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This meeting took place in 2007



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Host Cell Interaction and Response to the Cancer Cell (A8)


Organizer(s) David A. Cheresh and Nicholas P. Restifo
January 21—26, 2007
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 21, 2006
Late Abstract Deadline: Oct 24, 2006
Scholarship Deadline: Sep 21, 2006
Early Registration Deadline: Nov 21, 2006

Supported by the Director's Fund

Summary of Meeting:
Tumor growth and invasion depends on the ability of tumor cells to respond to a wide range of host cells. However, it is clear that host cells also respond to the presence of the tumor. In fact it is the outcome of these cellular interactions that may well predict the clinical course of a wide variety of cancers. During growth at the primary site, tumor cells interact locally with fibroblasts and their extracellular matrix. Tumors often produce an inflammatory response causing immune cell recruitment to the tumor; the ability of a tumor cell to evade this immune recognition is a critical determinant of the tumor’s capacity to spread. Tumor cell invasion and metastasis also depend on the ability of tumor cells to recruit a blood supply to nourish the tumor. The resulting blood vessels often serve as a conduit for metastasis. While in the circulation, interactions between tumor cells and platelets can further facilitate tumor metastasis. Ultimately, tumors respond to a variety of cells and microenvironments in a wide range of organs including the lymph node, lung, liver, brain, and bone. Given the critical role of tumor cell-host cell interactions in tumor growth and metatasis as well as the therapeutic potential offered by intervening in these interactions, developing a better understanding of the molecular basis for these cellular interactions is imperative. In addition, it is critical to determine how these cell-cell interactions directly influence the cancer cell and its gene expression, proliferation rate, and capacity to evade recognition by host immune cells. The goal of this meeting is to bring together experts in areas such as tumor immunology, angiogenesis and tumor cell biology to begin to define the host cellular response to the tumor and to identify new molecular pathways leading to a better understanding of tumor invasion and metastasis.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 21

15:00—19:30
Registration

Shavano Foyer
18:30—19:30
Refreshments

Shavano Foyer
19:30—20:30
Keynote Address: Cancer and the Inflammatory Response
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Michael Karin, University of California, San Diego, USA
Inflammation and Cancer


MONDAY, JANUARY 22

07:00—08:00
Breakfast

Torreys
08:00—11:00
Tumor Response to Host Cells
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Harold L. Moses, Vanderbilt University, USA
TGF-beta Regulation of Stromal Cells in Cancer Initiation and Progression

Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
FoxOs in Cancer and Aging

Filippo G. Giancotti, Memorial Sloan-Kettering Cancer Center, USA
Genetic Analysis of Integrin Signaling during Breast Tumorigenesis

Yves A. DeClerck, Children's Hospital Los Angeles, USA
Bone Marrow Microenvironment and Tumor Progression

Marina Bacac, University of Lausanne, Switzerland
Short Talk: A Mouse Stromal Response to Tumor Invasion Predicts Prostate and Breast Cancer Patient Survival

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Torreys
13:00—22:00
Poster Viewing

Torreys
16:30—17:00
Coffee Available

Shavano Foyer
17:00—19:00
Tumor Response to Host Cells II
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Site-Specific Metastasis Genes and Functions

Brunhilde Felding-Habermann, The Scripps Research Institute, USA
Platelet Adhesive Interactions with Tumor Cells

Ruth J. Muschel, John Radcliffe Hospital, UK
Coagulation, Blood Vessels and Pulmonary Metastasis

Jennifer Kirstein, University of Western Ontario, Canada
Short Talk: Effect of Coagulation on Melanoma Metastasis in Aprotinin Treated Animals

19:00—20:00
Social Hour with Lite Bites

Shavano Foyer
19:30—22:00
Poster Session 1

Torreys

TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Torreys
08:00—11:15
Vascular Response to the Tumor
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Gabriele A.I. Bergers, University of California, San Francisco, USA
Hypoxia-Dependent Mechanisms of Blood Vessel Formation in Tumors

Donald M. McDonald, University of California, San Francisco, USA
Imaging the Vascular Compartment in Tumors: Effects of Angiogenesis Inhibitors

Harold F. Dvorak, Beth Israel Deaconess Medical Center, USA
Building Tumor Blood Vessels

Bruce R. Zetter, Children's Hospital Boston, USA
Microenvironmental Control of Prostate Cancer Growth via Protein Degradation

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Matrix and Tumor Microenvironment in Cancer Progression and Metastasis

