Beaver Run Resort Floorplan

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This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Pathways in Cardiac Development and Disease (J3)


Organizer(s) Kenneth R. Chien, Eric N. Olson and Ketty Schwartz
January 22—27, 2007
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 22, 2006
Late Abstract Deadline: Oct 25, 2006
Scholarship Deadline: Sep 22, 2006
Early Registration Deadline: Nov 22, 2006

Supported by the Director's Fund


Summary of Meeting:
Over the past several years, it has become increasingly clear that converging biological pathways drive embryonic cardiovascular development and adult forms of human disease. The induction of embryonic gene programs has uncovered new molecular signals for cardiac disease and potential new therapeutic targets. Developmental defects in vasculogenesis and cardiovascular lineage specification have now been linked to cardiovascular diseases that present at the adult stage. Studies of cardiovascular stem cells underscore the value of insights derived from genetic pathways guiding formation of the distinct heart lineages to identify rare post-natal heart cells and the pathways that drive their formation, renewal, maturation and triggered differentiation into diverse cardiovascular cell lineages. In short, the barriers between development and disease in the cardiovascular setting are now largely erased. This meeting will highlight cutting edge work from a wide variety of investigators with expertise in diverse fields, ranging from pediatric to adult cardiology, developmental biology and physiology, and work in multiple model systems. The topics have been chosen to feature new approaches to mine disease genes, pathways, and therapeutic strategies by rigorous study of the developmental biology of the cardiovascular system.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 22

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 1 - 5
* Kenneth R. Chien, Karolinska Institutet, Sweden

* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA

James E. Rothman, Yale University School of Medicine, USA
Molecular Basis of Secretion and its Physiological Regulation


TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Peaks 6 - 12
08:00—11:30
Heart Progenitors and Regenerative Pathways
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Kenneth R. Chien, Karolinska Institutet, Sweden
Isl1 Cardiovascular Master Regulator

Kenneth D. Poss, Duke University Medical Center, USA
Cardiac Progenitor Activity during Zebrafish Heart Regeneration

Timothy C. Cox, University of Washington, USA
Regeneration of the Fetal Heart in a Model of Mitochondrial Respiratory Chain Deficiency

Jonathan A. Epstein, University of Pennsylvania, USA
HDAC2 Regulation of Cardiac Growth

Jean-Thomas Vilquin, INSERM, France
Short Talk: Cell Therapy and Heart Failure

Owen W. J. Prall, Victor Chang Cardiac Research Institute, Australia
Short Talk: An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Orchestrates Cardiac Progenitor Cell Specification and Proliferation in the Second Heart Field

Li Chen, University of Houston, USA
Short Talk: Characterization and Distribution of Tbx1-fated Cells in the Mature Heart Using a Novel Cre Knock-in Mouse Line

08:00—11:00
Cell Based Therapy I
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Stefanie Dimmeler, University of Frankfurt, Germany
Progenitor Cells for Cardiac Repair: Molecular Mechanisms and Clinical Application

Nadia A. Rosenthal, The Jackson Laboratory, USA
Growth Factors for Enhancement of Endogenous Repair

Bernhard Kühn, Children's Hospital of Pittsburgh, USA
Short Talk: Periostin-Stimulated Cardiomyocyte Proliferation Promotes Myocardial Regeneration

Michael D. Schneider, Imperial College London, UK
Cardiopoiesis: Mechanisms of Cardiac Myocyte Creation by Adult and Embryonic Progenitor Cells

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA
Chromatin Remodeling Complexes in Heart Development

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 14 - 17
13:00—22:00
Poster Viewing

Peaks 14 - 17
15:30—16:00
Coffee Available

Foyer
16:00—18:00
Cell Based Therapy Workshop Panel (Joint)

Peak 1 - 5
Nadia A. Rosenthal, The Jackson Laboratory, USA
Overview of Cardiac Stem Cell Therapy

Robert J. Schwartz, Texas A&M University, USA
Post-Translational Modification of Cardiovascular Transcriptional Factors: Roles for Sumoylation and Acetylation as Cardiogenic Molecular Switches

Stefanie Dimmeler, University of Frankfurt, Germany
Role of HDACs in Endothelial Specification

Jonathan A. Epstein, University of Pennsylvania, USA
Progressive Lineage Restriction

Elizabeth M. McNally, Northwestern University, USA
Cell Based Therapy for Striated Muscle

Michael D. Schneider, Imperial College London, UK

Kenneth R. Chien, Karolinska Institutet, Sweden

18:00—19:00
Social Hour with Lite Bites

Peaks 14 - 17
19:30—22:00
Poster Session 1

Peaks 14 - 17

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Peaks 6 - 12
08:00—11:15
Heart Failure and Arrhythmias (Joint)
Meeting has ended...abstracts no longer viewable online.

