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This meeting took place in 2007



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Diabetes: Molecular Genetics, Signaling Pathways and Integrated Physiology (J1)


Organizer(s) Domenico Accili and Takashi Kadowaki
January 14—19, 2007
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 14, 2006
Late Abstract Deadline: Oct 17, 2006
Scholarship Deadline: Sep 14, 2006
Early Registration Deadline: Nov 14, 2006

Sponsored by Biovitrum AB


Summary of Meeting:
Diabetes is a growing threat to public health worldwide. Type 2 diabetes results from insulin resistance and impaired beta cell function. Studies of insulin signaling and its interactions with nutrient and hormonal pathways remain central to ongoing research efforts to combat diabetes and its complications. The pace of discovery has been especially brisk in several areas: the mechanisms of inflammation-induced insulin resistance; the role of mitochondrial biogenesis and oxidative capacity in the susceptibility to the metabolic syndrome; the “endocrine” function of adipocytes by way of adipocytokine production; the mechanistic integration of beta cell failure and insulin resistance; the role of neural circuits in energy balance; and the mechanisms by which “non-canonical” insulin target tissues contribute to the onset of diabetes. The conference will act as a catalyst for further progress by bringing together leaders in the academic and pharmaceutical communities to present the latest developments in their research.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 14

15:00—19:30
Registration

Shavano Foyer
18:30—19:30
Refreshments

Longs Peak Foyer
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA

* Domenico Accili, Columbia University, USA

Bruce M. Spiegelman, Harvard Medical School, USA
PGC-1 Coactivators and the Control of Energy Homeostasis

D. Grahame Hardie, University of Dundee, UK
Sensing of Energy and Nutrients by the AMP-Activated Protein Kinase System


MONDAY, JANUARY 15

07:00—08:00
Breakfast

Crestone/ Red Cloud/ Shavano
08:00—11:00
Regulation of Neuronal Growth and Signaling (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Marc L. Reitman, NIDDK, National Institutes of Health, USA

Jeffrey M. Friedman, Rockefeller University, USA
Leptin and Neural Networks

Jeffrey Flier, Harvard University, USA
Alternative Approaches to the Central Regulation of Energy Balance: Neurogenesis

Richard B. Simerly, Vanderbilt University, USA
Leptin Signaling and Hypothalamic Development

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Brain Irs2 Signaling in Life-Span and Nutrient Homeostasis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Crestone/ Red Cloud/ Shavano
13:00—22:00
Poster Viewing

Crestone/ Red Cloud/ Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Adipokines
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Morris F. White, Boston Children's Hospital, Harvard Medical School, USA

Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors

Rexford S. Ahima, University of Pennsylvania, USA
Resistin

Bente Klarlund Pedersen, Rigshospitalet, Denmark
Cytokines, Metabolism and Exercise

Zhen Y. Jiang, Sanford-Burnham Medical Research Institute, USA
Short Talk: Rab3A is Required for Constitutive and Insulin-Stimulated Secretion of Adiponectin

17:00—19:00
The Role of the Gut in Energy Balance
Meeting has ended...abstracts no longer viewable online.

Quandary 1-3
* Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany

Daniele Piomelli, University of California, Irvine, USA
Oleoylethanolamide: Links Dietry Fat Absorption to Satiety

Mark Friedman, Monell Center, USA
Hepatic Control of Feeding Behavior: Low Liver Energy Status as a Stimulus for Overeating

Svetlana E. Nikoulina, Amylin Pharmaceuticals Inc., USA
Short Talk: Characterization of Gene Expression and Peptide Secretion in Primary Explant Cultures Generated from Colonic Crypts of Adult Mice

Haruka Okamoto, Regeneron Pharmaceuticals, Inc., USA
Short Talk: Proglucagon Deficient (PGCG-/-) Mice Exhibit a Predominate Metabolic Phenotype; Increased Body Weight and Food Intake with Accompanied Decrease in Energy Expenditure

Feifan Guo, Institute for Nutritional Sciences, China
Short Talk: GCN2 eIF2alpa Kinase Regulates Fatty Acid Homeostasis in the Liver During Deprivation of an Essential Amino Acid

