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This meeting took place in 2006



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NF-kappaB: 20 Years on the Road from Biochemistry to Pathology (D3)


Organizer(s) Alain Israël, David Baltimore and Yinon M. Ben-Neriah
March 23—28, 2006
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 23, 2005
Late Abstract Deadline: Dec 16, 2005
Scholarship Deadline: Nov 23, 2005
Early Registration Deadline: Jan 23, 2006

Supported by The Director's Fund

Summary of Meeting:
The NF-kB signaling pathway is a critical determinant of the inflammatory response, and is involved in both innate and acquired immunity. It also controls apoptosis and is becoming an important target for anticancer therapy. While the components that lead to NF-kB activation are progressively identified, evidence for involvement of NF-kB in multiple human pathologies (cancer, immune deficiencies, diabetes and atherosclerosis) is accumulating. However, a number of questions remain unanswered: the structure of the IKK complex needs to be solved to understand its mode of activation; the respective roles of the multiple NF-kB species have to be precisely defined; the exact function of the multiple components and branches of this cascade need to be addressed by biochemical and genetic approaches. This meeting will bring together people with diverse backgrounds and should generate interactions required for better understanding of this pathway and its associated pathophysiology. Ultimately, these interactions could be translated into new therapeutic modalities.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, MARCH 23

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
David Baltimore, California Institute of Technology, USA
NF-kappaB, 20 Years After


FRIDAY, MARCH 24

07:00—08:00
Breakfast

Alberta, New Brunswick, Riverview
08:00—11:15
Signaling 1
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Alain Israël, Institut Pasteur, France

Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Functions

Sankar Ghosh, Columbia University, USA
Regulation of NF-kappaB Transcriptional Activity

George Mosialos, B.S.R.C. Alexander Fleming, Greece
Short Talk: Targeted Inactivation of the Cylindromatosis Tumor Suppressor Gene Causes Perinatal Lethality in Mice

Jun Zhang, National Institutes of Health, USA
Short Talk: CYLD-deficient Mice Display Impaired Regulation of NF-kB and Increased Susceptibility to Colonic Inflammation and Tumorigenesis

Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Short Talk: CYLD: A Novel Target of IKK Regulating Lck Ubiquitination and T Cell Development

Thomas D. Gilmore, Boston University, USA
Short Talk

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15—13:00
Poster Setup

Alberta, New Brunswick, Riverview
13:00—22:00
Poster Viewing

Alberta, New Brunswick, Riverview
16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Signaling 2
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Vishva M. Dixit, Genentech, Inc., USA
Deciphering the Pathway from the TCR/BCR to NF-kappaB: New Functions for Old Molecules

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Mavericks Defense: A Tale of Host Defense Against Viral Offense

Jorge Moscat, Sanford Burnham Prebys Institute, USA
PKCzeta Signaling in the NF-kB Pathways

Ezra Burstein, University of Texas Southwestern Medical Center, USA
Short Talk: COMMD Proteins Inhibit kappaB-Mediated Transcription by Promoting the Ubiquitination of NF-kappaB Subunits through a Cullin E3 Ligase

19:00—20:00
Social Hour with Lite Bites

Alberta, New Brunswick, Riverview
19:30—22:00
Poster Session 1

Alberta, New Brunswick, Riverview

SATURDAY, MARCH 25

07:00—08:00
Breakfast

Alberta, New Brunswick, Riverview
08:00—11:15
Immunity 1
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
NF-kappaB Signaling during Bacterial and Fungal Infection

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT and NF-kappaB: Structural and Functional Similarities and Dissimiliarities

Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of the NFkB Pathways

* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
In vivo Analysis of NFkappaB Function in Normal and Malignant B Cell Development

Steven C. Ley, Francis Crick Institute, UK
Short Talk: Regulation of the TPL-2 / ERK MAP kinase pathway

Sophie Janssens, , Belgium
Short Talk

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:15—13:00
Poster Setup

Alberta, New Brunswick, Riverview
13:00—22:00
Poster Viewing

Alberta, New Brunswick, Riverview
14:30—16:30
Workshop 1: Systems Biology

Van Horne Ballroom AB
* Andre Levchenko, Yale University, USA

Kevin A. Janes, University of Virginia, USA
Data Models Linking Cytokines to NF-kappaB to Apoptosis

Erin H. Breese, Indiana University School of Medicine, USA
Elucidating SIMPL’s Co-Activator Function through Characterization of Protein-Protein Interactions and NF-kappaB Dependent Promoter Occupancy

Raymond Cheong, Johns Hopkins University, USA
Towards Systems-Level Understanding of NF-kappaB Signaling through Integrated Modeling and Experimentation

Barbara Kaltschmidt, Bielefeld University, Germany
NF-kappaB Regulates Memory Formation and Synaptic Plasticity through PKA/CREB Signaling

Stephnie M. Kennedy, University of Liverpool, UK
Development of Higher throughput Dynamic Imaging of the Function of NF-kappaB Proteins

Alison M. O'Mahony, Bioseek Inc, USA
NF-kappaB/Rel is a Key Regulator of Inhibitory Neuron Function and Synaptic Plasticity

Irina A. Udalova, University of Oxford, UK
Static and Dynamic Conservation of NF-kappaB Binding Sites in Drosophilid Genomes

