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This meeting took place in 2006



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G Protein-Coupled Receptors: Evolving Concepts and New Techniques (C1)


Organizer(s) Paul A. Insel, Graeme Milligan and Dianne M. Perez
February 12—17, 2006
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 12, 2005
Late Abstract Deadline: Nov 3, 2005
Scholarship Deadline: Oct 12, 2005
Early Registration Deadline: Dec 12, 2005

Supported by The Director's Fund

Summary of Meeting:
G-protein-coupled receptors (GPCRs), which comprise one of the largest gene families identified in the human genome, also represent the largest number of currently used targets of therapeutic drugs. Recent work has indicated a number of intriguing observations in terms of GPCR structure, function and regulation, including existence of receptor homodimers and heterodimers, genetic identification of orphan GPCRs, novel receptor interacting proteins, mechanisms involved in receptor deactivation/desensitization, and receptor targeting/action in signalling microdomains. Definitive information about each of these topics is still being developed. This symposium will focus on these and related topics with an emphasis on use of new tools, e.g., bioinformatic approaches to evaluate GPCR family members, novel strategies to identify ligands active at GPCRs, and insights from non-mammalian/lower eukaryotic systems.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 12

15:00—19:30
Registration

Shavano Peak Foyer
18:30—19:30
Refreshments

Shavano Peak Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Paul A. Insel, University of California, San Diego, USA

Charles S. Zuker, HHMI, Columbia University, USA
Molecular Approaches for the Study of Taste Recepters


MONDAY, FEBRUARY 13

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
GPCR Structure
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
Jean-Philippe Pin, Montpellier University, France
Asymmetric functioning of GPCR dimers

Jean-Louis Banères, CNRS - UMR5247 IBMM, France
Molecular Mechanisms of Activation of GPCRs

Edward C. Hulme, National Institute for Medical Research, UK
The Structure and Function of Muscarinic Cholinergic Receptors

Laurence J. Miller, Mayo Clinic, USA
GPCR Structures: Lessons from the Cholecystokinin Receptor

Marissa L. Matsumoto, Washington University School of Medicine, USA
Short Talk: A Comprehensive Genetic Map of the Intracellular Surface of the Human C5a Receptor

Paul S.H. Park, Case Western Reserve University, USA
Short Talk: Unfolding Pathways of the Light Receptor Rhodopsin Revealed By Single-Molecule Force Spectroscopy

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:15—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:00—16:30
Coffee Available

Shavano Peak Foyer
16:30—19:00
GPCR/G-Protein Interaction
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
GPCR Activation: Studies with FRET

* Heidi E. Hamm, , USA

William M. Oldham, Brigham and Women's Hospital, USA
How do GPCRs Catalyze G Protein Activation?

Eric R. Prossnitz, University of New Mexico, USA
Estrogen-mediated Signaling via GPR30

Douglas P. Gladue, Stony Brook University, USA
Short Talk: A Site Directed Chemical Crosslinking Approach for Mapping the Interface between Receptor and G Protein

Marie Mi Bonde, Institute for Neuroscience and Pharmacology, Denmark
Short Talk: Molecular Determinants of G-Protein Coupled Receptor Activation

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
19:30—22:00
Poster Session 1

Torreys Peak 1-4

TUESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:30
GPCR Dimerization
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Graeme Milligan, University of Glasgow, UK

Wayne A. Hendrickson, Columbia University, USA
Structural Studies on Receptors for Follicle Stimulating Hormone and for Serotonin

Michel Bouvier, University of Montreal, Canada
Oligomeric and Modular Protein Assemblies in 7TM Receptor Signaling

Susan R. George, University of Toronto, Canada
Implications of Heterooligomerization of Dopamine Receptors: Novel Insights into Function

Lakshmi A. Devi, Mount Sinai School of Medicine, USA
Opioid receptor dimerization: signaling, analgesia and addiction

Juan F. Lopez-Gimenez, IBLS,University of Glasgow, UK
Short Talk: Molecular Organization of the Alpha1b-Adrenoceptor Probed using Sequential Three Color Fluorescent Resonance Energy Transfer: Implications for Receptor Function

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:30—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:00—16:30
Coffee Available

Shavano Peak Foyer
16:30—19:00
Orphan GPCRs
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Susan R. George, University of Toronto, Canada

Robert Fredriksson, Uppsala University, Sweden
Evoulution of the GPCR family

Gozoh Tsujimoto, Kyoto University, Japan
GPR120 and Family of Fatty Acid Binding GPCRs

Ruben Abagyan, University of California, San Diego, USA
Predicting Biomolecular Interactions

Hans Bräuner-Osborne, University of Copenhagen, Denmark
Short Talk: Deorphanization of GPRC6A: A Receptor with Preference for Basic L-alpha-Amino Acids

Ralf Jockers, Institute Cochin, France
Short Talk: The Orphan GPR50 Receptor Specifically Antagonizes MT1 Melatonin Receptor Function through Heterodimerization

