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This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Nuclear Receptor Pathways to Metabolic Regulation (Z1)


Organizer(s) Mitchell A. Lazar and Richard A. Heyman
March 27—April 1, 2007
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Nov 27, 2006
Late Abstract Deadline: Dec 28, 2006
Scholarship Deadline: Nov 27, 2006
Early Registration Deadline: Jan 29, 2007

Supported by the Director's Fund


Summary of Meeting:
The most exciting current research on nuclear receptors and metabolism takes a systems approach, utilizing functional genomics, molecular biology, and bioinformatics to understand the role of nuclear receptors in physiology and in the pathophysiology of metabolic diseases such as obesity, diabetes ,and metabolic syndrome. The major roadblocks to this research include the biological variation and technical precision of the state-of-art-measures of RNA, protein, and gene occupation by transcription factors, and the ability to accurately relate changes in nuclear receptor ligands and abundance to phenotypic changes. The goal of this meeting is to bring together investigators working on different nuclear receptors, and the regulation of different metabolic pathways, to present the latest and most exciting paradigmatic and technical breakthroughs.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 27

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session: Clinical and Epidemiological Definition of the Metabolic Syndrome (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Bart Staels, Institut Pasteur de Lille, Université Lille, France

* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Gerald M. Reaven, Stanford University, USA
Insulin Resistance and the Many Faces of the Metabolic Syndrome

Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Obesity, Risk Factors and CV Disease: NHLBI Perspectives


WEDNESDAY, MARCH 28

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
NR and the MS I (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom
* Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA

Christopher K. Glass, University of California, San Diego, USA
Nuclear Receptors, Inflammation, and metabolic syndrome

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Energy Homeostasis and Metabolic Disease

Peter Tontonoz, University of California, Los Angeles, USA
PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Sunrise/Sunshine
13:00—22:00
Poster Viewing

Rainbow/Twilight/Sunrise/Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:00
NR Coregulators and Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
NR Corepressors and Metabolism

Malcolm G. Parker, Imperial College London, UK
Regulation of Metabolic Gene Networks by the RIP140 Transcriptional Cofactor

Ajay Chawla, University of California, San Francisco, USA
PPARs, Macrophage Activation and Insulin Resistance

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
Short Talk: The LKB1/AMPK Pathway Controls Key Transcriptional Programs

17:00—19:00
Novel Therapeutics for the MS
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Dawn M. Waterworth, GlaxoSmithKline, USA

Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome

Anne-Marie Galzin, Sanofi-Aventis Research & Development, France
The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors

Bei B. Zhang, Pfizer Inc., USA
Targeting the Glucagon Receptor for Glycemia Control and Beyond

Shin-ichiro Imai, Washington University School of Medicine, USA
Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme

19:00—20:00
Social Hour with Lite Bites

Rainbow/Twilight/Sunrise/Sunshine
19:30—22:00
Poster Session 1

Rainbow/Twilight/Sunrise/Sunshine

THURSDAY, MARCH 29

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
Nuclear Receptors and Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* Thomas P. Burris, Saint Louis University School of Medicine, USA

Vincent Giguère, McGill University, Canada
Genome-wide orchestration of cardiac energetics and functions by orphan nuclear receptors ERRalpha and gamma

Richard A. Heyman, ORIC Pharmaceuticals, USA
Targeting Metabolic Syndrome with Selective PPARgamma Agonist: Discovery and Clinical Development

Jorge Plutzky, Brigham and Women's Hospital, USA
PPARs and Lipases

Peter A. Edwards, UCLA, USA
FXR Modulates Lipid and Glucose Metabolism

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: PPARg Regulates Immune Cell Function by Turning on Retinoic Acid Synthesis and RAR-Dependent Gene Expression in Developing Human Dendritic Cells

08:00—11:15
Hepatic Steatosis: Cause or Consequence of the MS?
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Anna Krook, Karolinska Institutet, Sweden

Hannele Yki-Järvinen, University of Helsinki, Finland
Clinical Relevance and Pathogenesis of Hepatic Steatosis

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism

Jay D. Horton, University of Texas Southwestern Medical Center, USA
SREBPs and Components of the Metabolic Syndrome

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome

Carl de Luca, , USA
Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance

Kristiaan Wouters, Maastricht University, Netherlands
Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Sunrise/Sunshine
13:00—22:00
Poster Viewing

Rainbow/Twilight/Sunrise/Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:00
NRs and Energy Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* Susanne Mandrup, University of Southern Denmark, Denmark

Anastasia Kralli, Johns Hopkins Medical School, USA
ERRalpha, a Regulator of Mitochondrial Biogenesis and Adaptive Metabolism

Keith L. Parker, University of Texas Southwestern Medical Center, USA
Brain-Specific Inactivation of Steroidogenic Factor 1 Causes a Metabolic Syndrome and Anxiety-like Behavior

David D. Moore, Baylor College of Medicine, USA
SHP and Energy Metabolism, Bile Acids and Circadian Rhythm

Shamina M. Rangwala, Janssen, Johnson & Johnson, USA
Short Talk: Mice Overexpressing PGC-1alpha in Muscle Display Alterations in Fuel Selection and Oxidative Capacity

17:00—19:00
Cardiovascular Disease in the MS
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Nikolaus Marx, University Hospital Aachen, Germany

Daniel S. Ory, Washington University, USA
Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis

Gwendalyn J. Randolph, Washington University, USA
Monocyte Subpopulations: Evaluating their Roles

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms

Martin E. Young, University of Alabama at Birmingham, USA
Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function

19:00—20:00
Social Hour with Lite Bites

Rainbow/Twilight/Sunrise/Sunshine
19:30—22:00
Poster Session 2

Rainbow/Twilight/Sunrise/Sunshine

FRIDAY, MARCH 30

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
NRs and Glucose Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* Andrea L. Hevener, University of California, Los Angeles, USA

Joyce J. Repa, University of Texas Southwestern Medical Center, USA
Nuclear Hormone Receptors and the Endocrine Pancrease: LXRs and Glucose Metabolism

Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
HNF-4alpha in beta-cell proliferation and glucose homeostasis.