Zhong Chen, NIDCD, National Institutes of Health, USA
Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and p53 Status

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Immunity 2
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll pathway of innate immunity

Shizuo Akira, Osaka University, Japan
TLR-dependent and-independent signaling pathways in pathogen recognition

* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Roles of NF-kappaB in Control of Autoimmunity

Kenya Honda, School of Medicine, Keio University, Japan
Short Talk: Regulation of MyD88-Dependent Signaling Pathways by IRF-1

19:00—20:00
Social Hour with Lite Bites

Alberta, New Brunswick, Riverview
19:30—22:00
Poster Session 2

Alberta, New Brunswick, Riverview

SUNDAY, MARCH 26

07:00—08:00
Breakfast

Alberta, New Brunswick, Riverview
08:00—11:00
Transcription
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Tom Maniatis, Columbia University, USA
Distinct Roles of TBK1 AND IKKe in Anti-Viral Immunity

* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
NF-kappaB/IKK Pathways in Control of Gene Expression and Oncogenesis

Alexander Hoffmann, University of California, Los Angeles, USA
Achieving Stimulus-Specific Gene Expression via NF-kappaB

Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Tissue Specific Control of NF-kappaB Activation

Genhong Cheng, University of California, Los Angeles, USA
Short Talk: Rescue of TRAF3 Null Mice by p100 NF-kB Deficiency

Denis C. Guttridge, Ohio State University, USA
Short Talk

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

Alberta, New Brunswick, Riverview
13:00—22:00
Poster Viewing

Alberta, New Brunswick, Riverview
14:30—16:30
Workshop 2: Diseases and Therapeutics

Van Horne Ballroom AB
* Frank Mercurio, BioTheryX, Inc., USA

Roberta Brambilla, University of Miami, USA
Transgenic Inactivation of Astroglial NF-kappaB Improves Functional Recovery Following Spinal Cord Injury and Experimental Autoimmune Encephalomyelitis

Jessica E. Hutti, AbbVie Inc., USA
The Role of IKK Substrate Specificity in Coordinating Innate Immune Signaling Responses

Scott J. Russo, Icahn School of Medicine at Mount Sinai, USA
NF-kappaB Signaling Controls Behavioral and Cellular Plasticity Associated with Cocaine Addiction

Carter Van Waes, NIDCD, National Institutes of Health, USA
The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma

Catherine E. Wharry, University of Pennsylvania, USA
Non-Canonical NF-kappaB Regulation in Pancreatic Ductal Carcinoma

Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Increased IL-1beta Processing Leads to Impaired Survival of Myeloid Specific IKKbeta Deficient Mice during LPS-Induced Septic Shock

Derek A. Mann, Newcastle University, UK
Real-Time in vivo Analysis of NF-kappaB Activation Reveals a Role for the Liver as a Regulator of Acute Brain Inflammation

Thomas Wirth, Ulm University, Germany
Constitutive Activation of IKK2 is Sufficient to Induce Pancreatitis

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Mechanisms of NF-kappaB Activation in Response to Genotoxic Stimuli.

* Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB Function in Tumor Cells and Morphogenesis

Manolis Pasparakis, University of Cologne, Germany
Function of IKK Subunits in Physiology and Disease

Laura M. DeBusk, Vanderbilt University, USA
Short Talk: IKK-alpha Activation Induces Tumor Angiogenesis

19:00—20:00
Social Hour with Lite Bites

Alberta, New Brunswick, Riverview
19:30—22:00
Poster Session 3

Alberta, New Brunswick, Riverview

MONDAY, MARCH 27

07:00—08:00
Breakfast

Alberta, New Brunswick, Riverview
08:00—11:15
Human Pathologies/Global System Analysis 1
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Michael Karin, University of California, San Diego, USA
The IKK Complex and its Role in Normal and Diseased Tissues

* Steve D. Gerondakis, Monash University, Australia
NF-kappaB Regulation of Myeloid Differentiation

Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Mapping Complex Regulatory Networks

Mollie K. Meffert, Johns Hopkins University School of Medicine, USA
NF-kappaB in Synaptic Function:

Deborah Veis Novack, Washington University, USA
Short Talk: RelB is Critical for Stimulated Osteoclastogenesis

Brendan J. O'Sullivan, Centre for Immunology and Cancer Research, Australia
Short Talk: RelB Serves a Dual Role in Hemopoietic and Stromal Cell Compartments to Maintain Tolerance and Contain Inflammation through Dendritic Cells and Regulatory T Cells

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Human Pathologies/Global System Analysis 2
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Alain Israël, Institut Pasteur, France
Genetic and Biochemical Analysis of the NF-ƒÛB Signaling Cascade

Louis M. Staudt, National Cancer Institute, NIH, USA
Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer

Howard Y. Chang, Stanford University, USA
Short Talk: Reversal of Epidermal Aging by NF-kappaB Blockade

Daniel Krappmann, Helmholtz Zentrum München, Germany
Short Talk

19:00—20:00
Social Hour with Lite Bites

Alberta, New Brunswick
20:00—23:00
Entertainment

Alberta, New Brunswick

TUESDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 AI068378-01




We gratefully acknowledge additional support for this conference from:

Celgene Corporation Cell Signaling Technology, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Celgene Corporation


Genentech, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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