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
19:30—22:00
Poster Session 2

Torreys Peak 1-4

WEDNESDAY, FEBRUARY 15

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:15
GPCR Knockouts and Mouse Models
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Dianne M. Perez, Cleveland Clinic Foundation, USA

Jürgen Wess, National Institutes of Health, USA
Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes

Bruce R. Conklin, Gladstone Institutes, USA
Designing New GPCRs to RASSL with in vivo Responses

Paul C. Simpson, VA Medical Center & University of California, San Francisco, USA
Insights from Adrenergic Receptor Knockouts

Stefan Offermanns, Universität Heidelberg, Germany
Nicotinic Acid Receptor - Pharmacological and Physiological Functions

Richard Torres, Regeneron Pharmaceuticals Inc., USA
Short Talk: Age-Related Balance Impairment in Mice Lacking VG1037, an Orphan GPCR Localized to Brain Motor Systems

Javier González-Maeso, Mount Sinai School of Medicine, USA
Short Talk: Agonist-Directed Trafficking of 5-HT2A Receptor Signaling: Selective Cellular and Behavioral Response Induced by Hallucinogenic Drugs

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:00—16:30
Coffee Available

Shavano Peak Foyer
16:30—19:15
GPCR Desensitization and Turnover
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Michel Bouvier, University of Montreal, Canada

Jeffrey L. Benovic, Thomas Jefferson University, USA
Regulation of GPCR Endocytosis by Arrestins: A role for PI

Jennifer L. Whistler, University of California, San Francisco, USA
RAVE, Trafficking, and Addiction: A GPCRS Journey

Marc G. Caron, Duke University Medical Center, USA
A Role for the G protein-Coupled Receptor Kinase 2 (GRK2) in the Hedgehog/Patched/Smoothened Signaling Pathway

Laura R. Johnson, Medical Research Council, UK
Short Talk: Nuclear Localization of the GRK4 Subfamily of GRKs

Nicola J. Smith, Victor Chang Cardiac Research Institute, Australia
Short Talk: Beta-Arrestin-Dependent Erk1/2 Activation is Not Required for Epidermal Growth Factor Receptor Transactivation or Hypertrophy in Cardiomyocytes

Aliesha Araceli González-Arenas, Instituto de Fisiología Celular UNAM, Mexico
Short Talk: Estrogens Regulate alpha1b-Adrenergic Receptors Through Signalplex Formation

Faiza Baameur, University of Texas Health Science Center, USA
Short Talk: Rates of Dephosphorylation of â2-Adrenergic Receptor PKA and GRK Sites; Dissociation from Resensitization

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
19:30—22:00
Poster Session 3

Torreys Peak 1-4

THURSDAY, FEBRUARY 16

07:00—08:00
Breakfast

Torreys 1-4
08:00—11:00
GPCRs in Sensation and Inflammation
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Jean-Philippe Pin, Montpellier University, France

Thomas E. Angel, Pacific Northwest National Laboratory, USA
Antibody Imprinting- using an Anti-rhodopsin Antibody to Study Protein Surface Structure

Sarah Spiegel, Virginia Commonwealth University, USA
Sphingosine-1-Phosphate Receptors in Allergy and Inflammation

Richard D. Ye, University of Illinois, USA
Leukocyte Chemoattractant Receptors and Inflammatory Cytokine Expression

Ingrid Langer, Université Libre de Bruxelles, Belgium
Short Talk: New Mechanism of CCK2R Regulation through Direct Interaction with RGS2

Richard W. Roberts, University of Southern California, USA
Short Talk: Extension of Drosophila Lifespan using a Selected Peptide Inhibitors of the Methuselah G Protein-Coupled Receptor

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:00—16:30
Coffee Available

Shavano Peak Foyer
16:30—19:00
GPCRs and Human Disease
Meeting has ended...abstracts no longer viewable online.

RedCloud/Shavano
* Paul A. Insel, University of California, San Diego, USA

Gilbert Vassart, Université Libre de Bruxelles, Belgium
Glycoprotein Hormone Receptors: From Natural Variants to Structure and Function

Sheila Collins, Vanderbilt University Medical Center, USA
Adipocyte beta-ARs: Signaling Networks Linking PKA and MAPKs Regulating Metabolism and Thermogenesis

Roger D. Cone, University of Michigan, USA
Melanocortin Receptor Signaling

Holger Römpler, Max Planck Institute for Evolutionary Anthropology, Germany
Short Talk: Functional Analysis of a Complete Nuclear Genome from Pleistocene Mammoth

Zhaohui Jin, Children's Hospital Boston, USA
Short Talk: Posttranslational Modification of G Protein-coupled Receptor 56 (GPR56) is Essential for Its Function

19:00—20:00
Social Hour with Lite Bites

Torreys Peak 1-4
20:00—23:00
Entertainment

Torreys Peak 1-4

FRIDAY, FEBRUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676