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This meeting took place in 2006



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Malaria: Functional Genomics to Biology to Medicine (C5)


Organizer(s) Dyann F. Wirth, Carole A. Long and Alan Cowman
February 28—March 5, 2006
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 27, 2005
Late Abstract Deadline: Nov 21, 2005
Scholarship Deadline: Oct 27, 2005
Early Registration Deadline: Dec 28, 2005

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Malaria remains a major world health problem and with increasing resistance to antimalarial drugs, its health impact is increasing. New knowledge stimulated by sequencing of the genomes of both the parasite P. falciparum, P. vivax and others and the major mosquito vector, Anopheles gambiae, has led to an explosion in scientific activity, ranging from the elucidation of basic biological mechanisms to new insights into disease pathogenesis and transmission. This meeting seeks to bring together a diverse group of scientists working on different aspects of the biology and the disease in order to compare the latest discoveries and insights. The pace of scientific discovery in this area is accelerating and this meeting will seek to provide an overview of the most significant developments and serve to identify opportunities for new research areas and collaborations. Of particular importance in this field is the interplay between basic scientific discovery and the clinical and epidemiological discoveries in the natural population and this meeting seeks to identify these key interfaces. The specific aims of the meeting are the following: 1) Provide a forum for the presentation and discussion of latest and most significant developments in malaria biology 2) Provide an opportunity for exchange of ideas between scientists coming from different disciplines and for the potential development of new collaborations 3) Provide an enriched environment for trainees (graduate students, postdoctoral fellows) to interact with key researchers in this field 4) Provide an opportunity to identify the best strategies for the translation of basic knowledge into new interventions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 28

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Regina N. Rabinovich, ISGlobal, Spain / Harvard T.H. Chan School of Public Health, USA, Spain


WEDNESDAY, MARCH 1

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Systems Biology of Plasmodium
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Dyann F. Wirth, Harvard School of Public Health, USA

Kirk W. Deitsch, Cornell University, USA
Promoter-Promoter Interactions and var Gene Silencing

Artur Scherf, Institut Pasteur, FRANCE
Antigenic Variation in P. falciparum: 'Mind Games' or "Path for New Therapies'

Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia
Molecular Systems for Erythrocyte Remodelling and Trafficking in Plasmodium

L. David Sibley, Washington University School of Medicine, USA
Actin-based Motility and Cell Invasion by Apicomplexan Parasites.

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
From Genomes to Biology
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia

Elizabeth A. Winzeler, University of California, San Diego, USA
Molecular Networks in Malaria

Jane M. Carlton, Institute for Genomic Research, USA
Comparative Genomics: Insights into Plasmodium Biology

David Garboczi, NIAID, National Institutes of Health, USA
Short Talk: Structures of the Essential Mosquito-Stage Protein P25 and its Complex with a Transmission-Blocking Antibody

Niraj Tolia, Washington University School of Medicine, USA
Short Talk: Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium Falciparum

John H. Adams, University of South Florida College of Public Health, COPH, USA
Emergent Genome Wide Genetic Screens for Virulence Determinants in P. falciparum

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, MARCH 2

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Genetic Diversity in the Parasite and the Host
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* David J. Conway, London School of Hygiene and Tropical Medicine, UK

Dyann F. Wirth, Harvard School of Public Health, USA
A Haplotype Map for Plasmodium falciparum

Chetan E. Chitnis, International Centre for Genetic Engineering and Biotechnology, India
Targeting Malaria Proteins Involved in Erythrocyte Invasion

Xin-zhuan Su, NIAID, National Institutes of Health, USA
Population Structure and Evolution in P. falciparum

Lea Barfod, University of Oxford, UK
Short Talk: The Human IgG Response to Pregnancy-Associated Malaria is VAR2CSA Specific

Patrick E. Duffy, NIAID, National Institutes for Health, USA
Malaria Pathogenesis and the Parasite Genome

David A. Fidock, Columbia University Medical Center, USA
Short Talk: Rapid and Efficient Site-Specific Integration System in Plasmodium Falciparum Mediated by Mycobacteriophage Bxb1 Integrase

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
14:30—16:30
Workshop: Translation of Basic Science: The Gap from Knowledge to Practical Application

