St. John's College - Cambridge Floorplan

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This meeting took place in 2006



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Multi-Protein Complexes Involved in Cell Regulation (E6)


Organizer(s) Tom L. Blundell, Carol V. Robinson and Ralph A. Bradshaw
August 18—23, 2006
St. John's College - Cambridge • University of Cambridge, Cambridge UK
Abstract Deadline: May 9, 2006
Late Abstract Deadline: May 26, 2006
Scholarship Deadline: Apr 18, 2006
Early Registration Deadline: Jun 19, 2006

Supported by The Director's Fund

Summary of Meeting:
As knowledge of protein structure advances it has become increasingly clear that protein interactions, both transient and stable, are far more extensive than originally appreciated and that the resulting complexes, with a very wide range of stabilities, form highly coordinated networks that govern biological processes. Understanding the fluxes of information that are transmitted by these protein-protein contacts is the essence of systems biology and is dependent, at least to a first approximation, on determining the structures of the proteins involved. There have been multiple approaches to this challenging problem ranging from crystallography and 2D NMR to hybridization and mass spectrometry. This meeting will assess the state of determining the structural and functional bases for protein-protein interactions with the view of exploring how these approaches augment and extend each other.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, AUGUST 18

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Palmerston
Tom L. Blundell, University of Cambridge, UK
Multiprotein Assemblies: Structural Biology and Drug Discovery

Carol V. Robinson, University of Oxford, UK
Multi-Protein Complexes – New Insights from Old Tools


SATURDAY, AUGUST 19

07:30—08:30
Breakfast

Buttery
08:30—11:30
Technological Approaches: Studying Macromolecular Interactions and Dynamics I
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Mapping Molecular Landscapes inside Cells by Cryoelectron Tomography

Keiichi Namba, Osaka University, Japan
Molecular Mechanisms of Swimming and Tumbling in Bacterial Motility

F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Protein Folding Machines: Interactions between Chaperones and their Clients

James A. Wells, University of California, San Francisco, USA
Discovering Inhibitors of Protein Complexes

09:40—10:00
Coffee Break

Foyer
11:30—12:30
Lunch

The Hall
11:30—12:00
Poster Setup

Castlereagh Room/Foyer
12:30—14:30
Poster Session 1

Castlereagh Room/Foyer
14:30—16:30
Workshop 1: Dynamics and Regulation of Protein-Protein Interactions

Palmerston
* Nicholas J. Harmer, , UK

* Marko Hyvönen, University of Cambridge, UK

Ludovic Bannwarth, Centre National de la Recherche Scientifique, University Paris 6, France
Disabling a Protein Dimer with Rationally Designed Interface Peptidomimetics

Nadia Milech, University of Western Australia, Australia
Anti-Apoptotic Phylomer Peptides: Disruptors from Protein Folds

Alexis Gautreau, Centre National de la Recherche Scientifique, Institut Curie, France
Structural Conversion of Brick1 from a Free Trimer to a Single Subunit during the Assembly of the Wave Complex

Eric Underbakke, The Scripps Research Institute, USA
Illuminating Protein-Protein Interactions in Signal Transduction: Footprinting a Reconstituted Escherichia coli Chemotaxis Signaling Lattice

Angela Manegold Svendsen, Hagedorn Research Institute, Denmark
Kinetics of Insulin-Like Peptide 3 (INSL3) Binding to the Leucine-Rich Repeat-Containing G-Protein-Coupled Receptor 8 (LGR8): Evidence for Negative Cooperativity

Roopa Thapar, MD Anderson Cancer Center, USA
Allosteric Regulation of the SLBP-Histone mRNA Complex by Phosphorylation-Dependent Proline Isomerization

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Technological Approaches: Studying Macromolecular Interactions and Dynamics II
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Christopher M. Dobson, University of Cambridge, UK

Alexander Grishaev, NIDDK, National Institutes of Health, USA
Combining Solution NMR and Small Angle Scattering for Macromolecular Structure Determination

Laura S. Itzhaki, Hutchison/MRC Research Centre, UK
Analysis of the assembly and dynamics of the multi-subunit ubiquitin ligase SCFSkp2

Elizabeth A. Komives, University of California, San Diego, USA
Dynamics of the NF-kappaB - IkappaB Interaction


SUNDAY, AUGUST 20

07:30—08:30
Breakfast

Buttery
08:30—11:30
Cell Surface Receptors
Meeting has ended...abstracts no longer viewable online.