09:20—09:40
Coffee Break

Shavano Foyer
11:15—13:00
Poster Setup

Torreys
13:00—22:00
Poster Viewing

Torreys
16:30—17:00
Coffee Available

Shavano Foyer
17:00—19:00
Vascular Response to the Tumor II
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Judith A. Varner, University of California, San Diego, USA
Integrin Roles in Tumor Angiogenesis and Lymphangiogenesis

Elisabetta Dejana, Uppsala University, Sweden
Cadherins in Cancer and Tumor Vasculature

Alireza Alavi, GlaxoSmithKline, USA
Short Talk: Chemoresistance of Endothelial Cells Induced by bFGF Depends on Raf-1-Mediated Inhibition of the Pro-Apoptotic Kinase, ASK1

Carmen Z. Cantemir-Stone, Ohio State University, USA
Short Talk: Critical Role of Ets2 in Regulating Fibroblasts Survival and Activity in the Breast Cancer Microenvironment

19:00—20:00
Social Hour with Lite Bites

Shavano Foyer
19:30—22:00
Poster Session 2

Torreys

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Torreys
08:00—11:00
Vascular and Lymphatic Invasion
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* David A. Cheresh, University of California, San Diego, USA
Angiogenesis Inhibition by Stabilizing the DFG/P-Loop Interaction in Raf

Carlos Bais, Genentech, Inc., USA
Targeting VEGF to Attack Pathological Blood Supply

Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
Targeting the Plasticity of Metastatic Tumor Cells

Michael Christoph Schmid, Moores UCSD Cancer Center, USA
Short Talk: SDF-1alpha and IL-1beta Activate Integrin alpha4beta1 to Promote Homing of Bone Marrow Derived Cells to Tumor Vasculature

Young Chul Kim, University of Wisconsin, Madison, USA
Short Talk: Wnt1 Activates Stromal Cells and Mobilizes Endothelial Precursor Cells During Mouse Mammary Tumor Development

09:20—09:40
Coffee Break

Shavano Foyer
16:30—17:00
Coffee Available

Shavano Foyer
17:00—19:00
Recognition of the Cancer Cell
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Ulf R. Rapp, University of Wurzburg, Germany
Role of Angiogenic Switch Induction and Tumor Stem Cells in Progression of Raf-Induced Lung Tumors to Metastasis

Masataka Majima, Kitasato University School of Medicine, Japan
Inflammatory Response to Cancer. Role of Prostaglandins in Tumor-associated Angiogenesis

Thomas Blankenstein, Max Delbruck Center for Molecular Medicine, Germany
Transgenic Mice with Sporadic Immunogenic Tumors

Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Short Talk: Dynamic Imaging in Living Mice Reveals Effects of the Tumor Microenvironment on Leukocyte Behavior

19:00—20:00
Social Hour with Lite Bites

Shavano Foyer

THURSDAY, JANUARY 25

07:00—08:00
Breakfast

Torreys
08:00—11:30
How Tumor Cells Exploit Host Immune Defenses and Tissue / Stromal Barriers
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Judith Campisi, Buck Institute for Research on Aging, USA
Stromal-Epithelial Interactions in Aging and Cancer

Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Protease Requirements in Cancer Invasion in vitro and in Vivo: From Individual to Collective Cell Migration

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Tumor-Educated Macrophages as Promoters of Tumor Progression

Alberto Mantovani, Humanitas University, Italy
Smoldering Inflammation in the Initiation and Promotion of Malignant Disease

Michael Bouvet, University of California, San Diego, USA
Short Talk: In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver Metastases

Shahin Rafii, Weill Cornell Medical College, USA
Contribution of Bone Marrow's Vascular Microenvironment to Tumor Angiogenesis

09:20—09:40
Coffee Break

Shavano Foyer
16:30—17:00
Coffee Available

Shavano Foyer
17:00—19:00
New Therapies Based on Host Interactions with the Cancer Cell
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Hans Schreiber, University of Chicago, USA
New Strategies of Cancer Therapy by Targeting Antigens Resulting from Tumor-Specific Mutations

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
How Suppression of Stat3 Activation Potentiates Innate and Adaptive Anti-Tumor Immunity

Nicholas P. Restifo, NCI, National Institutes of Health, USA
Adoptive Immunotherapy: Building on Success

19:00—20:00
Social Hour with Lite Bites

Shavano Foyer
20:00—23:00
Entertainment

Castle Peaks

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

UCB Celltech

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676