Beaver Run Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Genome Instability and Repair (A5)


Organizer(s) Nancy Maizels, Ian D. Hickson and David B. Roth
January 17—22, 2007
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 18, 2006
Late Abstract Deadline: Oct 20, 2006
Scholarship Deadline: Sep 18, 2006
Early Registration Deadline: Nov 17, 2006

Sponsored by Genentech, Inc.

Summary of Meeting:
Genomic instability is a key event in aging, cancer and some heritable diseases. Highly conserved pathways have evolved to detect the presence of genome damage and to effect its repair. This meeting will explore recent advances in our understanding of the nature and causes of genomic instability, the mechanisms of DNA repair, and the consequences of failure in DNA repair with regard to human health and disease. The program will emphasize advances that provide mechanistic understanding of pathways that maintain genomic integrity, and the intersection of these pathways with normal cellular development, aging, and tumorigenesis. The molecular and mechanistic emphasis is designed to attract a broad cross-section of researchers. The goals of this meeting are to identify new avenues for investigation, to define therapeutic strategies for maintenance of genomic integrity, to stimulate collaborations, and to foster the long-term development of this rapidly emerging research area by encouraging participation of young investigators.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 17

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Frederick W. Alt, Boston Children's Hospital, USA
NHEJ and the Double-strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma


THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Avoiding DNA Damage
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Curtis C. Harris, NCI, National Institutes of Health, USA
p53 Biological Network: Inflammation, microRNA and Cancer

Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
Short Talk: HCLK2 is Essential for the Mammalian S-Phase Checkpoint and Impacts on Chk1Stability

Gregory L. Verdine, Harvard University, USA
The Lesion-Search Mechanism of DNA Glycosylases

Dipanjan Chowdhury, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Role of phosphatases in removal of Gamma-H2AX

Keith W. Caldecott, University of Sussex, UK
DNA Single-Strand Breaks and Neurodegeneration

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Chromatin, DNA Damage and Repair
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Michael J. Lichten, National Cancer Institute, National Institutes of Health, USA
Controlling the Outcome of Meiotic Double-Strand Break Repair

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin Assembly Factors, Histone H3 Variants and Cell Cycle

Jac A. Nickoloff, Colorado State University, USA
Short Talk: INO80-Dependent Chromatin Remodeling Regulates the Kinetics and Efficiency of DSB Repair by Homologous Recombination

Andrés Aguilera, University of Seville, CABIMER, Spain
Mechanisms of Transcription-Associated Genetic Instability

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 1

Peaks 14-17

FRIDAY, JANUARY 19

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Intersection of Damage, Repair and the Cell Cycle
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
DNA Damage and Cell Death

XiaoZhe Wang, Dana-Farber Cancer Institute, USA
Short Talk: The role of Chk1 in the Fanconi Anemia/BRCA Pathway

Michael B. Kastan, St. Jude Children's Research Hospital, USA
Roles of ATM and NBS1 in Modulating Chromatin Structure Changes and Repair of DNA Breaks

Sandy Chang, University of Texas MD Anderson Cancer Center, USA
Telomere End Protection in Senescence and Cancer

Travis H. Stracker, IRB Barcelona, Spain
Short Talk: The Apoptotic Functions of Chk2 Suppress Tumorigenesis in Mre11 Deficient Mice

Guillermina Lozano, University of Texas MD Anderson Cancer Center, USA
p53 Cell Cycle Control and Maintenance of Chromosomal Stability

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
14:30—16:30
Workshop 1: Dynamics, Modulation and Regulation of DNA Repair

Peaks 1-5
* Raymond J. Monnat Jr., University of Washington, USA

Prasad Tekkatte Krishnamurthy, Columbia University, USA
Visualizing Dynamics of Rdh54 on Single Double-Stranded DNA Molecule

Lisa Postow, Rockefeller University, USA
Damage-Dependent Ubiquitination and Degradation of Ku80

Eric T. Larson, University of Washington, USA
MutSalpha and UNG Direct Redundant Pathways for Faithful as well as Mutagenic Repair of U/G Mismatches

Marie Dutreix, Center National Scientific Research, Institut Curie, France
Baiting Double-Strand Break Repair Complex by Short Inhibitory DNA (siDNA)

David O. Ferguson, University of Michigan Medical School, USA
TPP1 and Mre11: Two Tales of Genomic Instability

Jillian L. Youds, University of British Columbia, Canada
Characterization of BRIP1/FANCJ Homologs in ICL Repair in C. elegans

Yannick Doyon, Laval University, Canada
High-Efficiency Targeted Integration in Human Cells using Designed Zinc Finger Nucleases

Wojciech Niedzwiedz, Oxford University, UK
The Possible Role for FANCM in DNA Cross-Links Repair

Sachin Katyal, St. Jude Children's Research Hospital, USA
Defective DNA Damage Responses in Mice Lacking TDP1

16:30—17:00
Coffee Available

Foyer
17:00—19:30
Mechanisms of Processing Repair Intermediates
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Ian D. Hickson, University of Copenhagen, Denmark
Functions of the BLM Protein at Damaged Replication Forks

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Choosing a Pathway for Break Repair

Bernard S. Lopez, Institut Gustave Roussy, France
Short Talk: PKBĄ/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a

