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This meeting took place in 2006



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HIV Pathogenesis (X5)


Organizer(s) Tristram G. Parslow, Julie M. Overbaugh and John M. Coffin
March 27—April 2, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 29, 2005
Late Abstract Deadline: Dec 20, 2005
Scholarship Deadline: Nov 29, 2005
Early Registration Deadline: Jan 27, 2006

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation

Joint Meeting: HIV Vaccines (X6)

Summary of Meeting:
Our agenda for the Pathogenesis meeting is organized in 10 plenary sessions, each showcasing the latest insights gained from studying a particular aspect or model of HIV and HIV-related illness. Individual sessions will, for example, highlight recent studies of the HIV virion, its growth in infected cells and tissues, its resistance to antiviral drugs, and its transmission in human populations. Others will feature illuminating work on related viruses and viral diseases, including simian AIDS. Two sessions on HIV immune responses will be convened jointly with the Vaccines symposium, as will the keynote address. We also envision at least two afternoon workshops featuring speakers chosen from submitted abstracts, as these offer an opportunity to involve new and lesser-known investigators.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 27

15:00—19:30
Registration

Longs Peak Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—21:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Longs/Grays Peak
* Tristram G. Parslow, Emory University, USA
Introduction of HIV Pathogenesis Meeting

Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Antiretroviral Activity of TRIM5 and Related TRIM Proteins

* Ruth M. Ruprecht, Texas Biomedical Research Institute, USA
Introduction of HIV Vaccines Meeting

Ulrich H. Von Andrian, Harvard Medical School, USA
Homing And Cellular Traffic In Lymphoid Tissues


TUESDAY, MARCH 28

07:00—08:00
Breakfast

Shavano/Torreys/Red Cloud
08:00—11:15
Lessons from the Virus
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Tristram G. Parslow, Emory University, USA

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Structural Basis for Specific Membrane Targeting by the HIV-1 Gag Protein

Hans-Georg Kräusslich, Universitat Heidelberg, Germany
HIV Assembly and its Inhibition

Peter E. Prevelige, University of Alabama, Birmingham, USA
HIV Core Assembly and Its Inhibitors

Wei-Shau Hu, National Cancer Institute, National Institutes of Health, USA
Recombination and Complementation: Two Modes of Interactions among HIVs

Jacob Anglister, Weizmann Institute of Science, Israel
Short Talk: Cross-Strand Electrostatic Interactions at the Base of the â-Hairpin of the HIV-1 V3 Region Create a Molecular Switch for Phenotype Conversion

Nathalie Arhel, Institut Pasteur, France
Short Talk: Video Imaging of HIV-1 Intracellular Transport and Role of the Central DNA Flap in Active Nuclear Import


Following Session is for HIV Vaccines (X6)

08:00—11:00
Antigen Presentation and Dendritic Cells
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

* Ulrich H. Von Andrian, Harvard Medical School, USA

Joana Loureieo, Whitehead Institute for Biomedical Research, USA
Antigen Presentation via MHC Class II

Robert A. Seder, NIAID, National Institutes of Health, USA
Toll-like Receptor Ligands Influence the Magnitude and Quality of HIV Specific Immune Responses in Non-human Primates

Mary A. Marovich, NIAID, National Institutes of Health, USA
DC Vaccinations with HIV Antigens in Humans

Donald I. Van Ryk, NIAID, National Institutes of Health, USA
Short Talk: DC-SIGN Capture of HIV gp120 Relies on Avidity Effects, and is Altered by CD4 Ligation

Paolo Monini, Istituto Superiore di Sanità, Italy
Short Talk: Native Tat Enters Preferentially Dendritic Cells Inducing Tumor Necrosis Factor-alpha-Mediated Th1-Polarized Maturation and Immune Responses in Monkeys

Christine Trumpfheller, Roche Glycart, Switzerland
Short Talk: Intensified and Protective CD4+ T Cell Immunity with Anti-Dendritic Cell HIV GAG Fusion Antibody Vaccine

