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This meeting took place in 2007



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Stem Cell Interactions with their Microenvironmental Niche (X1)


Organizer(s) David T. Scadden and Allan C. Spradling
March 2—7, 2007
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 2, 2006
Late Abstract Deadline: Dec 1, 2006
Scholarship Deadline: Nov 2, 2006
Early Registration Deadline: Jan 2, 2007

Supported by the Director's Fund


Summary of Meeting:
Stem cells are defined by their function in complex microenvironments that are just beginning to be defined. The architecture of these anatomic sites in molecular, cellular and developmental terms has provided insight into how tissues are formed and maintained throughout life. They now provide an opportunity for examining settings of disease and offering a distinct group of possible therapeutic interventions. This meeting will examine select stem cell niches to explore unifying principles and identify opportunities for application in tissue regeneration and cancer therapy.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, MARCH 2

15:00—19:30
Registration

Shavano Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Rockies Ballroom
Allan C. Spradling, HHMI/Carnegie Institute, USA
Analyzing Stem Cells Within Intact Drosophila Tissues


SATURDAY, MARCH 3

07:00—08:00
Breakfast

Grays/Longs Peak
08:00—11:00
Mechanisms Governing Normal and Malignant Stem Cells (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Rockies Ballroom
* Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Self-Renewal

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Prostaglandin E2 is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis

Haifan Lin, Yale University, USA
Stem Cells, Small RNAs, and Self-Renewal

Mary Armanios, Johns Hopkins University School of Medicine, USA
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

Andreas Androutsellis-Theotokis, NINDS, National Institutes of Health, USA
Short Talk: STAT3-Ser727: Integrator of Stem Cell Niche Survival Signals

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Grays/Longs Peak
13:00—22:00
Poster Viewing

Grays/Longs Peak

Following Session is for Stem Cells and Cancer (X2)

14:30—16:30
Workshop 1: Stem Cells on Hematopoietic Malignancies

Crestone/Red Cloud
* Catriona H.M. Jamieson, University of California, San Diego, USA

* Michael W. Becker, University of Rochester School of Medicine, USA

Eric R. Lechman, University Health Network, Canada
Identification of a Leukemia Stem Cell Specific miRNA Profile and the Requirement of miR-155 for the Maintenance of the Leukemogenic State

Naoki Hosen, Osaka University Graduate School of Medicine, Japan
CD96 is a Candidate for Leukemic Stem Cell-Specific Therapeutic Target

Yosuke Minami, Kobe University Hospital, Japan
Leukemia Stem Cells Induced by BCR-ABL Display Innate Resistance to Imatinib

Aniruddha Deshpande, Memorial Sloan-Kettering Cancer Center, USA
Acute Myeloid Leukemia is Propagated by a Leukemic Stem Cell with Lymphoid Characteristics in a Mouse Model of CALM/AF10 Positive Leukemia

Silvia Buonamici, New York University, School of Medicine, USA
Targeting the NF-kappaB Signaling Pathway in Notch1-Induced T Cell Leukemia

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for Stem Cells and Cancer (X2)

17:00—19:00
Hematopoietic and Model Microenvironments
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Tannishtha Reya, University of California, San Diego, USA
Wnt Signaling in Stem Cells and Cancer

Linheng Li, Stowers Institute for Medical Research, USA
Regulation of Stem Cells in Hematopoietic and Intestinal Niches by BMP and PTEN Pathways

* John E. Dick, Princess Margaret Cancer Centre, Canada
AML Stem cells

17:00—19:00
Remaking Cell Fate through Cell Interaction
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Gerd Hasenfuss, Georg-August-University of Göttingen, Germany
Pluripotency of Spermatogonial Stem Cells From Adult Mouse Testis

Erika Matunis, Johns Hopkins University School of Medicine, USA
Converting Differentiating Cells to Stem Cells in the Drosophila Testis

* Helen M. Blau, Stanford University, USA
Directing Behavior of Single Stem Cells in Bioengineered Arrayed Niches

Ian Chambers, University of Edinburgh, UK
Short Talk: Nanog Function in Pluripotency and Germ Cell Development

19:00—20:00
Social Hour with Lite Bites

Grays/Longs Peak
19:30—22:00
Poster Session 1

Grays/Longs Peak

SUNDAY, MARCH 4

07:00—08:00
Breakfast

Grays/Longs Peak
08:00—11:15
Cancer Microenvironment or Tumor Microenvironment and Blood Vessels (Joint)
Meeting has ended...abstracts no longer viewable online.

