Fairmont Banff Springs Floorplan

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This meeting took place in 2006



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Nuclear Receptors: Steroid Sisters (X4)


Organizer(s) Carole R. Mendelson, Donald P. McDonnell and Malcolm G. Parker
March 18—23, 2006
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Nov 17, 2005
Late Abstract Deadline: Dec 12, 2005
Scholarship Deadline: Nov 17, 2005
Early Registration Deadline: Jan 18, 2006

Supported by The Director's Fund


Summary of Meeting:
The overall goal of this conference is to provide the most important and up-to-date research in the nuclear receptor field. Topics presented will include the roles nuclear receptors in physiologic and pathophysiologic states, in development and in regulation of metabolic processes. Nuclear receptor-coregulator interactions, mechanisms in chromatin remodeling and transcriptional activation and repression also will be addressed, as will mechanisms of extranuclear signaling by steroid receptors. The roles of coregulators and nuclear receptors as potential targets for drug discovery will be considered, as well as structural properties of receptor domains complexed with ligands, cofactors, and DNA. It is our objective to highlight the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research and promote the productive interaction of scientists from academic institutions and industry. The meeting venue also will facilitate the interaction of leading experts in the field with younger scientists and trainees, with a particular emphasis on the inclusion of underrepresented groups.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, MARCH 18

15:00—19:30
Registration

Van Horne Ballroom Foyer
18:30—19:30
Refreshments

Van Horne Ballroom Foyer
19:30—20:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Vincent Giguère, McGill University, Canada

* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Transcriptional Control of Stem Cells and Their Lineages


SUNDAY, MARCH 19

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Steroid Receptors and Disease
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Carol A. Lange, University of Minnesota, USA
Integration of Progesterone Receptor and MAP Kinase Signaling in Breast Cancer Cell Models

* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Novel Modulators of Estrogen Receptor Function

Martin L. Privalsky, University of California, Davis, USA
Aberrant Thyroid Hormone Receptors: Mutations, Isoforms and Disease

Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Differential Physiological Gene Responsiveness in ERKO Mice

Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Short Talk: BRM ATPase Function in the Prostate: AR Regulation and Proliferative Control


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

08:00—11:00
Development and Differentiation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Sophia Y. Tsai, Baylor College of Medicine, USA
COUP-TFII in Development and Disease

Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Nurr1 and Other Factors in the Development and Stem Cell Engineering of Dopamine Neurons

* Malcolm G. Parker, Imperial College London, UK
The Ups and Downs of Nuclear Receptor Action in Fat and Fertility

Henry M. Krause, University of Toronto, Canada
Live Animal Screening for Nuclear Receptor Ligands

Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Epigenetic Regulation of ES Cell Gene Repression by GCNF

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
15:30—16:30
Hot Topics 1

Van Horne AB
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Mariam H. Al-Dhaheri, Medical University of Ohio, USA
Protein Kinase A (PKA)-Induced Ligand Independent Activity of Estrogen Receptor in Breast Cancer Cells is Accompanied by Decreased Estradiol Binding, Increased Association of ERalpha with HSP90 and Loss of Cell Viability

James Thompson, University of Helsinki, Finland
Small Carboxyl-Terminal Domain Phosphatase 2 Knock-Down Increases RNA Polymerase II Phosphorylation and Androgen-Dependent Transcription in Prostate Cancer Cells

Kirsten C. Fertuck, Dana Farber Cancer Institute, USA
Coactivation by AIB1 Contributes to Long-Range Association Between Proximal and Distal Estrogen Receptor Binding Sites in Breast Cancer Cells

Frederic D. Flamant, Ecole Normale Superieure, France
Inducible Expression of a TRalpha Receptor with a AF2 Domain Mutation to Identify the Cell Autonomous Effects of Thyroid Hormone in Mouse Development and Homeostasis


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

15:30—16:30
Hot Topics 1

Van Horne C
* Carl S. Thummel, University of Utah School of Medicine, USA

Robert B. Beckstead, Howard Hughes Medical Institute, University of Utah, USA
Regulation of DHR78 Activity through a SAM-Domain Containing Corepressor, Moses