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys/Red Cloud
13:00—22:00
Poster Viewing

Shavano/Torreys/Red Cloud

Following Session is for HIV Vaccines (X6)

14:30—16:30
Workshop 1: Boundary between Innate and Adaptive Immunity

Longs Peak
* Gene M. Shearer, National Cancer Institute, National Institutes of Health, USA

Susanna C. Trapp, University of Cologne, Germany
Co-Pathogens and HIV TLR3 Stimulation Dampens HIV Replication

Sophie Chabot, , USA
Mucosal Application of TLR2 Ligands Modulates the Gatekeeping Functions of the Follicle-Associated Epithelium to Promote Vaccine Uptake at Mucosal Surfaces

Daniel G. Kavanagh, , USA
Transfection of Antigen-Loaded Dendritic Cells With mRNA Encoding IL-12 p70 Leads to Increased Expansion of HIV-Specific T Cells and Activation of Natural Killer Cells in vitro

Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
Stimulation of Intracellular and Extracellular Innate Immune Responses to SIV and HIV-1

* Jay A. Berzofsky, NCI, National Institutes of Health, USA
Circumventing CD4 Deficiency to Induce Long-Lived Memory CTL

Marjorie Robert-Guroff, NCI, National Institutes of Health, USA
Cellular Immunity following Systemic SIV DNA Priming/Mucosal Replication-Competent Ad-SIV Boosting of Rhesus Macaques is Enhanced by Cytokine DNAs and Includes Potent Mucosal CD8+T Cell Memory Responses

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Lessons from the Target Cell (I) -- Factors that Inhibit
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
New Perspectives on APOBEC3G Anti-retroviral Action and Regulation

Kevin C. Klein, University of Washington, USA
Short Talk: Apobec3G Adopts Different Conformations in the Presence and Absence of RNA that may Correlate with Enzymatic Activity

Philippe Gallay, The Scripps Research Institute, USA
Short Talk: Selective Destruction of the HIV-1 Capsid Shell by TRIM5alpha

Klaus Strebel, NIAID, National Institutes of Health, USA
Short Talk: Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif

Kyeongeun Lee, NCI, National Institutes of Health, USA
Short Talk: HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6


Following Session is for HIV Vaccines (X6)

17:00—19:00
Harnessing Innate Immunity for Vaccines
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Robert A. Seder, NIAID, National Institutes of Health, USA

* Susan W. Barnett, Bill & Melinda Gates Foundation, USA

Nina Bhardwaj, Ichan School of Medicine at Mt Sinai, USA
Plasmacytoid DC: Linking Innate and Adaptive Immunity

Jay A. Levy, University of California, San Francisco, USA
Importance of Innate Immunity in HIV Infection and Vaccine Development

Galit Alter, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: NK Cells Respond Directly to HIV Derived Single-Stranded RNA via TLR in an APC Dependent Manner

Nada M. Melhem, University of Pittsburgh, USA
Short Talk: Dendritic Cells Expressing Autologous Viral RNA Stimulate T-Cell Responses that Accurately Reflecting Virus Evolution during SIV Infection

Wei Jiang, Case Western Reserve University, USA
Short Talk: TLR9 Ligation Induces Naïve B Cell Proliferation Independent of B Cell Receptor Activation

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys/Red Cloud
19:30—22:00
Poster Session 1

Shavano/Torreys/Red Cloud

WEDNESDAY, MARCH 29

07:00—08:00
Breakfast

Shavano/Torreys/Red Cloud

Following Session is for HIV Vaccines (X6)

08:00—11:30
B-Cell Development and Antibody Generation
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA

* John R. Mascola, NIAID, National Institutes of Health, USA

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Long Term Antibody Responses and B Cell Memory in Humans after Vaccination

Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
HIV-1 Envelope Glycoprotein Structural Analysis for Improved Immunogen Design