Peaks 1 - 5
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Molecular Basis for Treating Heart Failure and Arrhythmias

Yasuhiro Ikeda, Yamaguchi University School of Medicine, Japan
Short Talk: Translocation of Protein Phosphatase 1 Catalytic Subunit from Sarcoplasmic Reticulum to Cytosol Regulates Phospholamban Phosphorylation in Cardiomyocytes

Roger J. Hajjar, Mount Sinai School of Medicine, USA
Gene Therapy for Heart Failure: New Developments

Jennifer M. Davis, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Restrictive Cardiomyopathy Mutant Troponin I Results in Thin Filament-Mediated Pre-Contractile State and Blunted Contractile Reserve

* Eric N. Olson, University of Texas Southwestern Medical Center, USA
Control of Cardiac Gene Expression and Stress Responsiveness by a microRNA

Ivan P. Moskowitz, University of Chicago, USA
Short Talk: A Molecular Pathway Required for Cardiac Conduction System Development

Neil C. Chi, University of California, San Diego, USA
Short Talk: Zebrafish Cardiac Conduction/Rhythm Mutants: Cellular and Genetic Dissection of the Cardiac Electrical System

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14 - 17
13:00—22:00
Poster Viewing

Peaks 14 - 17
15:30—16:00
Coffee Available

Foyer
16:00—18:00
Heart Failure and Arrhythmias Workshop Panel (Joint)

Peak 1 - 5
Michael D. Schneider, Imperial College London, UK

Masafumi Yano, Yamaguchi University, Japan
Ryanodine Receptor Defects in Heart Failure

Stefan Janssens, University of Leuven, Belgium

Roger J. Hajjar, Mount Sinai School of Medicine, USA
Tracking & Delivery of Vectors & Stem Cells in Heart Failure

* Leslie A. Leinwand, University of Colorado Boulder, USA

Rolf Bodmer†, Sanford-Burnham Medical Research Institute, USA

Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA

Kenneth R. Chien, Karolinska Institutet, Sweden

Eric N. Olson, University of Texas Southwestern Medical Center, USA

18:00—19:00
Social Hour with Lite Bites

Peaks 14 - 17
19:30—22:00
Poster Session 2

Peaks 14 - 17

THURSDAY, JANUARY 25

07:00—08:00
Breakfast

Peaks 6 - 12
08:00—09:20
Bioengineering and Imaging Technologies
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
Kevin Kit Parker, Harvard University, USA
Structure-Function Relationships in Cardiac Myocytes

Joseph C. Wu, Stanford University School of Medicine, USA
Short Talk: "Molecular Imaging of Cardiovascular Stem Cell Therapy"

Gordana V. Vunjak-Novakovic, Columbia University, USA
Engineering a Contractile Cardiac Patch

08:00—11:00
Tissue Engineering
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Richard T. Lee, Harvard University, USA
Evidence that Stem Cells Refresh Cardiomyocytes Following Injury

Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Cardiac Tissue Engineering

Jeffrey A. Hubbell, University of Chicago, USA
Synthetic Biomaterials as Instructive Extracellular Microenvironments for Morphogenesis in Tissue Engineering

Thomas Langenickel, National Institutes of Health, USA
Short Talk: Deletion of KIS Accelerates Intimal Hyperplasia in Response to Vascular Injury and Enhances Migratory Activity of VSMC

09:00—09:20
Coffee Break

Foyer
09:20—11:15
Metabolic Diseases and the Heart
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
Daniel P. Kelly, University of Pennsylvania, USA
Metabolic Pathways for Cardiomyopathy

Robert E. Gerszten, Beth Israel Deaconess Medical Center, USA
Short Talk: Towards a Metabolomics Platform for Cardiovascular Disease