Carolyn L. Cummins, University of Toronto, Canada
LXR and Adrenal Cholesterol Homeostasis

William A. Alaynick, University of California, San Diego, The Salk Institute, USA
Loss of ERR3 Results in Cardiac Conduction Defects in Mouse

Daniel Malenfant, Centre de Recherche en Cancérologie de l'Université Laval, Canada
Genome-Wide Location Analysis of FTF/LRH-1 in Mouse Liver and Human Hepatoma Cells

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Coregulators and Chromatin (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Estrogen Signaling in the Nucleus: Role of Receptors, Coactivators, and Chromatin

Bert W. O'Malley, Baylor College of Medicine, USA
Birth to Death: Story of the SRC-3 Coactivator Complex

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Coregulatory Strategies Linking Nuclear Receptor Gene Activation Events and DNA Damage/Repair

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 1

New Brunswick, Alberta, Cascade

MONDAY, MARCH 20

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Molecular Pharmacology of Steroid Receptors
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Geoffrey L. Greene, University of Chicago, USA
Structural Basis for Differential Responses of ERα and ERβ to Diverse Ligands

Dean P. Edwards, Baylor College of Medicine, USA
Transcriptional and Extra-nuclear Signaling Activities of the Progesterone Receptor Mediated by the Amino-terminal Domain.

Nancy Lynn Weigel, Baylor College of Medicine, USA
Regulation of Progesterone Receptor Action by Cycline Dependent Kinases

* Myles Brown, Dana-Farber Cancer Institute, USA
Genome-Wide Analysis of Steroid Receptor Function

Michael A. Mancini, Baylor College of Medicine, USA
Short Talk: Visualizing Nuclear Receptor Function at the Single Cell Level


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

08:00—11:00
Metabolic Regulators and New Ligands
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* David D. Moore, Baylor College of Medicine, USA

Vincent Giguère, McGill University, Canada
Identification of ER and ERR-Driven Transcriptional Regulatory Networks: A Functional Genomic Approach to Uncover Nuclear Receptor Function in Physiology and Disease

Anastasia Kralli, Johns Hopkins Medical School, USA
ERRa, A Regulator of Mitochondrial Function and Other PGC-1 Controlled Metabolic Pathways

Beatrice Desvergne, University of Lausanne, Switzerland
Endocrine Disruptors Modulate PPAR Actions: A Live Study in the Living Cells

Holly A. Ingraham, University of California, San Francisco, USA
NR5A Receptors in Neuroendocrine Physiology and in Female Reproductive Disease

Janice Marie Huss, Beckman Research Institute at the City of Hope National Medical Center, USA
Short Talk: The Estrogen-Related Receptor alpha (ERRalpha) is Essential for Adaptive Cardiac Remodeling in Pressure Overload Models of Heart Failure

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
15:30—16:30
Hot Topics 2

Van Horne AB
* John A. Cidlowski, NIEHS, National Institutes of Health, USA

Wen Cai, Karolinska Institute, Sweden
Crosstalk between Circadian System and Nuclear Receptors

Eliot Michael Bourk, University of California, San Diego, USA
An Evolutionarily Conserved Nuclear Receptor Sensor System Mediates Inflammatory Control of Estrogen-Repressed Genes

Daniel B. Hardy, Children's Health Research Institute, Lawson Health Research Institute, Canada
The Anti-Inflammatory Actions of the Progesterone Receptor (PR) May Exert a Protective Role in Breast Cancer

Atish Mukherjee, Baylor College of Medicine, USA
Ablation of SRC2 Coactivator Function in Murine Cell Lineages that Express the Progesterone Receptor Results in Severe Defects in the Female Reproductive System and Mammary Gland


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

15:30—16:30
Hot Topics 2

Van Horne C
* Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland

Marie Lagouge, Centre de recherche des Cordeliers U1138, France
The SIRT-1 Activator, Resveratrol, Induces Weight Loss through Increasing Basal Energy Expenditure