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Co-Factors to Coordinate Energy Expenditure

Frank J. Gonzalez, National Institutes of Health, USA
PPARalpha Control of Hepatic Gene Expression and Carcinogenesis

Enrique Saez, The Scripps Research Institute, USA
Short Talk: The Oxysterol Receptor LXR is a Glucose Sensor

08:00—11:15
Energy Metabolism, Mitochondrial Function and Lipotoxicity in the MS
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Dennis Bruemmer, University of Kentucky, USA

Jean E. Schaffer, Washington University School of Medicine, USA
Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome

Robert V. Farese Jr., Harvard School of Public Health, USA
Metabolic Syndrome and Triglyceride Synthesis

Mary-Elizabeth Patti, Joslin Diabetes Center, USA
PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk

Karen Reue, University of California, Los Angeles, USA
The Role of Lipin Proteins in Metabolism

Peter A. Crawford, University of Minnesota, USA
Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota

Martin S. Obin, JMUSDA-HNRCA, Tufts University, USA
Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Rainbow/Twilight/Sunrise/Sunshine
13:00—22:00
Poster Viewing

Rainbow/Twilight/Sunrise/Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:00
NR and the MS II (Joint)
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
* Sander Kersten, Wageningen University, Netherlands

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nuclear Receptors and FGFs: The New Endocrinology of Metabolism

Takashi Kadowaki, University of Tokyo, Japan
Adiponectin, PPARs, IRSs, and Metabolic Syndrome

Daniel P. Kelly, University of Pennsylvania, USA
PPARs and Striated Muscle Lipid Metabolism

19:00—20:00
Social Hour with Lite Bites

Rainbow/Twilight/Sunrise/Sunshine
19:30—22:00
Poster Session 3

Rainbow/Twilight/Sunrise/Sunshine

SATURDAY, MARCH 31

07:00—08:00
Breakfast

3 Saddles/Bear River
08:00—11:00
New Insights into NRs and Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* Edwin R. Sanchez, University of Toledo College of Medicine, USA

Beatrice Desvergne, University of Lausanne, Switzerland
PPARbeta/delta in Gut Homeostasis

Timothy M. Willson, GlaxoSmithKline, USA
Orphan Nuclear Receptors: Drug Targets for Metabolic Diseases

Holly A. Ingraham, University of California, San Francisco, USA
Nuclear Receptors in Metabolism (in the CNS)

Jan-Åke Gustafsson, University of Houston, USA
Estrogen Signaling in Glucose Homeostasis

Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: LXRalpha Represses Uncoupling Protein-1 Gene Transcription and Mitochondriogenesis in Adipocytes.

08:00—11:15
Signaling Cascades in the MS
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Matthew Watt, Monash University, Australia

Juleen R. Zierath, Karolinska Institutet, Sweden
Targeting Signaling Cascades in Insulin Resistance

Gökhan S. Hotamisligil, Harvard University, USA
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

D. Grahame Hardie, University of Dundee, UK
Role of the AMPK System in the Metabolic Syndrome

Yannick Le Marchand-Brustel, INSERM, France
Defects in Insulin Signaling in Metabolic Syndrome

Daniel Lindén, AstraZeneca, Sweden
Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism

Giovanni Solinas, University of California, San Diego, USA
Short Talk: JNK in Macrophages Plays a Key Role in the Development of Obesity-Induced Insulin Resistance

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Classical NRs and Metabolism
Meeting has ended...abstracts no longer viewable online.

Mt Werner/Storm Peak
* John D. Baxter, University of California, San Francisco, USA
Using the Thyroid Hormone Receptor to Attack the Metabolic Syndrome

Jacques Samarut, Centre National de la Recherche Scientifique, France
Thyroid Hormone Receptors in the Control of Fat Metabolism

Antonio C. Bianco, University of Miami Miller School of Medicine, USA
Regulation of TR Ligand Production

Françoise Gofflot, , France
Short Talk: MousePat or Systematic Expression Mapping of Nuclear Receptors in the Mouse Brain

17:00—19:00
Dyslipidemia of the MS: The Atherogenic Triad
Meeting has ended...abstracts no longer viewable online.

Sunshine
* Ira J. Goldberg, New York University, USA

Henry N. Ginsberg, Columbia University College of Physicians and Surgeons, USA
Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma

Fred W. Turek, Northwestern University, USA
Circadian Control of Sleep and Energy Balance

Bart Staels, Institut Pasteur de Lille, Université Lille, France
FXR: A Target For The Metabolic Syndrome?

Brian N. Finck, Washington University School of Medicine, USA
Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion

20:00—21:00
Social Hour with Lite Bites

Rainbow/Twilight/Sunrise/Sunshine
20:00—23:00
Entertainment

Storm Peak/Sunshine/Mt. Werner

SUNDAY, APRIL 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK076500-01




We gratefully acknowledge additional support for this conference from:

Ariadne Genomics Invitrogen Corporation
Novus Biologicals, Inc. Seahorse Bioscience, Inc.
Takeda Pharmaceuticals America, Inc.
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline


Kalypsys, Inc.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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