Colorado Rockies Ballroom
* Patrick O. Brown, Stanford University, USA
Cancer Stroma

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis Initiating Functions

Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling in Stem Cells and Cancer

Napoleone Ferrara, University of California, San Diego, USA
VEGF and Angiogenesis

Louise E. Purton, St. Vincent's Institute of Medical Research, Australia
Short Talk: A Microenvironment-Induced Myeloproliferative Disease Caused by RARgamma Deficiency

Renee D. Read, Emory University School of Medicine, USA
Short Talk: Modeling Human Brain Cancer in Fruit Flies

Sophia W.M. Bruggeman, University Medical Center Groningen, Netherlands
Short Talk: Polycomb Group Proteins Control Neutral Stem Cells and Brain Development, and Contribute to Gliomagenesis in an Ink4a/Afr Independent Manner

09:20—09:40
Coffee Break

Longs Peak Foyer
11:30—13:00
Poster Setup

Grays/Longs Peak
13:00—22:00
Poster Viewing

Grays/Longs Peak
14:30—16:30
Workshop 1

Shavano/Torreys
* Haifan Lin, Yale University, USA

Maria Victoria Gómez-Gaviro, National Institute for Medical Research, UK
Role of the Vasculature in the Cytoarchitecture of the Neural Stem Niche

Laura A. Banaszynski, Rockefeller University, USA
Regulated Expression of Transcription Factors Involved in the Establishment and Maintenance of Pluripotency

Michaela Gruber, University of Pennsylvania, USA
HIF-2alpha‘s Role in Erythropoiesis and Adult Stem Cells

Matthias Kieslinger, Helmholtz Center - National Research Center for Environment and Health, Germany
Expression of EBF2 in Osteoblastic Cells is Required for Sustained Haematopoiesis

Drew L. Sellers, University of Washington, USA
Thrombin Acts as an Early Response Cue Within the Adult Neural Stem Niche to Direct Proliferation and Differentiation in Response to Traumatic Injury

Sharon Gerecht-Nir, , USA
Nanotopography Regulates Cytoskeletal Organization of Human Stem Cells


Following Session is for Stem Cells and Cancer (X2)

14:30—16:30
Workshop 2: Cancer Genes and Cancer Progressions

Crestone/Red Cloud
* Edison T. Liu, The Jackson Laboratory, USA

* Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands

Mark LaBarge, Lawrence Berkeley National Lab, USA
Cell-Microenvironment Interactions Guide Human Mammary Progenitor Cell Fate

Xin-Hai Pei, University of North Carolina, USA
Functional Collaboration of p18Ink4c and Brca1 in Mammary Stem Cell Regulation and Tumor Suppression

Susanne Schlisio, Karolinska Institute, Ludwig Institute for Cancer Research, Sweden
Neuronal Apoptosis by Prolyl hydroxylase EglN3: O2- Sensing and Cancer

Danielle Christina Shing, European Institute of Oncology, Italy
The PR Domain-negative Isoform of PRDM16 Induces a Stem Cell Phenotype and is Leukaemogenic

David M. Langenau, Massachusetts General Hospital, USA
Identifying the Cancer Stem Cell in Transgenic Zebrafish Models of Embryonal Rhabdomyosarcoma

Robert B. Clarke, University of Manchester, UK
Primary Human Breast Ductal Carcinoma in situ (DCIS) Mammosphere Formation: Importance of the EGF and Notch Receptor Signalling Pathways

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Organization of Skin
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Elaine V. Fuchs, HHMI/Rockefeller University, USA
From Stem Cells to Tissue: Signaling, Transcription and Cytoskeletal Dynamics in Skin Morphogenesis

Fiona M. Watt, King's College London School of Medicine, UK
Stem Cells and Lineage Selection in Mammalian Epidermis

Yann Barrandon, École Polytechnique Fédérale de Lausanne, Switzerland
Microenvironmental Changes and Stem Cell Behavior

Sergei Y. Sokol, Mount Sinai School of Medicine, USA
Short Talk: Regulation of Epidermal and Neuronal Progenitor Differentiation by aPKC and PAR-1


Following Session is for Stem Cells and Cancer (X2)

17:00—19:00
Normal and Neoplastic Stem Cells of Epithelial Tissues
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells

Michael F. Clarke, Stanford University, USA
Epithelial Cancer Stem Cells

Peter Dirks, Hospital for Sick Children, Canada
Brain Tumor Stem Cells

19:00—20:00
Social Hour with Lite Bites

Grays/Longs Peak
19:30—22:00
Poster Session 2

Grays/Longs Peak

MONDAY, MARCH 5

07:00—08:00
Breakfast

Grays/Longs Peak
08:00—11:15
Microenvironments of the Bone Marrow
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cells and their Niche(s)

