. Sullivan,
Vaccine Research Center, National Institutes of Health, USA
Ebola Virus Immunity
Ebola Virus Immunity
Curt M. Horvath,
Northwestern University, USA
Activation and Inhibition of Cellular Interferon Responses and Innate Antiviral Immunity
Activation and Inhibition of Cellular Interferon Responses and Innate Antiviral Immunity
17:00—19:00
Viral Disease and Pathogenesis
Meeting has ended...abstracts no longer viewable online.
*
Rafi Ahmed,
Emory University School of Medicine, USA
Francis V. Chisari,
The Scripps Research Institute, USA
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host
Herbert (Skip) W. Virgin,
Washington University School of Medicine, USA
Replication of, and Resistance to, a Novel Norovirus
Replication of, and Resistance to, a Novel Norovirus
Ann M. Arvin,
Stanford University, USA
New Insights into Varicella-Zoster Virus Pathogenesis
New Insights into Varicella-Zoster Virus Pathogenesis
*Session Chair †Invited, not yet responded.
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