Sagebrush Inn & Suites Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2007



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Mechanisms of Neurodegeneration (A4)


Organizer(s) Harry T. Orr, Stephen T. Warren and Huda Y. Zoghbi
January 16—21, 2007
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Sep 18, 2006
Late Abstract Deadline: Oct 19, 2006
Scholarship Deadline: Sep 18, 2006
Early Registration Deadline: Nov 16, 2006

Supported by the Director's Fund

Summary of Meeting:
Evidence is accumulating that in chronic neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are due to a combination of events triggered by expression and accumulation of misfolded proteins that impair neuronal function. More recent developments have shown that, in certain diseases, a mutant RNA triggers the formation of nuclear inclusions and pathogenesis. In this meeting, emphasis will placed on understanding cellular pathways that are implicated in some of the more common and intriguing neurodegenerative disorders, with the aim of providing a foundation for their treatment.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 16

15:00—19:30
Registration

Chamisa Lobby
18:30—19:30
Refreshments

Chamisa Lobby
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Hidde L. Ploegh, Boston Children's Hospital, USA
Cellular Response to Misfolded Proteins


WEDNESDAY, JANUARY 17

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Misfolded Proteins and Neurodegenerative Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Harry T. Orr, University of Minnesota, USA

Richard I. Morimoto, Northwestern University, USA
Protein Misfolding in Aging and Neurodegenerative Diseases

Nancy M. Bonini, University of Pennsylvania, USA
Drosophila as a Model for Human Neurodegenerative Disease: Modifier Pathways of Ataxin-3 Toxicity

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
The Role of Protein Conformation and Interactions in SCA1 Pathogenesis

Ron R. Kopito, Stanford University, USA
Ubiquitin in Neurodegnerative Disease

Yong Shen, Sun Health Research Institute, USA
Short Talk: Novel Roles of Complement C1q Protein in Amyloid Beta Protein Clearance

Rishi Rakhit, University of Toronto, Canada
Short Talk: An Immunological Epitope Selective for Pathological Monomer/Misfolded SOD1 in ALS

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Cellular Pathways in Neurodegenerative Disease-I (AD)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Nancy M. Bonini, University of Pennsylvania, USA

Thomas C. Südhof, Stanford School of Medicine, USA
Synuclein: Normal Function vs. Neurodegeneration

Karen Hsiao Ashe, University of Minnesota, USA
Amyloid-β Molecules Impairing Memory in Alzheimer's Disease

Lawrence S. B. Goldstein, University of California, San Diego, USA
Axonal Transport and Neurodegeneration in AD

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, JANUARY 18

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Cellular Pathways in Neurodegenerative Disease II (PD)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Karen Hsiao Ashe, University of Minnesota, USA

Ted M. Dawson, Johns Hopkins University School of Medicine, USA
The Role of Defective Genes in Parkinson’s Disease

Asa Abeliovich, Columbia University, USA
Making and Saving Dopamine Neuron

Jie Shen, Harvard Medical School, USA
Dopaminergic Circuit Dysfunction and Parkinson’s Disease

Ming Guo, University of California, Los Angeles, USA
Short Talk: Drosophila Pink1 is Required for Mitochondrial Function and Interacts Genetically with Parkin

Patrick A. Lewis, University of Reading, UK
Short Talk: Biochemical Analysis of LRRK2

S. Pablo Sardi, Children's Hospital Boston, USA
Short Talk: Presenilin-Dependent erbB4 Nuclear Signaling Regulates Neural Stem Cell Fate Choices

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Prion Disease: Basic Biology & Therapy
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Richard I. Morimoto, Northwestern University, USA

Joan Durbin, New York University, USA
Intra- and Inter-Molecular Modifiers of PolyQ Toxicity

Mathias Florian Heikenwälder, German Cancer Research Center, DKFZ, Germany
Peripheral Prion Pathogenesis

Jeppe Pedersen Falsig, IRBM Promidis, Italy
Short Talk: Prion Replication in Organotypic Slice Cultures in the Absence of Microglia