Paul J. Simmons, University of Texas Health Science Center at Houston, USA
Phenotypic Dissection of Stem Cell Niches and Mesenchymal Stem Cell Interactions in Bone Marrow

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Identification of Hematopoietic Stem Cells and Their Niches

Toshio Suda, Keio University, Japan
Molecular Interactions at the Bone: Stem Cell Interface

Ivan Maillard, University of Michigan, USA
Short Talk: Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver Through Effects on the Stem Cell Microenvironment

Masataka Kasai, National Institutes of Health, Japan
Short Talk: Negative Regulation of Stem Cell Self-Renewal and Osteoblast Formation


Following Session is for Stem Cells and Cancer (X2)

08:00—11:00
Cancer Genome Immunological Approaches Applicable to Cancer Stem Cell Therapies
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Mark M. Davis, Stanford University, USA
Title to be Determined

Philip D. Greenberg, University of Washington, USA
Isolating/Creating T Cells That Can Target and Eliminate Cancer Stem Cells

Jeffrey J. Molldrem, University of Texas MD Anderson Cancer Center, USA
Peptide Vaccination Against Proteases Reverses T Cell Tolerance and Eliminates Leukemia Stem Cells

James P. Allison, University of Texas MD Anderson Cancer Center, USA

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Grays/Longs Peak
13:00—22:00
Poster Viewing

Grays/Longs Peak

Following Session is for Stem Cells and Cancer (X2)

14:30—16:30
Workshop 3: Cancer Stem Cells

Crestone/Red Cloud
* Laurie Elizabeth Ailles, Stanford University, USA

* Mark E.P. Prince, University of Michigan, USA

Shideng Bao Bao, Duke University Medical Center, USA
Cancer Stem Cells Contribute to Glioblastoma Radioresistance through Preferential Activation of DNA Damage Checkpoint and Repair

Catherine A. O'Brien, University Health Network, Canada
Identification of a Human Colon Cancer Cell Capable of Initiating Tumor Growth

Scott J. Dylla, Stemcentrx, Inc., USA
Colorectal Cancer Stem Cells (CoCSC) are Enriched in Residual Tumors following Cyclophosphamide Administration

Kent L. Erickson, University of California, Davis, USA
Small Molecule Combinatorial Libraries to Identify New Mammary Stem Cell Markers

Sheila R. Alcantara, University of Texas Southwestern Medical Center at Dallas, USA
Isolation and Characterization of Cancer Stem Cells in a Glioma Mouse Model

Carol Ann Sartorius, University of Colorado Anschutz Medical Campus, USA
Rare CK5+ Cells in Experimental Human Breast Tumors Express a Panel of “Stem-like” Genes

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Neural Stem Cell Microenvironments
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Jeffrey D. Macklis, Harvard University-MGH-HMS, USA
Molecular Development and Repair of Corticospinal Motor Neuron and Other Forebrain Projection Neuron Circuitry

* Charles Ffrench-Constant, University of Edinburgh, UK
Regulation of Neural Stem Cells by Extracellular Matrix Molecules of the Ventricular Zone Niche

Chay T. Kuo, Duke University School of Medicine, USA
Short Talk: Postnatal Deletion of Numb/Numblike Reveals Remodeling Capacity in Neurogenic Niche


Following Session is for Stem Cells and Cancer (X2)

17:00—17:40
High Throughput Analysis of Cancer Genes Applicable to Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Frederick W. Alt, Boston Children's Hospital, USA
NHEJ and the Double-Strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma


Following Session is for Stem Cells and Cancer (X2)

17:40—19:00
Genetic and Epigenetic Alterations in Cancers & Epigenetic Regulation of Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Tim C.P. Somervaille, Stanford University School of Medicine, USA
Transformation of Myeloid Progenitors to Leukemia Stem Cells by MLL Oncogenes

Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Progression and Metastasis

19:00—20:00
Social Hour with Lite Bites

Longs Peak Foyer
19:30—22:00
Poster Session 3

Grays/Longs Peak

TUESDAY, MARCH 6

07:00—08:00
Breakfast

Grays/Longs Peak
08:00—11:15
Germ Cell Niche
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Margaret T. Fuller, Stanford University, USA
Stromal-Stem Cell Interactions in the Fruit Fly Set Up an Oriented Mitotic Spindle for Asymmetric Stem Cell Division

Judith E. Kimble, University of Wisconsin, Madison, USA
Controls of Germline Stem Cells in C. elegans

Ting Xie, Stowers Institute for Medical Research, USA
Interactions Between Germline Stem Cells and Their Niche in the Drosophila Ovary

