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This meeting took place in 2006



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Lipid Rafts and Cell Function (D2)


Organizer(s) Linda J. Pike and Michael A. Edidin
March 23—28, 2006
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 22, 2005
Late Abstract Deadline: Dec 16, 2005
Scholarship Deadline: Nov 22, 2005
Early Registration Deadline: Jan 23, 2006

Supported by The Director's Fund

Summary of Meeting:
Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They were originally implicated in lipid trafficking, but now appear to be involved in a plethora of biological processes including signal transduction, endocytosis and protein and lipid sorting. Studies of lipid rafts have been hampered by the lack of appropriate methods to analyze them in intact cells and an insufficient understanding of their mechanism of formation and biological function within cells. This conference will examine several important issues related to the structure and function of lipid rafts including: i) biophysical and biochemical methods for the visualization and analysis of lipid rafts; ii) biogenesis of rafts and their size; iii) the role of rafts in signal transduction.; and, iv) the role of rafts in endocytosis and protein processing.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 23

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Ari Helenius, ETH Zurich, Switzerland
The Role of Membrane Domains in Animal Virus Entry


FRIDAY, MARCH 24

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:00
Biophysics of Lipid Domains I
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Sarah L. Veatch, Cornell University, USA
Complex Phase Behavior in ‘Simple’ Membranes

John R. Silvius, McGill University, Canada
Physical Studies of Domains in Model and Biological Membranes

Stuart G. McLaughlin, Stony Brook University, USA
PIP2, Proteins, and Lipid Rafts

* Ken Jacobson, University of North Carolina at Chapel Hill, USA
Nanoscale Signal Transduction Across the Plasma Membrane

Luana Lea Scheffer, Weizmann Institute of Science, Israel
Short Talk: Antibody Detection of Plasma Membrane Domains Enriched in Ceramide and Cholesterol

09:20—09:40
Coffee Break

Sunshine
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Sunshine
17:00—19:00
Biophysics of Lipid Domains II
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Satyajit Mayor, National Centre for Biological Sciences, India
Size of Lipid Rafts in vivo: Lessons from Examining Segregation of GPI-Anchored Proteins in Membranes of Living Cells

Anne K. Kenworthy, Vanderbilt University School of Medicine, USA
Raft Dynamics: Chasing a Moving Target

* Barbara A. Baird, Cornell University, USA
Lipid Segregation and Plasma Membrane Interactions Related to IgE-Receptor Signaling

Fabien Pinaud, , USA
Short Talk: In & Out of Lipid Rafts: A Quantum Dot View of the Cell Membrane Structure

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 1

Sunshine

SATURDAY, MARCH 25

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:00
Rafts and Cell Signaling
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
* Paul A. Insel, University of California, San Diego, USA
Lipid Rafts in Signaling via Adenylyl Cyclase

James Alan Shayman, University of Michigan, USA
Using Small Molecule Inhibitors to Study the Role of Glycosphingolipids in the Regulation of Phospholipase C

Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
Insulin Receptor Signaling in Fyn Knockout Mice

Linda J. Pike, Washington University School of Medicine, USA
Cholesterol-dependent Clustering of the EGF Receptor Investigated in Live Cells by Fluorescence Cluster Analysis

Erik Hofman, University of Utrecht, Netherlands
Short Talk: EGF Receptor Colocalization with Gangliosides during Signalling

09:20—09:40
Coffee Break

Sunshine
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
14:30—16:30
Workshop: Visualizing Membrane Domains: The Size of Lipid Rafts

Storm Peak / Mt. Werner
* Michael A. Edidin, Johns Hopkins School of Medicine, USA

Toyoshi Fujimoto, Nagoya University Graduate School of Medicine, Japan
Immunoelectron Microscopy of Quick-Frozen and Freeze-Fractured Membranes Revealed Heterogeneous GM1 and GM3 Microdomains in the Cell Membrane

Alan R. Burns, Sandia National Laboratories, USA
Probing Domains in the Inner Plasma Membrane with Simultaneous Atomic Force Microscopy and Fluorescence Imaging

Anil Bamezai, Villanova University, USA
Role of a â2 Integrin in Spatial Organization of Cholesterol-Rich Microdomains on CD4+ T Cell Plasma Membrane during T Cell-Antigen Presenting Cell Interaction