Ping Zhu, Florida State University, USA
Short Talk: Distribution and Three-Dimensional Structure of AIDS Virus Envelope Spikes

Herman F. Staats, Duke University Medical Center, USA
Secretory IgA and HIV-1 Vaccines

Ruth M. Ruprecht, Texas Biomedical Research Institute, USA
Vaccine Development Against HIV clade C in a Primate Model Involving SHIV clade C Mucosal Challenges

Frederic Bibollet-Ruche, University of Alabama, Birmingham, USA
Short Talk: Detection of Novel Neutralizing Antibody Responses to the Membrane Proximal External Region (MPER) of GP41 following Infection by HIV-1 Subtypes A, B, C, D, F, G, H, CRF01, CRF02, OR CRF11

Amandeep K. Gakhal, Sutro Biopharma, USA
Short Talk: Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from HIV-1 Infected Donors

08:00—11:00
Lessons from the Target Cell (II) -- Factors that Enhance
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Carol A. Carter, State University of New York - Stony Brook, USA
Tsg101 and Other Cofactors of HIV Release

John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Cellular Cofactors in Early Steps of Retroviral Entry

Angela Ciuffi, Institute of Microbiology (IMUL-CHUV), Switzerland
Short Talk: HIV Integration Site Selection is Directed by Cellular LEDGF/p75

Vicente Planelles, University of Utah, USA
Short Talk: Vpr Induces Bax-Dependent Apoptosis Downstream of G2 Checkpoint Activation

Serge Benichou, Cochin Institute, France
Short Talk: Dynamic Interaction of HIV-1 Nef with Clathrin at the Plasma Membrane Revealed by Evanescent Wave Fluorescence Microscopy

René Daniel, Thomas Jefferson University, USA
Short Talk: Nijmegen Breakage Syndrome Protein 1 Controls the ATM-Dependent DNA Damage Response to HIV-1 Integration

Erik S. Zimmerman, University of Utah, USA
Short Talk: Mechanism of Induction of G2 Arrest by HIV-1 Vpr in vivo

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys/Red Cloud
13:00—22:00
Poster Viewing

Shavano/Torreys/Red Cloud
14:30—16:30
Workshop 1: Therapeutic Targets in the Virus and Host

Grays Peak
* Vinay K. Pathak, National Cancer Institute, National Institutes of Health, USA
Identification of APOBEC3G Mutants that Exhibit a Defect in Virion Incorporation

Krishan K. Pandey, St. Louis University Health Sciences Center, USA
Human LEDGF/p75 Modulates Assembly and Disassembly of HIV-1 Synaptic Complexes in vitro

Rik Gijsbers, Katholieke Universiteit Leuven, Belgium
Overexpression of the LEDGF/p75 Integrase Binding Domain abrogates HIV-1 Replication

Steven P. Edgcomb, The Scripps Research Institute, USA
Attenuation of Rev Function by Modulation of the Oligomerization Domain

Richard E. Sutton, Yale University School of Medicine, USA
Human Chromosome 2 Carries a Gene that Allows Infectious HIV Release from Mouse Cells

Katrina Nolan, University of Pennsylvania, USA
HIV-1 Variants Containing Partial Deletions within the V3 Loop: Effects on X4 vs. R5 Tropism and Sensitivity to Entry Inhibitors

Elena Gustchina, NIDDK, National Institutes of Health, USA
Fusion Inhibitors Targeting N- and C-Heptad Repeat Regions of Pre-hairpin Intermediate of gp41 Inhibit Fusion Synergistically

John J. Dwyer, Trimeris Inc., USA
Design and Mechanism of Action of Fusion Inhibitor Peptides with Enhanced Activity Against ENF-Resistant Virus

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Lessons from the Immune Response I (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Ruth M. Ruprecht, Texas Biomedical Research Institute, USA

* Nelson L. Michael, Walter Reed Army Institute of Research, USA

Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Defining Shared Epitopes that Induce Broadly Neutralizing Antibodies