Tanya T. Paull, University of Texas at Austin, USA
DNA Repair Activities of Mre11/Rad50 Complexes

Stephen C. West, Francis Crick Institute, UK
Resolution of Abortive DNA Ligation Intermediates by Aprataxin

19:30—20:30
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 2

Peaks 14-17

SATURDAY, JANUARY 20

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Pathways of Break Repair
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* David B. Roth, New York University School of Medicine, USA
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair

Piero R. Bianco, University at Buffalo, State University of New York, USA
Short Talk: Rad54 Protein Translocates and Cross-Bridges dsDNA to Stimulate the Synapsis Stage of Homologous Recombination

Minoru Takata, Radiation Biology Center, Japan
Interplay Between FANCD2, the Fanconi Anemia Core Complex, and FancJ in DNA Repair

John A. Tainer, The Scripps Research Institute, USA
The Double-Strand Break Repair Machinery

Les A. Hanakahi, University of Illinois at Chicago, Rockford Campus, USA
Short Talk: Inhibition of Non-Homologous End-Joining by Adenoviral Oncoproteins: Inactivation of DNA Repair Protein XRCC4

Graeme C. M. Smith, KuDOS Pharmaceuticals Ltd., UK
DNA Repair Pathways as Targets for Cancer Therapeutics

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
14:30—16:30
Workshop 2: Genomic Instability in Aging, Cancer and Genetic Disease

Peaks 1-5
* Judith Campisi, Buck Institute for Research on Aging, USA

Shan Zha, Columbia University Medical Center, USA

Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Positional Stability of Single Double Strand Breaks in Living Mammalian Cells

Kok Lung Chan, Weatherall Institute of Molecular Medicine, UK
The Localization of BLM Defines a Novel Class of Anaphase Bridges

Bin Wang, University of Texas MD Anderson Cancer Center, USA
Identification of a Novel Brca1 Associated Protein Complex that is Involved in the DNA Damage Response

Ciaran G. Morrison, National University of Ireland, Galway, Ireland
Distinct BRCT Domains in Mcph1/Brit1 Mediate Gamma-H2AX Interaction and Centrosomal Localisation

Patrick Ryan Potts, University of Texas Southwestern Medical Center, USA
Human SMC5/6 Complex Is Required for Telomere Recombination and Maintenance in ALT Cells

Susanna Maxwell Lewis, Harvard Medical School, USA
Coming and Going: Controlling Palindromy in Mammalian Genomes

Robert Hromas, University of New Mexico, USA
The Human Transposase Metnase Mediates NHEJ repair, HIV Integration, and Progression Through the Decatenation Cell Cycle Checkpoint

Patricia L. Opresko, University of Pittsburgh, USA
Processing of Telomere Ends by the Werner Syndrome Protein and Telomeric POT1 Protein

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Aging
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Human Premature Aging and DNA Repair

Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair in Cancer and Aging

Jung-Hyun Min, Memorial Sloan-Kettering Cancer Center, USA

JoAnn M. Sekiguchi, University of Michigan, USA
Short Talk: Dysfunctional Nuclease Activity Leads to Partial Immunodeficiency and Genomic Instability

Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Substantial Overlap in Acquired Chromosomal Aberrations in a Murine Model of Genomic Instability and Human Cancer

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 3

Peaks 14-17

SUNDAY, JANUARY 21

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Programmed Genomic Instability in the Immune Response
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* Nancy Maizels, University of Washington School of Medicine, USA
Molecular Mechanisms of Immunoglobulin Gene Diversification

Ronald Chalmers, University of Nottingham Medical School, UK
Short Talk: The Mechanism of Base Flipping and DNA Bending in V(D)J Recombination and DNA Transposition

Michael S. Neuberger, Medical Research Council, UK
Immunity through DNA Deamination

Myron F. Goodman, University of Southern California, USA
Biochemical Scanning Mechanisms of DNA Cytidine Deaminases AID and Apo3G

Katheryn D. Meek, Michigan State University, USA
Short Talk: The RAG Complex Physically Directs DSBs into the NHEJ Pathway

Bertrand Nadel, CNRS-INSERM - Universite de la Medditerranee, France
Reactive DNA Ends as Byproducts of Lymphocyte Receptor Construction

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Outcomes of Genomic Instability
Meeting has ended...abstracts no longer viewable online.

Peaks 1-5
* André Nussenzweig, NCI, National Institutes of Health, USA
Relationship between DNA Damage Detection and Signaling in Vivo

Jiri Bartek, Danish Cancer Society, Denmark
Coordination of DNA Repair with DNA Damage Checkpoints and Their Role in Cancer Pathogenesis

Chengming (Ben) Zhu, University of Texas MD Anderson Cancer Center, USA
Short Talk: Role of p53-Dependent Cell Cycle Arrest in Tumor Suppression

Peter J. McKinnon, St. Jude Children's Research Hospital, USA
Linking DNA Damage, Neurodegeneration and Brain Tumors

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
20:00—23:00
Entertainment

Peaks 14-17

MONDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA124284-01




We gratefully acknowledge additional support for this conference from:

Genentech, Inc. Novus Biologicals, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



KuDOS Pharmaceuticals Ltd.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676