Mika Ruonala, Center for Membrane Proteomics, Germany
The Segregation and Aggregation of Lipid Microdomains during Cytoskeletal Reorganization

John F. Hancock, University of Texas Health Science Center, USA

Satyajit Mayor, National Centre for Biological Sciences, India

Ken Jacobson, University of North Carolina at Chapel Hill, USA

16:30—17:00
Coffee Available

Sunshine
17:00—19:00
Targeting Proteins to Lipid Rafts
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
John F. Hancock, University of Texas Health Science Center, USA
Ras Plasma Membrane Signaling Platforms

Enrico Gratton, University of Illinois at Urbana Champaign, USA

* Deborah A. Brown, Stony Brook University, USA
Non-Clathrin-Mediated Endocytosis of ErbB2 in Geldanamycin-Treated Human Breast Cancer Cells

Natalie Bezman, Bristol-Myers Squibb Company, USA
Short Talk: Dissection of ITAM and Integrin Signaling Pathways in Hematopoietic Cells by Targeting SLP-76 to Lipid Rafts

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 2

Sunshine

SUNDAY, MARCH 26

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:00
Rafts and Immune Signaling
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Daved Fremont, Washington University School of Medicine, USA
Structural Biology of Immunoreceptors

Antonella Viola, University of Milan, Italy
Lipid Rafts in Lymphocyte Activation

Tony Magee, Imperial College London, UK
Lipid Rafts, Protein S-Acylation and Immune Cell Signaling

* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Antigen-Induced Association of the B Cell Receptor with Lipid Rafts Visualized in Living Cells by FRET

Neetu Gupta, Cleveland Clinic, USA
Short Talk: A Role for Ezrin in the Regulation of Lipid Raft Dynamics During B Cell Activation

09:20—09:40
Coffee Break

Sunshine
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Sunshine
17:00—19:00
Processing of Protein in Lipid Rafts
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
Albert Taraboulos, Hebrew University of Jerusalem, Israel
Prions and Lipid Rafts

Nicole Watt, University of Leeds, UK
Lipid Rafts in the Processing of the Amyloid Precursor Protein and Prion Protein

Gopal Thinakaran, University of Chicago, USA
Gamma-Secretase Localization and Processing of APP in Lipid Rafts

Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany
Short Talk: Application of Quantum Dots to Mimic Virus Binding and Uptake via Nanoclusters of the Pathogen Receptor DC-SIGN

19:00—20:00
Social Hour with Lite Bites

Foyer
19:30—22:00
Poster Session 3

Sunshine

MONDAY, MARCH 27

07:00—08:00
Breakfast

3 Saddles / Bear River
08:00—11:00
Caveolin and the Targeting of Lipids
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
* Richard G.W. Anderson, University of Texas Southwestern Medical Center, USA
Mechanism of Adiposome Biogenesis

T.Y. Chang, Dartmouth Medical School, USA
Cholesterol Sensing, Trafficking and Esterification

Cynthia Corley Mastick, University of Nevada, USA
Phosphorylation of Caveolin and Regulation of Src-Family Kinases by Csk

Miguel A. del Pozo, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
EMBO Young Investigator Lecture: Caveolin and Integrins in Internalization of Plasma Membrane Microdomains

Paul F. Pilch, Boston University School of Medicine, USA
Short Talk: Caveolin-1/Cholesterol Modulates Transmembrane Fatty Acid Movement

09:20—09:40
Coffee Break

Sunshine
16:30—17:00
Coffee Available

Sunshine
17:00—19:00
Endocytosis and Trafficking via Lipid Rafts
Meeting has ended...abstracts no longer viewable online.

Storm Peak / Mt. Werner
* Eric O. Freed, NCI, National Institutes of Health, USA
Role of Lipid Microdomains in HIV-1 Replication

Joshua Zimmerberg, NICHD, National Institutes of Health, USA
Self-Assembly of the Influenza Hemagglutinin in the Plasma Membrane

Wayne Lencer, Children's Hospital Boston, USA
Retrograde Trafficking of Cholera Toxin by Lipid Raft Gangliosides

Amit Choudhury, Mayo Clinic, USA
Short Talk: Regulation of Caveolar Endocytosis by Syntaxin 6-Dependent Delivery of Membrane Components to the Cell Surface

19:00—20:00
Social Hour with Lite Bites

Foyer
20:00—23:00
Entertainment

Sunshine

TUESDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 GM076901-01




We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


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