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This meeting took place in 2006



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Wnt and beta-Catenin Signaling in Development and Disease (E1)


Organizer(s) Mariann Bienz and Hans C. Clevers
April 7—12, 2006
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 7, 2005
Late Abstract Deadline: Dec 30, 2005
Scholarship Deadline: Dec 7, 2005
Early Registration Deadline: Feb 7, 2006

Sponsored by Genentech, Inc.

Summary of Meeting:
The Wnt/b-catenin pathway is a highly conserved signaling cascade that plays key roles during animal development. Deregulation of this pathway is often associated with cancer, especially in the human intestinal epithelium where hyperactive b-catenin is thought to initiate colorectal cancer. The basic outline of the Wnt/b-catenin cascade has been known since its discovery ten years ago by genetic analysis in Drosophila. How its components interact molecularly to transduce the Wnt signal from the plasma membrane to the nucleus is still poorly understood. Indeed, recent research in model systems has revealed new core components of this pathway. The main goal of this meeting is to promote insight into the molecular and cell-biological mechanisms of Wnt signal transduction in various cellular systems. Basic researchers and the pharmaceutical/biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 7

15:00—19:30
Registration

Ballroom Lobby
18:30—19:30
Refreshments

Ballroom Mezzanine & Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling in Development and Disease


SATURDAY, APRIL 8

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest/Superior Lobby
08:00—11:00
Wnt Signaling at the Plasma Membrane
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Walter Birchmeier, Max Delbruck Center for Molecular Medicine, Germany

Roeland Nusse, HHMI/Stanford University, USA
Wnt Proteins as Cell Fate Determinants

Konrad Basler, University of Zurich, Switzerland
Wnt Signaling during Drosophila Development

Xi He, Harvard Medical School, USA
Wnt coreceptor LRP6 phosphorylation and activation

Christof Niehrs, Deutsches Krebsforschungszentrum, Germany
Casein Kinase 1 gamma Couples Wnt Receptor Activation to Cytoplasmic Signal Transduction

Akira Kikuchi, Hiroshima University, Japan
Short Talk: Caveolin-Mediated Endocytosis of LRP6 is Required for Activation of Wnt/beta-Catenin Pathway

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:15
Wnt Signaling in the Cytoplasm and Nucleus
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Randall T. Moon, University of Washington School of Medicine, USA

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Wnt Signal Transduction by Dishevelled

William I. Weis, Stanford University, USA
Displacement of TLE/Groucho Proteins From Tcfs by beta-Catenin in Wnt-mediated Transcription Activation

Marian Waterman, University of California, Irvine, USA
TCF Diversity and Wnt Target Gene Regulation

Stefan Hoppler, University of Aberdeen, UK
Short Talk: Distinct Roles for Xenopus Tcf/Lef Genes in Mediating Specific Responses to Wnt/beta Catenin Signaling in Mesoderm Development

Xing Dai, University of California, Irvine, USA
Short Talk: Mouse Pygopus 2 is Required for Epithelial Morphogenesis and Controls the Amplitude of Canonical Wnt Signaling

19:15—20:15
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Maybird

SUNDAY, APRIL 9

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest/Superior Lobby
08:00—11:00
Nuclear Responses of Wnt Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Mariann Bienz, MRC Laboratory of Molecular Biology, UK

Wenqing Xu, University of Washington, USA
Structural Analysis of beta-Catenin and beta-Catenin Complexes

Ken M. Cadigan, University of Michigan, USA
Short Talk: Transcriptional Activation by Wnt Signaling Requires CtBP and CBP

Walter Birchmeier, Max Delbruck Center for Molecular Medicine, Germany
Essential Role of BCL9-2 in the Switch between ß-Catenin’s Adhesive and Transcriptional Functions

Marc van de Wetering, Netherlands Institute for Developmental Biology, Netherlands
Short Talk: TCF4 Target Genes in Intestinal Cancer

Katherine A. Jones, The Salk Institute, USA
The APC Tumor Suppressor Counteracts ß-Catenin Activation and H3K4 Trimethylation at Wnt Target Genes

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:15
Non-Nuclear Responses of Wnt Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Roeland Nusse, HHMI/Stanford University, USA

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Beta-Catenin Signaling during Skin Development

Jeffrey D. Axelrod, Stanford University, USA
Frizzled feedback loop function during Planar Cell Polarity Signaling

Sergei Y. Sokol, Mount Sinai School of Medicine, USA
Short Talk: Regulation of Epithelial Polarity by Lgl and Dishevelled

Randall T. Moon, University of Washington School of Medicine, USA
Beta-Catenin-Independent Wnt Signaling

