Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2006



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RNAi and Related Pathways (B2)


Organizer(s) Craig C. Mello, Phillip D. Zamore and James C. Carrington
January 26—31, 2006
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Sep 26, 2005
Late Abstract Deadline: Oct 19, 2005
Scholarship Deadline: Sep 26, 2005
Early Registration Deadline: Nov 23, 2005

Sponsored by Abbott Laboratories, Inc. and Alnylam Pharmaceuticals, Inc.

Summary of Meeting:
RNA silencing phenomena in a variety of plants, animals and fungi share a common underlying mechanism. At the heart of this mechanism lies an ancient double-stranded RNA processing machinery that functions in RNA-based immunity, developmental gene regulation, transcriptional silencing and genomic stability. The aim of this meeting is to explore similarities and differences between these related pathways, to probe the underlying molecular mechanisms and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 26

15:00—19:30
Registration

BC Foyer
18:30—19:30
Refreshments

BC Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Craig C. Mello, University of Massachusetts Medical School, USA

David C. Baulcombe, University of Cambridge, UK
RNA Silencing in Defense and Development

Victor R. Ambros, University of Massachusetts, USA
MicroRNAs in Flies and Worms


FRIDAY, JANUARY 27

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:30
RNAi, Development and Systemic Silencing
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* James C. Carrington, Donald Danforth Plant Science Center, USA

Craig C. Mello, University of Massachusetts Medical School, USA
RNAi and Development in C. elegans

Richard W. Carthew, Northwestern University, USA
Genetics of miRNAs in Drosophila

William Theurkauf, University of Massachusetts Medical Center, USA
Drosophila RNAi Mutations Disrupt Embryonic Axis Specification through Activation of the ATR/Chk2 Tumor Suppressor Pathway

Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
Cell Autonomous and Systemic Mechanisms that Account for Antiviral RNA Silencing in Plants

Craig P. Hunter, Harvard University, USA
Systemic RNAi in C. elegans

Markus Stoffel, ETH Zürich, Switzerland
Short Talk: Silencing of microRNAs in vivo

09:20—09:40
Coffee Break

BC Foyer
11:30—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Regulation of Small RNA Processing and Function
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* V. Narry Kim, Institute for Basic Science, South Korea

Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Reversibility of the miRNA-Mediated Repression / Chromatoid Body: A Giant P-Body of Germ Cells?

Mikiko C. Siomi, University of Tokyo, Japan
Biochemical Characterization of RNAi and miRNA Pathways in Drosophila

Herve Vaucheret, Institut National de la Recherche Agronomique, France
Regulation of Small RNA Pathways in Plants

Amy E. Pasquinelli, University of California, San Diego, USA
Short Talk: Regulation of Gene Expression by miRNAs in C. elegans

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 1

Pacific Ballroom

SATURDAY, JANUARY 28

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:30
miRNA Mechanisms
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* David P. Bartel, HHMI, MIT and Whitehead Institute, USA

Joel R. Neilson, Baylor College of Medicine, USA
Short Talk: Dynamic regulation of small RNA expression during T lymphocyte development

Alan M. Zahler, University of California, Santa Cruz, USA
Short Talk: A Purified lin-4 miRNP Complex Directs Cleavage of its Native mRNA Substrate

David T. Humphreys, Victor Chang Cardiac Research Institute, Australia
Short Talk: MicroRNAs Control Translation Initiation by Inhibiting Eukaryotic Initiation Factor 4E/cap and poly(A) Tail Function

* V. Narry Kim, Institute for Basic Science, South Korea
Molecular Basis for pri-miRNA Processing by the Drosha-DGCR8 Complex and A Role for the NMD Factor Upf1 in RNA Silencing

Xuemei Chen, University of California, Riverside, USA
Methylation of microRNAs and Small Interfering RNAs in Arabidopsis

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Short Talk: A Conserved miRNA regulates Timing of Neurotransmitter Synthesis and Axon Outgrowth

09:20—09:40
Coffee Break

BC Foyer
11:30—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
miRNA and Their Targets
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Andrew Fire, Stanford University, USA