* Takashi Shinohara, Kyoto University, Japan
Culture and Genetic Modification of Mouse Germline Stem (GS) Cells

Niels Geijsen, Massachusetts General Hospital, USA
Short Talk: “Humanized” Murine Embryonic Stem Cells

Paul S. Cooke, University of Illinois at Urbana-Champaign, USA
Short Talk: Ets-Related Molecule (ERM) and Spermatogonial Stem Cell Self-Renewal


Following Session is for Stem Cells and Cancer (X2)

08:00—11:00
Finding Therapeutic Targets in Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Tessa L. Holyoake, University of Glasgow, UK
Characterisation of Cancer Stem Cells in CML

A. Thomas Look, Dana-Farber Cancer Institute, USA
Gamma Secretase Inhibitors for the Treatment of ALL

D. Gary Gilliland, Merck & Co., Inc., USA
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Gregory L. Verdine, Harvard University, USA
Drugging the Undruggable

09:20—09:40
Coffee Break

Longs Peak Foyer
14:30—16:30
Workshop 2

Shavano/Torreys
* Allan C. Spradling, HHMI/Carnegie Institute, USA

Arianna DellaValle, San Raffaele Scientific Institute, Italy
Pericytes of Human Post-Natal Skeletal Muscle are Myogenic Precursors, Distinct From Satellite Cells, and Efficiently Repair Dystrophic Muscle

Xudong Shi, University of Wisconsin, Madison, USA
Anchorage Independent Culture Maintains a Population of Prostate Progenitor Cells In Vitro

David R. Whikehart, University of Alabama at Birmingham, USA
Stem Cells in the Human Ocular Limbus Are Contained in a Niche Defined by Schwalbe’s Line

Indira U. Mysorekar, Washington University School of Medicine, USA
Molecular Regulation of the Bladder Epithelial Stem Cell Niche

John Yu, Institute of Stem Cell and Translational Cancer Research, Taiwan
Characterization of Pulmonary Stem Cells as Model for SARS and H5N1 Virus Infections


Following Session is for Stem Cells and Cancer (X2)

14:30—16:30
Workshop 4: Novel Cancer Therapies

Crestone/Red Cloud
* Austin Gurney, OncoMed Pharmaceuticals, Inc., USA
Prognostic Role of Cancer Stem Cell Gene Signatures and Strategies to Target Tumorigenic Cell Populations

Chris Alan Joseph Folkins, Sunnybrook Health Sciences Centre, Canada
Therapies Combining Cytotoxic and Anti-angiogenic Effects Reduce the Fraction of Tumor Sphere Forming Cells in Glioma Xenograft Tumors

Christine E. Brown, Beckman Research Institute, City of Hope, USA
Targeted Elimination of Brain Tumor Initiating Cells with Adoptively Transferred T Cells

Xing Fan, Johns Hopkins University School of Medicine, USA
Depleting Cancer Stem Cells in Glioblastoma by Notch Pathway Blockade

Jie Zheng, St. Jude Children's Research Hospital, USA
Structure-based Investigation of Wnt Signaling Inhibitors

Craig Gedye, Melbourne Center for Clinical Science, Australia
Melanoma Stem-like Cells can be Eliminated by Targeting Cancer/Testis Antigens

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Designer Niches: Modeling and Making Microenvironments
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanical Control of Cell Fate Switching

David J. Mooney, Harvard University, USA
Constructing Tissue Microenvironments

Geeta Mehta, University of Michigan, USA
Short Talk: Creating Ex Vivo Niches for Hematopoeitic Stem Cells

Seth A. Townsend, Massachusetts Institute of Technology, USA
Short Talk: Novel Three-Dimensional Environments for in Vitro Growth of Stem Cells


Following Session is for Stem Cells and Cancer (X2)

17:00—19:00
Normal and Neoplastic Stem Cells
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Nobuko Uchida, StemCells, Inc., USA
Biology of Human Neural Stem Cells

* Irving L. Weissman, Stanford University, USA
Normal and Leukemic Stem Cells

Jeremy Naftali Rich, Cleveland Clinic, USA
Glioma Cancer Stem Cells Promote Tumor Radioresistance and Angiogenesis

Diane M. Simeone, University of Michigan, USA
Short Talk: Identification of Pancreatic Cancer Stem Cells

19:00—20:00
Social Hour with Lite Bites

Grays/Longs Peak
20:00—23:00
Entertainment

Grays/Longs Peak

WEDNESDAY, MARCH 7

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL088881-01




We gratefully acknowledge additional support for this conference from:

JDRF

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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