Junichiro Sonoda, Genentech, Inc., USA
Metabolic Activation of Macrophage Function by ERRalpha

Y. Lynn Wang, Weill Medical College of Cornell University, USA
PPARgamma Promotes Cell Survival through Its Actions on Cellular Metabolic Activities

Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain
Macrophage Specific PPAR-gamma Gene Deletion Causes Whole Body Insulin Resistance and Glucose Intolerance

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Nuclear Receptors and Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Vincent Giguère, McGill University, Canada

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Ligand-dependent Regulation of Metabolism and Reproduction: Evolution of the Nuclear Receptor Paradigm

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
PPARd at the Crossroads of Inflammation and Metabolism

Bruce M. Spiegelman, Harvard Medical School, USA
PGC-1 Coactivators and the Control of Energy Homeostasis

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 2

New Brunswick, Alberta, Cascade

TUESDAY, MARCH 21

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Steroid Receptors and Chromatin
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
* Michael R. Stallcup, University of Southern California, USA
The p160 Coactivator Signaling Pathway: Roles of Secondary Coactivators and Protein Methylation in Transcriptional Regulation

Jiemin Wong, Baylor College of Medicine, USA
Function of Androgen Receptor in Chromatin

Catherine C. Thompson, Pfizer, USA
Linking Corepressor Action and Wnt Signaling: Epithelial Stem Cell Differentiation

Carolyn L. Smith, Baylor College of Medicine, USA
Short Talk: Corepressor Contribution to Activation of Estrogen Receptor-a-Dependent Gene Expression


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

08:00—11:00
Immune System
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Christopher K. Glass, University of California, San Diego, USA

Xiao-Kun Zhang, Sanford-Burnham Medical Research Institute, USA
The Nur77-Bcl-2 apoptotic pathway in cancer cells.

Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of ROR?t in Development and Homeostasis of the Immune System

Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptors, Metabolism and Inflammation

Timothy M. Willson†, GlaxoSmithKline, USA
Structure-Guided Design of Anti-Inflammatory LXR Modulators

Ajay Chawla, University of California, San Francisco, USA
Short Talk: Transcriptional Crosstalk between Metabolism and Inflammation

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
11:00—13:00
Poster Setup

New Brunswick, Alberta, Cascade
13:00—22:00
Poster Viewing

New Brunswick, Alberta, Cascade
15:30—16:30
Hot Topics 3

Van Horne AB
* Carolyn L. Smith, Baylor College of Medicine, USA

Didier Auboeuf, Institut Universitaire d'hématologie/ Hôpital Saint Louis, France
Control of the Synthesis and the Fate of Gene Transcripts by Transcriptional Coregulators

Sung Hee Baek, Seoul National University, South Korea
Roles of Nuclear Receptor Coregulators and their Modification Codes in Regulation of a Metastasis Suppressor Gene

Suzanne E. Wardell, Duke University Medical Center, USA
Circumventing Glucocorticoid Resistance in Multiple Myeloma Using Histone Deacetylase Inhibitors to Down-Regulate Growth Factor Receptor Expression

Shane M. Colley, Western Australian Institute for Medical Research, Australia
Characterization of Four Novel SRA-Binding Coregulators that Modulate Nuclear Receptor Signaling in Cancer


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

15:30—16:30
Hot Topics 3

Van Horne C
Kendall W. Nettles, The Scripps Research Institute, USA
Structural Features of the Phantom Ligand Effect in RXR Heterodimers

Ines Pineda-Torra, University College London, UK
Phosphorylation of LXRalpha Reprograms Target Gene Expression in Macrophages

* Frances M. Sladek, University of California, Riverside, USA
Phosphorylation of a Conserved Serine in the Nuclear Receptor DNA Binding Domain Stimulates Nuclear Export

Susanne Mandrup, University of Southern Denmark, Denmark
PPAR Subtype Specific Activation of Genomic Target Genes in Hepatocytes upon Adenoviral Transgene Delivery

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Transcriptional Control Mechanisms (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Bert W. O'Malley, Baylor College of Medicine, USA