Sam Saghafi, University of California, San Francisco, USA
Short Talk: Conformational Heterogeneity of PrPC Regulates Pro- and Anti-Apoptotic Functions in Health and Disease

Giovanna R. Mallucci, University of Leicester, UK
Short Talk: Targeting Cellular Prion Protein Reverses Early Cognitive Deficits in Prion-Infected Mice

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, JANUARY 19

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Cellular Pathways in Neurodegenerative Disease III (HD)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA

Michael R. Hayden, University of British Columbia and Teva Pharmaceutical Industries Ltd., Canada
Proteolysis of Huntingtin and its Role in the Pathogenesis of Huntington Disease

Marcy E. MacDonald, Massachusetts General Hospital, USA
Huntington's Disease Genetic Modifiers

Elena Cattaneo, University of Milano, Italy
Huntingtin Function in Huntington's Disease

Xiao-Jiang Li, Emory University School of Medicine, USA
Glial Pathology in HD

Marc I. Diamond, University of Texas Southwestern Medical Center, USA
Short Talk: Profilin, a Target of p160ROCK, Inhibits Polyglutamine Aggregation and Toxicity

Lisa M. Imboden, Emory University School of Medicine, USA
Short Talk: Interaction of TorsinA with Novel Protein Printor is Disrupted by Dystonia-Associated Mutation

Ronald D. McKay, Lieber Institute for Brain Development, USA
Short Talk: The Floor Plate Forkhead Gene, foxa2, Is Required for the Differentiation and Survival of Midbrain Dopamine Neurons

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
RNA-Mediated Neurodegenerative Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA

Maurice S. Swanson, University of Florida, USA
RNA, Muscleblind and Myotonic Dystrophy

Thomas A. Cooper, Baylor College of Medicine, USA
Disruption of Developmentally Regulated Alternative Splicing in Myotonic Dystrophy

Stephen T. Warren, Emory University School of Medicine, USA
Fragile X-Associated Tremor/Ataxia Syndrome

Jean-Marc Gallo, King's College London, UK
Short Talk: Characterization of the Neuronal RNA-Binding Protein CELF3, a Modulator of Tau Exon 10 Alternative Splicing

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, JANUARY 20

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Cellular Pathways in Neurodegenerative Disease IV
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Stephen T. Warren, Emory University School of Medicine, USA

Don W. Cleveland, University of California, San Diego, USA
Mechanisms of Motor Neuron Death in ALS: A Gene Therapy for Human Neurodegenerative Disease

Laura Ranum, University of Florida, USA
Neurodegenerative Pathways: Lessons from the Ataxias

Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
TDP-43 is the Disease Protein Ubiquitinated in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Robert B. Darnell, HHMI/Rockefeller University, USA
RNA and Splicing Regulation in Neurologic Disease

Stanley H. Appel, Methodist Neurological Institute, USA
Short Talk: Do Microglia Contribute to the Pathogenesis of Motor Neuron Injury and Repair?

Yang Lu, Johns Hopkins University, USA
Short Talk: Targeting of Viral Vectors to Motor Neurons by Botulinum Toxin Binding Domain to Treat ALS

09:20—09:40
Coffee Break

Chamisa Lobby
16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Therapeutic Approaches to Neurodegenerative Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Don W. Cleveland, University of California, San Diego, USA

Toni Williamson, Amgen, Inc., USA
Beta-Secretase

Beverly L. Davidson, Children’s Hospital of Philadelphia and The University of Pennsylvania, USA
RNAi Approaches in Neurodegenerative Disease

Jeffrey D. Rothstein, Johns Hopkins University, USA
ALS: Development of Small Molecule, Protein and Cellular Therapeutics

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, JANUARY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 NS056841-01




We gratefully acknowledge additional support for this conference from:

Alzheimer's Drug Discovery Foundation Educational donation provided by Amgen
National Ataxia Foundation Novus Biologicals, Inc.

Alzheimer's Association

 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Educational donation provided by Amgen


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676