Palmerston
* John E. Ladbury, University College London, UK
Protein assemblies dictate specificity in tyrosine kinase-mediated signal transduction

Colin W. Ward, University of New South Wales, Australia
Structural Insights into Signaling by the EGF and Insulin Receptor Families

Nicholas J. Harmer, , UK
Signaling Clusters in the Fibroblast Growth Factor System

Johanna Mari Ivaska, University of Turku, Finland
Integrating Matrix Messages and Motility

09:40—10:00
Coffee Break

Foyer
23:30—12:30
Lunch

The Hall
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Peter J. Parker, Cancer Research UK, UK
Multiple signalling pathways regulate the assembly of a PKCepsilon complex

Yosef Yarden, Weizmann Institute of Science, Israel
Oncogenic growth factor signaling: a system perspective

Bertrand Séraphin, Universite Paris 6, France
Structural and Functional Analysis of Protein Complexes Involved in Pathways Controlling Gene Expression


MONDAY, AUGUST 21

07:30—08:30
Breakfast

Buttery
08:30—11:30
Intracellular Signaling – Structural Aspects
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Louise N. Johnson, University of Oxford, UK
Why Do Mammalian Cells Need More Than One Cyclin?

John Kuriyan, University of California, Berkeley, USA
Structural Insights Into the Regulation of Tyrosine Kinase Signaling

David Barford, Institute of Cancer Research, UK
Function and Structure of the Anaphase Promoting Complex, a Multi-Subunit Ubiquitin Ligase

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Apoptosis: Structural Biology and Drug Design

09:40—10:00
Coffee Break

Foyer
11:30—12:30
Lunch

The Hall
11:30—12:00
Poster Setup

Castlereagh Room/Foyer
12:30—14:30
Poster Session 2

Castlereagh Room/Foyer
14:30—16:30
Workshop 2: Diverse Methods for the Study of Protein-Protein Interactions

Palmerston
* Jane Clarke, University of Cambridge, UK

Ananth Krupa, London Research Institute, Cancer Research UK, UK
Substrate Recognition by CDKs: Role of Consensus Sequence Motifs and Implications for Identification of Novel Substrates

Yingnan Zhang, Genentech, Inc., USA
Genome-Wide Analysis of the PDZ Domain Family

Jacqui M. Matthews, University of Sydney, Australia
The Assembly Of A Transcriptional Complex

Ricardo M. Biondi, University of Saarland, Germany
Modulation of Phosphorylation-Dependent Protein Kinase Conformational Transitions with Low Molecular Weight Compounds

Narayanaswamy Srinivasan, Indian Institute of Science, India
Interaction Interfaces of Protein Domains are not Topologically Equivalent Across Families within Superfamilies: Evolutionary Dynamics and Implications for Metabolic and Signalling Pathways

Carla F. Cervantes, University of California, San Diego, USA
Dynamics of IkappaBalpha Probed by NMR

Franca Fraternali, King's College London, UK
Molecular Dynamics Study of Hydration Properties of Prion Proteins

Lan Huang, University of California, Irvine, USA
Proteomic Analysis of Human 26S Proteasome Complex Using Mass Spectrometry

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cellular Processes
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Dale B. Wigley, Institute of Cancer Research, UK
Crystal Structure of RecBCD: A Machine for Processing DNA Breaks

Andrej Sali, University of California, San Francisco, USA
Modeling the Structures of Proteins and Macromolecular Assemblies

Marko Hyvönen, University of Cambridge, UK
Extracellular Regulation of TGFbeta Family Growth Factors


TUESDAY, AUGUST 22

07:30—08:30
Breakfast

Buttery
08:30—11:30
Computational Analyses: Docking and Protein-Protein Interactions
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Janet M. Thornton, European Bioinformatics Institute, UK
Structure to Function: Recognising Interaction Partners

Robert B. Russell, University of Heidelberg, Germany
Predicting Molecular Details for Protein-Interaction Networks

Joël Janin, CNRS/Université Paris-Sud, France
Protein-protein recognition sites: structural analysis and prediction

Juan Fernandez-Recio, Institute of Biomedical Research (IRB-PCB), Spain
Computational Protein-Protein Docking: Present and Future Challenges

09:40—10:00
Coffee Break

Foyer
11:30—12:30
Lunch

The Hall
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Protein Folding, Aggregation and Diseases
Meeting has ended...abstracts no longer viewable online.

Palmerston
* Christopher M. Dobson, University of Cambridge, UK
Protein Folding , Molecular Evolution and Human Disease

David Eisenberg, University of California, Los Angeles, USA
Structures of Febryl-Forming Segments from Amyloid Proteins

Sheena E. Radford, University of Leeds, UK
Life on a knife edge: Tipping the balance between folding and aggregation

19:00—20:00
Dinner

The Hall
20:00—23:00
Entertainment

The Hall

WEDNESDAY, AUGUST 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

BBSRC - Biotechnology & Biological Sciences Research Council, UK Royal Society of Chemistry
UCB Celltech
 

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