Gary J. Nabel, Sanofi, USA
New Antigen Designs for Env Responses

Barton F. Haynes, Duke University Medical Center, USA
Immunoregulation of Broadly Reactive Anti-HIV Antibody Responses

Morgane Bomsel, Institut Cochin, France
Short Talk: Characterization of HIV-1 Neutralizing Anti gp41-IgA by Screening a Phage-Display Fab IgA Library Derived from Mucosal Cells from HIV Highly Exposed but IgG sero Negative Individuals

George M. Shaw, University of Pennsylvania, USA
Short Talk: Characterization of HIV-1 Envelope in Acute HIV-1 Infection

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys/Red Cloud
19:30—22:00
Poster Session 2

Shavano/Torreys/Red Cloud

THURSDAY, MARCH 30

07:00—08:00
Breakfast

Shavano/Torreys/Red Cloud
08:00—11:30
Lessons from the Immune Response II (Joint)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jay A. Levy, University of California, San Francisco, USA

* Judy Lieberman, Harvard University, USA
Mechanisms of CTL Killing

Rafick-Pierre Sékaly, Case Western Reserve University, USA
Memory T Cell Homeostasis in the Natural History of HIV Infection

Sarah L. Rowland-Jones, Oxford University, UK
Long-Term Non-Progression with HIV Infection: Lessons from HIV-2

Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships in Nonpathogenic SIV Infections

David Price, Cardiff University School of Medicine, UK
Short Talk: Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery

Arne Schneidewind, Massachusetts General Hospital, USA
Short Talk: Impact of HLA-B27-Associated CTL Escape Mutations on HIV-1 Replicative Fitness

Photini Kiepiela, University of KwaZulu Natal, South Africa
Short Talk: Epitope-Specific Differences in Control of HIV-1 Infection

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys/Red Cloud
13:00—22:00
Poster Viewing

Shavano/Torreys/Red Cloud
14:30—16:30
Workshop 2: HIV Pathogenesis in Host Cells and Tissues

Grays Peak
* Anna Aldovini, Boston Children's Hospital and Harvard Medical School, USA
TRAIL-Mediated Apoptosis is Induced by HIV and SIV in Human and Macaque CD4+ T Cells but does Not Occur in Virus-Exposed CD4+ T cells from AIDS-Resistant Species

Elena Martinelli, Population Council, USA
HIV-1 gp120 Inhibits TLR9 Mediated Activation and IFN-gamma Secretion in Plasmacytoid Dendritic Cells

Ivona Pandrea, University of Pittsburgh, USA
Dramatic CD4+ T Cell Depletion in the Intestine is a Hallmark of SIVagm.sab Infection in Caribbean AGMs

David E. Verhoeven, Iowa State University, USA
Mechanistic and Phenotypic Analysis of Delayed Restoration of Intestinal CD4+ Lymphocytes during Antiviral Therapy of SIV Infected Rhesus Macaques

Desiree Kunkel, BCRT, Germany
Regulatory T Cells in the Gastrointestinal Mucosa in HIV/SIV Infection

Bin Li, , USA
Rapid Reversion of Transmitted Sequence Polymorphisms Dominates Early HIV-1 Evolution

James P. Gregson, Brigham Young University, USA
Distinct HIV Compartmentalization In and Among Secondary Lymphoid Tissues

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Lessons from Other Viruses
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Stephen P. Goff, Columbia University, USA
Host Restriction of Retrovirus Replication

Jonathan P. Stoye, National Institute for Medical Research, UK
A Collection Of Retrovirus Restriction Factors

Hung Y. Fan, University of California, Irvine, USA
Oncogenic Properties of the Envelope Protein of Jaagsiekte Sheep Retrovirus

James H. McLinden, University Of Iowa, USA
Short Talk: Hepatitis C Virus and GB Viruses B and C NS5A Proteins Inhibit HIV Replication in Jurkat Cells