Ping Chen, Emory University, USA
Short Talk: A Non-Canonical Wnt Pathway during Inner Ear Development

19:00—20:00
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Maybird

MONDAY, APRIL 10

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest/Superior Lobby
08:00—11:00
Wnt Signaling in Development
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Mark Peifer, University of North Carolina at Chapel Hill, USA

Alan R. Clarke, Cardiff University, UK
Investigating The Wnt Pathway In Vivo Through Inactivation of Apc and c-Myc

Thomas W. Holstein, Heidelberg University, Germany
Wnt Signaling in Cnidarians

Kyung-Ah Kim, Nuvelo, Inc., USA
Beta-Catenin-Mediated Mitogenic Effect of R-spondin

Tannishtha Reya, University of California, San Diego, USA
Molecular Regulation of Stem Cell Renewal and Regeneration

Juan Carlos Izpisua-Belmonte, The Salk Institute for Biological Studies, USA
Short Talk: Wnt Signaling and Tissue Regeneration

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby/Maybird
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Maybird
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:15
Wnt Signaling and Colorectal Cancer
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* William I. Weis, Stanford University, USA

Raymond N. DuBois, Arizona State University, USA
Important Crosstalk between the COX-2--prostaglandin E2 and Wnt Signaling Pathways

David A. Jones, University of Utah, USA
Analysis of Colorectal Cancer Signaling Pathways by Microarray.

Owen J. Sansom, Beatson Institute of Cancer Research, UK
Short Talk: C-Myc is Essential for all the Intestinal Phenotypes (including tumourigenesis) caused by Apc Deficiency in vivo

Makoto Mark Taketo, Kyoto University, Japan
Wnt Signaling and Chromosomal Instability in Gastrointestinal Cancer

Christine Perret, Institut Cochin, France
Short Talk

19:15—20:15
Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Maybird

TUESDAY, APRIL 11

07:00—08:00
Breakfast

Golden Cliff/Eagles Nest/Superior Lobby
08:00—11:00
Exploiting Model Systems
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Paul G. Polakis, Genentech, Inc., USA

Mark Peifer, University of North Carolina at Chapel Hill, USA
APC Family Proteins as Regulators of Wnt Signaling and the Cytoskeleton

Katherine E. Harris, University of California, Berkeley, USA
Short Talk: WNT5 Signaling Acts through the Atypical Receptor, DERAILED, to Guide Salivary Gland Migration

Laura W. Burrus, San Francisco State University, USA
Short Talk: Analysis of the Role of Porcupine/Palmitoylation in the Formation of the Wnt Gradient in the Chick Neural Tube

Hendrik C. Korswagen, Netherlands Institute for Developmental Biology, Netherlands
Wnt gradient formation requires retromer function in Wnt producing cells

Anna Bafico, Mount Sinai School of Medicine, USA
Short Talk: Characterization of Endogenous LRP6 Receptor Signaling in Model Cells and Breast/Ovarian Tumor Cells

Michel Aguet, Swiss Institute for Experimental Cancer Research, Switzerland
Mouse Mutants of the Wnt Signaling Components Bcl9 and Pygo

09:20—09:40
Coffee Break

Ballroom Mezzanine & Lobby
16:30—17:00
Coffee Available

Superior/Superior Lobby/Maybird
17:00—19:15
Drug Targets in the Wnt Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Makoto Mark Taketo, Kyoto University, Japan

Paul G. Polakis, Genentech, Inc., USA
Therapeutic intervention in the wnt signaling pathway.

David M. Jablons, University of California, San Francisco, USA
Developing Therapeutic Inhibitors of Wnt Signaling for Cancer Treatment: Antibodies to Small Molecules

Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA
Small-Molecule Antagonists of the beta-Catenin/TCF Interaction

Xiaoyan Michelle Zhang, Curis, Inc, USA
Short Talk: Identification of Small Molecule Antagonists of Wnt Signaling

Mark Lee, Google, Inc., USA
Short Talk: Systemically Expressed Wnt Inhibitors as Probes for Wnt Pathway Functions in Cancer and Normal Adult Physiology

Jie Zheng, St. Jude Children's Research Hospital, USA
Short Talk: Structure-Based Investigation of Wnt Signaling Inhibitors

19:30—20:30
Social Hour with Lite Bites

Golden Cliff/Superior/Superior Lobby/Wasatch
20:00—23:00
Entertainment

Golden Cliff

WEDNESDAY, APRIL 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 HD052386-01




We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Genentech, Inc.
Novartis Institutes for BioMedical Research
 

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