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This meeting took place in 2006
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RNAi and Related Pathways (B2)
Organizer(s) Craig C. Mello, Phillip D. Zamore and James C. Carrington
January 26—31, 2006
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Sep 26, 2005
Late Abstract Deadline: Oct 19, 2005
Scholarship Deadline: Sep 26, 2005
Early Registration Deadline: Nov 23, 2005
Sponsored by Abbott Laboratories, Inc. and Alnylam Pharmaceuticals, Inc.
Summary of Meeting:
RNA silencing phenomena in a variety of plants, animals and fungi share a common underlying mechanism. At the heart of this mechanism lies an ancient double-stranded RNA processing machinery that functions in RNA-based immunity, developmental gene regulation, transcriptional silencing and genomic stability. The aim of this meeting is to explore similarities and differences between these related pathways, to probe the underlying molecular mechanisms and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.
View Scholarships/Awards
RNA silencing phenomena in a variety of plants, animals and fungi share a common underlying mechanism. At the heart of this mechanism lies an ancient double-stranded RNA processing machinery that functions in RNA-based immunity, developmental gene regulation, transcriptional silencing and genomic stability. The aim of this meeting is to explore similarities and differences between these related pathways, to probe the underlying molecular mechanisms and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, JANUARY 26
FRIDAY, JANUARY 27
SATURDAY, JANUARY 28
SUNDAY, JANUARY 29
MONDAY, JANUARY 30
TUESDAY, JANUARY 31
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, JANUARY 26
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.
*
Craig C. Mello,
University of Massachusetts Medical School, USA
Victor R. Ambros,
University of Massachusetts, USA
MicroRNAs in Flies and Worms
MicroRNAs in Flies and Worms
08:00—11:30
RNAi, Development and Systemic Silencing
Meeting has ended...abstracts no longer viewable online.
*
James C. Carrington,
Donald Danforth Plant Science Center, USA
Craig C. Mello,
University of Massachusetts Medical School, USA
RNAi and Development in C. elegans
RNAi and Development in C. elegans
Richard W. Carthew,
Northwestern University, USA
Genetics of miRNAs in Drosophila
Genetics of miRNAs in Drosophila
William Theurkauf,
University of Massachusetts Medical Center, USA
Drosophila RNAi Mutations Disrupt Embryonic Axis Specification through Activation of the ATR/Chk2 Tumor Suppressor Pathway
Drosophila RNAi Mutations Disrupt Embryonic Axis Specification through Activation of the ATR/Chk2 Tumor Suppressor Pathway
Olivier Voinnet,
Swiss Federal Institute of Technology, Zürich, Switzerland
Cell Autonomous and Systemic Mechanisms that Account for Antiviral RNA Silencing in Plants
Cell Autonomous and Systemic Mechanisms that Account for Antiviral RNA Silencing in Plants
Craig P. Hunter,
Harvard University, USA
Systemic RNAi in C. elegans
Systemic RNAi in C. elegans
17:00—19:00
Regulation of Small RNA Processing and Function
Meeting has ended...abstracts no longer viewable online.
Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Reversibility of the miRNA-Mediated Repression / Chromatoid Body: A Giant P-Body of Germ Cells?
Reversibility of the miRNA-Mediated Repression / Chromatoid Body: A Giant P-Body of Germ Cells?
Mikiko C. Siomi,
University of Tokyo, Japan
Biochemical Characterization of RNAi and miRNA Pathways in Drosophila
Biochemical Characterization of RNAi and miRNA Pathways in Drosophila
Herve Vaucheret,
Institut National de la Recherche Agronomique, France
Regulation of Small RNA Pathways in Plants
Regulation of Small RNA Pathways in Plants
Amy E. Pasquinelli,
University of California, San Diego, USA
Short Talk: Regulation of Gene Expression by miRNAs in C. elegans
Short Talk: Regulation of Gene Expression by miRNAs in C. elegans
08:00—11:30
miRNA Mechanisms
Meeting has ended...abstracts no longer viewable online.
Joel R. Neilson,
Baylor College of Medicine, USA
Short Talk: Dynamic regulation of small RNA expression during T lymphocyte development
Short Talk: Dynamic regulation of small RNA expression during T lymphocyte development
Alan M. Zahler,
University of California, Santa Cruz, USA
Short Talk: A Purified lin-4 miRNP Complex Directs Cleavage of its Native mRNA Substrate
Short Talk: A Purified lin-4 miRNP Complex Directs Cleavage of its Native mRNA Substrate
David T. Humphreys,
Victor Chang Cardiac Research Institute, Australia
Short Talk: MicroRNAs Control Translation Initiation by Inhibiting Eukaryotic Initiation Factor 4E/cap and poly(A) Tail Function
Short Talk: MicroRNAs Control Translation Initiation by Inhibiting Eukaryotic Initiation Factor 4E/cap and poly(A) Tail Function
*
V. Narry Kim,
Institute for Basic Science, South Korea
Molecular Basis for pri-miRNA Processing by the Drosha-DGCR8 Complex and A Role for the NMD Factor Upf1 in RNA Silencing
Molecular Basis for pri-miRNA Processing by the Drosha-DGCR8 Complex and A Role for the NMD Factor Upf1 in RNA Silencing
Xuemei Chen,
University of California, Riverside, USA
Methylation of microRNAs and Small Interfering RNAs in Arabidopsis
Methylation of microRNAs and Small Interfering RNAs in Arabidopsis
Frank J. Slack,
BIDMC Cancer Center/Harvard Medical School, USA
Short Talk: A Conserved miRNA regulates Timing of Neurotransmitter Synthesis and Axon Outgrowth
Short Talk: A Conserved miRNA regulates Timing of Neurotransmitter Synthesis and Axon Outgrowth
17:00—19:00
miRNA and Their Targets
Meeting has ended...abstracts no longer viewable online.