Melody G. Duvall, NIAID, National Institutes of Health, USA
Short Talk: Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection


Following Session is for HIV Vaccines (X6)

17:00—19:15
T Cells: Effectors versus Suppressors
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Richard A. Koup, NIAID, National Institutes of Health, USA

Susan L. Swain, University of Massachusetts Medical School, USA
Mechanisms of Influenza Protection by Primed CD4 T Cells

* Nina Bhardwaj, Ichan School of Medicine at Mt Sinai, USA

David A. Hafler, Yale University School of Medicine, USA
Human T Regulatory Cells

Chungwon Chung, VMRD, USA
Short Talk: Clonal Variation of CD8+ T Lymphocyte Efficacy in Suppression of SIV Replication

Adriano Boasso, Imperial College London, UK
Short Talk: Increased Regulatory T Cell Markers and Indoleamine 2,3 Dioxygenase in Spleen and Gut of SIV-Infected Macaques

Elizabeth Ramona Sharp, University of California, San Francisco, USA
Short Talk: The Influence of CD4+CD25+ Regulatory T Cells on HLA-A2 Restricted HIV-Specific Immune Responses during Early and Chronic Infection

Jakob Nilsson, Karolinska Institute, Sweden
Short Talk: A Direct Correlation between FOXP3 Expressing Regulatory T- Cells Present in Lymphoid Tissue and Viral Load of Untreated Chronically HIV-1 Infected Individuals

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys/Red Cloud
19:30—22:00
Poster Session 3

Shavano/Torreys/Red Cloud

FRIDAY, MARCH 31

07:00—08:00
Breakfast

Shavano/Torreys/Red Cloud
08:00—11:15
Lessons from Therapy
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John M. Coffin, Tufts University, USA
Host-Virus Interactions

François Clavel, IUH, Université Paris Diderot, France
HIV Drug Resistance : Viral Strategies for Treatment Escape

Roland Marquet, IBMC du Centre National de la Recherche Scientifique, France
Short Talk: Targeting the Dimerization Initiation Site of HIV-1 Genomic RNA with Aminoglycosides: From Crystal to Cell

Andreas Schweizer, University Hospital Zurich, Switzerland
Short Talk: CD4-Specific Designed Ankyrin Repeat Proteins Potently Inhibit HIV Entry

Monica Macal, Five Prime Therapeutics, Inc, USA
Short Talk: Restoration of the Gut Mucosal Immune System in HIV Infected Patients during HAART

Ruy M. Ribeiro, University of Lisbon, Portugal
Short Talk: Naïve and Memory Cell Turnover as Drivers of CCR5 to CXCR4-Tropism Switch in HIV-1: Implications for Therapy


Following Session is for HIV Vaccines (X6)

08:00—11:30
Mucosal Immunity / Preclinical Studies
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Satya Dandekar, University of California, Davis, USA

* Herman F. Staats, Duke University Medical Center, USA

Barbara L. Shacklett, University of California, Davis, USA
HIV-1 Specific T-Cell Responses in Mucosal Tissues

Susan W. Barnett, Bill & Melinda Gates Foundation, USA
Trimeric HIV Env: Improved Adjuvants and Delivery

Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA
Distinct Immunogenic Properties of the SF162 Env on Infectious Virions and Soluble gp140 Protein

Julia L. Hurwitz, St. Jude Children's Research Hospital, USA
Pre-Clinical and Clinical Development of a Multi-Envelope HIV-1 Vaccine

Thorsten Demberg, NCI, National Institutes of Health, USA
Short Talk: Immunogenicity and Protective Efficacy of Prime/Boost Vaccine Regimens based on Replication-Competent Ad Recombinants Encoding HIVtat, HIVenv, SIVgag, and SIVnef in a Rhesus Macaque SHIV89.6P Challenge Model

Andreas Mörner, Public Health Agency of Sweden, Sweden
Short Talk: CD4 and CD8 IFN-gamma and IL-2 Responses and Control of SHIV Replication in Macaques Immunized with Multi-Gene Cocktail DNA or SFV followed by MVA