David P. Bartel, HHMI, MIT and Whitehead Institute, USA
MicroRNA Targets and Functions in Animals and Plants

Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
Function and Specificity of Plant Micrornas: Insights from Whole-Genome Studies

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
miRNA Targets: Identification, Conservation, Cell-Type Specific Signatures of microRNA on their mRNA Targets, and a System for in-vivo Validation

Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

SUNDAY, JANUARY 29

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:30
RNAi: Immunity and Development
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Herve Vaucheret, Institut National de la Recherche Agronomique, France

Andrew Fire, Stanford University, USA
Investigating Tumor-Related Changes in Small RNA Profile

Christopher S. Sullivan, University of California, San Francisco, USA
Short Talk: Non-Homologous microRNAs in Two Different Polyomaviruses Share a Conserved Target and Function

Eric C. Lai, Sloan-Kettering Institute, USA
Short Talk: The Drosophila microRNA iab-4-5p has Homeotic Activity and Directly Represses Ultrabithorax

James C. Carrington, Donald Danforth Plant Science Center, USA
Diversification of Small RNA Pathways in Plants

Zhengying He, Northwestern University, USA
Short Talk: Structural Features of miRNA/miRNA* Duplexes that Specify Dicer-2-Independent RISC Assembly in Drosophila

Shou-Wei Ding, University of California, Riverside, USA
Antiviral Silencing in Plants and Invertebrate Animals

09:20—09:40
Coffee Break

BC Foyer
11:00—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Structure and Function
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Traci M.T. Hall, NIEHS, National Institutes of Health, USA

Phillip D. Zamore, University of Massachusetts Medical School, USA
Mechanism of Risc Assembly and Function

Antonio J. Giraldez, Yale University School of Medicine, USA
Short Talk: Zebrafish miR340 accelerates target deadenylation & cleavage during maternal to zygotic transition

David Barford, Institute of Cancer Research, UK
Studies of Argonaute Proteins: Central Mediators of RNA Silencing

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Insights into Protein-RNA Recognition Along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally-Bound siRNA

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

MONDAY, JANUARY 30

07:00—08:00
Breakfast

Pacific Ballroom
08:00—11:30
Mechanism and Applications
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Victor R. Ambros, University of Massachusetts, USA

Michelle Carmell, Cold Spring Harbor Laboratory, USA
The Piwi Subfamily of Argonaute Proteins Interact with a Novel Class of Small RNA in Testes

René Bernards, Netherlands Cancer Institute, Netherlands
Identification of Novel Cancer-Relevant Genes through Loss of Function Genetic Screens

Judy Lieberman, Harvard University, USA
The Silent Treatment: Delivering RNA Interference

Pamela A. Pavco, , USA
Small Interfering RNA (siRNA) as Potential Therapy for Inhibition of Ocular Neovascularization

Antonin de Fougerolles, Ablynx NV, Belgium
Therapeutic Silencing through Local and Systemic Delivery of Short Interfering RNA

Tariq M. Rana, University of California, San Diego, USA
Short Talk: In vivo RNAi

09:20—09:40
Coffee Break

BC Foyer
16:30—17:00
Coffee Available

BC Foyer
17:00—19:00
Transcriptional Silencing and Genomic Stability
Meeting has ended...abstracts no longer viewable online.

British / Columbia Ballroom
* Phillip D. Zamore, University of Massachusetts Medical School, USA

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Mediated Epigenetic Control of the Fission Yeast Genome

Sarah C.R. Elgin, Washington University, USA
Targeting Heterochromatin Formation in Drosophila

Steven E. Jacobsen, , USA
Genetic Analysis of DNA Methylation and Gene Silencing

Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Tethering RITS to Drive Heterochromatin Formation

19:00—20:00
Social Hour with Lite Bites

Pacific Ballroom
20:00—23:00
Entertainment

Pacific Ballroom

TUESDAY, JANUARY 31

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA117393-01




We gratefully acknowledge additional support for this conference from:

Abbott Laboratories Alnylam Pharmaceuticals, Inc.
Ambion, Inc. Integrated DNA Technologies
Invitrogen Corporation Isis Pharmaceuticals, Inc.
Novartis Institutes for BioMedical Research
 

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