Chamisa Ballroom 1
Filip Dubovsky, Malaria Vaccine Initiative, PATH, USA

J. Carl Craft, Medicines for Malaria Venture, Switzerland

Lee Hall, NIAID, National Institutes of Health, USA

Val Snewin, Wellcome Trust, UK

Solomon O. Nwaka, World Health Organization, Switzerland

Victoria McGovern, Burroughs-Wellcome Fund, USA

Daniel J. Carucci, Foundation for the National Institutes of Health, USA

Douglas Andrew Holtzman, Palindrome BioConsulting, USA

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Natural Populations: Insights into Parasite Biology
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Elizabeth A. Winzeler, University of California, San Diego, USA

Eleanor M. Riley, Roslin Institute, UK
Balancing Immunity and Immunopathology in Malaria Infections

David J. Conway, London School of Hygiene and Tropical Medicine, UK
Virulence and Genetic Diversity

Abdoulaye Djimdé, University of Science, Techniques and Technologies, Mali
A Holistic Approach to Antimalarial Drug Resistance

Daniel C. Jeffares, Wellcome Trust Sanger Institute, UK
Short Talk: A Genome-Wide Analysis of Genetic Diversity and Evolution between three P. falciparum Isolates and P. reichenowi

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, MARCH 3

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Host Immune Response to Malaria: Biology and Genetics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Brendan S. Crabb, Burnet Institute, Australia

Carole A. Long, National Institutes of Health, USA
Evaluation of AMA-1 and MSP-1 Vaccine Candidates

Ann M. Moormann, University of Massachusetts Medical School, USA
Short Talk: Children Living in a Malaria Holoendemic Region of Western Kenya with Both IFN-gamma Responses and Antibodies to MSP-1 Showed the Greatest Protection from Plasmodium Falciparum Infection

Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA
CD8+ T Cells and Liver Stages

W. Ripley Ballou, GlaxoSmithKline Vaccines, USA
Prospects for a Malaria Vaccine: Recent Results with RTS,S

William R. Heath, University of Melbourne, Australia
Dissecting the Initiation of Immunity to P.berghei

Mats Wahlgren, Karolinska Institutet, Sweden
Short Talk: Identification of SURFIN by Surfeomics

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Mosquito-Parasite Interactions: Biology and Genetics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Carole A. Long, National Institutes of Health, USA

Fotis C. Kafatos, Imperial College London, UK
Malaria: A Disease that Requires 3 Organisms

Prakash Srinivasan, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: PbCAP1 is Essential for Plasmodium Oocyst Development

Andrew P. Waters, University of Glasgow, UK
Gametocytes in the Starting Blocks: The Control of RNA Homeostasis

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, MARCH 4

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
From Biology to Drugs and Vaccines
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Eleanor M. Riley, Roslin Institute, UK

Pradipsinh K. Rathod, University of Washington, USA
Biochemical Correlates of Drug Sensitivity: From Target Proteins to Cell Populations

Jose F. Garcia-Bustos, GlaxoSmithKline, Spain
4-(1H)Pyridones: Novel Inhibitors for a Proven Target

Yongyuth Yuthavong, BIOTEC, Thailand National Science and Technology Development Agency, Thailand
Structural Biology and Drug Design: Dihydrofolate Reductases as Targets for Antiprotozoal Drugs

Tamara K. Berthoud, Oxford University, UK
Short Talk: Measurement of Immunogenicity Following Malaria Vaccination in Humans

Ana Júlia Afonso, Instituto de Higiene e Medicina Tropical, Portugal
Short Talk: Molecular and Genetic Analysis Of Malaria Parasites Displaying Stable Resistance to Artemisinin and Artesunate

Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Antimalarial Chemotherapy: Exploiting the Parasite's Achilles Heel

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
New Frontiers in Host-Parasite Interactions
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Jane M. Carlton, Institute for Genomic Research, USA

Stefan Kappe, Seattle BioMed, USA
Liver Stage Development and Host Interactions

Cristina Dias Rodrigues, Instituto de Medicina Molecular, Portugal
Short Talk: Identification of host factors required for liver stage infection by Plasmodium using RNA interference

Brendan S. Crabb, Burnet Institute, Australia
New Insights into Merozoite Surface Antigens

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, MARCH 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068319-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


GlaxoSmithKline Biologicals


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