Siew Yen Chong, Wyeth Pharmaceuticals, USA
Short Talk: Immunogenicity of Attenuated Recombinant Vesicular Stomatitis Virus Vectors Expressing HIV GAG in Rhesus Macaques

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys/Red Cloud
13:00—22:00
Poster Viewing

Shavano/Torreys/Red Cloud

Following Session is for HIV Vaccines (X6)

14:30—16:30
Workshop 2: Neutralizing Antibodies

Longs Peak
* Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA

Miroslaw K. Gorny, New York University School of Medicine, USA
A Neutralizing Epitope is Present on Env Trimers but not Monomers Expressed on the Virions Pseudotyped with Env SF162

* Harriet L. Robinson, GeoVax Inc., USA
Correlation of the Avidity of anti-Env Ab with Neutralizing Activity for Incident Isolates

Yuxing Li, University of Maryland, USA
Analysis of the Neutralizing Specificity in Complex Polyclonal Sera

Rogier W. Sanders, Weill Medical College of Cornell University, USA
Functional Improvement of V1/V2-Deleted HIV-1 gp120 through Forced Virus Evolution

Hui Li, University of Pennsylvania, USA
Conservation of the Neutralization Epitope for 4E10, but not 2F5, in Human and Simian Immunodeficiency Viruses of Diverse Evolutionary Origins

Madhumita Mahalanabis, University of Washington, USA
Key Mutations in SIV Envelope of Macaques with Heterologous Neutralizing Antibody Responses

Dan H. Barouch, Harvard Medical School/Beth Israel Deaconess Medical Center, USA
Hexon-Chimeric Adenovirus Serotype 5 Vectors Effectively Circumvent Pre-Existing Anti-Vector Immunity

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Lessons from the Tissues
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* James E.K. Hildreth, UC Davis College of Biological Sciences, USA

Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
HIV Resevoirs, Latency, and Evolution

Thijs van Montfort, Academic Medical Center, Netherlands
Short Talk: Transfer of Antibody Neutralized HIV-1 from Dendritic Cells and DC-SIGN Expressing Cells to CD4 Lymphocytes

Jason M. Brenchley, NIAID, National Institutes of Health, USA
Short Talk: Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy

Paul J. Peters, University of Massachusetts, USA
Short Talk: Macrophage-Tropic R5 Envelopes are Infrequent in Blood, Lymph Nodes and Semen: Implications for Transmission and Pathogenesis

Jacob D. Estes, Frederick National Laboratory / LBR, Inc., USA
Short Talk: Rapid Secondary Lymphatic Tissue Fibrosis in Pathogenic SIV-Infected Rhesus Macaques Mediated by TGFbeta1+ Tregs

Jean-Charles J. B. Grivel, NICHHD, National Institutes of Health, USA
Short Talk: HIV-1 Replication in Rectal Mucosa and Tonsillar Explant


Following Session is for HIV Vaccines (X6)

17:00—19:30
Correlates of Protection Against Infection or Disease
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Louis J. Picker, Oregon Health & Science University, USA

Marta L. Marthas, California National Primate Research Center, USA
Role for Innate Immunity in Protection of Vaccinated Infant Macaques Against Oral SIV: Has Terminology Limited How We Evaluate Vaccine Immunogenicity and Efficacy?