11:00—13:00
Poster Setup

Peaks 14 - 17
13:00—20:00
Poster Viewing

Peaks 14 - 17
17:00—20:00
Poster Session 3

Peaks 14 - 17
18:00—19:00
Social Hour with Lite Bites

Peaks 14 - 17
20:00—21:30
Workshop Panel on Tissue Engineering, Imaging and Devices (Joint)

Peak 1 - 5
Richard T. Lee, Harvard University, USA
Self Assembling Peptides for Cardiac Repair

Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Tissue Engineering: Bottlenecks and Perspectives

Karl Ludwig Laugwitz, Technical University Munich, Germany
Lineage Diversification of Embryonic Isl1+ Cardiovascular Progenitor Cells

* Daniel J. Garry, University of Minnesota, USA
Identification of Nkx2-5 Downstream Targets

16:00—18:00
Imaging and Devices for Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Smadar Cohen, Ben-Gurion University, Israel
Injectable Alginate: A New Strategy to Reload the Extracellular Matrix

Leslie A. Leinwand, University of Colorado Boulder, USA
A Tale of Two Diets: Diet Affects Cardiac Disease and Exercise

Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM), USA
Proteomic Mapping and Imaging of Vascular Endothelium & Its Caveolae for Tissue Targeting and Penetration


FRIDAY, JANUARY 26

07:00—08:00
Breakfast

Peaks 6 - 12
08:00—11:30
Genetic Pathways in Cardiac Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genomic Variation and the Inherited Basis of Common Disease

Aravinda Chakravarti, Johns Hopkins University School of Medicine, USA
Genetic Variants that Regulate QT Interval in Human Populations

Gisèle Bonne, INSERM UR 582, France
The Cardiac Laminopathy: From Gene Defects to Possible Pathomechanisms?

* Kevin P. Campbell, University of Iowa, USA
Maintenance of Muscle Cell Membrane Integrity

Brian L. Black, University of California, San Francisco, USA
Short Talk: Development of Cardiac Heart Fields

Ferhaan Ahmad, University of Iowa, USA
Short Talk: Cardiomyopathies Secondary to Cardiac Troponin T Mutations Result from Abnormal Protein Function Rather than Haploinsufficiency

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Polygentic Basis of Cardiac Disease in Flies

08:00—10:20
Chemical Genomics
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Virginia W. Cornish, Columbia University, USA
Trimethoprim Conjugates: A Chemical Surrogate to GFP for Live Cell Imaging

Mathias Uhlén, Royal Institute of Technology, Sweden
A Human Protein Atlas for Normal and Disease Tissues

Jules L. Griffin, University of Cambridge, UK
Metabolomics/metabonomics: NMR Spectroscopy and Pattern Recognition Analysis of Body Fluids and Tissues for Characterisation of Cardiovascular Disease Diagnosis

Timothy J. Aitman, MRC Clinical Sciences Centre, UK
A Systems Approach to Complex Cardiovascular Phenotypes

09:20—09:40
Coffee Break

Foyer
10:20—11:00
Drug Development
Meeting has ended...abstracts no longer viewable online.

Peak 5
* Virginia W. Cornish, Columbia University, USA

Timothy J. Aitman, MRC Clinical Sciences Centre, UK

15:30—16:00
Coffee Available

Foyer
16:00—17:00
Fetal Gene Program in Cardiac Development and Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 1-4
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA
Role of Micrornas during Cardiac Progenitor Selection and Cardiac Disease

Paul R. Riley, University of Oxford, UK
Thymosin beta4 Pathways for Coronary Arteriogenesis and Epicardial Progenitor Mobilisation

17:00—18:00
Workshop Panel in Cardiovascular Genetics (Joint)

Peak 1 - 5
Timothy J. Aitman, MRC Clinical Sciences Centre, UK
A Systems Approach to Complex Cardiovascular Phenotypes

* Gisèle Bonne, INSERM UR 582, France
Genetics Spectrum of Cardiac Laminopathies

Jonathan A. Epstein, University of Pennsylvania, USA

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease and University of California, San Francisco, USA

18:00—19:00
Social Hour with Lite Bites

Peaks 14 - 17
19:00—23:00
Entertainment

Peaks 14 - 17

SATURDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL087686-01




We gratefully acknowledge additional support for this conference from:

Boehringer Ingelheim Pharmaceuticals, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676