19:00—20:00
Social Hour with Lite Bites

Crestone/ Red Cloud/ Shavano
19:30—22:00
Poster Session 1

Crestone/ Red Cloud/ Shavano

TUESDAY, JANUARY 16

07:00—08:00
Breakfast

Crestone/ Red Cloud/ Shavano
08:00—11:00
Nutrient Sensing (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Stephen O'Rahilly, University of Cambridge, UK

Luciano Rossetti, Merck Research Laboratories, USA
Hypothalamic Nutrient Sensing and Liver Glucose Metabolism

Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Glucose-Sensing in Beta-Cells and POMC Neurons: Defects in Obesity and Role of UCP2

Bernard Thorens, University of Lausanne, Switzerland
Central Glucose Sensing in the Control of Feeding and Energy Expenditure

Randy J. Seeley, University of Michigan, USA
The Role of mTOR in the Hypothalamic Control of Food Intake and Body Weight

Jeong Ho Kim, The Salk Institute, USA
Short Talk: mTOR Mediates IL-6-induced Insulin Resistance by Regulating STAT3/SOCS3

Sean H. Adams, University of Arkansas for Medical Sciences, USA
Short Talk: Tusc5, a Temperature-Sensitive PPARgamma-Responsive Adipocyte Gene Co-Expressed in Somatosensory Neurons

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Crestone/ Red Cloud/ Shavano
13:00—22:00
Poster Viewing

Crestone/ Red Cloud/ Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mechanisms of beta Cell Failure in Diabetes
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Anna Krook, Karolinska Institutet, Sweden

Daniel J. Drucker, Lunenfeld-Tanenbaum Research Institute, Canada
Physiological Role and Therapeutic Potential of Incretins in Modulating Beta Cell Survival

Lori Sussel, University of Colorado, USA
Islet Cell Development

Masato Kasuga, National Center for Global Health and Medicine, Japan
Insulin Signaling in Pancreatic beta Cells

Jun Ding, Model Animal Research Center, China
Short Talk: Mutation of PAX6 Leads to Down-Regulation of GLP-1 Causing Insufficient Insulin Secretion and Islet Defect

17:00—19:15
Integration in the Central Nervous System
Meeting has ended...abstracts no longer viewable online.

Quandary 1-3
* Deborah Clegg, Cedars-Sinai Medical Center, USA

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Pathways Regulating Body Weight and Glucose Homeostasis

Ronald M. Lechan, Tufts-New England Medical Center, USA
Arcuate to Paraventricular Nucleus Signals and Control of the Hypothalamic-Pituitary-Thyroid Axis

Sharon L. Wardlaw, Columbia University College of Physicians and Surgeons, USA
The Hypothalamic Melanocortin System: Regulation of Energy Balance and Neuroendocrine Function

Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Short Talk: Food Reward and Obesity: Accumbens-Hypothalamic Pathway and Orexin Signaling Drive High-Fat Intake

Pavlos Pissios, Beth Israel Deaconess Medical Center, USA
Short Talk: Regulation of the Mesolimbic Dopamine System by Melanin-Concentrating Hormone

19:00—20:00
Social Hour with Lite Bites

Crestone/ Red Cloud/ Shavano
19:30—22:00
Poster Session 2

Crestone/ Red Cloud/ Shavano

WEDNESDAY, JANUARY 17

07:00—08:00
Breakfast

Crestone/ Red Cloud/ Shavano
08:00—11:00
Modulation of Gene Function / Gene Expression (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Takashi Kadowaki, University of Tokyo, Japan

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Retinol Binding Protein 4 and Insulin Resistance

David D. Moore, Baylor College of Medicine, USA
Diabetes, Drug Metabolism and Vice Versa

Catherine Postic, Institut Cochin, France
Role of ChREBP in the Physiopathology of Obesity and Insulin Resistance

Marc R. Montminy, The Salk Institute for Biological Studies, USA
The TORC Family of CREB Coactivators: Regulators of Energy Balance

Michihiro Matsumoto, Diabetes Research Center, National Center for Global Health and Medicine, Japan
Short Talk: Central Role of the Transcription Factor FoxO1 in Hepatic Glucose Metabolism

Jean Francois Louet, Centre Méditerranéen de Médecine Moléculaire-C3M, France
Short Talk: The Coactivator SRC-3 is a Critical Regulator of the White Adipogenic Program

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Crestone/ Red Cloud/ Shavano
13:00—22:00
Poster Viewing