* Neil Almond, National Institute Biology Standards, UK
The Characterisation of Protection Conferred by Live Attenuated SIV


Short Talk: New Innate Immune Correlates in Caucasian HIV Exposed Uninfected Individuals

Genoveffa Franchini, NCI, National Institutes of Health, USA
Importance of CD4+ T Cells in the Maintenance of SIV-Specific CD8+ T Memory Cells and their Role in Protection from SIVmac251

Melissa Precopio, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Immunization with Vaccinia Virus Induces Polyfunctional T Cell Responses

Scott A. Brown, St. Jude Children's Research Hospital, USA
Short Talk: HIV-1-Envelope-Specific CD4+ T-Cells Control Virus Challenge without CD8+ T-Cell or B-Cell Contributions in a Mouse Model System

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys/Red Cloud
19:30—22:00
Poster Session 4

Shavano/Torreys/Red Cloud

SATURDAY, APRIL 1

07:00—08:00
Breakfast

Shavano/Torreys/Red Cloud
08:00—11:15
Lessons from Animal Models
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
Ronald C. Desrosiers, University of Miami Miller School of Medicine, USA
Replication-Competent and Replication-Incompetent SIV as Vaccines

Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Inactivated Vaccines

Louis J. Picker, Oregon Health & Science University, USA
New Insights in SIV Immunopathogenesis -- Connecting Viral Replication to Disease

* Janice E. Clements, Johns Hopkins University, USA
Innate Immune Responses Regulate SIV Replication in Macrophages In Vivo

Miles P. Davenport, University of New South Wales, Australia
Short Talk: Viral Load Predicts CD4+ T Cell Depletion in Acute SHIV Infection of Macaques

Julie TerWee, Colorado State University, USA
Short Talk: Cellular Signaling following Receptor Engagement: Correlates with Pathogenicity


Following Session is for HIV Vaccines (X6)

08:00—11:00
Clinical Trials: Prophylactic Vaccines
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Gary J. Nabel, Sanofi, USA

* Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA

Barney S. Graham, NIAID, National Institutes of Health, USA
Update on VRC Clinical Trials

John A. Hural, HIV Vaccine Trials Network, USA
Short Talk

Barbara Ensoli, Istituto Superiore di Sanita, Italy
Tat-Based Vaccines: From Basic Science to Clinical Trials

Nelson L. Michael, Walter Reed Army Institute of Research, USA
U.S. Military HIV Research Program Preventive Vaccine Trials

Shan Lu, University of Massachusetts Medical Center, USA
Short Talk: Update on the Immunogenicity and Safety of the Polyvalent DNA Prime-Protein Boost HIV-1 Vaccine Formulation DP6-001 in Healthy Volunteers

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Lessons from the Real World
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA

Grace John-Stewart, University of Washington, USA
Maternal-Infant HIV-1 Transmission

Eric Hunter, Emory University, USA
Early Events in HIV Infection: Lessons from Transmission Pairs

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Elite Control of HIV Replication: Towards an Understanding of the Correlates of Immune Control

Anu Rebbapragada, University of Toronto, Canada
Short Talk: HSV2 and HIV Interaction: Negative Synergy in the Female Genital Tract


Following Session is for HIV Vaccines (X6)

17:00—19:00
Immune Therapy in HIV and Cancer
Meeting has ended...abstracts no longer viewable online.

Longs Peak
* Genoveffa Franchini, NCI, National Institutes of Health, USA

* Barney S. Graham, NIAID, National Institutes of Health, USA

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Interstitial Dendritic Cells and Langerhans Cells Prime Humoral and Cellular Immunity Respectively

Montserrat Plana, Hospital Clinic, Spain
Short Talk: Functional and Phenotypic Characterization of HIV-Specific CD8 T Cells after Autologous Dendritic Cells Based Therapeutic Vaccine

Monica Vaccari, NCI, National Institutes of Health, USA
Short Talk: CTLA4 Blockade In Antiretroviral Therapy-Treated SIVmac251-Infected Macaques Does Not Augment Global T Cell Activation And Viral Replication

Johan K. Sandberg, Karolinska Institute, Sweden
Short Talk: Expansion of CD1d-Restricted NKT Cells in Patients with Primary HIV-1 Infection Treated with Interleukin-2

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys/Red Cloud
20:00—23:00
Entertainment

Shavano/Torreys/Red Cloud

SUNDAY, APRIL 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068352-01




We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Gilead Sciences, Inc.
Office of AIDS Research, NIH
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676