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This meeting took place in 2007



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Mechanisms Linking Inflammation and Cancer (B6)


Organizer(s) Lisa M. Coussens, Frances R. Balkwill and Glenn Dranoff
February 10—15, 2007
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 10, 2006
Late Abstract Deadline: Nov 9, 2006
Scholarship Deadline: Oct 10, 2006
Early Registration Deadline: Dec 11, 2006

Supported by the Director's Fund

Summary of Meeting:
Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of tumors as entities that can hijack and exploit various normal physiologic processes of the host. The frequent presence of inflammatory cell infiltrates and chemical mediators of inflammation in tumors has been recognized for over a century, although an understanding of their role during cancer development has been elusive. Leukocytic infiltrates and cytokine/chemokine networks in premalignant tissues and tumors can be distinct, depending upon the stage of malignant development and organ microenvironment. Current thinking is that activated immune cells provide both anti- and pro-tumorigenic signals, thus representing targets to be harnessed or attacked for therapeutic advantage depending upon environmental and/or cellular context. T lymphocytes are being exploited for their ability to induce tumor regression, as are strategies that disable innate immune cells or neutralize immunosuppressive or pro-inflammatory microenvironments. Such approaches may also provide clinical benefit for at-risk cancer patients and those with pre-malignant lesions. This meeting will link innate and adaptive immune regulatory mechanisms with cancer development and cancer treatment by focusing on relevant basic research, preclinical, translational and clinical studies.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 10

15:00—19:30
Registration

Promenade
18:30—19:30
Refreshments

Promenade
19:30—20:30
Keynote Session: Cancer as an Evolving Organ: A Central Role for Inflammation and the Microenviroment
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Zena Werb, University of California, San Francisco, USA
The Co-Evolution of Neoplastic Cells and Their Microenvironment During Tumor Progression


SUNDAY, FEBRUARY 11

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Infection, Persistent Inflammation and Epidemiology: Linking Inflammation and Cancer
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Martin J. Blaser, New York University School of Medicine, USA
Genomic Plasticity of Persistent Microbial Colonizers Affects Host Cell Phenotypes: A Model for Carcinogenesis

* Richard M. Peek, Jr., Vanderbilt University, USA
Pathogenesis of H. pylori-Induced Carcinogenesis

Hui Xiao, Institut Pasteur of Shanghai, China
Short Talk: The Regulatory Role of SIGIRR in Colonic Epithelial Homeostasis, Inflammation and Tumorigenesis

Khashayarsha Khazaie, Northwestern University, USA
Short Talk: Inflammation is an Inherent and Essential Component of Colon Cancer.

Mirna Perez-Moreno, Spanish Cancer Research Centre, Spain
Links Between Cell Adhesion, Inflammation and Cancer

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Ortiz
13:00—22:00
Poster Viewing

Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:15
INITIATION: Mechanisms Linking Inflammation and Cancer - A
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Anil K. Sood, University of Texas MD Anderson Cancer Center, USA
Influence of Biobehavioral Factors on Tumor Biology: Pathways and Mechanisms

Sonia Vallet, Dana Farber Cancer Institute, USA
The Role of MIP1alpha/CCR1 in the Pathogenesis of Osteolytic Bone Lesions in Multiple Myeloma

* Dafna Bar-Sagi, New York University School of Medicine, USA
Assessing the Link Between Chronic Pancreatitis and the Evolution of Pancreatic Cancer

David H. Raulet, University of California, Berkeley, USA
Natural Killer Cells, DNA Damage and Cancer

19:15—20:15
Social Hour with Lite Bites

Ortiz/Chamisa
19:30—22:00
Poster Session 1

Ortiz/Chamisa

MONDAY, FEBRUARY 12

07:00—08:00
Breakfast

Chamisa
08:00—11:00
PROMOTION: Mechanisms Linking Inflammation and Cancer - B
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Alberto Mantovani, Humanitas University, Italy
Tumor-Associated Macrophages in Extrinsic and Intrinsic Pathways of Tumor Promotion

Merav Darash-Yahana, NIAID, National Institutes of Health, USA
Short Talk: A Possible Role for the Transmembrane Chemokine CXCL16 in Inflammation-Associated Cancers

Michael Karin, University of California, San Diego, USA
Crosstalk Between Inflammation Cells and Carcinomas

Barrett J. Rollins, Dana Farber Cancer Institute, USA
Chemokines as Soluble Mediators

Roberta B. Ness, University of Texas, USA
Inflammation and Ovarian Cancer: An Epidemiologist’s Perspective

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Ortiz
13:00—22:00
Poster Viewing

Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:15
PROGRESSION: Mechanisms Linking Inflammation and Cancer
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation, Proteolysis and Cancer Development

Sung Hee Baek, Seoul National University, South Korea
Short Talk: Macrophage and Hormone-Dependent Cancer

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages: A Cellular Toolbox Used by Tumors to Promote Progression and Metastasis