Crestone/ Red Cloud/ Shavano
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
* Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA

Alan R. Tall, Columbia University, USA
Insulin Resistance and Atherosclerosis in Insulin Receptor Deficient Mice

Karin E. Bornfeldt, University of Washington School of Medicine, USA
Diabetes and Lesion Initiation and Progression in the LDL Receptor-Deficient Mouse

Christopher K. Glass, University of California, San Diego, USA
Anti-Inflammatory and Antidiabetic Roles of PPAR in Macrophages

Bai Luo, University of Utah, USA
Short Talk: Protein O-GlcNAc Modification Reduces Angiogenesis in Endothelial Cells

17:00—19:00
Nutrient Sensing
Meeting has ended...abstracts no longer viewable online.

Quandary 1-3
* Yoshihiro Ogawa, Kyushu University, Japan

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Signaling through the mTORC1 and mTORC2 Pathways

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Restriction Response Controlled through PGC-1a/SIRT1 Transcriptional Complexes

Ralph DiLeone, Yale University School of Medicine, USA
Short Talk: Leptin Regulates Food Intake via Action on Dopamine Neurons of the Ventral Tegmental Area

Gina M. Leinninger, Michigan State University, USA
Short Talk: Leptin Activates a Novel Population of LRb-Expressing Lateral Hypothalamic Neurons that Innervate the Ventral Tegmental Area

Kamal N. Bharucha, University of California, Los Angeles, USA
Short Talk: Regulation of Energy Homeostasis by the Drosophila AKH Receptor

19:00—20:00
Social Hour with Lite Bites

Crestone/ Red Cloud/ Shavano
19:30—22:00
Poster Session 3

Crestone/ Red Cloud/ Shavano

THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Crestone/ Red Cloud/ Shavano
08:00—11:15
Mitochondria (Joint)
Meeting has ended...abstracts no longer viewable online.

Columbine Ballroom
* Juleen R. Zierath, Karolinska Institutet, Sweden

Robert S. Garofalo, , USA
Nutrient Regulation of Energy Metabolism in Drosophila

Tamas L. Horvath, Yale School of Medicine, USA
UCPs

Kitt F. Petersen, Yale University School of Medicine, USA
Mitochondria in Aging and Diabetes

Vamsi K. Mootha, Massachusetts General Hospital, USA
Systems Analysis of Mitochondrial Dysfunction in Human Diabetes

Ruojing Yang, Merck & Co. Inc., USA
Short Talk: Targeting Insulin Resistance with RNA Interference

Mathias Treier, Max-Delbrueck-Center for Molecular Medicine, Germany
Short Talk: Identification of a Transcriptional Regulator Required for Locomotor Activity and Hyperphagia

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Insulin Action
Meeting has ended...abstracts no longer viewable online.

Grays/Longs Peak
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Critical Nodes in Insulin Signaling and Insulin Resistance

Alan R. Saltiel, UC, San Diego, USA
G Proteins as Signal Integrators in the Regulation of Glucose Transport

* Rudolph L. Leibel, Columbia University, USA
Selected Shorts

William L. Holland, University of Texas Southwestern Medical Center, USA
Short Talk: Ceramide Involvment in Saturated Fat and Glucocorticord Induced Insulin Resistance

17:00—19:00
Genes versus Diet
Meeting has ended...abstracts no longer viewable online.

Quandary 1-3
* Eric Ravussin, Louisiana State University, Pennington Biomedical Research Center, USA

I. Sadaf Farooqi, University of Cambridge, UK
Insights from Genetic Disruption of the Leptin-Melanocortin Pathway in Humans

Donald J. Marsh, Merck Research Laboratories, USA
Validating Central Obesity Targets

John Speakman, Institute of Genetics and Developmental Biology, CAS, China
The Evolutionary Context of the Modern Obesity Epidemic

19:00—20:00
Social Hour with Lite Bites

Crestone/ Red Cloud/ Shavano
20:00—23:00
Entertainment

Crestone/Red Cloud/ Shavano

FRIDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK076500-01




We gratefully acknowledge additional support for this conference from:

ALPCO Diagnostics Biovitrum AB
Cell Signaling Technology, Inc. Isis Pharmaceuticals, Inc.
JDRF
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Abbott Laboratories


Merck Research Laboratories


Pfizer Inc.


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