Christopher K. Glass, University of California, San Diego, USA
Mechanisms Mediating Anti-Inflammatory Activities of Nuclear Receptors

Pierre H. Chambon, Institut de Génétique Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Genetic and pharmacological dissection of the (patho)physiological function of RXR/Nuclear Receptor heterodimers in epidermal keratinocytes of the mouse skin

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
The Ups and Downs of Repression

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
19:30—22:00
Poster Session 3

New Brunswick, Alberta, Cascade

WEDNESDAY, MARCH 22

07:00—08:00
Breakfast

New Brunswick, Alberta, Cascade
08:00—11:00
Steroid Receptor Biology
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom AB
Jan-Åke Gustafsson, University of Houston, USA
Biology of estrogen receptor beta - New Insights

* Keith R. Yamamoto, University of California, San Francisco, USA
GR Ligands Differentially Modulate GR:GRE Occupancy or GR Regulatory Activity

John A. Cidlowski, NIEHS, National Institutes of Health, USA
The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-inflammatory Actions

Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in the Decline of Progesterone Receptor Function Leading to Parturition

Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: The GRIP1:IRF3 Interaction as a Target for Glucocorticoid Receptor-Mediated Immunosuppression


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

08:00—11:00
Physiology and Cancer
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Anastasia Kralli, Johns Hopkins Medical School, USA

Carlie J. M. de Vries, University of Amsterdam, Netherlands
Nur77-Like Nuclear Receptors in Atherosclerosis

David D. Moore, Baylor College of Medicine, USA
Nuclear Receptors and Liver Regeneration

Joyce J. Repa, University of Texas Southwestern Medical Center, USA
LXR-mediated Regulation of Glucose and Lipid Metabolism.

Jacques Drouin, Institut de Recherches Cliniques de Montréal, Canada
NGFIB and GR: Molecular Pathogenesis of Glucocorticoid Resistance in Cushing’s Disease

Richard A. Heyman, ORIC Pharmaceuticals, USA
Short Talk

09:20—09:40
Coffee Break

Van Horne Ballroom Foyer
15:30—16:30
Hot Topics 4

Van Horne AB
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Kerstin W. Sinkevicius, Children's Hospital Boston, USA
Estrogen Receptor Alpha G525L Knock-In Mice

Jan P. Tuckermann, Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany
Glucocorticoid induced Osteoporosis requires the Glucocorticoid Receptor in Osteoblasts and does not Depend on DNA Binding of the Receptor

Eriko Matsuura, University of Tokyo, Japan
E2F Transcriptional Activation as a Potential Mechanism of Neurodegeneration of Polyglutamine Expansion Androgen Receptor Mutants


Following Session is for Nuclear Receptors: Orphan Brothers (X3)

15:30—16:30
Hot Topics 4

Van Horne C
* Ming-Jer Tsai, Baylor College of Medicine, USA

Xin Xie, Baylor College of Medicine, USA
The Orphan Nuclear Receptor COUP-TFII Plays an Important Role in Adipogenesis

Takeshi Inagaki, University of Tokyo, Japan
Regulation of Mucosal Defense in Intestine by the Nuclear Bile Acid Receptor

Grace L. Guo, Rutgers University, USA
Role of the Farnesoid X Receptor in Foam-Cell Formation and Atherosclerosis Development

Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
NR4A Orphan Nuclear Receptors Regulate Hepatic Glucose Metabolism in Fasting and Diabetes

16:30—17:00
Coffee Available

Van Horne Ballroom Foyer
17:00—19:00
Nuclear Receptors and Biological Function (Joint), Supported by Invitrogen Corporation
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Donald P. McDonnell, Duke University School of Medicine, USA
The Biological Consequences of Differential Receptor-Cofactor Interactions

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
French Women Don't Get Fat

19:00—20:00
Social Hour with Lite Bites

New Brunswick, Alberta, Cascade
20:00—23:00
Entertainment

New Brunswick, Alberta, Cascade

THURSDAY, MARCH 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13 DK074313-01




We gratefully acknowledge additional support for this conference from:

Invitrogen Corporation Novartis Institutes for BioMedical Research

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676