Dmitry I. Gabrilovich, Wistar Institute, USA
Dendritic Cells Inflammation and Cancer

Laura Soucek, University of California, San Francisco, USA
Short Talk: Mast Cells Are Required for Expansion of Myc-Dependent Tumors

19:15—20:15
Social Hour with Lite Bites

Ortiz/Chamisa
19:30—22:00
Poster Session 2

Ortiz/Chamisa

TUESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Balancing Pro- and Anti-Tumor Responses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Suzanne Ostrand-Rosenberg, University of Maryland, USA
Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

Martin Oft, ARMO BioSciences, USA
IL-23 Subverts Immunesurveilance and Promotes Tumor Growth

Christoffer Gebhardt, German Cancer Research Center, Germany
Short Talk: The Receptor for Advanced Glycation End-Products (RAGE) Drives Tumor Development by Sustaining Inflammation

Randall S. Johnson, University of Cambridge, UK
Inflammatory Cell Production of HIF1alpha and VEGF During Cancer Development

Luigi M. Naldini, San Raffaele Telethon Institute, Italy
Tie2-Expressing Monocytes: A Novel Lineage of Proangiogenic Cells

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Ortiz
13:00—22:00
Poster Viewing

Ortiz
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Immune Resistance and Cancer
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Mark J. Smyth, QIMR Berghofer Medical Research Institute, Australia
Host Immune Resistance and Regulation in Cancer

Susan E. Erdman, Massachusetts Institute of Technology, USA
Protective Role of Regulatory T Cells in Inhibiting Inflammation-Induced Cancer

George C. Prendergast, Lankenau Institute for Medical Research, USA
Short Talk: BAR Adapters and IDO in Tumoral Immune Escape

* Robert D. Schreiber, Washington University School of Medicine, USA
The Role of Immunity in Cancer Protection, Persistence and Progression

19:00—20:00
Social Hour with Lite Bites

Ortiz/Chamisa
19:30—22:00
Poster Session 3

Ortiz/Chamisa

WEDNESDAY, FEBRUARY 14

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Mechanisms-Based Therapies for Innate Responses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Raymond N. DuBois, Arizona State University, USA
Inflammation and Cancer: The PGE2—COX-2—Wnt Pathway

* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
Inflammation and Cancer: The TNF-alpha Connection

Anuradha Budhu, NCI, National Institutes of Health, USA
Short Talk: A Predominant Th2 Cytokine Profile in the Hepatic Microenvironment of Metastatic Hepatocellular Carcinoma Patients May be Promoted by Colony Stimulating Factor 1/osteopontin

Olivera J. Finn, University of Pittsburgh School of Medicine, USA
MUC1, Inflammation and Cancer

Claire E. Lewis, University of Sheffield Medical School, UK
Hypoxic Macrophages in Tumors: Targets and Vehicles for Anti-Cancer Therapy

09:20—09:40
Coffee Break

Promenade
14:30—16:30
Workshop: Lymphocyte Responses to Cancer

Mesa A-B
* Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK

* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA

* Lisa M. Coussens, Oregon Health & Science University, USA

Sharon S. Evans, Roswell Park Memorial Institute, USA
Role of Interleukin-6 Trans-Signaling in Overcoming Hurdles to T Lymphocyte Trafficking in the Tumor Microenvironment

Jennifer K.L. Colby, University of Texas M.D. Anderson Cancer Center Science Park, USA
Inflammatory Cell Infiltrate and Tumor Immune Tolerance in the BK5.COX-2 Mouse Model of Pancreatitis and Pancreatic Tumorigenesis

Michael Girardi, Yale University School of Medicine, USA
Characterizing Tumor-Promoting T Cells in Chemically-Induced Cutaneous Carcinogenesis

Lillian Maggio-Price, University of Washington, USA
Helicobacter-Infected Smad3-Deficient Mice with Impaired TGF-beta Signaling: A Model to Study Inflammation Associated Colon Cancer

Jacqueline S. Papkoff, JSP3 Consulting, USA
Discovery and Validation of a Promising New Target for Therapeutic Monoclonal Antibodies: The Immuno-Modulatory Protein B7-H4 is Overexpressed in Human Breast and Ovarian Cancers

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Mechanisms-Based Therapies for Adaptive Responses
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Marcin T. Kortylewski, Beckman Research Institute, City of Hope, USA
Targeting Stat3 Enhances CpG Based Therapy

James P. Allison, University of Texas MD Anderson Cancer Center, USA
Progress with CTLA4-based Strategies

* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
The Interplay of Inflammation and Cancer. Meeting Summary

20:00—21:00
Social Hour with Lite Bites

Mesa C
21:00—23:00
Entertainment

Mesa C

THURSDAY, FEBRUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA124284-01




We gratefully acknowledge additional support for this conference from:

Celgene Corporation EntreMed, Inc.
UCB Celltech
 

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