David P. Bartel,
HHMI, MIT and Whitehead Institute, USA
MicroRNA Targets and Functions in Animals and Plants
MicroRNA Targets and Functions in Animals and Plants
Detlef Weigel,
Max Planck Institute for Developmental Biology, Germany
Function and Specificity of Plant Micrornas: Insights from Whole-Genome Studies
Function and Specificity of Plant Micrornas: Insights from Whole-Genome Studies
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
miRNA Targets: Identification, Conservation, Cell-Type Specific Signatures of microRNA on their mRNA Targets, and a System for in-vivo Validation
miRNA Targets: Identification, Conservation, Cell-Type Specific Signatures of microRNA on their mRNA Targets, and a System for in-vivo Validation
08:00—11:30
RNAi: Immunity and Development
Meeting has ended...abstracts no longer viewable online.
*
Herve Vaucheret,
Institut National de la Recherche Agronomique, France
Christopher S. Sullivan,
University of California, San Francisco, USA
Short Talk: Non-Homologous microRNAs in Two Different Polyomaviruses Share a Conserved Target and Function
Short Talk: Non-Homologous microRNAs in Two Different Polyomaviruses Share a Conserved Target and Function
Eric C. Lai,
Sloan-Kettering Institute, USA
Short Talk: The Drosophila microRNA iab-4-5p has Homeotic Activity and Directly Represses Ultrabithorax
Short Talk: The Drosophila microRNA iab-4-5p has Homeotic Activity and Directly Represses Ultrabithorax
James C. Carrington,
Donald Danforth Plant Science Center, USA
Diversification of Small RNA Pathways in Plants
Diversification of Small RNA Pathways in Plants
Zhengying He,
Northwestern University, USA
Short Talk: Structural Features of miRNA/miRNA* Duplexes that Specify Dicer-2-Independent RISC Assembly in Drosophila
Short Talk: Structural Features of miRNA/miRNA* Duplexes that Specify Dicer-2-Independent RISC Assembly in Drosophila
Shou-Wei Ding,
University of California, Riverside, USA
Antiviral Silencing in Plants and Invertebrate Animals
Antiviral Silencing in Plants and Invertebrate Animals
17:00—19:00
Structure and Function
Meeting has ended...abstracts no longer viewable online.
*
Traci M.T. Hall,
NIEHS, National Institutes of Health, USA
Phillip D. Zamore,
University of Massachusetts Medical School, USA
Mechanism of Risc Assembly and Function
Mechanism of Risc Assembly and Function
Antonio J. Giraldez,
Yale University School of Medicine, USA
Short Talk: Zebrafish miR340 accelerates target deadenylation & cleavage during maternal to zygotic transition
Short Talk: Zebrafish miR340 accelerates target deadenylation & cleavage during maternal to zygotic transition
David Barford,
Institute of Cancer Research, UK
Studies of Argonaute Proteins: Central Mediators of RNA Silencing
Studies of Argonaute Proteins: Central Mediators of RNA Silencing
Dinshaw J. Patel,
Memorial Sloan Kettering Cancer Center, USA
Insights into Protein-RNA Recognition Along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally-Bound siRNA
Insights into Protein-RNA Recognition Along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally-Bound siRNA
08:00—11:30
Mechanism and Applications
Meeting has ended...abstracts no longer viewable online.
*
Victor R. Ambros,
University of Massachusetts, USA
Michelle Carmell,
Cold Spring Harbor Laboratory, USA
The Piwi Subfamily of Argonaute Proteins Interact with a Novel Class of Small RNA in Testes
The Piwi Subfamily of Argonaute Proteins Interact with a Novel Class of Small RNA in Testes
René Bernards,
Netherlands Cancer Institute, Netherlands
Identification of Novel Cancer-Relevant Genes through Loss of Function Genetic Screens
Identification of Novel Cancer-Relevant Genes through Loss of Function Genetic Screens
Pamela A. Pavco,
, USA
Small Interfering RNA (siRNA) as Potential Therapy for Inhibition of Ocular Neovascularization
Small Interfering RNA (siRNA) as Potential Therapy for Inhibition of Ocular Neovascularization
Antonin de Fougerolles,
Ablynx NV, Belgium
Therapeutic Silencing through Local and Systemic Delivery of Short Interfering RNA
Therapeutic Silencing through Local and Systemic Delivery of Short Interfering RNA
17:00—19:00
Transcriptional Silencing and Genomic Stability
Meeting has ended...abstracts no longer viewable online.
Shiv I. S. Grewal,
NCI, National Institutes of Health, USA
RNAi-Mediated Epigenetic Control of the Fission Yeast Genome
RNAi-Mediated Epigenetic Control of the Fission Yeast Genome
Sarah C.R. Elgin,
Washington University, USA
Targeting Heterochromatin Formation in Drosophila
Targeting Heterochromatin Formation in Drosophila
Steven E. Jacobsen,
University of California, Los Angeles, USA
Genetic Analysis of DNA Methylation and Gene Silencing
Genetic Analysis of DNA Methylation and Gene Silencing
Marc Bühler,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Tethering RITS to Drive Heterochromatin Formation
Short Talk: Tethering RITS to Drive Heterochromatin Formation
*Session Chair †Invited, not yet responded.
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